LeslieJParentMD

Associate Vice President for Health Sciences Research, Penn State University Vice Dean for Research and Graduate Studies Professor, Medicine and Microbiology & Immunology, Pennsylvania State University College of Medicine

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Office
500 University Drive, H175
Hershey, PA 17033
Phone+1 800-233-4082
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Education & Training

Penn State Milton S Hershey Medical CenterFellowship, Infectious Disease, 1991 - 1994
Duke University HospitalResidency, Internal Medicine, 1987 - 1991
Duke University School of MedicineClass of 1987

Certifications & Licensure

PA State Medical License 1991 - 2024
NC State Medical License 1987 - 1991
American Board of Internal Medicine Infectious Disease

Publications & Presentations

PubMed

1 citations
The Rous sarcoma virus Gag Polyprotein Forms Biomolecular Condensates Driven by Intrinsically-disordered Regions.
Rebecca Kaddis Maldonado, Gregory S Lambert, Breanna L Rice, Malgorzata Sudol, John M Flanagan, Leslie J Parent> ;Journal of Molecular Biology. 2023 Aug 15
6 citations
Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication.
Bao-An Chau, Venessa Chen, Alan W Cochrane, Leslie J Parent, Andrew J Mouland> ;Cell Reports. 2023 Jan 31
6 citations
Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency.
Subha Dahal, Kiera Clayton, Terek Been, Raphaële Fernet-Brochu, Alonso Villasmil Ocando, Ahalya Balachandran, Mikaël Poirier, Rebecca Kaddis Maldonado, Lulzim Shkreta,...> ;Retrovirology. 2022 Aug 19
119 citations
SARS-CoV-2 vaccine effectiveness against infection, symptomatic and severe COVID-19: a systematic review and meta-analysis.
Paddy Ssentongo, Anna E Ssentongo, Navya Voleti, Destin Groff, Ashley Sun, Djibril M Ba, Jonathan Nunez, Leslie J Parent, Vernon M Chinchilli, Catharine I Paules> ;BMC Infectious Diseases. 2022 May 7
Clinician-Scientist Faculty Mentoring Program (FAME) - A New Inclusive Training Model at Penn State Increases Scholarly Productivity and Extramural Grant Funding.
Sinisa Dovat, Chandrika Gowda, Richard B Mailman, Leslie J Parent, Xuemei Huang> ;Advances in Medical Education and Practice. 2022 Jan 1
32 citations
Diabetes, Drug Treatment and Mortality in COVID-19: A Multinational Retrospective Cohort Study.
Jennifer E. Nyland, Nazia Raja-Khan, Kerstin Bettermann, Philippe Haouzi, Douglas L. Leslie, Jennifer L. Kraschnewski, Leslie J. Parent, Patricia S. Grigson> ;Diabetes. 2021 Sep 27
3 citations
Monoclonal Antibodies to S and N SARS-CoV-2 Proteins as Probes to Assess Structural and Antigenic Properties of Coronaviruses.
Rinki Kumar, Neil D. Christensen, Rebecca J. Kaddis Maldonado, Maria C. Bewley, Alexandria Ostman, Malgorzata Sudol, Eunice C. Chen, Natalie W. Buchkovich, Abhinay Gon...> ;Viruses. 2021 Sep 22
4 citations
Visualizing Rous Sarcoma Virus Genomic RNA Dimerization in the Nucleus, Cytoplasm, and at the Plasma Membrane.
Eunice C. Chen, Rebecca J. Kaddis Maldonado, Leslie J. Parent> ;Viruses. 2021 May 13
7 citations
Building a System to Engage and Sustain Research Careers for Physicians.
Xuemei Huang, Sinisa Dovat, Richard B. Mailman, Diane Thiboutot, Deborah Berini, Leslie J. Parent> ;Academic Medicine. 2021 Apr 1
18 citations
HIV-1 Gag Forms Ribonucleoprotein Complexes with Unspliced Viral RNA at Transcription Sites
Kevin M. Tuffy, Rebecca J. Kaddis Maldonado, Jordan Chang, Paul Rosenfeld, Alan Cochrane, Leslie J. Parent> ;Viruses. 2020 Nov 9
4 citations
TNPO3-Mediated Nuclear Entry of the Rous Sarcoma Virus Gag Protein Is Independent of the Cargo-Binding Domain.
Breanna L. Rice, Matthew S. Stake, Leslie J. Parent> ;Journal of Virology. 2020 Aug 17
8 citations
Rous Sarcoma Virus Genomic RNA Dimerization Capability In Vitro Is Not a Prerequisite for Viral Infectivity
Shuohui Liu, Rebecca J. Kaddis Maldonado, Tiffiny Rye-McCurdy, Christiana Binkley, Aissatou Bah, Eunice C. Chen, Breanna L. Rice, Leslie J. Parent, Karin Musier-Forsyth> ;Viruses. 2020 May 22
17 citations
Visualizing Association of the Retroviral Gag Protein with Unspliced Viral RNA in the Nucleus
