LuqiChiMDMSCE, FACP

Pulmonology • Brentwood, MO

Sleep Medicine

Clinical Professor, Washington University Sleep Medicine Center Washington University School of Medicine

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Office
1600 S Brentwood Blvd
Ste 600
Brentwood, MO 63144
Phone+1 314-362-4342

Fax+1 314-747-3813
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Summary

Dr. Chi received her medical degree and a master’s degree in cardiopulmonary pathophysiology in China. She subsequently completed her residency training in internal medicine and fellowship training in pulmonary and critical care medicine. After coming to the US in 1998, she went on to complete her US residency in Rochester General Hospital and fellowship training in sleep medicine at the University of Pennsylvania School of Medicine. She also received a master’s degree in Clinical Epidemiology (MSCE) at the University of Pennsylvania. Prior to joining Washington University, Dr. Chi practiced sleep medicine in Philadelphia, holding a faculty position at both the University of Pennsylvania School of Medicine and Jefferson Medical College.

Areas of Clinical Interest:
Outpatient sleep medicine consultation and hospital sleep medicine.

Sleep disorders: obstructive and central sleep apnea, treatment adherence issues associated with positive airway pressure therapy, sleep related hypoventilation, obesity hypoventilation syndrome, circadian rhythm disorders, insomnia, hypersomnia, narcolepsy, restless leg syndrome, periodic limb movement disorder, and parasomnias.

Respiratory failure caused by neuromuscular disease, chest wall deformity, lung disease and congestive heart failure using noninvasive ventilation (NIV) delivered through a variety of ventilatory modes.

Clinical research:
Dr. Chi is a site principle investigator and co-investigator for NIH-sponsored clinical trials:

1. The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep Apnea
2. The impact of treating obstructive sleep apnea on mild cognitive impairment
3. The effect of CPAP on cardiac function in hospitalized patients with obstructive sleep apnea and heart failure
4. Reducing heart failure re-admissions by enhancing CPAP adherence

The Mobile Sleep Medicine Care Model Welcome to the Future!!!

This video introduces the Mobile Sleep Care Model. It won the People's Choice competition held by the AASM in 2021.

Education & Training

University of Pennsylvania Health System/Children's Hospital of PhiladelphiaFellowship, Sleep Medicine, 2006 - 2008
University of PennsylvaniaMaster of Science, Clinical Epidemiology, 2006 - 2008
Rochester General HospitalResidency, Internal Medicine, 2004 - 2006
Kingsbrook Jewish Medical CenterResidency, Internal Medicine, 2003 - 2004
Military Postgraduate Medical SchoolMS, Pulmonary Pathophysiology, 1994 - 1997
OtherClass of 1997, MD & MS

Certifications & Licensure

IL State Medical License 2021 - 2026
MO State Medical License 2014 - 2025
PA State Medical License 2006 - 2016
American Board of Internal Medicine Sleep Medicine

Clinical Trials

Reducing Heart Failure Re-admissions by Enhancing Sleep Apnea Treatment Adherence Start of enrollment: 2014 Nov 01
Completed
Not Applicable
MCI: CPAP Treatment of OSA (Memories2) Start of enrollment: 2018 Jan 19
Active, not recruiting
Not Applicable
The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep Apnea Start of enrollment: 2019 Apr 15
Terminated
Phase 3

