LorraineCherylPelosofMD

Oncology • Washington, DC

Physician

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Office
3800 Reservoir Rd NW
Washington, DC 20007
Phone+1 202-444-3976

Fax+1 202-444-5104
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Education & Training

Johns Hopkins UniversityFellowship, Hematology and Medical Oncology, 2010 - 2013
University of Texas Southwestern Medical CenterResidency, Internal Medicine, 2007 - 2010
Washington University in St. Louis School of MedicineClass of 2007

Certifications & Licensure

TX State Medical License 2010 - 2024
DC State Medical License 2017 - 2024
MD State Medical License 2010 - 2023
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Medical Oncology

Clinical Trials

Lung-MAP: Taselisib as Therapy in Treating Patients With Stage IV Squamous Cell Lung Cancer and Positive Biomarker Matches Start of enrollment: 2014 Nov 01
Completed
Phase 2
Lung-MAP: Palbociclib as Second-Line Therapy in Treating Cell Cycle Gene Alteration Positive Patients With Recurrent Stage IV Squamous Cell Lung Cancer Start of enrollment: 2014 Sep 01
Completed
Phase 2, Phase 3
Lung-MAP: Nivolumab With or Without Ipilimumab as Second-Line Therapy in Treating Patients With Recurrent Stage IV Squamous Cell Lung Cancer and No Matching Biomarkers Start of enrollment: 2015 Dec 29
Active, not recruiting
Phase 3

Publications & Presentations

PubMed

9 citations
Association between antibiotics and adverse oncological outcomes in patients receiving targeted or immune-based therapy for hepatocellular carcinoma.
David J Pinato, Xiaoxue Li, Pallavi Mishra-Kalyani, Antonio D'Alessio, Claudia A M Fulgenzi, Bernhard Scheiner, Matthias Pinter, Guo Wei, Julie Schneider, Donna R Rive...> ;JHEP Reports. 2023 Jun 1
14 citations
Oncologic emergencies and urgencies: A comprehensive review.
Bonnie E Gould Rothberg, Tammie E Quest, Sai-Ching J Yeung, Lorraine C Pelosof, David E Gerber, Justin A Seltzer, Jason J Bischof, Charles R Thomas Jr, Nausheen Akhter...> ;CA. 2022 Nov 1
1 citations
Comparative Characterization of Different Molecular Formats of Bispecific Antibodies Targeting EGFR and PD-L1.
Nishant Mohan, Atul Agrawal, Yi Shen, Katie L Winarski, Yukinori Endo, Milos Dokmanovic, Deborah Schmiel, Jiwen Zheng, David S Rotstein, Lorraine C Pelosof, Wen Jin Wu> ;Pharmaceutics. 2022 Jun 29
40 citations
Treatment-related toxicity and improved outcome from immunotherapy in hepatocellular cancer: Evidence from an FDA pooled analysis of landmark clinical trials with vali...
David J. Pinato, Thomas U. Marron, Pallavi S. Mishra-Kalyani, Yutao Gong, Guo Wei, David Szafron, Elad Sharon, Anwaar Saeed, Tomi Jun, Sirish Dharmapuri, Abdul Rafeh N...> ;European Journal of Cancer. 2021 Sep 8
45 citations
FDA Approval Summary: Nivolumab Plus Ipilimumab for the Treatment of Patients with Hepatocellular Carcinoma Previously Treated with Sorafenib
May Tun Saung, Lorraine Pelosof, Sandra Casak, Martha Donoghue, Steven Lemery, Mengdie Yuan, Lisa Rodriguez, Peter Schotland, Meredith K. Chuk, Gina Davis, Kirsten B. ...> ;The Oncologist. 2021 Sep 1
Deciphering the Dynamic Complexities of the Liver Microenvironment - Toward a Better Understanding of Immune-Mediated liver Injury Caused by Immune Checkpoint Inhibito...
Tao Wang, Matthew M. Yeh, Mark I. Avigan, Lorraine Pelosof, Gerald M. Feldman> ;The AAPS Journal. 2021 Aug 16
47 citations
Systematic Review of PD-1/PD-L1 Inhibitors in Oncology: From Personalized Medicine to Public Health
Elaine Chang, Lorraine Pelosof, Steven Lemery, Yutao Gong, Kirsten B. Goldberg, Ann T. Farrell, Patricia Keegan, Janaki Veeraraghavan, Guo Wei, Gideon M. Blumenthal, L...> ;The Oncologist. 2021 Oct 1
6 citations
Benefit-Risk Summary of Nivolumab for the Treatment of Patients with Unresectable Advanced, Recurrent, or Metastatic Esophageal Squamous Cell Carcinoma After Prior Flu...
Lorraine Pelosof, May Tun Saung, Martha Donoghue, Sandra Casak, Sirisha Mushti, Joyce Cheng, Xiling Jiang, Jiang Liu, Hong Zhao, Maryam Khazraee, Kirsten B. Goldberg, ...> ;The Oncologist. 2021 Apr 1
18 citations
A Novel Bispecific Antibody Targeting EGFR and VEGFR2 Is Effective against Triple Negative Breast Cancer via Multiple Mechanisms of Action.
Nishant Mohan, Xiao Luo, Yi Shen, Zachary Olson, Atul Kumar Agrawal, Yukinori Endo, David S. Rotstein, Lorraine Pelosof, Wen Jin Wu> ;Cancers. 2021 Mar 1
15 citations
Concentration-dependent Early Antivascular and Antitumor Effects of Itraconazole in Non–Small Cell Lung Cancer
David E. Gerber, William C. Putnam, Farjana J. Fattah, Kemp H. Kernstine, Rolf A. Brekken, Ivan Pedrosa, Rachael Skelton, Jessica Saltarski, Robert E. Lenkinski, Richa...> ;Clinical Cancer Research. 2020 Nov 15
12 citations
NGS Evaluation of Colorectal Cancer Reveals Interferon Gamma Dependent Expression of Immune Checkpoint Genes and Identification of Novel IFNγ Induced Genes.
Lai Xu, Lorraine Pelosof, Rong Wang, Hugh I. McFarland, Wells W. Wu, Je-Nie Phue, Chun-Ting Lee, Rong-Fong Shen, Hartmut Juhl, Lei-Hong Wu, Wei-Lun Alterovitz, Emanuel...> ;Frontiers in Immunology. 2020 Mar 19
14 citations
Novel reference genes in colorectal cancer identify a distinct subset of high stage tumors and their associated histologically normal colonic tissues.
Lai Xu, Helen Luo, Rong Wang, Wells W. Wu, Je-Nie Phue, Rong Fong Shen, Hartmut Juhl, Leihong Wu, Wei-Lun Alterovitz, Vahan Simonyan, Lorraine Pelosof, Amy S. Rosenberg> ;BMC Medical Genetics. 2019 Aug 13
140 citations
Hepatotoxicity of immune checkpoint inhibitors: An evolving picture of risk associated with a vital class of immunotherapy agents.
Daniel L. Suzman, Lorraine Pelosof, Amy S. Rosenberg, Mark I. Avigan> ;Liver International. 2018 Jun 1
188 citations
A 25-Year Experience of US Food and Drug Administration Accelerated Approval of Malignant Hematology and Oncology Drugs and Biologics: A Review.
Julia A. Beaver, Lynn J. Howie, Lorraine Pelosof, Kim Ts, Jinzhong Liu, Kirsten B. Goldberg, Rajeshwari Sridhara, Gideon M. Blumenthal, Ann T. Farrell, Patricia Keegan...> ;JAMA Oncology. 2018 Jun 1
11 citations
Benefit‐Risk Summary of Regorafenib for the Treatment of Patients with Advanced Hepatocellular Carcinoma That Has Progressed on Sorafenib
Lorraine Pelosof, Steven Lemery, Sandra Casak, Xiaoping Jiang, Lisa Rodriguez, Vadryn Pierre, Youwei Bi, Jiang Liu, Jeanne Fourie Zirkelbach, Anuja Patel, Kirsten B. G...> ;The Oncologist. 2018 Apr 1
Response.
Lorraine Pelosof, Chul Ahn, Joan Schiller> ;Journal of the National Cancer Institute. 2018 Apr 1
20 citations
Transcriptome analysis of human colorectal cancer biopsies reveals extensive expression correlations among genes related to cell proliferation, lipid metabolism, immun...
Lai Xu, Rong Wang, Joseph M. Ziegelbauer, Wells W. Wu, Rong Fong Shen, Hartmut Juhl, Yaqin Zhang, Lorraine Pelosof, Amy S. Rosenberg> ;Oncotarget. 2017 Aug 18
41 citations
GPX3 promoter methylation predicts platinum sensitivity in colorectal cancer.
Lorraine Pelosof, Sashidhar R. Yerram, Todd D. Armstrong, Nina Chu, Ludmila Danilova, Breann Yanagisawa, Manuel Hidalgo, Nilofer S. Azad, James G. Herman> ;Epigenetics. 2017 Jul 3
77 citations
Proportion of Never-Smoker Non-Small Cell Lung Cancer Patients at Three Diverse Institutions.
Lorraine Pelosof, Chul Ahn, Ang Gao, Leora Horn, Alejandra Madrigales, Joan Cox, Dauphne McGavic, John D. Minna, Adi F. Gazdar, Joan H. Schiller> ;Journal of the National Cancer Institute. 2017 Jul 1
113 citations
Whole-exome sequencing of pancreatic neoplasms with acinar differentiation.
Yuchen Jiao, Raluca Yonescu, G. Johan A. Offerhaus, David S. Klimstra, Anirban Maitra, James R. Eshleman, James G. Herman, Weijie Poh, Lorraine Pelosof, Christopher L....> ;The Journal of Pathology. 2014 Mar 1
18 citations
CHFR silencing or microsatellite instability is associated with increased antitumor activity of docetaxel or gemcitabine in colorectal cancer
Lorraine Pelosof, Sashidhar R. Yerram, Nita Ahuja, Andrew Delmas, Ludmila Danilova, James G. Herman, Nilofer S. Azad> ;International Journal of Cancer. 2014 Feb 1
378 citations
Paraneoplastic Syndromes: An Approach to Diagnosis and Treatment
Lorraine Pelosof, David E. Gerber> ;Mayo Clinic Proceedings. 2010 Sep 1
11 citations
Co-ordinate but disproportionate activation of apoptotic, regenerative and inflammatory pathways characterizes the liver response to acute amebic infection.
Lorraine C. Pelosof, Paul H. Davis, Zhi Zhang, Xiaochun Zhang, Samuel L. Stanley> ;Cellular Microbiology. 2006 Mar 1
298 citations
Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine
Ritu Banerjee, Jun Liu, Wandy L. Beatty, Lorraine C. Pelosof, Michael Klemba, Daniel E. Goldberg> ;Proceedings of the National Academy of Sciences of the United States of America. 2002 Jan 22
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