LynnetteNiemanMD

Endocrinology • Bethesda, MD

Diabetes, Lipid Metabolism

Physician

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Office
9309 Old Georgetown Rd
Bethesda, MD 20814
Phone+1 301-493-2400
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Education & Training

University at BuffaloFellowship, Endocrinology, Diabetes, and Metabolism, 1981 - 1982
University at BuffaloResidency, Internal Medicine, 1978 - 1980
Jacobs School of Medicine and Biomedical Sciences at the University at BuffaloClass of 1978

Certifications & Licensure

NY State Medical License 1980 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Clinical Trials

Jugular Vein Sampling for Hormone Levels for the Diagnosis of Cushing Syndrome Start of enrollment: 1995 Apr 10
Completed
Hormonal Effects on the Uterus and Endometrium Start of enrollment: 1995 Apr 21
Completed
New Imaging Techniques in the Evaluation of Patients With Ectopic Cushing Syndrome Start of enrollment: 1999 May 20
Completed
Phase 2
Evaluation of Patients With Endocrine-Related Conditions Start of enrollment: 2000 May 22
Terminated
Treatment of Uterine Fibroids With CDB-2914, an Experimental Selective Progesterone Receptor Antagonist Start of enrollment: 2002 Sep 02
Completed
Phase 2
Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag Start of enrollment: 2004 Dec 21
Completed
Phase 2
Adrenal Function in Critical Illness Start of enrollment: 2004 Nov 12
Completed
Treatment of Uterine Fibroids With the Selective Progesterone Receptor Modulator CDB-2914 Start of enrollment: 2006 Feb 01
Completed
Phase 2
Diagnostic Performance of Screening Tests for Cushing s Syndrome Start of enrollment: 2002 Sep 19
Completed
Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion Start of enrollment: 2007 May 15
Terminated
Phase 2
Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men Start of enrollment: 2011 Jan 24
Completed
Phase 2
Mifepristone Effects on Glucose Intolerance in Obese/Overweight Adults Start of enrollment: 2011 Nov 29
Completed
Phase 1, Phase 2
Prospective Evaluation of 68Ga-DOTATATE PET/CT, Octreotide and F-DOPA PET Imaging in Ectopic Cushing Syndrome Start of enrollment: 2014 Feb 12
Recruiting
Phase 2
A Study to Evaluate the Safety and PK of CRN04894 for the Treatment of Cushing's Syndrome Start of enrollment: 2023 Oct 12
Recruiting
Phase 1, Phase 2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

