LeopoldoNicolasSegalMD

PubMed

• Vive la Resistome: Are We Ready for a Metagenomics Revolution in Bronchiectasis?
  Shivani Singh, Leopoldo N Segal> ;American Journal of Respiratory and Critical Care Medicine. 2024 Mar 26
• Longitudinal Lower Airway Microbial Signatures of Acute Cellular Rejection in Lung Transplantation.
  Natalini, J., Wong, K., Nelson, N., Wu, B., Rudym, D., Lesko, M., Qayum, S., Lewis, T., Wong, A., Chang, S., Chan, J., Geraci, T., Li, Y., Wang, C., Li, H., Pamar, P.,...> ;American Journal of Respiratory and Critical Care Medicine. 2024 Feb 15
• Faecal microbial transfer and complex carbohydrates mediate protection against COPD.
  Kurtis F Budden, Shakti D Shukla, Kate L Bowerman, Annalicia Vaughan, Shaan L Gellatly, David L A Wood, Nancy Lachner, Sobia Idrees, Saima Firdous Rehman, Alen Faiz, V...> ;Gut. 2024 Apr 5
• Looking Beyond the Lower Airways for Microbes Affecting Pulmonary Fibrosis.
  Darawshy, F., Molyneaux, P., Segal, L.> ;American Journal of Respiratory and Critical Care Medicine. 2024 Jan 16
• Pulmonary microbiome and transcriptome signatures reveal distinct pathobiologic states associated with mortality in two cohorts of pediatric stem cell transplant patie...
  Gertz, S. J., Gertz, S. J., Hanisch, B. R., Matt S Zinter, Christopher C Dvorak, Madeline Y Mayday, Gustavo Reyes, Miriam R Simon, Emma M Pearce, Hanna Kim, Peter J Sh...> ;Medrxiv. 2023 Nov 29
• Inflammation in the tumor-adjacent lung as a predictor of clinical outcome in lung adenocarcinoma.
  Igor Dolgalev, Hua Zhou, Nina Murrell, Hortense Le, Theodore Sakellaropoulos, Nicolas Coudray, Kelsey Zhu, Varshini Vasudevaraja, Anna Yeaton, Chandra Goparaju, Yonghu...> ;Nature Communications. 2023 Nov 8
• 4 citations
  Lower Airway Dysbiosis Augments Lung Inflammatory Injury in Mild-to-Moderate Chronic Obstructive Pulmonary Disease.
  Imran Sulaiman, Benjamin G Wu, Matthew Chung, Bradley Isaacs, Jun-Chieh J Tsay, Meredith Holub, Clea R Barnett, Benjamin Kwok, Matthias C Kugler, Jake G Natalini, Shiv...> ;American Journal of Respiratory and Critical Care Medicine. 2023 Nov 15
• Correcting dysbiosis in the lungs of COPD, one pathogen at a time.
  Kendrew K Wong, Leopoldo N Segal> ;Cell Host & Microbe. 2023 Jun 14
• Microbial Inflammatory Networks in Bronchiectasis Exacerbators With Pseudomonas aeruginosa.
  Andrea Gramegna, Jayanth Kumar Narayana, Francesco Amati, Anna Stainer, Benjamin Wu, Letizia Corinna Morlacchi, Leopoldo N Segal, Krasimira Tsaneva-Atanasova, Paola Ma...> ;Chest. 2023 Jul 1
• 4 citations
  Perceived Hospital Stress, Severe Acute Respiratory Syndrome Coronavirus 2 Activity, and Care Process Temporal Variance During the COVID-19 Pandemic.
  George L Anesi, Adair Andrews, He Julia Bai, Pavan K Bhatraju, David M Brett-Major, M Jana Broadhurst, Elizabeth Salvagio Campbell, J Perren Cobb, Martin Gonzalez, Son...> ;Critical Care Medicine. 2023 Apr 1
• 1 citations
  Pleural fluid microbiota as a biomarker for malignancy and prognosis.
  Kwok, B., Wu, B., Kocak, I., Sulaiman, I., Schluger, R., Li, Y., Anwer, R., Goparaju, C., Ryan, D., Sagatelian, M., Dreier, M., Murthy, V., Rafeq, S., Michaud, G., Ste...> ;Scientific Reports. 2023 Feb 8
• 5 citations
  Angiopoietin-Like4 Is a Novel Marker of COVID-19 Severity.
  Pavan K Bhatraju, Eric D Morrell, Ian B Stanaway, Neha A Sathe, Avantika Srivastava, Radu Postelnicu, Richard Green, Adair Andrews, Martin Gonzalez, Christopher J Krat...> ;Critical Care Explorations. 2023 Jan 1
• 1 citations
  More thansite-of-disease microbial communities, and their functional and clinical profiles in tuberculous lymphadenitis.
