MaherYounesMD

PubMed

• 105 citations
  Erratum: Epidermal Growth Factor Receptor (EGFR) is overexpressed in anaplastic thyroid cancer, and the EGFR inhibitor gefitinib inhibits the growth of anaplastic thyr...
  Bradley A. Schiff, Andrea B. McMurphy, Samar A. Jasser, Maher N. Youne, Dao Doan, Orhan G. Yigitbasi, Seungwon Kim, Ge Zhou, Mahitosh Mandal, Benjamin N. Bekele, FChri...> ;Clinical Cancer Research. 2019 Aug 1
• 35 citations
  Erratum: Identification of insulin-like growth factor binding protein-3 as a farnesyl transferase inhibitor SCH66336-induced negative regulator of angiogenesis in head...
  Seung Hyun Oh, Woo-Young Kim, Jai-Hyun Kim, Maher N. Younes, Adel K. El-Naggar, Jeffrey N. Myers, Merril S. Kies, Pinchas Cohen, Fadlo R. Khuri, Waun Ki Hong, Ho-Young...> ;Clinical Cancer Research. 2019 Aug 1
• 46 citations
  Dual inhibition of epidermal growth factor receptor and insulin-like growth factor receptor I: reduction of angiogenesis and tumor growth in cutaneous squamous cell ca...
  Chad E. Galer, Christina L. Corey, Zhuoying Wang, Maher N. Younes, Fernando Gomez-Rivera, Samar A. Jasser, Dale L. Ludwig, Adel K. El-Naggar, Randal S. Weber, Jeffrey ...> ;Head & Neck. 2011 Feb 1
• 9 citations
  Branchiogenic carcinoma of a first branchial cleft cyst.
  Joseph P. Roche, Maher N. Younes, William K. Funkhouser, Mark C. Weissler> ;Otolaryngology--Head and Neck Surgery. 2010 Jul 1
• 50 citations
  Reciprocal negative regulation between S100A7/psoriasin and β-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity
  Ge Zhou, T. X. Xie, Mei Zhao, Samar A. Jasser, Maher N. Younes, Daisuke Sano, Jing Lin, Michael E. Kupferman, Alfredo A. Santillan, Vyomesh Patel, Jorge S. Gutkind, A....> ;Oncogene. 2008 Jun 5
• 52 citations
  Recent Advances in Thyroid Cancer
  Elizabeth G. Grubbs, Thereasa A. Rich, Guojun Li, Erich M. Sturgis, Maher N. Younes, Jeffrey N. Myers, Beth S Edeiken-Monroe, Bruno D. Fornage, Douglas P. Monroe, Greg...> ;Current Problems in Surgery. 2008 Mar 1
• 10 citations
  Recent advances in thyroid cancer. In brief.
  Elizabeth G. Grubbs, Tyvin A. Rich, Guojun Li, Erich M. Sturgis, Maher N. Younes, Jeffrey N. Myers, Beth S Edeiken-Monroe, Bruno D. Fornage, Douglas P. Monroe, Gregg A...> ;Current Problems in Surgery. 2008 Mar 1
• 34 citations
  The Tyrosine Kinase Inhibitor, AZD2171, Inhibits Vascular Endothelial Growth Factor Receptor Signaling and Growth of Anaplastic Thyroid Cancer in an Orthotopic Nude Mo...
  Fernando Gomez-Rivera, Alfredo A. Santillan-Gomez, Maher N. Younes, Seungwon Kim, David Fooshee, Mei Zhao, Samar A. Jasser, Jeffrey N. Myers> ;Clinical Cancer Research. 2007 Aug 1
• 108 citations
  Sorafenib inhibits the angiogenesis and growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice.
  Seungwon Kim, Yasemin D. Yazici, Gabriel G. Calzada, Zhuo Ying Wang, Maher N. Younes, Samar A. Jasser, Adel K. El-Naggar, Jeffrey N. Myers> ;Molecular Cancer Therapeutics. 2007 Jun 1
• 33 citations
  Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck.
