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Lu Le, MD, Dermatology, Charlottesville, VA, William P. Clements, Jr. University Hospital

LuQ.LeMDPhD

Dermatology Charlottesville, VA

Professor and Chair of the Department of Dermatology at The University of Virginia School of Medicine

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Summary

  • Dr. Le is a Professor of Dermatology at UT Southwestern Medical School with clinical and scientific interest in Neurofibromatosis. He received his Ph.D. degree in Immunology and Molecular Genetics, and a medical degree (M.D.) from the Medical Scientist Training Program at the University of California, Los Angeles (UCLA). He completed an Internship in Internal Medicine at UCLA/St. Mary Medical Center, residency training in Dermatology and a postdoctoral research fellowship in Cancer Biology from University of Texas Southwestern Medical Center. He is board certified by the American Board of Dermatology. Dr. Le sees patients in the Dermatology clinic and at the UTSW Comprehensive Neurofibromatosis clinic. As a principal investigator in cancer biology, his research bridges the fields of Cancer Biology, Developmental Biology, and Stem Cell Biology that focuses on neural-crest derived tissue development, regeneration and tumorigenesis, in particular the biology of neurofibromatosis. Dr. Le’s laboratory investigates how tumor cell of origin and tumor microenvironment interplay to regulate NF1-associated tumorigenesis. A major contribution of Dr. Le’s laboratory is the generation and exploitation of different Neurofibromatosis models to decipher mechanisms that initiate neurofibroma development and drive their malignant transformation [Cancer Cell 26(5): 695-706; Cell Stem Cell 4(5):453-63; Cell, 152(5): 1077-1090; Cell Reports, 6(1): 81-92; Cancer Research, 74(2): 586-97]. In addition, it was this work in neurofibromatosis and mechanisms whereby neural-crest derived tissues and nerves can affect tumor development in skin and other tissues that serendipitously lead his group to uncover the identity of follicular epithelial cells that directly give rise to hair and mechanisms that cause hair to turn gray [Genes & Development. 31(8): 744-756] – findings that could one day help identify possible treatments for balding and hair graying.
  • The Le Laboratory at UT Southwestern Medical School

    The Le Laboratory is composed of a core group of talented research scientists, postdoctoral fellows, students and research associates. Our work bridges the fiel

Education & Training

  • University of Texas M D Anderson Cancer Center
    University of Texas M D Anderson Cancer CenterFellowship, Cancer Biology, 2006 - 2009
  • University of Texas Southwestern Medical Center
    University of Texas Southwestern Medical CenterResidency, Dermatology, 2004 - 2007
  • St Mary Medical Center
    St Mary Medical CenterInternship, Internal Medicine, 2003 - 2004
  • David Geffen School of Medicine at UCLA
    David Geffen School of Medicine at UCLAClass of 2003
  • UCLA
    UCLAPhD, Microbiology, Immunology and Molecular Genetics, 1998 - 2002

Certifications & Licensure

  • VA State Medical License
    VA State Medical License 2023 - 2026
  • TX State Medical License
    TX State Medical License 2007 - 2024
  • CA State Medical License
    CA State Medical License 2005 - 2023
  • American Board of Dermatology Dermatology

Awards, Honors, & Recognition

  • Elected to membership in the American Society for Clinical Investigation (ASCI) American Society for Clinical Investigation, 2015
  • Thomas L. Shields, M.D. Endowed Professorship in Dermatology UT Southwestern Medical Center, 2015
  • CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2012
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Clinical Trials

Publications & Presentations

PubMed

Journal Articles

  • Training Physician-Scientists for Careers in Investigative Dermatology  
    Li, S., Yancey, K.B., Cruz, P.D., Le, L.Q., JID Innovations, 10/19/2021
  • Insights into the pathogenesis of NF1-associated neoplasms  
    Bui, A., Jiang, C., McKay, R.M., Klesse, L.J., and Le, L.Q., JID Innovations, 7/29/2021
  • New insights into the neurofibroma tumor cells of origin  
    Stephen Li, Zhiguo Chen and Lu Q Le, Neuro-Oncology Advances, 11/11/2019
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Books/Book Chapters

Press Mentions

  • Dr. Le named Chair of UVA Department of Dermatology
    Dr. Le named Chair of UVA Department of DermatologyOctober 19th, 2023
  • Marker Found for NF1, Condition That Causes Numerous Tumors
    Marker Found for NF1, Condition That Causes Numerous TumorsOctober 22nd, 2018
  • KROX20 Study: Balding, Grey Hair Due to Skin Cells
    KROX20 Study: Balding, Grey Hair Due to Skin CellsJune 3rd, 2017
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Grant Support

  • Career Awards for Medical ScientistsThe Burroughs Wellcome FundPresent
  • NF Research GrantTexas Neurofibromatosis FoundationPresent
  • Pilot & Feasibility Study GrantGaldermaPresent
  • Investigator Initiated Neurofibromatosis Research ProgramU.S. Department of DefensePresent
  • R01NIH - National Cancer InstitutePresent

Professional Memberships

Other Languages

  • Vietnamese

Hospital Affiliations