LucyAWaskellMD

PubMed

• 1 citations
  The FMN "140s Loop" of Cytochrome P450 Reductase Controls Electron Transfer to Cytochrome P450.
  Freeborn Rwere, Sang Choul Im, Lucy Waskell> ;International Journal of Molecular Sciences. 2021 Sep 30
• 13 citations
  Expression, purification, and functional reconstitution of 19F-labeled cytochrome b5 in peptide nanodiscs for NMR studies.
  Jia Bai, Jian Wang, Thirupathi Ravula, Sang Choul Im, Gattadahalli M. Anantharamaiah, Lucy Waskell, Ayyalusamy Ramamoorthy> ;Biochimica Et Biophysica Acta. Biomembranes. 2020 Jan 15
• 40 citations
  Effect of polymer charge on functional reconstitution of membrane proteins in polymer nanodiscs
  Thirupathi Ravula, Nathaniel Z. Hardin, Jia Bai, Sang Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy> ;Chemical Communications. 2018 Aug 23
• 31 citations
  A Minimal Functional Complex of Cytochrome P450 and FBD of Cytochrome P450 Reductase in Nanodiscs.
  Elke Prade, Mukesh Mahajan, Sang Choul Im, Meng Zhang, Katherine A. Gentry, Gattadahalli M. Anantharamaiah, Lucy Waskell, Ayyalusamy Ramamoorthy> ;Angewandte Chemie. 2018 Jul 9
• 1 citations
  Structure of cytochrome P450 2B4 with an acetate ligand and an active site hydrogen bond network similar to oxyferrous P450cam.
  Yuting Yang, Weishu Bu, Sang Choul Im, Jennifer L. Meagher, Jeanne A. Stuckey, Lucy Waskell> ;Journal of Inorganic Biochemistry. 2018 Apr 30
• 39 citations
  Cytochrome-P450-Induced Ordering of Microsomal Membranes Modulates Affinity for Drugs
  Carlo Barnaba, Bikash R. Sahoo, Thirupathi Ravula, Ilce G. Medina-Meza, Sang Choul Im, Gattadahalli M. Anantharamaiah, Lucy Waskell, Ayyalusamy Ramamoorthy> ;Angewandte Chemie. 2018 Mar 19
• 3 citations
  Structural and Kinetic Studies of Asp632 Mutants and Fully Reduced NADPH-Cytochrome P450 Oxidoreductase Define the Role of Asp632 Loop Dynamics in the Control of NADPH...
  Chuanwu Xia, Freeborn Rwere, Sangchoul Im, Anna L Shen, Lucy Waskell, Jung-Ja P Kim> ;Biochemistry. 2018 Feb 13
• 31 citations
  Membrane environment drives cytochrome P450's spin transition and its interaction with cytochrome b5.
  Thirupathi Ravula, Carlo Barnaba, Mukesh Mahajan, Gattadahalli M. Anantharamaiah, Sang Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy> ;Chemical Communications. 2017 Nov 28
• 14 citations
  Kinetic and Structural Characterization of the Effects of Membrane on the Complex of Cytochrome b 5 and Cytochrome c.
  Katherine A. Gentry, Elke Prade, Carlo Barnaba, Meng Zhang, Mukesh Mahajan, Sang Choul Im, Gattadahalli M. Anantharamaiah, Satoshi Nagao, Lucy Waskell, Ayyalusamy Rama...> ;Scientific Reports. 2017 Aug 10
• 28 citations
  Transmembrane Interactions of Full-length Mammalian Bitopic Cytochrome-P450-Cytochrome-b 5 Complex in Lipid Bilayers Revealed by Sensitivity-Enhanced Dynamic Nuclear P...
  Kazutoshi Yamamoto, Marc A. Caporini, Sang Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy> ;Scientific Reports. 2017 Jun 23
• 15 citations
  Protonation of the Hydroperoxo Intermediate of Cytochrome P450 2B4 Is Slower in the Presence of Cytochrome P450 Reductase Than in the Presence of Cytochrome b5
  Naw May Pearl, Jarett Wilcoxen, Sang Choul Im, Ryan C. Kunz, Joseph E. Darty, R. David Britt, Stephen W. Ragsdale, Lucy Waskell> ;Biochemistry. 2016 Nov 8
• 34 citations
  Cytochrome b5 Activates the 17,20-Lyase Activity of Human Cytochrome P450 17A1 by Increasing the Coupling of NADPH Consumption to Androgen Production.
  Hwei Ming Peng, Sang Choul Im, Naw May Pearl, Adina F. Turcu, Juilee Rege, Lucy Waskell, Richard J. Auchus> ;Biochemistry. 2016 Jul 29
• 18 citations
  Mutants of Cytochrome P450 Reductase Lacking Either Gly-141 or Gly-143 Destabilize Its FMN Semiquinone