Publications & Presentations

PubMed

The mobile sleep medicine model in neurologic practice: Rationale and application.
Mark I Boulos, Luqi Chi, Oleg Y Chernyshev> ;Frontiers in Neurology. 2022 Jan 1
16 citations
Top Ten Tips Palliative Care Clinicians Should Know About Amyotrophic Lateral Sclerosis.
Elyse A. Everett, Elizabeth Pedowitz, Samuel Maiser, Joss C Cohen, Jessica Besbris, Ambereen K. Mehta, Luqi Chi, Christopher A Jones> ;Journal of Palliative Medicine. 2020 May 29
35 citations
Differences in three-dimensional upper airway anatomy between Asian and European patients with obstructive sleep apnea.
Liyue Xu, Brendan T. Keenan, A S Wiemken, Luqi Chi, Bethany Staley, Zhifang Wang, Jianjun Wang, Bryndis Benedikstdottir, Sigurdur Juliusson, Allan I. Pack, Thorarinn G...> ;Sleep. 2020 May 12
68 citations
Web-Based Access to Positive Airway Pressure Usage with or without an Initial Financial Incentive Improves Treatment Use in Patients with Obstructive Sleep Apnea.
Samuel T. Kuna, David Shuttleworth, Luqi Chi, Sharon Schutte-Rodin, Eliot Friedman, Hengyi Guo, Sandeep Dhand, Lin Yang, Jingsan Zhu, Scarlett L. Bellamy, Kevin G. Vol...> ;Sleep. 2015 Aug 1
36 citations
Heritability of craniofacial structures in normal subjects and patients with sleep apnea.
Luqi Chi, Francois-Louis Comyn, Brendan T. Keenan, Jacqueline R. Cater, Greg Maislin, Allan I. Pack, Richard Schwab> ;Sleep. 2014 Oct 1
107 citations
Identification of craniofacial risk factors for obstructive sleep apnoea using three-dimensional MRI.
Luqi Chi, Francois-Louis Comyn, Nandita Mitra, Muredach P. Reilly, Fei Wan, Greg Maislin, Lauren Chmiewski, Matthew D. Thorne-FitzGerald, UN Victor, Allan I. Pack, Ric...> ;The European Respiratory Journal. 2011 Aug 1
8 citations
Signal transduction pathways in mast cell granule-mediated endothelial cell activation.
Luqi Chi, Lisa Stehno-Bittel, Irina V. Smirnova, Daniel J. Stechschulte, Kottarappat N. Dileepan> ;Mediators of Inflammation. 2003 Apr 1
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Journal Articles

Heritability of Craniofacial Structures in Normal Subjects and Patients with Obstructive Sleep Apnea
Chi, L., Comyn, F., Keenan, B.T., Cater, J., Maislin, G., Pack, A.I., Schwab, R.J., Sleep, 10/1/2014

Abstracts/Posters

Heritability of Craniofacial Structures in Normal Subjects and Patients with Sleep Apnea
K. Wang, J. Wang, Z. Wang, Y. Sun, X. Li, W. Qu, C. F-L. Comyn, S. Shinde, T. Gislason, B. Benediktsdottir, L. Chi, R. J. Schwab, Am J Respir Crit Care Med 189;2014:A5336, American Thoracic Society International Conference, San Diego, 2014
High Prevalence of Cognitive Deficits in Older Patients with Sleep Apnea Identified by a Sleep Lab Questionnaire and Telephone Interview
S. Rangu, S.Moelter, A. Hanlon, D. Wolk, L. Chi, E. Davis, MD, C. Cheng, D. Thompson, A. Huang, M. Barrett, M. Loftspring, V. Vallabhaneni, K. Doghramji, K. Richards, ..., Associated Professional Sleep Societies (APSS) annual conference, San Antonio, TX, June 8-12, 2019
Interethnic Comparison of Inter-Mandibular and Soft Tissue Volume among Native Chinese, Icelandic Caucasian and African American Apneics
C. Lin, A.S. Wiemken, S.E. Leinwand, S. Wang, B.T. Keenan, J. Wang, Z. Wang, Y. Sun, X. Li, W. Qu, T. Gislason, B. Benediktsdottir, L. Chi, R.J. Schwab., Associated Professional Sleep Societies (APSS) annual conference, Boston, MA, June 3-7, 2017
Interethnic Comparison of Anatomic Risk Factors for OSA between Native Chinese and Icelandic Caucasians
L. Chi, J. Wang, Y. Sun, Z. Wang, X. Li, W. Qu, D. Wang, C. Bearn, F-L. Comyn, S. Shinde, K. Wang, T. Gislason, B. Benediktsdottir, R. J. Schwab, Am J. Resp. Crit. Care Med. 187A: 5935, 2013
Differential Upper Airway Anatomic Risk Factors between Native Chinese and Icelandic Caucasian Apneics
J. Wang, Z. Wang, Y. Sun, X. Li, W. Qu, C. F-L. Comyn, S. Shinde, K. Wang, L. Chi, R. J. Schwab, Am J Respir Crit Care Med 189;2014:A6360
Interethnic Comparison of Abdominal Fat Deposition between Native Chinese and Icelandic Caucasians Measured by Volumetric MRI.
K. Wang, Z. Wang, G. Wang, J. Wang, X. Li, W. Qu, D. Wang, C. Bearn, Sarika Shinde, T. Gislason, B. Benediktsdottir, L. Chi, R. J. Schwab, Am J. Resp. Crit. Care Med. 187A: 5936, 2013
Effect of Weight Loss on Upper Airway Anatomic Structures in Obese Normals and Apneics
Chi, L., Kim, C., Kim, A.M., Jackson, N., Chan, E.L., Schwab, R.J., Am J. Resp. Crit. Care Med. 185A: 2444, 2012
Comparison of upper airway anatomic structures between obese normal subjects and obese apneic subjects
Chi, L., Kim, C., Jackson, N., Maislin, G., Schwab, R.J., Am. J. Respir. Crit. Care Med. 183: A3670, 2011
Upper airway anatomic structures in apneic men and women, matched on age, BMI and AHI
Chi, L., Thorne-Fitzgerald, M., Gislason, T., Arnardottir, E.S., Benedikstdottir, B., Einarsdóttir, H., S Juliusson, S., Pack, A.I., Schwab, R.J., Am. J. Respir. Crit. Care Med. 181: A2201, 2010
Gender differences in upper airway size, soft tissue and craniofacial structures in patients with OSA
Chi, L., Thorne-Fitzgerald, M., Gislason, T., Arnardottir, E.S., Benedikstdottir, B., Einarsdóttir, H., S Juliusson, S., Pack, A.I., Schwab, R.J., Am. J. Respir. Crit. Care Med. 179: A5404, 2009
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Lectures

Non-Invasive Ventilation in OHS, COPD and NMD
Washington University School of Medicine Pulmonary and Critical Care Grand Rounds - 12/5/2019
Hospital Sleep Medicine
Associated Professional Sleep Societies (APSS) annual conference, San Antonio, TX, June 8-12, 2019 - 6/10/2019
Postgraduate courses: Trends in sleep medicine - Hospital sleep medicine
Associated Professional Sleep Societies (APSS) 2018, Baltimore, MD, June 2-6, 2018 - 6/2/2018
Gender differences in upper airway size, soft tissue and craniofacial structures in patients with OSA
American Thoracic Society (ATS) International Conference, San Diego, CA May 15-20, 2009
Differential Upper Airway Anatomic Risk Factors between Native Chinese and Icelandic Caucasian Apneics
American Thoracic Society (ATS) International Conference, San Diego, CA May 16-21, 2014
Identification of Upper Airway Cranial Facial Risk Factors
11th International Symposium on Sleep and Breathing Conference, September 10-12, Pittsburg, PA,
Current Evidence Addressing the Link between Obstructive Sleep Apnea and Type 2 Diabetes
The 3rd Annual Pennsylvania State Diabetes Conference, State College, PA May 1-2, 2014
Ethnic Differences in Anatomical Risk Factors for Obstructive Sleep Apnea
10th International Symposium on Respiratory Diseases, Shanghai, China November 7-9, 2014
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Grant Support

The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in patients with Heart Failure and Central Sleep Apnea (LOFT-HF)NIH2019–Present
Changing the Trajectory of Mild Cognitive Impairment with CPAP treatment of obstructive sleep apneaNIH-NIA2017–2021

Research History

Site PIThe Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in patients with Heart Failure and Central Sleep Apnea (LOFT-HF)2019 - Present
Site PIChanging the Trajectory of Mild Cognitive Impairment with CPAP treatment of obstructive sleep apnea (Memory 2)2017 - 2021
Site PIRegistry to Examine the Effect of CPAP on Cardiac Function in Hospitalized Patients with OSA and Heart Failure (completed, data being analyzed)2017 - 2019
Co-investigatorInter-ethnicity study: Identify Anatomic Risk Factors for Sleep Apnea in Native Chinese Population Using 3-D MRI2014 - 2017
Site PIReducing heart failure re-admissions by enhancing sleep apnea treatment adherence (enrollment completed, data being analyzed)2015 - 2016
Site PICPAP compliance trial: Way-to-Sleep (Completed, published)2009 - 2011