3 citations
Pituitary adenoma or neuroendocrine tumour: the need for an integrated prognostic classification.
Ken K Y Ho, Ursula B Kaiser, Phillippe Chanson, Monica Gadelha, John Wass, Lynnette Nieman, Andrew Little, Manish K Aghi, Lori Raetzman, Kalmon Post, Gerald Raverot, A...> ;Nature Reviews. Endocrinology. 2023 Nov 1
3 citations
Ovine CRH Stimulation and 8 mg Dexamethasone Suppression Tests in 323 Patients With ACTH-Dependent Cushing's Syndrome.
Henrik Elenius, Raven McGlotten, Lynnette K Nieman> ;The Journal of Clinical Endocrinology and Metabolism. 2023 Dec 21
Diurnal Range and Intra-patient Variability of ACTH Is Restored With Remission in Cushing's Disease.
Reinier Alvarez, Elizabeth Hogan, David T Asuzu, Tianxia Wu, Gloria Oshegbo, Raven McGlotten, Michaela Cortes, Christina Hayes, Constantine A Stratakis, Christina Tats...> ;The Journal of Clinical Endocrinology and Metabolism. 2023 Oct 18
Cortisol and ACTH Measurements at Extubation From Pituitary Surgery Predicts Hypothalamic-Pituitary-Adrenal Axis Function.
David T Asuzu, Shyama Bhatt, Christina Hayes, Michaela Cortes, Raven McGlotten, Meg Keil, Christina Tatsi, Lynnette Nieman, Prashant Chittiboina, Diana Nwokoye> ;Journal of the Endocrine Society. 2023 Feb 9
5 citations
Hypercoagulability in Cushing's syndrome: incidence, pathogenesis and need for thromboprophylaxis protocols.
Richard A Feelders, Lynnette K Nieman> ;Pituitary. 2022 Oct 1
4 citations
Selective progesterone receptor modulators and reproductive health.
Lynnette K Nieman> ;Current Opinion in Endocrinology, Diabetes, and Obesity. 2022 Aug 1
Septic Shock: A Disruptor of the Hypothalamic-Adrenal Axis as We Know It.
Lynnette K Nieman> ;Endocrinology. 2022 May 1
9 citations
Molecular derangements and the diagnosis of ACTH-Dependent Cushing's syndrome.
Lynnette K. Nieman> ;Endocrine Reviews. 2021 Nov 29
230 citations
Consensus on diagnosis and management of Cushing's disease: a guideline update.
Maria Fleseriu, Richard J. Auchus, Irina Bancos, Anat Ben-Shlomo, Jérôme Bertherat, Nienke R. Biermasz, Cesar Luiz Boguszewski, Marcello D. Bronstein, Michael Buchfeld...> ;The Lancet. Diabetes & Endocrinology. 2021 Dec 1
3 citations
Diagnostic pitfalls in Cushing's disease impacting surgical remission rates; test thresholds and lessons learned in 105 patients.
Regin Jay Mallari, Jai Deep Thakur, Garni Barkhoudarian, Amy Eisenberg, Amanda Rodriguez, Sarah Rettinger, Pejman Cohan, Lynnette K. Nieman, Daniel F. Kelly> ;The Journal of Clinical Endocrinology and Metabolism. 2021 Sep 3
2 citations
Characterization of Outcomes by Surgical Management of Lung Neuroendocrine Tumors Associated With Cushing Syndrome
Kenneth P Seastedt, George Alyateem, Seth M. Steinberg, David S. Schrump, Lynnette K. Nieman, Chuong D. Hoang, Karthik Pittala> ;JAMA Network Open. 2021 Sep 1
9 citations
Patient and Provider Perspectives on Postsurgical Recovery of Cushing Syndrome.
Rachel Acree, Caitlin M Miller, Brent S. Abel, Nicola M. Neary, Karen Campbell, Lynnette K. Nieman> ;Journal of the Endocrine Society. 2021 Jun 14
6 citations
The NIMH Intramural Longitudinal Study of the Endocrine and Neurobiological Events Accompanying Puberty: Protocol and Rationale for Methods and Measures.
Katherine M. Cole, Shau-Ming Wei, Pedro E. Martinez, Tuong-Vi Nguyen, Michael D. Gregory, J. Shane Kippenhan, Philip Kohn, Steven J. Soldin, Lynnette K. Nieman, Jack A...> ;Neuroimage. 2021 Mar 24
26 citations
Approach to the Patient Treated with Steroidogenesis Inhibitors
Frederic Castinetti, Lynnette K. Nieman, Martin Reincke, John Newell-Price> ;The Journal of Clinical Endocrinology and Metabolism. 2021 Jun 16
9 citations
Mifepristone Improves Adipose Tissue Insulin Sensitivity in Insulin Resistant Individuals
Sriram Gubbi, Ranganath Muniyappa, Susmeeta T. Sharma, Shivraj Grewal, Raven McGlotten, Lynnette K. Nieman> ;The Journal of Clinical Endocrinology and Metabolism. 2021 Apr 23
7 citations
The short-term effects of estradiol, raloxifene, and a phytoestrogen in women with perimenopausal depression.
Peter J. Schmidt, Shau-Ming Wei, Pedro E. Martinez, Rivka Ben Dor, Gioia M Guerrieri, Paula P Palladino, Veronica L Harsh, Howard J. Li, Paul Wakim, Lynnette K. Nieman...> ;Menopause. 2021 Jan 15
7 citations
Is it Time for a New Approach to the Differential Diagnosis of ACTH-Dependent Cushing Syndrome?
Lynnette K. Nieman> ;The Journal of Clinical Endocrinology and Metabolism. 2020 Dec 1
13 citations
The Hypothalamic-Pituitary-Thyroid Axis in Cushing Syndrome Before and After Curative Surgery
Skand Shekhar, Raven McGlotten, Sunyoung Auh, Kristina I. Rother, Lynnette K. Nieman> ;The Journal of Clinical Endocrinology and Metabolism. 2021 Mar 8
Response to: Primary Adrenal Insufficiency due to Immune Checkpoint Inhibitors; more common than we thought
Sriram Gubbi, Lisa M. Cordes, Joanna Klubo-Gwiezdzinska, Ravi A. Madan, Lynnette K. Nieman, James L. Gulley, Jaydira Del Rivero> ;The Oncologist. 2020 Nov 5
50 citations
ENDOCRINOLOGY IN THE TIME OF COVID-19: Management of Cushing's syndrome.
John Newell-Price, Lynnette K. Nieman, Martin Reincke, Antoine Tabarin> ;European Journal of Endocrinology. 2020 Jul 1
13 citations
Transdermal estradiol for postpartum depression: results from a pilot randomized, double-blind, placebo-controlled study
Howard J. Li, Pedro E. Martinez, Xiaobai Li, Linda A. Schenkel, Lynnette K. Nieman, David R. Rubinow, Peter Schmidt> ;Archives of Women's Mental Health. 2020 Jun 1
26 citations
Endocrine-Related Adverse Events Related to Immune Checkpoint Inhibitors: Proposed Algorithms for Management.
Jaydira Del Rivero, Lisa M Cordes, Joanna Klubo-Gwiezdzinska, Ravi A Madan, Lynnette K Nieman, James L Gulley> ;The Oncologist. 2020 Apr 1
4 citations
Remission of hypertension after surgical cure of Cushing's syndrome.
Smita Jha, Ninet Sinaii, Raven McGlotten, Lynnette K. Nieman> ;Clinical Endocrinology. 2020 Feb 1
13 citations
Assessment of thyroid function tests and harmonization: opinion on thyroid hormone harmonization.
Katherine A Araque, Joanna Klubo-Gwiezdzinska, Lynnette K. Nieman, Kerry J. Welsh, Steven J. Soldin> ;Therapeutic Advances in Endocrinology and Metabolism. 2019 Dec 24
23 citations
Hypertension and Cardiovascular Mortality in Patients with Cushing Syndrome
Lynnette K. Nieman> ;Endocrinology and Metabolism Clinics of North America. 2019 Sep 19
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Lectures