Rebecca J. Kaddis Maldonado, Breanna L. Rice, Eunice C. Chen, Kevin M. Tuffy, Estelle F. Chiari, Kelly M. Fahrbach, Thomas J. Hope, Leslie J. Parent> ;Mbio. 2020 Apr 28
1 citations
RNA-Binding Domains of Heterologous Viral Proteins Substituted for Basic Residues in the RSV Gag NC Domain Restore Specific Packaging of Genomic RNA.
Breanna L. Rice, Timothy L. Lochmann, Leslie J. Parent> ;Viruses. 2020 Mar 27
A trip down memory lane with Retrovirology
Monsef Benkirane, Ben Berkhout, Persephone Borrow, Ariberto Fassati, Masahiro Fujii, J. Victor Garcia-Martinez, David J. Margolis, Monique Nijhuis, Leslie J. Parent, K...> ;Retrovirology. 2019 Aug 21
12 citations
A non-cleavable hexahistidine affinity tag at the carboxyl-terminus of the HIV-1 Pr55Gag polyprotein alters nucleic acid binding properties.
Maria C. Bewley, Lisa Reinhart, Matthew S. Stake, Shorena Nadaraia-Hoke, Leslie J. Parent, John M. Flanagan> ;Protein Expression and Purification. 2017 Feb 1
26 citations
Orchestrating the Selection and Packaging of Genomic RNA by Retroviruses: An Ensemble of Viral and Host Factors.
Rebecca J. Kaddis Maldonado, Leslie J. Parent> ;Viruses. 2016 Sep 20
17 citations
Functional Equivalence of Retroviral MA Domains in Facilitating Psi RNA Binding Specificity by Gag.
Tiffiny Rye-McCurdy, Erik D. Olson, Shuohui Liu, Christiana Binkley, Joshua-Paolo C. Reyes, Brian R. Thompson, John M. Flanagan, Leslie J. Parent, Karin Musier-Forsyth> ;Viruses. 2016 Sep 19
19 citations
HIV-1 and two avian retroviral 5' untranslated regions bind orthologous human and chicken RNA binding proteins
Matthew S. Stake, Deepali Singh, Gatikrushna Singh, J. Marcela Hernandez, Rebecca J. Kaddis Maldonado, Leslie J. Parent, Kathleen Boris-Lawrie> ;Virology. 2015 Dec 1
6 citations
Interplay between the alpharetroviral Gag protein and SR Proteins SF2 and SC35 in the nucleus
Breanna L. Rice, Rebecca J. Kaddis, Matthew S. Stake, Timothy L. Lochmann, Leslie J. Parent> ;Frontiers in Microbiology. 2015 Sep 8
10 citations
Mechanistic differences between nucleic acid chaperone activities of the gag proteins of rous sarcoma virus and human immunodeficiency virus type 1 are attributed to t...
Tiffiny Rye-McCurdy, Shorena Nadaraia-Hoke, Nicole Gudleski-O'Regan, John M. Flanagan, Leslie J. Parent, Karin Musier-Forsyth> ;Journal of Virology. 2014 Jul 15
9 citations
A Murine Retrovirus Co-Opts YB-1, a Translational Regulator and Stress Granule-Associated Protein, To Facilitate Virus Assembly
Darrin V. Bann, Andrea R. Beyer, Leslie J. Parent> ;Journal of Virology. 2014 Apr 15
22 citations
Nuclear trafficking of retroviral RNAs and Gag proteins during late steps of replication.
Matthew S. Stake, Darrin V. Bann, Rebecca J. Kaddis, Leslie J. Parent> ;Viruses. 2013 Nov 18
70 citations
Distinct binding interactions of HIV-1 Gag to Psi and non-Psi RNAs: implications for viral genomic RNA packaging.
Joseph A. Webb, Christopher P. Jones, Leslie J. Parent, Ioulia Rouzina, Karin Musier-Forsyth> ;RNA. 2013 Jun 24
24 citations
Alterations in the MA and NC Domains Modulate Phosphoinositide-Dependent Plasma Membrane Localization of the Rous Sarcoma Virus Gag Protein
Shorena Nadaraia-Hoke, Darrin V. Bann, Timothy L. Lochmann, Nicole Gudleski-O'Regan, Leslie J. Parent> ;Journal of Virology. 2013 Mar 15
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Press Mentions

The Medical Minute: What to Know About the Delta VariantJuly 14th, 2021
College of Medicine Celebrates Student Achievements VirtuallyMay 6th, 2020
Central Pennsylvania Native Helps Lead the Nation's Fight Against COVID-19March 25th, 2020

Grant Support

Nuclear Trafficking Of The Retroviral GAG ProteinNational Cancer Institute2003–2011
Matrix Protein And Retrovirus InfectionNational Cancer Institute1998–2002
HIV-1 GAG Mediated AssemblyNational Institute Of Allergy And Infectious Diseases1994–1997
Analysis Of HIV-1 Gag-Mediated AssemblyNational Institute Of Allergy And Infectious Diseases1993

Hospital Affiliations

Penn State Milton S. Hershey Medical CenterHershey, Pennsylvania