  Georgina R Nyawo, Charissa C Naidoo, Benjamin Wu, Imran Sulaiman, Jose C Clemente, Yonghua Li, Stephanie Minnies, Byron W P Reeve, Suventha Moodley, Cornelia Rautenbac...> ;Thorax. 2023 Mar 1
• 68 citations
  The dynamic lung microbiome in health and disease.
  Jake G Natalini, Shivani Singh, Leopoldo N Segal> ;Nature Reviews. Microbiology. 2023 Apr 1
• 13 citations
  The lung microbiome, peripheral gene expression, and recurrence-free survival after resection of stage II non-small cell lung cancer.
  Brandilyn A Peters, Harvey I Pass, Robert D Burk, Xiaonan Xue, Chandra Goparaju, Christopher C Sollecito, Evan Grassi, Leopoldo N Segal, Jun-Chieh J Tsay, Richard B Ha...> ;Genome Medicine. 2022 Oct 27
• 2 citations
  Severe Acute Respiratory Infection-Preparedness: Protocol for a Multicenter Prospective Cohort Study of Viral Respiratory Infections.
  Radu Postelnicu, Avantika Srivastava, Pavan K Bhatraju, Mark M Wurfelc, George L Anesi, Martin Gonzalez, Adair Andrews, Karen Lutrick, Vishakha K Kumar, Timothy M Uyek...> ;Critical Care Explorations. 2022 Oct 1
• 2 citations
  A lung pathobiont story: Thinking outside the Koch's postulate box.
  Shivani Singh, Leopoldo N Segal> ;Cell Host & Microbe. 2022 Sep 14
• 7 citations
  Immunologic and imaging signatures in post tuberculosis lung disease.
  S Singh, B W Allwood, T L Chiyaka, L Kleyhans, C C Naidoo, S Moodley, G Theron, L N Segal> ;Tuberculosis. 2022 Sep 1
• 13 citations
  ACE2-containing defensosomes serve as decoys to inhibit SARS-CoV-2 infection.
  Krystal L Ching, Maren de Vries, Juan Gago, Kristen Dancel-Manning, Joseph Sall, William J Rice, Clea Barnett, Alireza Khodadadi-Jamayran, Aristotelis Tsirigos, Feng-X...> ;Plos Biology. 2022 Sep 1
• 7 citations
  Microbial risk score for capturing microbial characteristics, integrating multi-omics data, and predicting disease risk.
  Chan Wang, Leopoldo N Segal, Jiyuan Hu, Boyan Zhou, Richard B Hayes, Jiyoung Ahn, Huilin Li> ;Microbiome. 2022 Aug 5
• 1 citations
  Untangling Lower Airway Dysbiosis in Critically Ill Patients with COVID-19.
  Clea R Barnett, Leopoldo N Segal> ;American Journal of Respiratory and Critical Care Medicine. 2022 Oct 1
• 8 citations
  Microbial Risk Score for Capturing Microbial Characteristics, Integrating Multi-omics Data, and Predicting Disease Risk.
  Chan Wang, Leopoldo N Segal, Jiyuan Hu, Boyan Zhou, Richard Hayes, Jiyoung Ahn, Huilin Li> ;Biorxiv. 2022 Jun 8
• 17 citations
  Therapeutic Targeting of the Respiratory Microbiome.
  Sanjay H Chotirmall, Debby Bogaert, James D Chalmers, Michael J Cox, Philip M Hansbro, Yvonne J Huang, Philip L Molyneaux, David N O'Dwyer, Alexa A Pragman, Geraint B ...> ;American Journal of Respiratory and Critical Care Medicine. 2022 Sep 1
• 9 citations
  Lung microbial-host interface through the lens of multi-omics.
  Shivani Singh, Jake G Natalini, Leopoldo N Segal> ;Mucosal Immunology. 2022 May 1
• 3 citations
  Identifying correlations driven by influential observations in large datasets.
  Kevin Bu, David S Wallach, Zach Wilson, Nan Shen, Leopoldo N Segal, Emilia Bagiella, Jose C Clemente> ;Briefings in Bioinformatics. 2022 Jan 17
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Journal Articles

• Translating Microbiome Futures  
  Leopoldo Segal, Martin Blaser, Nature
• Airway Microbiota Is Associated with up-Regulation of the PI3K Pathway in Lung Cancer  
  Benjamin G Wu, Harvey Pass, William N Rom, Daniel H Sterman, Vivek Murthy, Martin J Blaser, Michael D Weiden, Leopoldo N Segal, ATS Journals