LinmarieSikichMD

Child & Adolescent Psychiatry

Director, ASPIRE (Adolescent, School-age & Preschool Psychiatric Intervention Research and Evaluation) Program , University of North Carolina (UNC). Associate Professor, Division TEACCH and Division of Child and Adolescent Psychiatry, University of North Carolina (UNC).

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Office
2608 Erwin Road
suite 300, Duke Center for Autism & Brain Development
Durham, NC 27705
Phone+1 919-681-0026

Fax+1 919-681-1600
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Education & Training

Yale-New Haven Medical CenterFellowship, Child and Adolescent Psychiatry, 1992 - 1995
Yale-New Haven Medical CenterResidency, Child and Adolescent Psychiatry, 1989 - 1992
Washington University in St. Louis School of MedicineClass of 1987

Certifications & Licensure

NC State Medical License 1995 - 2024
CT State Medical License 1991 - 1995
American Board of Psychiatry and Neurology Psychiatry
American Board of Psychiatry and Neurology Child & Adolescent Psychiatry

Clinical Trials

Treatment of Early Onset Schizophrenia Spectrum Disorders (TEOSS) Start of enrollment: 2002 Feb 01
Completed
Phase 4
Early Intervention With Fluoxetine in Autism Start of enrollment: 2005 Jul 01
Completed
Phase 2
Improving Metabolic Parameters of Antipsychotic Child Treatment With Ziprasidone, Aripiprazole, and Clozapine Start of enrollment: 2007 Mar 01
Terminated
Phase 2
Strategies to Reduce Antipsychotic-Associated Weight Gain in Youth Start of enrollment: 2007 Jan 01
Completed
Phase 2
Study of Aripiprazole to Treat Children and Adolescents With Autism Start of enrollment: 2006 Jan 01
Completed
Phase 2
Safety, Tolerability and Efficacy Study of STX209 in Subjects With Fragile X Syndrome Start of enrollment: 2008 Nov 01
Completed
Phase 2
Reducing Weight Gain and Improving Metabolic Function in Children Being Treated With Antipsychotics Start of enrollment: 2009 Jan 01
Completed
Phase 4
Biomarker Testing and DNA Collection in Subjects Participating in Protocol 22001 Start of enrollment: 2009 Jan 01
Completed
Open-Label Study of the Safety and Tolerability of STX209 in Subjects With Autism Spectrum Disorders Start of enrollment: 2009 Feb 01
Completed
Phase 2
Biomarker and DNA Collection in Subjects Participating in Protocol 22003 Start of enrollment: 2009 May 01
Completed
Ziprasidone in Early Onset Schizophrenia Spectrum Disorders Start of enrollment: 2002 Dec 01
Completed
Phase 2
FMRI Brain Activation of Aripiprazole Treatment in Autism Spectrum Disorders Start of enrollment: 2009 Aug 01
Completed
Phase 4
A Study of Oxytocin in Children and Adolescents With Autistic Disorder Start of enrollment: 2011 Mar 01
Completed
Phase 2
Brain Connectivity in Neurodevelopmental Disorders in Response to Treatment Start of enrollment: 2011 Sep 01
Completed
Study of Lurasidone in Treating Antipsychotic Naive or Quasi-Naive Children and Adolescents Start of enrollment: 2012 Dec 01
Completed
Phase 2
Lurasidone Pediatric Autism Study Start of enrollment: 2013 Aug 01
Completed
Phase 3
Study of Oxytocin in Autism to Improve Reciprocal Social Behaviors Start of enrollment: 2014 Aug 01
Completed
Phase 2
Brain Imaging of Intranasal Oxytocin Treatment in Autism Start of enrollment: 2014 Sep 01
Completed
Phase 1
Oxytocin Levels in Typically Developing Boys Start of enrollment: 2013 Dec 01
Completed
Cortical Metrics in Intervention Trials With Autism Spectrum Disorders Start of enrollment: 2015 Aug 01
Withdrawn
Phase 2, Phase 3
Long-term Antipsychotic Pediatric Safety Trial Start of enrollment: 2019 Jan 10
Completed
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Publications & Presentations