  Maher N. Younes, Orhan G. Yigitbasi, Yasemin D. Yazici, Samar A. Jasser, Cora Bucana, Adel K. El-Naggar, Gordon B. Mills, Jeffrey N. Myers> ;Archives of Otolaryngology--Head & Neck Surgery. 2007 Jan 1
• 54 citations
  Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary aden...
  Maher N. Younes, Young Wook Park, Yasemin D. Yazici, Meirong Gu, Alfredo A. Santillan, Xiaolin Nong, Seungwon Kim, Samar A. Jasser, Adel K. El-Naggar, Jeffrey N. Myers> ;Molecular Cancer Therapeutics. 2006 Nov 1
• 33 citations
  Growth-Inhibitory Effects of Human Anti-Insulin-Like Growth Factor-I Receptor Antibody (A12) in an Orthotopic Nude Mouse Model of Anaplastic Thyroid Carcinoma
  Zhuoying Wang, Geetika Chakravarty, Seungwon Kim, Yasemin D. Yazici, Maher N. Younes, Samar A. Jasser, Alfredo A. Santillan, Corazon D. Bucana, Adel K. El-Naggar, Jeff...> ;Clinical Cancer Research. 2006 Aug 1
• 29 citations
  Dual Epidermal Growth Factor Receptor and Vascular Endothelial Growth Factor Receptor Inhibition with NVP-AEE788 for the Treatment of Aggressive Follicular Thyroid Cancer
  Maher N. Younes, Yasemin D. Yazici, Seungwon Kim, Samar A. Jasser, Adel K. El-Naggar, Jeffrey N. Myers> ;Clinical Cancer Research. 2006 Jun 1
• 51 citations
  The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck
  Mahitosh Mandal, Maher N. Younes, Eric A. Swan, Samar A. Jasser, Dao Doan, Orhan G. Yigitbasi, Andrea Barber McMurphey, James Ludwick, Adel K. El-Naggar, Cora Bucana, ...> ;Oral Oncology. 2006 Apr 1
• Identification of insulin-like growth factor binding protein-3 as a farnesyl transferase inhibitor SCH66336-induced negative regulator of angiogenesis in head and neck...
  Oh, S., Kim, W., Kim, J., Younes, M.N., El-Naggar, A.K., Myers, J.N., Kies, M., Cohen, P., Khuri, F., Hong, W.K., Lee, H.> ;Clin Cancer Res. 2006 Jan 15
• 76 citations
  Cetuximab and irinotecan interact synergistically to inhibit the growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice.
  Seungwon Kim, Christopher N. Prichard, Maher N. Younes, Yasemin D. Yazici, Samar A. Jasser, B. Nebiyou Bekele, Jeffrey N. Myers> ;Clinical Cancer Research. 2006 Jan 15
• 68 citations
  Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer.
  Maher N. Younes, Seungwon Kim, Orhan G. Yigitbasi, Mahitosh Mandal, Samar A. Jasser, Yasemin D. Yazici, Bradley A. Schiff, Adel K. El-Naggar, Benjamin N. Bekele, Gordo...> ;Molecular Cancer Therapeutics. 2005 Aug 1
• 45 citations
  Antivascular therapy of human follicular thyroid cancer experimental bone metastasis by blockade of epidermal growth factor receptor and vascular growth factor recepto...
  Maher N. Younes, Orhan G. Yigitbasi, Young Wook Park, Sun Jin Kim, Samar A. Jasser, Valerie S. Hawthorne, Yasemin D. Yazici, Mahitosh Mandal, Benjamin N. Bekele, Coraz...> ;Cancer Research. 2005 Jun 1
• 75 citations
  The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells
  Mahitosh Mandal, Sun Jin Kim, Maher N. Younes, Samar A. Jasser, Adel K. El-Naggar, Gordon B. Mills, Jeffrey N. Myers> ;British Journal of Cancer. 2005 May 23
• 42 citations
  AEE788, a Dual Tyrosine Kinase Receptor Inhibitor, Induces Endothelial Cell Apoptosis in Human Cutaneous Squamous Cell Carcinoma Xenografts in Nude Mice
  Young Wook Park, Maher N. Younes, Samar A. Jasser, Orhan G. Yigitbasi, Ge Zhou, Corazon D. Bucana, Benjamin N. Bekele, Jeffrey N. Myers> ;Clinical Cancer Research. 2005 Mar 1
• 54 citations
  An orthotopic model of anaplastic thyroid carcinoma in athymic nude mice.
