Lynnette Nieman MD

Endocrinology•Bethesda, MD

Diabetes, Lipid Metabolism

Physician

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9309 Old Georgetown RdBethesda, MD 20814
Phone+1 301-493-2400

Education & Training

University at BuffaloFellowship, Endocrinology, Diabetes, and Metabolism, 1981 - 1982
University at BuffaloResidency, Internal Medicine, 1978 - 1980
Jacobs School of Medicine and Biomedical Sciences at the University at BuffaloClass of 1978

Certifications & Licensure

NY State Medical License 1980 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Clinical Trials

Jugular Vein Sampling for Hormone Levels for the Diagnosis of Cushing Syndrome Start of enrollment: 1995 Apr 10
Completed
Hormonal Effects on the Uterus and Endometrium Start of enrollment: 1995 Apr 21
Completed
New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome Start of enrollment: 1999 May 20
Completed
Phase 2
Evaluation of Patients With Endocrine-Related Conditions Start of enrollment: 2000 May 22
Terminated
Treatment of Uterine Fibroids With CDB-2914, an Experimental Selective Progesterone Receptor Antagonist Start of enrollment: 2002 Sep 02
Completed
Phase 2
Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag Start of enrollment: 2004 Dec 21
COMPLETED
PHASE2
Adrenal Function in Critical Illness Start of enrollment: 2004 Nov 12
COMPLETED
Treatment of Uterine Fibroids With the Selective Progesterone Receptor Modulator CDB-2914
COMPLETED
PHASE2
Diagnostic Performance of Screening Tests for Cushing s Syndrome Start of enrollment: 2002 Sep 19
Completed
Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion Start of enrollment: 2007 May 15
Terminated
Phase 2
Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men Start of enrollment: 2011 Jan 24
COMPLETED
PHASE2
Mifepristone Effects on Glucose Intolerance in Obese/Overweight Adults Start of enrollment: 2011 Nov 29
Completed
Phase 1, Phase 2
Prospective Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Ectopic Cushing Syndrome Start of enrollment: 2014 Feb 12
RECRUITING
PHASE2
A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's Syndrome Start of enrollment: 2023 Oct 12
RECRUITING
PHASE1, PHASE2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

Prospective Evaluation of 68Ga-DOTATATE and 18F-DOPA PET Scans in Detecting Tumors Causing Ectopic ACTH Syndrome.
Henrik Elenius, Raven McGlotten, Chuong D Hoang, Clara C Chen, Corina Millo
The Journal of Clinical Endocrinology and Metabolism. 2025-02-28
Cushing syndrome.
Lynnette K Nieman, Frederic Castinetti, John Newell-Price, Elena Valassi, Jacques Drouin
Nature Reviews. Disease Primers. 2025-01-23
1 citations
Longitudinal Evaluation of Reproductive Endocrine Function in Men With ACTH-Dependent Cushing Syndrome.
Skand Shekhar, Raven N McGlotten, Gordon B Cutler Jr, Matthew J Crowley, Carl F Pieper
The Journal of Clinical Endocrinology and Metabolism. 2025-01-21

Lectures

Approach to Pituitary- and Ectopic ACTH-Secreting Tumors (Repeat)
ENDO 2019 - New Orleans, LA - 3/24/2019
Approach to Pituitary- and Ectopic ACTH-Secreting Tumors
ENDO 2019 - New Orleans, LA - 3/24/2019
Overcoming Obesity: Evaluating Evidence-Based Integrated Action for the Future
ENDO 2018: 100th Endocrine Society Annual Meeting - Chicago, Illinios - 03/17/2018
Taking Your Science to Market
ENDO 2018: 100th Endocrine Society Annual Meeting - Chicago, Illinios - 03/17/2018
Endocrinology & Diabetes Update
University of Michigan Medical School, Plymouth, Michigan - 10/27/2012
ENDO 2012: The 94th Annual Meeting of The Endocrine Society
The Endocrine Society, Houston, Texas - 6/23/2012
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Other