PubMed

Retrospective Comparison of Patients Evaluated for Pediatric Autoimmune Encephalitis with Typical and Atypical Premorbid Neuropsychiatric Development.
Kira Panzer, Alexis Harmon, Reginald Lerebours, Linmarie Sikich, Samuel Pullen, Heather Van Mater> ;Journal of Autism and Developmental Disorders. 2023 Jul 26
2 citations
Evaluation of clinical assessments of social abilities for use in autism clinical trials by the autism biomarkers consortium for clinical trials.
Susan Faja, Maura Sabatos-DeVito, Aksheya Sridhar, Jocelyn L Kuhn, Julia I Nikolaeva, Catherine A Sugar, Sara Jane Webb, Raphael A Bernier, Linmarie Sikich, Gerhard He...> ;Autism Research. 2023 May 1
3 citations
Genetic and epigenetic signatures associated with plasma oxytocin levels in children and adolescents with autism spectrum disorder.
Stephen K Siecinski, Stephanie N Giamberardino, Marina Spanos, Annalise C Hauser, Jason R Gibson, Tara Chandrasekhar, Maria Del Pilar Trelles, Carol M Rockhill, Michel...> ;Autism Research. 2023 Mar 1
1 citations
An Optimized Version of the Positive and Negative Symptoms Scale (PANSS) for Pediatric Trials.
Robert L Findling, Eric A Youngstrom, Jon M McClellan, Jean A Frazier, Linmarie Sikich, David Gordon Daniel, Joan Busner> ;Journal of the American Academy of Child and Adolescent Psychiatry. 2023 Apr 1
3 citations
Rapid and Deferred Help Seeking Among African American Parents of Children With Emotional and Behavioral Difficulties.
Jennifer Richmond, Leslie B Adams, Izabela E Annis, Alan R Ellis, Twyla Perryman, Linmarie Sikich, Kathleen C Thomas> ;Psychiatric Services. 2022 Dec 1
2 citations
Adaptive Behavior in Young Autistic Children: Associations with Irritability and ADHD Symptoms.
Kimberly L H Carpenter, Naomi O Davis, Marina Spanos, Maura Sabatos-DeVito, Rachel Aiello, Grace T Baranek, Scott N Compton, Helen L Egger, Lauren Franz, Soo-Jeong Kim...> ;Journal of Autism and Developmental Disorders. 2022 Oct 12
15 citations
Balovaptan vs Placebo for Social Communication in Childhood Autism Spectrum Disorder: A Randomized Clinical Trial.
Eric Hollander, Suma Jacob, Roger Jou, Nora McNamara, Linmarie Sikich, Russell Tobe, Janice Smith, Kevin Sanders, Lisa Squassante, Lorraine Murtagh, Teresa Gleissl, Ch...> ;JAMA Psychiatry. 2022 Aug 1
8 citations
Large multicenter randomized trials in autism: key insights gained from the balovaptan clinical development program.
Suma Jacob, Evdokia Anagnostou, Eric Hollander, Roger Jou, Nora McNamara, Linmarie Sikich, Russell Tobe, Declan Murphy, James McCracken, Elizabeth Ashford, Christopher...> ;Molecular Autism. 2022 Jun 11
Citalopram Did Not Significantly Improve Anxiety in Children with Autism Spectrum Disorder Undergoing Treatment for Core Symptoms: Secondary Analysis of a Trial to Red...
Emily Simonoff, Florence Mowlem, Oliver Pearson, Evdokia Anagnostou, Craig Donnelly, Eric Hollander, Bryan H King, James T McCracken, Lawrence Scahill, Linmarie Sikich...> ;Journal of Child and Adolescent Psychopharmacology. 2022 May 1
100 citations
Intranasal Oxytocin in Children and Adolescents with Autism Spectrum Disorder.
Linmarie Sikich, Alexander Kolevzon, Bryan H. King, Christopher J McDougle, Kevin B. Sanders, Soo Jeong Kim, Marina Spanos, Tara Chandrasekhar, M. Pilar Trelles, Carol...> ;The New England Journal of Medicine. 2021 Oct 14
17 citations
Predictors of Caregiver Strain for Parents of Children with Autism Spectrum Disorder.
Jessica Bradshaw, Scott Gillespie, Courtney McCracken, Bryan H. King, James T. McCracken, Cynthia R. Johnson, Luc Lecavalier, Tristram Smith, Naomi B. Swiezy, Karen Be...> ;Journal of Autism and Developmental Disorders. 2021 Sep 1
3 citations
Dietary Consumption Among Youth with Antipsychotic-Induced Weight Gain and Changes Following Healthy Lifestyle Education.
Kristin Bussell, Gloria Reeves, Erin R. Hager, Shijun Zhu, Christoph U. Correll, Mark A. Riddle, Linmarie Sikich> ;Journal of Child and Adolescent Psychopharmacology. 2021 Jun 16
9 citations
Pragmatic adaptations of telehealth-delivered caregiver coaching for children with autism in the context of COVID-19: Perspectives from the United States and South Afr...
Lauren Franz, Jill Howard, Marisa Viljoen, Linmarie Sikich, Tara Chandrasekhar, Scott H. Kollins, Lawrence Lee, Minkateko Ndlovu, Maura Sabatos-DeVito, Noleen Seris, N...> ;Autism. 2021 Jun 8
Healthy-Weight Kindergarten Children with Autism Spectrum Disorder May Become Overweight and Obese during the First Few Years of Elementary School.
Misha Eliasziw, Tanja V E Kral, Mary Segal, Linmarie Sikich, Sarah Phillips, David J Tybor, Linda G Bandini, Carol Curtin, Aviva Must> ;The Journal of Pediatrics. 2021 Jan 1
Parent Activation and Child Mental Health Service use in African American Families in a Large Cross-Sectional Study.
Kathleen C. Thomas, Izabela E. Annis, Alan R. Ellis, Leslie B Adams, Scott A. Davis, Tywanda Lightfoot, Twyla Perryman, Madeline Wheeley, Linmarie Sikich, Joseph P. Mo...> ;The Permanente Journal. 2020 Dec 1
23 citations
The SOFIA Study: Negative Multi-center Study of Low Dose Fluoxetine on Repetitive Behaviors in Children and Adolescents with Autistic Disorder.
Paul Herscu, Benjamin L. Handen, L. Eugene Arnold, Snape Michael Frederick, Joel D. Bregman, Lawrence D. Ginsberg, Robert L. Hendren, Alexander Kolevzon, Raun D. Melme...> ;Journal of Autism and Developmental Disorders. 2020 Sep 1
9 citations
Rationale, design, and methods of the Autism Centers of Excellence (ACE) network Study of Oxytocin in Autism to improve Reciprocal Social Behaviors (SOARS-B).
Marina Spanos, Tara Chandrasekhar, Soo Jeong Kim, Robert M. Hamer, Bryan H. King, Christopher J. McDougle, Kevin B. Sanders, Simon G. Gregory, Alexander Kolevzon, Jere...> ;Contemporary Clinical Trials. 2020 Aug 8
26 citations
A Phase II Randomized Clinical Trial of the Safety and Efficacy of Intravenous Umbilical Cord Blood Infusion for Treatment of Children with Autism Spectrum Disorder.
Geraldine Dawson, Jessica Sun, J.H. Baker, Kimberly L. H. Carpenter, Scott N. Compton, Megan Deaver, Lauren Franz, Nicole Heilbron, Brianna Herold, Joseph P. Horrigan,...> ;The Journal of Pediatrics. 2020 Jul 1
63 citations
The Autism Biomarkers Consortium for Clinical Trials (ABC-CT): Scientific Context, Study Design, and Progress Toward Biomarker Qualification.
James C. McPartland, Raphael Bernier, Shafali S. Jeste, Geraldine Dawson, Charles A. Nelson, Katarzyna Chawarska, Rachel K. Earl, Susan Faja, Scott P. Johnson, Linmari...> ;Frontiers in Integrative Neuroscience. 2020 Apr 9
85 citations
Practice guideline: Treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder: Report of the Guideline Development,...
Ashura W. Buckley, Deborah Hirtz, Maryam Oskoui, Melissa J. Armstrong, Anshu Batra, Carolyn Bridgemohan, Daniel L. Coury, Geraldine Dawson, Diane Donley, Robert L. Fin...> ;Neurology. 2020 Mar 3
58 citations
Metformin add-on vs. antipsychotic switch vs. continued antipsychotic treatment plus healthy lifestyle education in overweight or obese youth with severe mental illnes...
Christoph U. Correll, Linmarie Sikich, Gloria Reeves, Jacqueline L. Johnson, Courtney P. Keeton, Marina Spanos, Sandeep Kapoor, Kristin Bussell, Leslie Miller, Tara Ch...> ;World Psychiatry. 2020 Feb 1
15 citations
Autism, Psychosis, or Both? Unraveling Complex Patient Presentations.
Tara Chandrasekhar, John Nathan Copeland, Marina Spanos, Linmarie Sikich> ;Child and Adolescent Psychiatric Clinics of North America. 2020 Jan 1
28 citations
Brief Report: Pilot Study of a Novel Interactive Digital Treatment to Improve Cognitive Control in Children with Autism Spectrum Disorder and Co-occurring ADHD Symptoms
Benjamin E. Yerys, Jennifer R. Bertollo, Lauren Kenworthy, Geraldine Dawson, Elysa J. Marco, Robert T. Schultz, Linmarie Sikich> ;Journal of Autism and Developmental Disorders. 2019 Apr 1
17 citations
Parental concern regarding obesity in children with autism spectrum disorder in the United States: National Survey of Children's Health 2016.
David J. Tybor, Misha Eliasziw, Tanja V.E. Kral, Mary Segal, Nancy E. Sherwood, Linmarie Sikich, Heidi I. Stanish, Linda G. Bandini, Carol Curtin, Aviva Must> ;Disability and Health Journal. 2019 Jan 1
9 citations
A Review of Methods for Monitoring Adverse Events in Pediatric Psychopharmacology Clinical Trials.
Margaret Coates, Marina Spanos, Pooja Parmar, Tara Chandrasekhar, Linmarie Sikich> ;Drug Safety. 2018 May 1
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Press Mentions

'Feel Good' Hormone Won't Help Ease Kids' Autism, Study FindsOctober 14th, 2021
Study: 'Sociability' Hormone Didn't Help Kids with AutismOctober 13th, 2021
Intranasal Oxytocin Ineffective for Autism in Large TrialOctober 13th, 2021
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Grant Support

2/3-Improving Metabolic Parameters Of Antipsychotic Child TreatmentNational Institute Of Mental Health2008–2011
Mitochondrial Localization Of Proteins Containing Coiled Coil-Helix DomainsNational Center For Research Resources2010
Intensive Brain Training In Early Onset Schizophrenia &Schizoaffective DisorderNational Institute Of Mental Health2009–2010
Clinical Trial: Pediatric Pharmacokinetic And Tolerability Study Of Lithium ForNational Center For Research Resources2008
Clinical Trial: Metformin Mitigation Of Antipsychotic-Induced Metabolic DysregulNational Center For Research Resources2008
Treatment Of Early Onset Schizophrenia Spectrum (TEOSS)National Institute Of Mental Health2004–2006
Treatment Of Psychotic Disorders In YouthNational Institute Of Mental Health2002–2006
Treatment ProjectNational Institute Of Mental Health2002

Hospital Affiliations

Duke University HospitalDurham, North Carolina