Approach to Pituitary- and Ectopic ACTH-Secreting Tumors
ENDO 2019 - New Orleans, LA - 3/24/2019
Approach to Pituitary- and Ectopic ACTH-Secreting Tumors (Repeat)
ENDO 2019 - New Orleans, LA - 3/24/2019
Overcoming Obesity: Evaluating Evidence-Based Integrated Action for the Future
ENDO 2018: 100th Endocrine Society Annual Meeting - Chicago, Illinios - 03/17/2018
Taking Your Science to Market
ENDO 2018: 100th Endocrine Society Annual Meeting - Chicago, Illinios - 03/17/2018
Endocrinology & Diabetes Update
University of Michigan Medical School, Plymouth, Michigan - 10/27/2012
ENDO 2012: The 94th Annual Meeting of The Endocrine Society
The Endocrine Society, Houston, Texas - 6/23/2012
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Other

Persistent or recurrent Cushing’s disease: Surgical adrenalectomy
Nieman LK, UpToDate, Wolters Kluwer Health
http://www.uptodate.com/contents/persistent-or-recurrent-cushings-disease-surgical-adrenalectomy
UpToDate, Wolters Kluwer Health - 2013-03-04 - 03/04/2013
Medical therapy of hypercortisolism (Cushing’s syndrome)
Nieman LK, UpToDate, Wolters Kluwer Health
http://www.uptodate.com/contents/medical-therapy-of-hypercortisolism-cushings-syndrome
UpToDate, Wolters Kluwer Health - 2013-01-18 - 01/18/2013
Clinical manifestations of adrenal insufficiency in adults
Nieman LK
http://www.uptodate.com/contents/clinical-manifestations-of-adrenal-insufficiency-in-adults
UpToDate, Wolters Kluwer Health - 2013-02-01
Epidemiology and clinical manifestations of Cushing's syndrome
Nieman LK
http://www.uptodate.com/contents/epidemiology-and-clinical-manifestations-of-cushings-syndrome
UpToDate, Wolters Kluwer Health - 2013-01-31
Overview of the treatment of Cushing's syndrome
Nieman LK
http://www.uptodate.com/contents/overview-of-the-treatment-of-cushings-syndrome
UpToDate, Wolters Kluwer Health - 2013-01-17
Treatment of adrenal insufficiency in adults
Nieman LK
http://www.uptodate.com/contents/treatment-of-adrenal-insufficiency-in-adults
UpToDate, Wolters Kluwer Health - 2013-01-11
Adrenal steroid biosynthesis
Nieman LK
http://www.uptodate.com/contents/adrenal-steroid-biosynthesis
UpToDate, Wolters Kluwer Health - 2012-11-29
Basic principles in the laboratory evaluation of adrenocortical function
Nieman LK
http://www.uptodate.com/contents/basic-principles-in-the-laboratory-evaluation-of-adrenocortical-fun
UpToDate, Wolters Kluwer Health - 2012-11-29
Causes and pathophysiology of Cushing's syndrome
Nieman LK
http://www.uptodate.com/contents/causes-and-pathophysiology-of-cushings-syndrome
UpToDate, Wolters Kluwer Health - 2012-10-01
Causes of primary adrenal insufficiency (Addison's disease)
Nieman LK
http://www.uptodate.com/contents/causes-of-primary-adrenal-insufficiency-addisons-disease
UpToDate, Wolters Kluwer Health - 2013-02-01
Causes of secondary and tertiary adrenal insufficiency in adults
Nieman LK
http://www.uptodate.com/contents/causes-of-secondary-and-tertiary-adrenal-insufficiency-in-adults
UpToDate, Wolters Kluwer Health - 2013-01-31
Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency
Nieman LK
http://www.uptodate.com/contents/congenital-adrenal-hyperplasia-due-to-11-beta-hydroxylase-deficienc
UpToDate, Wolters Kluwer Health - 2013-02-06
Establishing the cause of Cushing's syndrome
Nieman LK
http://www.uptodate.com/contents/establishing-the-cause-of-cushings-syndrome
UpToDate, Wolters Kluwer Health - 2012-02-16
Pharmacologic use of glucocorticoids
Nieman LK
http://www.uptodate.com/contents/pharmacologic-use-of-glucocorticoids
UpToDate, Wolters Kluwer Health - 2013-01-30
Diagnosis of adrenal insufficiency in adults
Nieman LK
http://www.uptodate.com/contents/diagnosis-of-adrenal-insufficiency-in-adults
UpToDate, Wolters Kluwer Health - 2013-02-01
Establishing the diagnosis of Cushing's syndrome
Nieman LK
http://www.uptodate.com/contents/establishing-the-diagnosis-of-cushings-syndrome
UpToDate, Wolters Kluwer Health - 2013-01-31
Measurement of ACTH, CRH, and other hypothalamic and pituitary peptides
Nieman LK
http://www.uptodate.com/contents/measurement-of-acth-crh-and-other-hypothalamic-and-pituitary-peptid
UpToDate, Wolters Kluwer Health - 2012-08-07
Measurement of cortisol in serum and saliva
Nieman LK
http://www.uptodate.com/contents/measurement-of-cortisol-in-serum-and-saliva
UpToDate, Wolters Kluwer Health - 2013-01-30
Measurement of urinary excretion of endogenous and exogenous glucocorticoids
Nieman LK
http://www.uptodate.com/contents/measurement-of-urinary-excretion-of-endogenous-and-exogenous-glucoc
UpToDate, Wolters Kluwer Health - 2012-12-05
Measurement of adrenal androgens
Nieman LK
http://www.uptodate.com/contents/measurement-of-adrenal-androgens
UpToDate, Wolters Kluwer Health - 2012-11-29
Evaluation of the response to ACTH in adrenal insufficiency
Nieman LK
http://www.uptodate.com/contents/evaluation-of-the-response-to-acth-in-adrenal-insufficiency
UpToDate, Wolters Kluwer Health - 2013-01-03
Insulin-induced hypoglycemia test
Nieman LK
http://www.uptodate.com/contents/insulin-induced-hypoglycemia-test
UpToDate, Wolters Kluwer Health - 2012-08-09
Pathogenesis of autoimmune adrenal insufficiency
Nieman LK
http://www.uptodate.com/contents/pathogenesis-of-autoimmune-adrenal-insufficiency
UpToDate, Wolters Kluwer Health - 2013-02-07
Unusual causes of adrenal insufficiency
Nieman LK
http://www.uptodate.com/contents/unusual-causes-of-adrenal-insufficiency
UpToDate, Wolters Kluwer Health - 2013-01-30
Diagnosis and treatment of nonclassic (late-onset) congenital adrenal hyperplasia due to 21-hydroxylase deficiency
Nieman LK
http://www.uptodate.com/contents/diagnosis-and-treatment-of-nonclassic-late-onset-congenital-adrenal
UpToDate, Wolters Kluwer Health - 2013-01-31
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Press Mentions

Cerebral Edema in Diabetic Ketoacidosis: A Look Beyond RehydrationSeptember 17th, 2020

Grant Support

The Physiology Of HypercortisolismEunice Kennedy Shriver National Institute Of Child Health &Human Development2009–2011
The Physiology Of Adrenal InsufficiencyEunice Kennedy Shriver National Institute Of Child Health &Human Development2009–2011
The Differential Diagnosis And Treatment Of Cushing'S SyndromeEunice Kennedy Shriver National Institute Of Child Health &Human Development2009–2011
Steroid Hormone Action In Female ReproductionEunice Kennedy Shriver National Institute Of Child Health &Human Development2009–2011
Fellowship Training Program In Endocrinology--NichdEunice Kennedy Shriver National Institute Of Child Health &Human Development2009–2011
Endometrial PhysiologyEunice Kennedy Shriver National Institute Of Child Health &Human Development2009–2011
Endometrial PhysiologyEunice Kennedy Shriver National Institute Of Child Health &Human Development2008
The Physiology Of HypercortisolismEunice Kennedy Shriver National Institute Of Child Health &Human Development1994
Steroid Hormone Action In Female ReproductionEunice Kennedy Shriver National Institute Of Child Health &Human Development1994