LoisEhSmithMD

Ophthalmology • Boston, MA

Pediatric & Strabismus

Professor of Ophthalmology, Boston Children's Hospital

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Office
300 Longwood Ave
Boston, MA 02115
Phone+1 617-355-8531

Fax+1 617-730-0305
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Education & Training

Harvard UniversityMA, honorary, 2008
Children's Hospital/Boston Medical CenterResidency, Pediatrics, 1982 - 1983
Massachusetts Eye and Ear Infirmary/Harvard Medical SchoolResidency, Ophthalmology, 1979 - 1982
Beth Israel Deaconess Medical CenterInternship, Internal Medicine, 1978 - 1979
Boston University School of MedicineClass of 1978
California Institute of TechnologyPh.D., Chemistry, 1973
Univ. of British ColumbiaB.Sc., Chemistry, First Class Honors, 1968

Certifications & Licensure

MA State Medical License 1982 - 2025
American Board of Ophthalmology Ophthalmology

Awards, Honors, & Recognition

Distinguished Lecturer Tufts Medical School, 2013
Dr. Ramadan Distinguished Lecturer University of Oklahoma, 2013
Distinguished Speaker Series Wayne State University, 2013
Achievement Award American Academy of Ophthalmology, 2012
Distinguished Visiting Lecturer Ross Eye Institute University of Buffalo, 2012
Silverman Award American Academy of Pediatrics, Pediatric Academic Societies and Asian Society for Pediatric Research, 2011
Gold Medal Fellow Assoc. Research in Vision and Ophthal. (FARVO), 2010
2010 Joseph M Bryan Lecturer Duke University, 2010
Silver medal ARVO, 2009
Research to Prevent Blindness Senior Investigator Award 2009
NIH Director WALS lecturer for outstanding contributions to science 2009
The Friedenwald Award for outstanding research in the basic or clinical sciences as applied to ophthalmology Association for Research in Vision and Ophthalmology, 2008
Cless Best of the Best Lecture 2008 ARVO and AAO meeting, 2008
Award for outstanding contributions to ophthalmic research Alcon Research Institute, 2007
Alfred W. Bressler Prize in Vision Science 2006
J. Donald Gass M.D. Memorial Lecture UCLA, 2006
Best Doctors in America (peer elected) 2006
RPB Lew Wasserman Merit Award 2005
Alcon Visiting Professor and City Wide Rounds Lecturer Department of Ophthalmology University of Toronto Medical School, 2005
Lloyd Morgan Lecturer Department of Pediatric Ophthalmology University of Toronto Medical School, 2005
Dr. John Fangman Lectureship, and Visiting Professor Children’s Hospital, Minneapolis, MN, 2005
2004 Rich Lecturer University of Alabama, 2004
2002 Deborah Iverson, M.D. Memorial Lecturer and visiting professor The Kresge Eye Institute, Wayne State University School of Medicine, 2002
Research Award 2001 for work in Retinopathy of Prematurity Pediatric Physician's Organization, 2001
2000 Roger Johnson Lecturer and Visiting Professor Children’s Hospital and Medical Center, Seattle, WA, 2000
1997 Merck Senior Fellows Award The Endocrine Society, 1997
Distinguished Ophthalmologist and Visiting Professor Doheny Eye Institute, University of Southern California, Los Angeles, 1997
Research Fellow in Ophthalmology Massachusetts Eye and Ear Infirmary, 1982
Fellow in Pediatric Ophthalmology Children's Hospital, Harvard Medical School, Boston, 1982
Heed Ophthalmic Foundation Fellowship 1982
Summer Research Fellow Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, 1977
Alpha Omega Alpha Honor Society 1977
IBM Graduate Research Fellow California Institute of Technology, 1972
Woodrow Wilson Special Research Fellow California Institute of Technology, 1971
Postgraduate Fellowship National Research Council (Canada), 1968
Predoctoral Research Fellow Department of Chemistry; California Institute of Technology, 1968
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Publications & Presentations