Persistent or recurrent Cushing’s disease: Surgical adrenalectomy
Nieman LK, UpToDate, Wolters Kluwer Health
http://www.uptodate.com/contents/persistent-or-recurrent-cushings-disease-surgical-adrenalectomy
UpToDate, Wolters Kluwer Health - 2013-03-04 - 03/04/2013
Medical therapy of hypercortisolism (Cushing’s syndrome)
Nieman LK, UpToDate, Wolters Kluwer Health
http://www.uptodate.com/contents/medical-therapy-of-hypercortisolism-cushings-syndrome
UpToDate, Wolters Kluwer Health - 2013-01-18 - 01/18/2013
Establishing the cause of Cushing's syndrome
Nieman LK
http://www.uptodate.com/contents/establishing-the-cause-of-cushings-syndrome
UpToDate, Wolters Kluwer Health - 2012-02-16
Primary therapy of Cushing's disease: Transsphenoidal surgery and pituitary irradiation
Nieman LK
http://www.uptodate.com/contents/primary-therapy-of-cushings-disease-transsphenoidal-surgery-and-pit
UpToDate, Wolters Kluwer Health - 2012-01-25
Cushing's syndrome in pregnancy
Nieman LK
http://www.uptodate.com/contents/cushings-syndrome-in-pregnancy
UpToDate, Wolters Kluwer Health - 2012-11-28
Corticotropin-releasing hormone stimulation test
Nieman LK
http://www.uptodate.com/contents/corticotropin-releasing-hormone-stimulation-test
UpToDate, Wolters Kluwer Health - 2012-04-27
Uncommon causes of congenital adrenal hyperplasia
Nieman LK
http://www.uptodate.com/contents/uncommon-causes-of-congenital-adrenal-hyperplasia
UpToDate, Wolters Kluwer Health - 2013-01-30
Treatment of classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency in adults
Nieman LK
http://www.uptodate.com/contents/treatment-of-classic-congenital-adrenal-hyperplasia-due-to-21-hydro
UpToDate, Wolters Kluwer Health - 2013-01-31
Genetics and clinical presentation of nonclassic (late-onset) congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Nieman LK
http://www.uptodate.com/contents/genetics-and-clinical-presentation-of-nonclassic-late-onset-congeni
UpToDate, Wolters Kluwer Health - 2012-09-28
Diagnosis and treatment of nonclassic (late-onset) congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Nieman LK
http://www.uptodate.com/contents/diagnosis-and-treatment-of-nonclassic-late-onset-congenital-adrenal
UpToDate, Wolters Kluwer Health - 2013-01-31
Unusual causes of adrenal insufficiency
Nieman LK
http://www.uptodate.com/contents/unusual-causes-of-adrenal-insufficiency
UpToDate, Wolters Kluwer Health - 2013-01-30
Pathogenesis of autoimmune adrenal insufficiency
Nieman LK
http://www.uptodate.com/contents/pathogenesis-of-autoimmune-adrenal-insufficiency
UpToDate, Wolters Kluwer Health - 2013-02-07
Insulin-induced hypoglycemia test
Nieman LK
http://www.uptodate.com/contents/insulin-induced-hypoglycemia-test
UpToDate, Wolters Kluwer Health - 2012-08-09
Evaluation of the response to ACTH in adrenal insufficiency
Nieman LK
http://www.uptodate.com/contents/evaluation-of-the-response-to-acth-in-adrenal-insufficiency
UpToDate, Wolters Kluwer Health - 2013-01-03
Measurement of adrenal androgens
Nieman LK
http://www.uptodate.com/contents/measurement-of-adrenal-androgens
UpToDate, Wolters Kluwer Health - 2012-11-29
Pharmacologic use of glucocorticoids
Nieman LK
http://www.uptodate.com/contents/pharmacologic-use-of-glucocorticoids
UpToDate, Wolters Kluwer Health - 2013-01-30
Clinical manifestations of adrenal insufficiency in adults
Nieman LK
http://www.uptodate.com/contents/clinical-manifestations-of-adrenal-insufficiency-in-adults
UpToDate, Wolters Kluwer Health - 2013-02-01
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency
Nieman LK
http://www.uptodate.com/contents/congenital-adrenal-hyperplasia-due-to-11-beta-hydroxylase-deficienc
UpToDate, Wolters Kluwer Health - 2013-02-06
Causes of secondary and tertiary adrenal insufficiency in adults
Nieman LK
http://www.uptodate.com/contents/causes-of-secondary-and-tertiary-adrenal-insufficiency-in-adults
UpToDate, Wolters Kluwer Health - 2013-01-31
Causes of primary adrenal insufficiency (Addison's disease)
Nieman LK
http://www.uptodate.com/contents/causes-of-primary-adrenal-insufficiency-addisons-disease
UpToDate, Wolters Kluwer Health - 2013-02-01
Causes and pathophysiology of Cushing's syndrome
Nieman LK
http://www.uptodate.com/contents/causes-and-pathophysiology-of-cushings-syndrome
UpToDate, Wolters Kluwer Health - 2012-10-01
Basic principles in the laboratory evaluation of adrenocortical function
Nieman LK
http://www.uptodate.com/contents/basic-principles-in-the-laboratory-evaluation-of-adrenocortical-fun
UpToDate, Wolters Kluwer Health - 2012-11-29
Adrenal steroid biosynthesis
Nieman LK
http://www.uptodate.com/contents/adrenal-steroid-biosynthesis
UpToDate, Wolters Kluwer Health - 2012-11-29
Measurement of urinary excretion of endogenous and exogenous glucocorticoids
Nieman LK
http://www.uptodate.com/contents/measurement-of-urinary-excretion-of-endogenous-and-exogenous-glucoc
UpToDate, Wolters Kluwer Health - 2012-12-05
Measurement of cortisol in serum and saliva
Nieman LK
http://www.uptodate.com/contents/measurement-of-cortisol-in-serum-and-saliva
UpToDate, Wolters Kluwer Health - 2013-01-30
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Press Mentions

Cerebral Edema in Diabetic Ketoacidosis: A Look Beyond RehydrationSeptember 17th, 2020

Grant Support

The Physiology Of HypercortisolismEunice Kennedy Shriver National Institute Of Child Health &Human Development2009–2011
The Physiology Of Adrenal InsufficiencyEunice Kennedy Shriver National Institute Of Child Health &Human Development2009–2011
The Differential Diagnosis And Treatment Of Cushing'S SyndromeEunice Kennedy Shriver National Institute Of Child Health &Human Development2009–2011
Steroid Hormone Action In Female ReproductionEunice Kennedy Shriver National Institute Of Child Health &Human Development2009–2011
Fellowship Training Program In Endocrinology--NichdEunice Kennedy Shriver National Institute Of Child Health &Human Development2009–2011
Endometrial PhysiologyEunice Kennedy Shriver National Institute Of Child Health &Human Development2009–2011
Endometrial PhysiologyEunice Kennedy Shriver National Institute Of Child Health &Human Development2008
The Physiology Of HypercortisolismEunice Kennedy Shriver National Institute Of Child Health &Human Development1994
Steroid Hormone Action In Female ReproductionEunice Kennedy Shriver National Institute Of Child Health &Human Development1994
The Physiology Of HypercortisolismNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESPresent
The differential diagnosis and treatment of Cushing's syndromeNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESPresent
The differential diagnosis and treatment of Cushing's syndromeNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESPresent
The Physiology Of HypercortisolismNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESPresent