LiCheDO

PubMed

• 42 citations
  Focal adhesion kinase (FAK) promotes cholangiocarcinoma development and progression via YAP activation.
  Xinhua Song, Hongwei Xu, Pan Wang, Jingxiao Wang, Silvia Affò, Haichuan Wang, Meng Xu, Binyong Liang, Li Che, Wei Qiu, Robert F. Schwabe, Tammy T. Chang, Marion Vogl, ...> ;Journal of Hepatology. 2021 Oct 1
• 20 citations
  Overexpression of Mothers Against Decapentaplegic Homolog 7 Activates the Yes-Associated Protein/NOTCH Cascade and Promotes Liver Carcinogenesis in Mice and Humans.
  Haichuan Wang, Xinhua Song, Haotian Liao, Pan Wang, Yi Zhang, Li Che, Jie Zhang, Yi Zhou, Antonio Cigliano, Cindy Ament, Daphne Superville, Silvia Ribback, Melissa Ree...> ;Hepatology. 2021 Jul 1
• 16 citations
  Distinct and Overlapping Roles of Hippo Effectors YAP and TAZ During Human and Mouse Hepatocarcinogenesis.
  Haichuan Wang, Jingxiao Wang, Shanshan Zhang, Jiaoyuan Jia, Xianqiong Liu, Jie Zhang, Pan Wang, Xinhua Song, Li Che, Ke Liu, Silvia Ribback, Antonio Cigliano, Matthias...> ;Cellular and Molecular Gastroenterology and Hepatology. 2021 Jan 1
• 16 citations
  Pivotal Role of Fatty Acid Synthase in c-MYC Driven Hepatocarcinogenesis
  Jiaoyuan Jia, Li Che, Antonio Cigliano, Xue Wang, Graziella Peitta, Junyan Tao, Sheng Zhong, Silvia Ribback, Matthias Evert, Xin Chen, Diego F. Calvisi> ;International Journal of Molecular Sciences. 2020 Nov 11
• 51 citations
  Cabozantinib-based combination therapy for the treatment of hepatocellular carcinoma
  Runze Shang, Xinhua Song, Pan Wang, Yi Zhou, Xinjun Lu, Jingxiao Wang, Meng Xu, X Chen, Kirsten Utpatel, Li Che, Binyong Liang, Antonio Cigliano, Matthias Evert, Diego...> ;Gut. 2021 Sep 1
• 6 citations
  Mammalian Target of Rapamycin Complex 2 Signaling Is Required for Liver Regeneration in a Cholestatic Liver Injury Murine Model.
  Yi Zhou, Meng Xu, Pin Liu, Binyong Liang, Manning Qian, Haichuan Wang, Xinhua Song, Pranavanand Nyshadham, Li Che, Diego F. Calvisi, Feng Li, Shumei Lin, Xin Chen> ;The American Journal of Pathology. 2020 Apr 7
• 12 citations
  mTORC2 Signaling Is Necessary for Timely Liver Regeneration after Partial Hepatectomy.
  Meng Xu, Haichuan Wang, Jingxiao Wang, Deviana Burhan, Runze Shang, Pan Wang, Yi Zhou, Rong Li, Bingyong Liang, Katja Evert, Kirsten Utpatel, Zhong Xu, Xinhua Song, Li...> ;The American Journal of Pathology. 2020 Feb 5
• 24 citations
  Oncogene-dependent function of BRG1 in hepatocarcinogenesis.
  Pan Wang, Xinhua Song, Dan Cao, Kairong Cui, Jingxiao Wang, Kirsten Utpatel, Runze Shang, Haichuan Wang, Li Che, Matthias Evert, Keji Zhao, Diego F. Calvisi, Xin Chen> ;Cell Death & Disease. 2020 Feb 4
• 101 citations
  Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans.
  Li Che, Wenna Chi, Yu Qiao, Jie Zhang, Xinhua Song, Ye Liu, Lei Li, Jiaoyuan Jia, Maria G. Pilo, Jingxiao Wang, Antonio Cigliano, Zhilong Ma, Wenhua Kuang, Zefang Tang...> ;Gut. 2020 Jan 1
• 37 citations
  Pathogenetic, Prognostic, and Therapeutic Role of Fatty Acid Synthase in Human Hepatocellular Carcinoma.
  Li Che, Panagiotis Paliogiannis, Antonio Cigliano, Maria G. Pilo, Xin Chen, Diego F. Calvisi> ;Frontiers in Oncology. 2019 Dec 11
• 34 citations
  Axis inhibition protein 1 (Axin1) Deletion–Induced Hepatocarcinogenesis Requires Intact β‐Catenin but Not Notch Cascade in Mice
  Yu Qiao, Jingxiao Wang, Eylul Karagoz, Binyong Liang, Xinhua Song, Runze Shang, Katja Evert, Meng Xu, Li Che, Matthias Evert, Diego F. Calvisi, Junyan Tao, Bruce Wang,...> ;Hepatology. 2019 Dec 1
• 63 citations
  The mTORC2-Akt1 Cascade Is Crucial for c-Myc to Promote Hepatocarcinogenesis in Mice and Humans
  Zhong Xu, Meng Xu, Pin Liu, Shu Zhang, Runze Shang, Yu Qiao, Li Che, Silvia Ribback, Antonio Cigliano, Katja Evert, Rosa Maria Pascale, Frank Dombrowski, Matthias Ever...> ;Hepatology. 2019 Nov 1
• 11 citations
  SNAI1 Promotes the Cholangiocellular Phenotype, but not Epithelial-Mesenchymal Transition, in a Murine Hepatocellular Carcinoma Model.
  Meng Xu, Jingxiao Wang, Zhong Xu, Rong Li, Pan Wang, Runze Shang, Antonio Cigliano, Silvia Ribback, Antonio Solinas, Giovanni Mario Pes, Katja Evert, Haichuan Wang, Xi...> ;Cancer Research. 2019 Nov 1
• 41 citations
  Loss of Fbxw7 synergizes with activated Akt signaling to promote c-Myc dependent cholangiocarcinogenesis
  Jingxiao Wang, Haichuan Wang, Michele Peters, Ning Ding, Silvia Ribback, Kirsten Utpatel, Antonio Cigliano, Frank Dombrowski, Meng Xu, X Chen, Xinhua Song, Li Che, Mat...> ;Journal of Hepatology. 2019 Oct 1
• 8 citations
  Combined Treatment with MEK and mTOR Inhibitors is Effective in In Vitro and In Vivo Models of Hepatocellular Carcinoma.
  Xianqiong Liu, Junjie Hu, Xinhua Song, Kirsten Utpatel, Yi Zhang, Pan Wang, Xinjun Lu, Jie Zhang, Meng Xu, Tao Su, Li Che, Jingxiao Wang, Matthias Evert, Diego F. Calv...> ;Cancers. 2019 Jul 3
• 19 citations
  TEA Domain Transcription Factor 4 Is the Major Mediator of Yes-Associated Protein Oncogenic Activity in Mouse and Human Hepatoblastoma.
  Jie Zhang, Pin Liu, Junyan Tao, Pan Wang, Yi Zhang, Xinhua Song, Li Che, Pavel Sumazin, Silvia Ribback, András Kiss, Zsuzsa Schaff, Antonio Cigliano, Frank Dombrowski,...> ;The American Journal of Pathology. 2019 Feb 19
• 14 citations
  Functional role of SGK3 in PI3K/Pten driven liver tumor development.
  Hui Cao, Zhong Xu, Jingxiao Wang, Antonio Cigliano, Maria G. Pilo, Silvia Ribback, Shu Zhang, Yu Qiao, Li Che, Rosa Maria Pascale, Diego F. Calvisi, Xin Chen> ;BMC Cancer. 2019 Apr 11
• 10 citations
  MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment.
  Pan Wang, Xinhua Song, Kirsten Utpatel, Runze Shang, Yoon Mee Yang, Meng Xu, Jie Zhang, Li Che, John D. Gordan, Antonio Cigliano, Ekihiro Seki, Matthias Evert, Diego F...> ;Cell Death & Disease. 2019 Feb 11
• 49 citations
  Combined CDK4/6 and Pan-mTOR Inhibition Is Synergistic Against Intrahepatic Cholangiocarcinoma
  Xinhua Song, Xianqiong Liu, Haichuan Wang, Jingxiao Wang, Yu Qiao, Antonio Cigliano, Kirsten Utpatel, Silvia Ribback, Maria G. Pilo, Marina Serra, John D. Gordan, Li C...> ;Clinical Cancer Research. 2019 Jan 1
• 10 citations
  Focal adhesion kinase activation limits efficacy of Dasatinib in c-Myc driven hepatocellular carcinoma.
  Xianqiong Liu, Xinhua Song, Jie Zhang, Zhong Xu, Li Che, Yu Qiao, Yunuen Ortiz Pedraza, Antonio Cigliano, Rosa Maria Pascale, Diego F. Calvisi, Yanju Liu, Xin Chen> ;Cancer Medicine. 2018 Oct 28
• 15 citations
  Oncogenic potential of N-terminal deletion and S45Y mutant β-catenin in promoting hepatocellular carcinoma development in mice
  Yu Qiao, Meng Xu, Junyan Tao, Li Che, Antonio Cigliano, Satdarshan P.S. Monga, Diego F. Calvisi, Xin Chen> ;BMC Cancer. 2018 Nov 12
• 9 citations
  Oncogene-dependent addiction to carbohydrate-responsive element binding protein in hepatocellular carcinoma.
  Silvia Ribback, Li Che, Maria G. Pilo, Antonio Cigliano, Gavinella Latte, Giovanni Mario Pes, Alberto Porcu, Rosa Maria Pascale, Lei Li, Yu Qiao, Frank Dombrowski, Xin...> ;Cell Cycle. 2018 Jul 18
• 22 citations
  Hippo Cascade Controls Lineage Commitment of Liver Tumors in Mice and Humans.
  Shanshan Zhang, Jingxiao Wang, Haichuan Wang, Lingling Fan, Biao Fan, Billy Zeng, Junyan Tao, Xiaolei Li, Li Che, Antonio Cigliano, Silvia Ribback, Frank Dombrowski, B...> ;The American Journal of Pathology. 2018 Apr 1
• 68 citations
  Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice.
  Jingxiao Wang, Mingjie Dong, Zhong Xu, Xinhua Song, Shanshan Zhang, Yu Qiao, Li Che, John D. Gordan, Kaiwen Hu, Yan Liu, Diego F. Calvisi, Xin Chen> ;Oncogene. 2018 Mar 16
• 18 citations
  Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model
  Mingjie Dong, Xianqiong Liu, Katja Evert, Kirsten Utpatel, Michele Peters, Shanshan Zhang, Zhong Xu, Li Che, Antonio Cigliano, Silvia Ribback, Frank Dombrowski, Antoni...> ;Cell Death & Disease. 2018 Jan 18
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