PubMed

Arachidonic acid and docosahexaenoic acid levels correlate with the inflammation proteome in extremely preterm infants.
Susanna Klevebro, Simon Kebede Merid, Ulrika Sjöbom, Wen Zhong, Hanna Danielsson, Dirk Wackernagel, Ingrid Hansen-Pupp, David Ley, Karin Sävman, Mathias Uhlén, Ann Hel...> ;Clinical Nutrition. 2024 Apr 3
1 citations
A versatile pumpless multi-channel fluidics system for maintenance and real-time functional assessment of tissue and cells.
Varun Kamat, Matthew K Grumbine, Khang Bao, Kedar Mokate, Gamal Khalil, Daniel Cook, Brandon Clearwater, Richard Hirst, Jarrod Harman, Myriam Boeck, Zhongjie Fu, Lois ...> ;Cell Reports Methods. 2023 Nov 20
1 citations
Visual outcome at 2.5 years of age in ω-3 and ω-6 long-chain polyunsaturated fatty acid supplemented preterm infants: a follow-up of a randomized controlled trial.
Pia Lundgren, Lena Jacobson, Lotta Gränse, Anna-Lena Hård, Karin Sävman, Ingrid Hansen-Pupp, David Ley, Anders K Nilsson, Aldina Pivodic, Lois E Smith, Ann Hellström> ;The Lancet Regional Health. Europe. 2023 Sep 1
Metabolomic Profiling of Long-Chain Polyunsaturated Fatty Acid Oxidation in Adults with Retinal Vein Occlusion: A Case-Control Study.
Jiangbo Ren, Anli Ren, Zhengrong Huang, Xizhi Deng, Ziyu Jiang, Yanni Xue, Zhongjie Fu, Lois Eh Smith, Min Ke, Yan Gong> ;The American Journal of Clinical Nutrition. 2023 Sep 1
1 citations
Prognostic Value of Parenteral Nutrition Duration on Risk of Retinopathy of Prematurity: Development and Validation of the Revised DIGIROP Clinical Decision Support Tool.
Aldina Pivodic, Gerd Holmström, Lois E H Smith, Anna-Lena Hård, Chatarina Löfqvist, Abbas Al-Hawasi, Eva Larsson, Pia Lundgren, Lotta Gränse, Kristina Tornqvist, Agnet...> ;JAMA Ophthalmology. 2023 Aug 1
In vivo noninvasive mitochondrial redox assessment of the optic nerve head to predict disease.
Bertan Cakir, Yohei Tomita, Hitomi Yagi, Padraic Romfh, William Allen, Minji Ko, Peili Chen, Zhongjie Fu, Daryoosh Vakhshoori, Lois E H Smith> ;PNAS Nexus. 2023 May 1
3 citations
Modification of serum fatty acids in preterm infants by parenteral lipids and enteral docosahexaenoic acid/arachidonic acid: A secondary analysis of the Mega Donna Meg...
Ulrika Sjöbom, Mats X Andersson, Aldina Pivodic, Anna-My Lund, Mireille Vanpee, Ingrid Hansen-Pupp, David Ley, Dirk Wackernagel, Karin Sävman, Lois E H Smith, Chatarin...> ;Clinical Nutrition. 2023 Jun 1
2 citations
FGF21 via mitochondrial lipid oxidation promotes physiological vascularization in a mouse model of Phase I ROP.
Zhongjie Fu, Pia Lundgren, Aldina Pivodic, Hitomi Yagi, Jarrod C Harman, Jay Yang, Minji Ko, Katherine Neilsen, Saswata Talukdar, Ann Hellström, Lois E H Smith> ;Angiogenesis. 2023 Aug 1
1 citations
Therapeutic activation of endothelial sphingosine-1-phosphate receptor 1 by chaperone-bound S1P suppresses proliferative retinal neovascularization.
Colin Niaudet, Bongnam Jung, Andrew Kuo, Steven Swendeman, Edward Bull, Takahiro Seno, Reed Crocker, Zhongjie Fu, Lois E H Smith, Timothy Hla> ;EMBO Molecular Medicine. 2023 May 8
4 citations
Retinopathy of prematurity: Metabolic risk factors.
Zhongjie Fu, Anders K Nilsson, Ann Hellstrom, Lois E H Smith> ;Elife. 2022 Nov 24
4 citations
Murine endothelial serine palmitoyltransferase 1 (SPTLC1) is required for vascular development and systemic sphingolipid homeostasis.
Andrew Kuo, Antonio Checa, Colin Niaudet, Bongnam Jung, Zhongjie Fu, Craig E Wheelock, Sasha A Singh, Masanori Aikawa, Lois E Smith, Richard L Proia, Timothy Hla> ;Elife. 2022 Oct 5
5 citations
Cytochrome P450 oxidase 2J inhibition suppresses choroidal neovascularization in mice.
Yan Gong, Yohei Tomita, Matthew L Edin, Anli Ren, Minji Ko, Jay Yang, Edward Bull, Darryl C Zeldin, Ann Hellström, Zhongjie Fu, Lois E H Smith> ;Metabolism. 2022 Sep 1
1 citations
Retrospective evaluation of ophthalmological and neurological outcomes for infants born before 24 weeks gestational age in a Swedish cohort.
Ann Hellström, Lena Jacobson, Abbas Al-Hawasi, Lena Hellström-Westas, Alexander Rakow, Mats Johnson, Karin Sävman, Gerd Holmstrom, Eva Larsson, Lotta Gränse, Marie Sar...> ;BMJ Open. 2022 Aug 3
