LindsayAFarrerMD

PubMed

• A comparative study of structural variant calling in WGS from Alzheimer's disease families.
  John S Malamon, John J Farrell, Li Charlie Xia, Beth A Dombroski, Rueben G Das, Jessica Way, Amanda B Kuzma, Otto Valladares, Yuk Yee Leung, Allison J Scanlon, Irving ...> ;Life Science Alliance. 2024 May 1
• Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.
  Caroline M Nievergelt, Adam X Maihofer, Elizabeth G Atkinson, Chia-Yen Chen, Karmel W Choi, Jonathan R I Coleman, Nikolaos P Daskalakis, Laramie E Duncan, Renato Polim...> ;Nature Genetics. 2024 Apr 18
• APOE genotype-specific methylation patterns are linked to Alzheimer disease pathology and estrogen response.
  Rebecca Panitch, Nathan Sahelijo, Junming Hu, Kwangsik Nho, David A Bennett, Kathryn L Lunetta, Rhoda Au, Thor D Stein, Lindsay A Farrer, Gyungah R Jun> ;Translational Psychiatry. 2024 Feb 29
• Human whole-exome genotype data for Alzheimer's disease.
  Yuk Yee Leung, Adam C Naj, Yi-Fan Chou, Otto Valladares, Michael Schmidt, Kara Hamilton-Nelson, Nicholas Wheeler, Honghuang Lin, Prabhakaran Gangadharan, Liming Qu, Ka...> ;Nature Communications. 2024 Jan 23
• Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alz...
  Jeffery M Vance, Lindsay A Farrer, Yadong Huang, Carlos Cruchaga, Bradley T Hyman, Margaret A Pericak-Vance, Alison M Goate, Michael D Greicius, Anthony J Griswold, Jo...> ;Annals of Neurology. 2024 Apr 1
• Comparison of Commonly Measured Plasma and Cerebrospinal Fluid Proteins and Their Significance for the Characterization of Cognitive Impairment Status.
  Rehman, H., Ang, T., Tao, Q., Espenilla, A., Au, R., Zhang, X., Qiu, W., , Farrer, L.> ;Journal of Alzheimer's Disease. 2024 Jan 1
• 1 citations
  Patterns of Gene Expression, Splicing, and Allele-Specific Expression Vary among Macular Tissues and Clinical Stages of Age-Related Macular Degeneration.
  Treefa Shwani, Charles Zhang, Leah A Owen, Akbar Shakoor, Albert T Vitale, John H Lillvis, Julie L Barr, Parker Cromwell, Robert Finley, Nadine Husami, Elizabeth Au, R...> ;Cells. 2023 Nov 21
• 11 citations
  APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry.
  Michael E Belloy, Shea J Andrews, Yann Le Guen, Michael Cuccaro, Lindsay A Farrer, Valerio Napolioni, Michael D Greicius> ;JAMA Neurology. 2023 Dec 1
• Bulk brain tissue cell-type deconvolution with bias correction for single-nuclei RNA sequencing data using DeTREM.
  Nicholas K O'Neill, Thor D Stein, Junming Hu, Habbiburr Rehman, Joshua D Campbell, Masanao Yajima, Xiaoling Zhang, Lindsay A Farrer> ;BMC Bioinformatics. 2023 Sep 19
• 4 citations
  Structural Variation Detection and Association Analysis of Whole-Genome-Sequence Data from 16,905 Alzheimer's Diseases Sequencing Project Subjects.
  Hui Wang, Beth A Dombroski, Po-Liang Cheng, Albert Tucci, Ya-Qin Si, John J Farrell, Jung-Ying Tzeng, Yuk Yee Leung, John S Malamon, , Li-San Wang, Badri N Vardarajan,...> ;Medrxiv. 2023 Sep 13
• 1 citations
  Machine learning-based quantification for disease uncertainty increases the statistical power of genetic association studies.
  Jun Young Park, Jang Jae Lee, Younghwa Lee, Dongsoo Lee, Jungsoo Gim, Lindsay Farrer, Kun Ho Lee, Sungho Won> ;Bioinformatics. 2023 Sep 2
• 1 citations
  DNA from multiple viral species is associated with Alzheimer's disease risk.
  Marlene Tejeda, John Farrell, Congcong Zhu, Lee Wetzler, Kathryn L Lunetta, William S Bush, Eden R Martin, Li-San Wang, Gerard D Schellenberg, Margaret A Pericak-Vance...> ;Alzheimer's & Dementia. 2024 Jan 1
• Genetics of Alzheimer's Disease in the African American Population.
  Mark W Logue, Shoumita Dasgupta, Lindsay A Farrer> ;Journal of Clinical Medicine. 2023 Aug 9
• 1 citations
  A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores.
  Moonil Kang, Ting Fang Alvin Ang, Sherral A Devine, Richard Sherva, Shubhabrata Mukherjee, Emily H Trittschuh, Laura E Gibbons, Phoebe Scollard, Michael Lee, Seo-Eun C...> ;Molecular Neurodegeneration. 2023 Jun 22
• 4 citations
