LiangGuMD

PubMed

• MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric acute lymphoblastic leukemia cells with wild-type p53 and overexpression of MDM2.
  Gu, L.,Zhu, N.,Findley, H. W.,Zhou, M.> ;Leukemia. 2008 Feb 15
• Mycobacterium tuberculosis Hsp16.3 nonamers are assembled and re-assembled via trimer and hexamer intermediates.
  Abulimiti, A., Fu, X., Gu, L., Feng, X., Chang, Z.> ;J Mol Biol. 2003 Feb 28
• [Solubilization on cryptotanshinone by hydroxypropyl-beta-cyclodextrin and preparation of their inclusion compound].
  Luo, X., Xu, Y. H., Chen, B., Gu, L. Q., Huang, M., Liu, P. Q.> ;Zhongguo Zhong Yao Za Zhi. 2005 Sep
• G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells.
  Zhou, W. J., Deng, R., Zhang, X. Y., Feng, G. K., Gu, L. Q., Zhu, X. F.> ;Mol Cancer Ther. 2009 Dec 01
• Screening novel, potent multidrug-resistant modulators from imidazole derivatives.
  Chen, L. M., Wu, X. P., Ruan, J. W., Liang, Y. J., Ding, Y., Shi, Z., Wang, X. W., Gu, L. Q., Fu, L. W.> ;Oncol Res. 2004
• Synthesis and cytotoxicity study of alkannin derivatives.
  Huang, Z. S., Wu, H. Q., Duan, Z. F., Xie, B. F., Liu, Z. C., Feng, G. K., Gu, L. Q., Chan, A. S., Li, Y. M.> ;Eur J Med Chem. 2004 Sep
• Curcumin analogs as potent aldose reductase inhibitors.
  Du, Z. Y., Bao, Y. D., Liu, Z., Qiao, W., Ma, L., Huang, Z. S., Gu, L. Q., Chan, A. S.> ;Arch Pharm (Weinheim). 2006 Mar
• High performance liquid chromatography with ultraviolet detection for the determination of SYUIQ-5, a novel telomerase inhibitor for cancer therapy: application to an ...
  Su, Q. B., He, F., Guan, S., Lu, Y. J., Gu, L. Q., Huang, Z. S., Chen, X., Huang, M., Li, C. G., Chowbay, B., Zhou, S. F.> ;J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jul 1
• Spectroscopic studies of DNA binding modes of cation-substituted anthrapyrazoles derived from emodin.
  Tan, J. H., Lu, Y. J., Huang, Z. S., Gu, L. Q., Wu, J. Y.> ;Eur J Med Chem. 2007 Sep
• Apoptosis-inducing activity of new pyrazole emodin derivatives in human hepatocellular carcinoma HepG2 cells.
  Wang, X. D., Gu, L. Q., Wu, J. Y.> ;Biol Pharm Bull. 2007 Jun
• Isaindigotone derivatives: a new class of highly selective ligands for telomeric G-quadruplex DNA.
  Tan, J. H., Ou, T. M., Hou, J. Q., Lu, Y. J., Huang, S. L., Luo, H. B., Wu, J. Y., Huang, Z. S., Wong, K. Y., Gu, L. Q.> ;J Med Chem. 2009 May 14
• Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinesterase/butyrylcholinest...
  Tang, H., Wei, Y. B., Zhang, C., Ning, F. X., Qiao, W., Huang, S. L., Ma, L., Huang, Z. S., Gu, L. Q.> ;Eur J Med Chem. 2009 Jun
• Inhibition of thioredoxin reductase by mansonone F analogues: Implications for anticancer activity.
  Liu, Z., Huang, S. L., Li, M. M., Huang, Z. S., Lee, K. S., Gu, L. Q.> ;Chem Biol Interact. 2009 Jan 15
• Inhibition of thioredoxin reductase by curcumin analogs.
  Liu, Z., Du, Z. Y., Huang, Z. S., Lee, K. S., Gu, L. Q.> ;Biosci Biotechnol Biochem. 2008 Aug
• Synthesis, cytotoxic activities and structure-activity relationships of topoisomerase I inhibitors: indolizinoquinoline-5,12-dione derivatives.
  Cheng, Y., An, L. K., Wu, N., Wang, X. D., Bu, X. Z., Huang, Z. S., Gu, L. Q.> ;Bioorg Med Chem. 2008 Apr 15
• Solvent-free thermocyclization of the unactivated linear gramicidin S precursor and analogues.
  An, L. K., Li, R. L., Zuo, Y. L., Gu, L. Q.> ;Org Lett. 2011 Jan 7
• Studies on the binding of 5-N-methylated quindoline derivative to human telomeric G-quadruplex.
  Xu, W., Tan, J. H., Chen, S. B., Hou, J. Q., Li, D., Huang, Z. S., Gu, L. Q.> ;Biochem Biophys Res Commun. 2011 Mar 18
• Synthesis and biological evaluation of novel N,N''-bis-methylenedioxybenzyl-alkylenediamines as bivalent anti-Alzheimer disease ligands.
  Luo, W., Li, Y. P., Tan, J. H., Gu, L. Q., Huang, Z. S.> ;J Enzyme Inhib Med Chem. 2011 Oct
• New insights into the structures of ligand-quadruplex complexes from molecular dynamics simulations.
  Hou, J. Q., Chen, S. B., Tan, J. H., Ou, T. M., Luo, H. B., Li, D., Xu, J., Gu, L. Q., Huang, Z. S.> ;J Phys Chem B. 2010 Nov 25
• Selective recognition of oncogene promoter G-quadruplexes by Mg2+.
  Yan, Y. Y., Lin, J., Ou, T. M., Tan, J. H., Li, D., Gu, L. Q., Huang, Z. S.> ;Biochem Biophys Res Commun. 2010 Nov 26
• Icariin derivative inhibits inflammation through suppression of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways.
  Chen, S. R., Xu, X. Z., Wang, Y. H., Chen, J. W., Xu, S. W., Gu, L. Q., Liu, P. Q.> ;Biol Pharm Bull. 2010
• Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities.
  An, Z. Y., Yan, Y. Y., Peng, D., Ou, T. M., Tan, J. H., Huang, S. L., An, L. K., Gu, L. Q., Huang, Z. S.> ;Eur J Med Chem. 2010 Sep
• Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives.
  Wang, X. D., Ou, T. M., Lu, Y. J., Li, Z., Xu, Z., Xi, C., Tan, J. H., Huang, S. L., An, L. K., Li, D., Gu, L. Q., Huang, Z. S.> ;J Med Chem. 2010 Jun 10
• Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives.
  Wu, X. W., Wu, Z. P., Wang, L. X., Zhang, H. B., Chen, J. W., Zhang, W., Gu, L. Q., Huang, Z. S., An, L. K.> ;Eur J Med Chem. 2011 Sep
• Impact of planarity of unfused aromatic molecules on G-quadruplex binding: learning from isaindigotone derivatives.
  Hou, J. Q., Tan, J. H., Wang, X. X., Chen, S. B., Huang, S. Y., Yan, J. W., Chen, S. H., Ou, T. M., Luo, H. B., Li, D., Gu, L. Q., Huang, Z. S.> ;Org Biomol Chem. 2011 Sep 21
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