LouisGhanemMDPhD

PubMed

• 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity.
  Khanh B Trang, Matthew C Pahl, James A Pippin, Chun Su, Sheridan H Littleton, Prabhat Sharma, Nikhil N Kulkarni, Louis R Ghanem, Natalie A Terry, Joan M O'Brien, Yadav...> ;Medrxiv. 2024 Feb 5
• The poly(C)-binding protein Pcbp2 is essential for CD4T cell activation and proliferation.
  Massimo Martinelli, Gabrielle Aguilar, David S M Lee, Andrew Kromer, Nhu Nguyen, Benjamin J Wilkins, Tatiana Akimova, Ulf H Beier, Louis R Ghanem> ;Iscience. 2023 Jan 20
• Patient-derived Colonoids From Disease-spared Tissue Retain Inflammatory Bowel Disease-specific Transcriptomic Signatures.
  Tatiana A Karakasheva, Yusen Zhou, Hongbo M Xie, Gloria E Soto, Tiana D Johnson, Madison A Stoltz, Daana M Roach, Noor Nema, Chizoba N Umeweni, Kaitlyn Naughton, Laure...> ;Gastro Hep Advances. 2023 Jan 1
• 3 citations
  CYP11B1 variants influence skeletal maturation via alternative splicing.
  Olja Grgic, Matthew R. Gazzara, Alessandra Chesi, Carolina Medina-Gomez, Diana L. Cousminer, Jonathan A. Mitchell, Vid Prijatelj, Jard H. de Vries, Enisa Shevroja, Sha...> ;Communications Biology. 2021 Nov 9
• 4 citations
  RNA-binding proteins PCBP1 and PCBP2 are critical determinants of murine erythropoiesis
  Xinjun Ji, Anupama Jha, Jesse Humenik, Louis R. Ghanem, Andrew Kromer, Christopher Duncan-Lewis, Elizabeth A. Traxler, Mitchell J. Weiss, Yoseph Barash, Stephen A. Lie...> ;Molecular and Cellular Biology. 2021 Jun 28
• 28 citations
  Disrupting upstream translation in mRNAs is associated with human disease
  David Lee, Joseph Park, Andrew Kromer, Aris Baras, Daniel J. Rader, Marylyn D. Ritchie, Louis R. Ghanem, Yoseph Barash> ;Nature Communications. 2021 Mar 9
• 9 citations
  Variant-to-Gene-Mapping Analyses Reveal a Role for the Hypothalamus in Genetic Susceptibility to Inflammatory Bowel Disease
  Chiara Lasconi, Matthew C. Pahl, Diana L. Cousminer, Claudia A. Doege, Alessandra Chesi, Kenyaita M. Hodge, Michelle E. Leonard, Sumei Lu, Matthew E. Johnson, Chun Su,...> ;Cellular and Molecular Gastroenterology and Hepatology. 2021 Jan 1
• 122 citations
  Lactate Limits T Cell Proliferation via the NAD(H) Redox State.
  William J. Quinn, Jing Jiao, Tara TeSlaa, Jason Stadanlick, Zhonglin Wang, Liqing Wang, Tatiana Akimova, Alessia Angelin, Patrick M. Schäfer, Michelle D. Cully, Caroli...> ;Cell Reports. 2020 Dec 15
• 47 citations
  Integrative analysis reveals RNA G-quadruplexes in UTRs are selectively constrained and enriched for functional associations
  David Lee, Louis R. Ghanem, Yoseph Barash> ;Nature Communications. 2020 Jan 27
• 41 citations
  The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution
  Deanne Taylor, Bruce J. Aronow, Kai Tan, Kathrin M. Bernt, Nathan Salomonis, Casey S. Greene, Alina Frolova, Sarah E. Henrickson, Andrew D. Wells, Liming Pei, Jyoti K....> ;Developmental Cell. 2019 Apr 8
• 8 citations
  Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript.
  Louis R. Ghanem, Andrew Kromer, Ian M. Silverman, Xinjun Ji, Matthew R. Gazzara, Nhu Nguyen, Gabrielle Aguilar, Massimo Martinelli, Yoseph Barash, Stephen A. Liebhaber> ;Molecular and Cellular Biology. 2018 Jul 30
• 46 citations
  The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development
  Louis R. Ghanem, Andrew Kromer, Ian M. Silverman, Priya Chatterji, Elizabeth A. Traxler, Alfredo I. Penzo-Méndez, Mitchell J. Weiss, Ben Z. Stanger, Stephen A. Liebhaber> ;Molecular and Cellular Biology. 2015 Nov 2
• 11 citations
  Specific enrichment of the RNA-binding proteins PCBP1 and PCBP2 in chief cells of the murine gastric mucosa.
  Louis R. Ghanem, Priya Chatterji, Stephen A. Liebhaber> ;Gene Expression Patterns. 2014 Jan 28
• 9 citations
  IL-3 and oncogenic Abl regulate the myeloblast transcriptome by altering mRNA stability.
  Jason Ernst, Louis R. Ghanem, Ziv Bar-Joseph, Michael J. McNamara, Jason L. Brown, Richard A. Steinman> ;Plos One. 2009 Oct 15
• 27 citations
  p21(Waf1/Cip1) deficiency stimulates centriole overduplication.
  Anette Duensing, Louis R. Ghanem, Richard A. Steinman, Ying Liu, Stefan Duensing> ;Cell Cycle. 2006 Nov 28
• 11 citations
  p21Waf1 inhibits granulocytic differentiation of 32Dcl3 cells.
  Louis R. Ghanem, Richard A. Steinman> ;Leukemia Research. 2006 Oct 1
• 27 citations
  A proapoptotic function of p21 in differentiating granulocytes
  Louis R. Ghanem, Richard A. Steinman> ;Leukemia Research. 2005 Nov 1
• 70 citations
  Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage.
  Surender Kharbanda, Pramod Pandey, Teruo Yamauchi, Shailender Kumar, Masao Kaneki, Vijay Kumar, Ajit Bharti, Zhi-Min Yuan, Louis R. Ghanem, Ajay Rana, Ralph R. Weichse...> ;Molecular and Cellular Biology. 2000 Jul 15
• 121 citations
  Activation of p38 Mitogen-activated Protein Kinase by PYK2/Related Adhesion Focal Tyrosine Kinase-dependent Mechanism
  Pramod Pandey, Shalom Avraham, Shailender Kumar, Atsuko Nakazawa, Andrew E. Place, Louis R. Ghanem, Ajay Rana, Vijay Kumar, Pradip K. Majumder, Hava Avraham, Roger J. ...> ;The Journal of Biological Chemistry. 1999 Apr 9
• 90 citations
  Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy.
  Vincent L. Cryns, Youngsup Byun, Ajay Rana, Harry Mellor, Kevin D. Lustig, Louis R. Ghanem, Peter J. Parker, Marc W. Kirschner, Junying Yuan> ;The Journal of Biological Chemistry. 1997 Nov 21
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