  Freeborn Rwere, Chuanwu Xia, Sang Choul Im, Mohammad Mahfuzul Haque, Dennis J. Stuehr, Lucy Waskell, Jung-Ja P. Kim> ;The Journal of Biological Chemistry. 2016 Jul 8
• 64 citations
  Reconstitution of the Cytb5–CytP450 Complex in Nanodiscs for Structural Studies using NMR Spectroscopy
  Meng Zhang, Rui Huang, Rose Ackermann, Sang Choul Im, Lucy Waskell, Anna Schwendeman, Ayyalusamy Ramamoorthy> ;Angewandte Chemie. 2016 Mar 24
• 22 citations
  Role of the Proximal Cysteine Hydrogen Bonding Interaction in Cytochrome P450 2B4 Studied by Cryoreduction, Electron Paramagnetic Resonance, and Electron-Nuclear Doubl...
  Roman Davydov, Sang Choul Im, Muralidharan Shanmugam, William A. Gunderson, Naw May Pearl, Brian M. Hoffman, Lucy Waskell> ;Biochemistry. 2016 Feb 3
• 26 citations
  Effects of Membrane Mimetics on Cytochrome P450-Cytochrome b5 Interactions Characterized by NMR Spectroscopy
  Meng Zhang, Rui Huang, Sang Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy> ;The Journal of Biological Chemistry. 2015 May 15
• 18 citations
  Kinetic and structural characterization of the interaction between the FMN binding domain of cytochrome P450 reductase and cytochrome c.
  Rui Huang, Meng Zhang, Freeborn Rwere, Lucy Waskell, Ayyalusamy Ramamoorthy> ;The Journal of Biological Chemistry. 2015 Feb 20
• 21 citations
  Insights into the role of substrates on the interaction between cytochrome b5 and cytochrome P450 2B4 by NMR.
  Meng Zhang, Stéphanie V. Le Clair, Rui Huang, Shivani Ahuja, Sang Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy> ;Scientific Reports. 2015 Feb 17
• 12 citations
  Temperature-resistant bicelles for structural studies by solid-state NMR spectroscopy.
  Kazutoshi Yamamoto, Paige Pearcy, Dong Kuk Lee, Changsu Yu, Sang Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy> ;Langmuir. 2015 Jan 17
• 67 citations
  Cellular solid-state NMR investigation of a membrane protein using dynamic nuclear polarization.
  Kazutoshi Yamamoto, Marc A. Caporini, Sang Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy> ;Biochimica Et Biophysica Acta. 2015 Jan 1
• 24 citations
  Distinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, e...
  Mohammad Mahfuzul Haque, Mekki Bayachou, Jesús Tejero, Claire Kenney, Naw May Pearl, Sang Choul Im, Lucy Waskell, Dennis J. Stuehr> ;The FEBS Journal. 2014 Dec 1
• 6 citations
  1H, 13C and 15N resonance assignments for the full-length mammalian cytochrome b5 in a membrane environment
  Subramanian Vivekanandan, Shivani Ahuja, Sang Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy> ;Biomolecular NMR Assignments. 2014 Oct 1
• 12 citations
  Structural and functional characterization of a cytochrome P450 2B4 F429H mutant with an axial thiolate-histidine hydrogen bond.
  Yuting Yang, Haoming Zhang, Dandamudi Usharani, Weishu Bu, Sang Choul Im, Michael Tarasev, Freeborn Rwere, Naw May Pearl, Jennifer L. Meagher, Cuthbert Sun, Jeanne A. ...> ;Biochemistry. 2014 Aug 12
• 31 citations
  Probing the Transmembrane Structure and Dynamics of Microsomal NADPH-cytochrome P450 oxidoreductase by Solid-State NMR
  Rui Huang, Kazutoshi Yamamoto, Meng Zhang, Nataliya Popovych, Ivan Hung, Sang Choul Im, Zhehong Gan, Lucy Waskell, Ayyalusamy Ramamoorthy> ;Biophysical Journal. 2014 May 20
• 14 citations
  Proton-detected 2D radio frequency driven recoupling solid-state NMR studies on micelle-associated cytochrome-b5
  Manoj Kumar Pandey, Subramanian Vivekanandan, Kazutoshi Yamamoto, Sang Choul Im, Lucy Waskell, Ayyalusamy Ramamoorthy> ;Journal of Magnetic Resonance. 2014 May 1
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Lectures

• Characterization of Cytochrome P450 Reductase Mutants that Control its Activity with Cytochrome P450 
  Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA - 10/14/2014