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Office
Primary Care Center, Third floor
1221 Lee Street
Charlottesville, VA 22908Phone+1 434-924-5115- Is this information wrong?
Summary
- Dr. Le is a Professor of Dermatology at UT Southwestern Medical School with clinical and scientific interest in Neurofibromatosis. He received his Ph.D. degree in Immunology and Molecular Genetics, and a medical degree (M.D.) from the Medical Scientist Training Program at the University of California, Los Angeles (UCLA). He completed an Internship in Internal Medicine at UCLA/St. Mary Medical Center, residency training in Dermatology and a postdoctoral research fellowship in Cancer Biology from University of Texas Southwestern Medical Center. He is board certified by the American Board of Dermatology. Dr. Le sees patients in the Dermatology clinic and at the UTSW Comprehensive Neurofibromatosis clinic. As a principal investigator in cancer biology, his research bridges the fields of Cancer Biology, Developmental Biology, and Stem Cell Biology that focuses on neural-crest derived tissue development, regeneration and tumorigenesis, in particular the biology of neurofibromatosis. Dr. Le’s laboratory investigates how tumor cell of origin and tumor microenvironment interplay to regulate NF1-associated tumorigenesis. A major contribution of Dr. Le’s laboratory is the generation and exploitation of different Neurofibromatosis models to decipher mechanisms that initiate neurofibroma development and drive their malignant transformation [Cancer Cell 26(5): 695-706; Cell Stem Cell 4(5):453-63; Cell, 152(5): 1077-1090; Cell Reports, 6(1): 81-92; Cancer Research, 74(2): 586-97]. In addition, it was this work in neurofibromatosis and mechanisms whereby neural-crest derived tissues and nerves can affect tumor development in skin and other tissues that serendipitously lead his group to uncover the identity of follicular epithelial cells that directly give rise to hair and mechanisms that cause hair to turn gray [Genes & Development. 31(8): 744-756] – findings that could one day help identify possible treatments for balding and hair graying.
Education & Training
- University of Texas M D Anderson Cancer CenterFellowship, Cancer Biology, 2006 - 2009
- University of Texas Southwestern Medical CenterResidency, Dermatology, 2004 - 2007
- St Mary Medical CenterInternship, Internal Medicine, 2003 - 2004
- David Geffen School of Medicine at UCLAClass of 2003
- UCLAPhD, Microbiology, Immunology and Molecular Genetics, 1998 - 2002
Certifications & Licensure
- VA State Medical License 2023 - 2026
- TX State Medical License 2007 - 2024
- CA State Medical License 2005 - 2023
- American Board of Dermatology Dermatology
Awards, Honors, & Recognition
- Elected to membership in the American Society for Clinical Investigation (ASCI) American Society for Clinical Investigation, 2015
- Thomas L. Shields, M.D. Endowed Professorship in Dermatology UT Southwestern Medical Center, 2015
- CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2012
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Clinical Trials
- Study of CPI-0610 in Patients With Malignant Peripheral Nerve Sheath Tumors Start of enrollment: 2017 May 05
- NFX-179 Topical Gel Treatment in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF) Start of enrollment: 2020 Aug 21
Publications & Presentations
PubMed
- Stem cell modeling of nervous system tumors.Furnari, F., Anastasaki, C., Bian, S., Fine, H., Koga, T., Gutmann, D., Le, L., Rodriguez, F.> ;Disease Models & Mechanisms. 2024 Feb 1
- Econazole selectively induces cell death in NF1-homozygous mutant tumor cells.Lakes, Y., Moye, S., Mo, J., Tegtmeyer, M., Nehme, R., Charlton, M., Salinas, G., McKay, R., Eggan, K., Le, L.> ;Cell Reports. Medicine. 2023 Dec 19
- Association of plexiform and diffuse neurofibromas with malignant peripheral nerve sheath tumor in NF I patients: a whole-body MRI assessment.Sarah Attia, Mina Guirguis, Lu Q Le, Avneesh Chhabra> ;Skeletal Radiology. 2024 Apr 1
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Journal Articles
- Training Physician-Scientists for Careers in Investigative DermatologyLi, S., Yancey, K.B., Cruz, P.D., Le, L.Q., JID Innovations, 10/19/2021
- Insights into the pathogenesis of NF1-associated neoplasmsBui, A., Jiang, C., McKay, R.M., Klesse, L.J., and Le, L.Q., JID Innovations, 7/29/2021
- New insights into the neurofibroma tumor cells of originStephen Li, Zhiguo Chen and Lu Q Le, Neuro-Oncology Advances, 11/11/2019
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Books/Book Chapters
Press Mentions
- Dr. Le named Chair of UVA Department of DermatologyOctober 19th, 2023
- Marker Found for NF1, Condition That Causes Numerous TumorsOctober 22nd, 2018
- KROX20 Study: Balding, Grey Hair Due to Skin CellsJune 3rd, 2017
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Grant Support
- Career Awards for Medical ScientistsThe Burroughs Wellcome FundPresent
- NF Research GrantTexas Neurofibromatosis FoundationPresent
- Pilot & Feasibility Study GrantGaldermaPresent
- Investigator Initiated Neurofibromatosis Research ProgramU.S. Department of DefensePresent
- R01NIH - National Cancer InstitutePresent
Professional Memberships
- Fellow
- Member
- Society for Investigative DermatologyMember
- American Society for Clinical Investigation (ASCI)Elected Member
Other Languages
- Vietnamese
Hospital Affiliations
- William P. Clements, Jr. University HospitalDallas, Texas
External Links
- UT Southwestern Medical Center Medical Centerhttp://www.utsouthwestern.edu/
- The Le Laboratory Websitehttps://labs.utsouthwestern.edu/le-lab
- Lu Le, M.D., Ph.D. - Faculty Profilehttp://profiles.utsouthwestern.edu/profile/68552/lu-le.html
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