  A systems biology approach uncovers novel disease mechanisms in age-related macular degeneration.
  Luz D Orozco, Leah A Owen, Jeffrey Hofmann, Amy D Stockwell, Jianhua Tao, Susan Haller, Vineeth T Mukundan, Christine Clarke, Jessica Lund, Akshayalakshmi Sridhar, Ole...> ;Cell Genomics. 2023 Jun 14
• 1 citations
  Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews.
  Donghe Li, John J Farrell, Jesse Mez, Eden R Martin, William S Bush, Agustin Ruiz, Mercè Boada, Itziar de Rojas, Richard Mayeux, Jonathan L Haines, Margaret A Pericak ...> ;Alzheimer's & Dementia. 2023 Dec 1
• Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profiles.
  Jaeyoon Chung, Nathan Sahelijo, Toru Maruyama, Junming Hu, Rebecca Panitch, Weiming Xia, Jesse Mez, Thor D Stein, , Andrew J Saykin, Haruko Takeyama, Lindsay A Farrer,...> ;Alzheimer's & Dementia. 2023 Nov 1
• 1 citations
  A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease.
  Haimeng Bai, Adam C Naj, Penelope Benchek, Logan Dumitrescu, Timothy Hohman, Kara Hamilton-Nelson, Asha R Kallianpur, Anthony J Griswold, Badri Vardarajan, Eden R Mart...> ;Alzheimer's & Dementia. 2023 Nov 1
• 11 citations
  Association of African Ancestry-Specific APOE Missense Variant R145C With Risk of Alzheimer Disease.
  Yann Le Guen, Ana-Caroline Raulin, Mark W Logue, Richard Sherva, Michael E Belloy, Sarah J Eger, Annabel Chen, Gabriel Kennedy, Lindsey Kuchenbecker, Justin P O'Leary,...> ;JAMA. 2023 Feb 21
• Author Correction: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.
  Itziar de Rojas, Sonia Moreno-Grau, Niccolo Tesi, Benjamin Grenier-Boley, Victor Andrade, Iris E Jansen, Nancy L Pedersen, Najada Stringa, Anna Zettergren, Isabel Hern...> ;Nature Communications. 2023 Feb 9
• Pleiotropy analysis between lobar intracerebral hemorrhage and CSF β-amyloid highlights new and established associations.
  Sandro Marini, Jaeyoon Chung, Xudong Han, Xinyu Sun, Livia Parodi, Lindsay A Farrer, Jonathan Rosand, Jose Rafael Romero, Christopher D Anderson> ;International Journal of Stroke. 2023 Aug 1
• Heritability of cognitive abilities and regional brain structures in middle-aged to elderly East Asians.
  Younghwa Lee, Jun Young Park, Jang Jae Lee, Jungsoo Gim, Ah Ra Do, Jinyeon Jo, Juhong Park, Kangjin Kim, Kyungtaek Park, Heejin Jin, Kyu Yeong Choi, Sarang Kang, Hoowo...> ;Cerebral Cortex. 2023 May 9
• 3 citations
  Genome-Wide Pleiotropy Study Identifies Association ofwith Age-Related Macular Degeneration and COVID-19 Infection Outcomes.
  Jaeyoon Chung, Viha Vig, Xinyu Sun, Xudong Han, George T O'Connor, Xuejing Chen, Margaret M DeAngelis, Lindsay A Farrer, Manju L Subramanian> ;Journal of Clinical Medicine. 2022 Dec 23
• 13 citations
  African ancestry GWAS of dementia in a large military cohort identifies significant risk loci.
  Richard Sherva, Rui Zhang, Nathan Sahelijo, Gyungah Jun, Tori Anglin, Catherine Chanfreau, Kelly Cho, Jennifer R Fonda, J Michael Gaziano, Kelly M Harrington, Yuk-Lam ...> ;Molecular Psychiatry. 2023 Mar 1
• 6 citations
  The impact of increasing levels of blood C-reactive protein on the inflammatory loci SPI1 and CD33 in Alzheimer's disease.
  Jinghan Huang, Qiushan Tao, Ting Fang Alvin Ang, John Farrell, Congcong Zhu, Yixuan Wang, Thor D Stein, Kathryn L Lunetta, Joseph Massaro, Jesse Mez, Rhoda Au, Lindsay...> ;Translational Psychiatry. 2022 Dec 22
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Journal Articles

• Dissecting the Genetic Relationship Between Cardiovascular Risk Factors and Alzheimer’s Disease  
  Christine M Glastonbury, Fanny M Elahi, Reisa A Sperling, William P Dillon, Lindsay A Farrer, Rahul S Desikan, Christopher P Hess, James B Brewer, Bradley T Hyman, Kri..., Acta Neuropathologica
• Genome‐Wide Association Meta‐Analysis of Age at First Cannabis Use  
  Henry R Kranzler, Joel Gelernter, Tamara L Wall, Lindsay Farrer, Christian J Hopfer, Addiction
• Translational Studies Support a Role for Serotonin 2B Receptor (HTR2B) Gene in Aggression-Related Cannabis Response  
  Kerry J Ressler, Joel Gelernter, Henry R Kranzler, Lindsay A Farrer, Nature