8 citations
National cohort of infants born before 24 gestational weeks showed increased survival rates but no improvement in neonatal morbidity.
Pia Lundgren, Eva Morsing, Anna-Lena Hård, Alexander Rakow, Lena Hellström-Westas, Lena Jacobson, Mats Johnson, Gerd Holmström, Staffan Nilsson, Lois E Smith, Karin Sä...> ;Acta Paediatrica. 2022 Aug 1
23 citations
Neurodevelopmental disorders and somatic diagnoses in a national cohort of children born before 24 weeks of gestation.
Eva Morsing, Pia Lundgren, Anna-Lena Hård, Alexander Rakow, Lena Hellström-Westas, Lena Jacobson, Mats Johnson, Staffan Nilsson, Lois E H Smith, Karin Sävman, Ann Hell...> ;Acta Paediatrica. 2022 Jun 1
10 citations
Plasma Levels of Bevacizumab and Vascular Endothelial Growth Factor After Low-Dose Bevacizumab Treatment for Retinopathy of Prematurity in Infants.
, M Elizabeth Hartnett, David K Wallace, Trevano W Dean, Zhuokai Li, Charline S Boente, Eniolami O Dosunmu, Sharon F Freedman, Richard P Golden, Lingkun Kong, S Grace ...> ;JAMA Ophthalmology. 2022 Apr 1
11 citations
Omega-3/Omega-6 Long-Chain Fatty Acid Imbalance in Phase I Retinopathy of Prematurity.
Zhongjie Fu, Wenjun Yan, Chuck T Chen, Anders K Nilsson, Edward Bull, William Allen, Jay Yang, Minji Ko, John Paul SanGiovanni, James D Akula, Saswata Talukdar, Ann He...> ;Nutrients. 2022 Mar 23
6 citations
Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation.
Emilie Heckel, Gael Cagnone, Tapan Agnihotri, Bertan Cakir, Ashim Das, Jin Sung Kim, Nicholas Kim, Geneviève Lavoie, Anu Situ, Sheetal Pundir, Ye Sun, Florian Wünneman...> ;JCI Insight. 2022 Mar 22
4 citations
Validation of DIGIROP models and decision support tool for prediction of treatment for retinopathy of prematurity on a contemporary Swedish cohort.
Aldina Pivodic, Lois E H Smith, Anna-Lena Hård, Chatarina Löfqvist, Ana Catarina Almeida, Abbas Al-Hawasi, Eva Larsson, Pia Lundgren, Birgitta Sunnqvist, Kristina Torn...> ;The British Journal of Ophthalmology. 2023 Aug 1
1 citations
Evaluation of the Retinopathy of Prematurity Activity Scale (ROP-ActS) in a randomised controlled trial aiming for prevention of severe ROP: a substudy of the Mega Don...
Aldina Pivodic, Helena Johansson, Lois Eh Smith, Chatarina Löfqvist, Kerstin Albertsson-Wikland, Staffan Nilsson, Ann Hellström> ;BMJ Open Ophthalmology. 2022 Jan 1
13 citations
Müller glial responses compensate for degenerating photoreceptors in retinitis pigmentosa.
Yohei Tomita, Chenxi Qiu, Edward Bull, William Allen, Yumi Kotoda, Saswata Talukdar, Lois E.H. Smith, Zhongjie Fu> ;Experimental & Molecular Medicine. 2021 Nov 19
23 citations
Association of Docosahexaenoic Acid and Arachidonic Acid Serum Levels With Retinopathy of Prematurity in Preterm Infants.
Ann Hellström, Aldina Pivodic, Lotta Gränse, Pia Lundgren, Ulrika Sjöbom, Anders Nilsson, Helena Söderling, Anna-Lena Hård, Lois E.H. Smith, Chatarina Löfqvist> ;JAMA Network Open. 2021 Oct 1
4 citations
Insulin-Like Growth Factor 1 in the Preterm Rabbit Pup: Characterization of Cerebrovascular Maturation following Administration of Recombinant Human Insulin-Like Growt...
Magnus Gram, Claes Ekström, Bo Holmqvist, Galen Carey, Xiaoyang Wang, Suvi Vallius, William Hellström, Niklas Ortenlöf, Alex Adusei Agyemang, Lois E.H. Smith, Ann Hell...> ;Developmental Neuroscience. 2021 Jan 1
2 citations
Iris metastasis as the initial presentation of metastatic esophageal cancer diagnosed by fine needle aspiration biopsy: A case report.
Hiroko Ozawa, Yoshihiko Usui, Yoji Takano, Naoki Horiuchi, Tohru Kuribayashi, Toshihide Kurihara, Lois E.H. Smith, Kazuo Tsubota, Yohei Tomita> ;Medicine. 2021 Jun 4
6 citations
Development and validation of a new clinical decision support tool to optimize screening for retinopathy of prematurity.
Aldina Pivodic, Helena Johansson, Lois E.H. Smith, Anna-Lena Hård, Chatarina Löfqvist, Bradley A. Yoder, M. Elizabeth Hartnett, Carolyn Wu, Marie Christine Bründer, Wo...> ;The British Journal of Ophthalmology. 2021 May 12
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Journal Articles

Association of Somatic GNAQ Mutation with Capillary Malformations in a Case of Choroidal Hemangioma
Lois E Smith, Marcelo Hochman, Sanda Alexandrescu, JAMA
Retinal expression of Wnt-pathway mediated genes in low-density lipoprotein receptor-related protein 5 (Lrp5) knockout mice
Jing Chen, Andreas Stahl, Nathan M. Krah, Molly R. Seaward, Jean-Sebastian Joyal, Aimee M. Juan, Colman J. Hatton, Christopher M. Aderman, Roberta J. Dennison, Keirnan..., PLoS One., 1/1/2012
Maternal and neonatal factors associated with poor early weight gain and later retinopathy of prematurity
Wikstrand MH, Hard AL, Niklasson A, Smith L, Lofqvist C, Hellstrom A, Acta Paediatr, 12/1/2011
Stereoacuity in children with anisometropic amblyopia
Wallace DK, Lazar EL, Melia M, Birch EE, Holmes JM, Hopkins KB, Kraker RT, Kulp MT, Pang Y, Repka MX, Tamkins SM, Weise KK, Pediatric Eye Disease Investigator Group., J AAPOS, 10/1/2011
Ghrelin Modulates Physiologic and Pathologic Retinal Angiogenesis through GHSR-1a
Zaniolo K, Sapieha P, Shao Z, Stahl A, Zhu T, Tremblay S, Picard E, Madaan A, Blais M, Lachapelle P, Mancini J, Hardy P, Smith LE, Ong H, Chemtob S., Invest Ophthalmol Vis Sci., 7/1/2011
The insulin / IGF-1 system in neuroprotection
Andreas Stahl, Hormones in neurodegeneration, neuroprotection and neurogenesis., 1/1/2010
Quantification and localization of the IGF/insulin system expression in retinal blood vessels and neurons during oxygen-induced retinopathy in mice
Chatarina Lofqvist, Keirnan Willett*, Oskar Aspegren*, Alexandra C.H. Smith*, Christopher Aderman*, Kip Connor2, Jing Chen, Ann Hellstrom, Lois E. H. Smith, Invest Ophthalmol Vis Sci., 4/1/2009
Retinopathy of Prematurity Retinopathy of Prematurity: Current Concepts in Molecular Pathogenesis
Heidary G Vanderveen DK Smith LE, Semin Ophthalmol., 3/1/2009
Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy
Jing Chen, Kip M. Connor, Christopher M. Aderman, Keirnan L. Willett, Oskar P. Aspegren, Lois E.H. Smith, Investigative Ophthalmology and Visual Science, 1/1/2009
Retinopathy of Prematurity: Clinical Insights from Molecular Studies
Gena Heidary, Chatarina Lofqvist, Iason S. Mantagos, Deborah K. Vanderveen, Ann Hellstrom, Lois E. Smith, Neoreviews, 1/1/2009
Through the eyes of a child: understanding retinopathy through ROP: the Friedenwald lecture
Smith LE, Invest Ophthalmol Vis Sci., 12/1/2008
Macular Telangiectasia Research GroupThe National Eye Institute Visual Function Questionnaire in the Macular Telangiectasia (MacTel) Project
Clemons TE, Gillies MC, Chew EY, Bird AC, Peto T, Figueroa M, Harrington MW, Macular Telangiectasia Research Group.The National Eye Institute Visual Function Questionnaire in the Macular Telangiectasia (MacTel) Project., 10/1/2008
Erythropoietin Deficiency Decreases Vascular Stability (cover article)
Chen J, Connor K, Aderman C, Smith LEH, J Clin Invest, 1/1/2008
Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration
Chen J, Connor KM, Smith, LE., J Clin Invest., 10/1/2007
Increased dietary intake of Omega 3 PUFA reduces pathological retinal angiogenesis (cover article)
Kip M. Connor, John Paul SanGiovanni, Chatarina Lofqvist, Christopher M. Aderman, Jing Chen, Akiko Higuchi, Song Hong, Elke A. Pravda, Sharon Majchrzak, Deborah Carper..., Nat Med., 7/1/2007
Insulin-like growth factor binding protein 3 dose dependently suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular re-gr...
Chatarina Lofqvist, Jing Chen, Kip M. Connor, Alexandra C.H. Smith, Christopher M. Aderman, Nan Liu, John E. Pintar, Thomas Ludwig, Ann Hellstrom, Lois E.H. Smith, Proceedings of the National Academy of Sciences, 1/1/2007
Longitudinal postnatal weight and IGF-I measurements improve prediction of ROP
Chatarina Lofqvist, Eva Andersson, Jon Sigurdsson, Eva Engstrom, Anna-Lena Hard, Aimon Niklasson, Lois E. H. Smith, and Ann Hellstrom, Archives of Ophthalmology, 12/1/2006
Postnatal head growth deficit in premature infants parallels retinopathy of prematurity and IGF-1 deficit
Lofqvist C, Egstrom E, Sigurdsson J, Hard A-L, Niklasson A, Ewald U, Holmstrom G, Smith LEH*, Hellstrom A*, Pediatrics., 6/1/2006
Oxygen and retinopathy of prematurity
OD Saugstad, Journal Of Perinatology, 1/1/2006
A radically twisted lipid regulates vascular death
Smith L. E. H., Connor, K., Nat Med., 12/1/2005
Periorbital Lymphatic Malformation: Clinical Course and management in 42 patients
Greene AK, Burrows PE, Smith L, Mulliken JB, Plastic and Reconstructive Surgery, 1/1/2005
Quantitative Multi-Gene Transcriptional Profiling using Real-time PCR with a Master Template
Shih S-C, Smith LEH, Experimental and Molecular Pathology, 1/1/2005
Periorbital lymphatic malformation: clinical course and management in 42 patients Review
Greene AK, Burrows PE, Smith L, Mulliken JB, Plast Reconstr Surg., 1/1/2005
IGF-1 and retinopathy of prematurity in the preterm infant
Smith, LEH, Biology of the Neonate, 1/1/2005
Can we restore the in utero environment in premature infants to prevent disease?
Smith L.E. H., Pediatrics, 8/11/2004
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Press Mentions

Pet Owners in Need to Get Relief This WeekendJune 19th, 2020

Grant Support

Neuronal Guidance Molecules Control Revascularization In RetinopathyNational Eye Institute2012
Dietary Control Of Angiogenesis In Retinopathy ModelsNational Eye Institute2011
Dietary Control Of Angiogenesis In Retinopathy Model;Basis For Clinical TrialsNational Eye Institute2006–2010
Developmental Retinal NeovascularizationNational Eye Institute2003–2007
Surrogate Markers For Early Stage Diabetic RetinopathyNational Eye Institute2002–2003
Retinopathy Of Prematurity--Therapies And MechanismNational Eye Institute1998–2002
Hormonal Regulation Of Juvenile HemangiomasNational Center For Research Resources1996–1997
Vascular Cell Immaturity In Retinopathy Of PrematurityNational Eye Institute1992–1996