  Seungwon Kim, Young Wook Park, Bradley A. Schiff, Dao D. Doan, Yasemin D. Yazici, Samar A. Jasser, Maher N. Younes, Mahitosh Mandal, Benjamin N. Bekele, Jeffrey N. Myers> ;Clinical Cancer Research. 2005 Mar 1
• Epidermal growth factor receptor (EGFR) is overexpressed in anaplastic thyroid cancer, and the EGFR inhibitor gefitinib inhibits the growth of anaplastic thyroid cancer.
  Schiff, B.A., McMurphy, A.B., Jasser, S.A., Younes, M.N., Doan, D., Yigitbasi, O.G., Kim, S., Zhou, G., Mandal, M., Bekele, B.N., Holsinger, F.C., Sherman, S.I., Yeung...> ;Clin Cancer Res. 2004 Dec 15
• 66 citations
  Tumor Cell and Endothelial Cell Therapy of Oral Cancer by Dual Tyrosine Kinase Receptor Blockade
  Orhan G. Yigitbasi, Maher N. Younes, Dao Doan, Samar A. Jasser, Bradley A. Schiff, Corazon D. Bucana, Benjamin N. Bekele, Isaiah J. Fidler, Jeffrey N. Myers> ;Cancer Research. 2004 Nov 1
• 31 citations
  Melanoma of the head and neck: current concepts in staging, diagnosis, and management.
  Maher N. Younes, Jeffrey N. Myers> ;Surgical Oncology Clinics of North America. 2004 Jan 1
• 35 citations
  Epidermal Growth Factor Receptor Blockade Potentiates Apoptosis Mediated by Paclitaxel and Leads to Prolonged Survival in a Murine Model of Oral Cancer
  F. Christopher Holsinger, Dao D. Doan, Samar A. Jasser, Eric A. Swan, Jayson S. Greenberg, Bradley A. Schiff, B. Nebiyou Bekele, Maher N. Younes, Corazon D. Bucana, Is...> ;Clinical Cancer Research. 2003 Aug 1
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Abstracts/Posters

• In vivo Imaging of Primary Recurrence and Cervical Lymph Node Metastases in an Orthotopic Nude Mouse Model of Squamous Cell Carcinoma of the Head and Neck.
  Younes MN, Zhou G, Jasser SA, Myers JN, Combined Otolaryngological Spring Meeting, San Diego, CA, 4/26/2007
• Psoriasin/S100A7 modulates b-catenin signaling and inhibits tumor growth and progression of oral cavity squamous cell carcinoma.
  Zhou G, Mandal M, Jasser SA, Zhao M, Yazici YD, Xie T, Younes MN, Kupferman ME, Patel V, Gutkind SJ, EI-Naggar AK, Emberley ED, Watson PH, Bucana CD, Myers JN, 97th Annual American Association for Cancer Research meeting (AACR), Los Angeles, CA, 4/14/2007
• The A12 Antibody To the Insulin-like Growth Factor Receptor-I Inhibits the Growth of Anaplastic Thyroid Carcinoma in an Orthotopic Nude Mouse Model.
  Wang ZY, Kim S, Yazici YD, Younes MN, Jasser SA, Myers JN, AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications, Philadelphia, PA, 11/14/2005
• Sorafenib (BAY 43-9006) inhibits the growth and angiogenesis of orthotopic anaplastic thyroid carcinoma xenografts in nude mice.
  Kim S, Yazici YD, Calzada G, Wang ZY, Younes MN, Jasser SA, Myers JN, AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications, Philadelphia, PA, 11/14/2005
• Concomitant Inhibition of Epidermal Growth Factor and Vascular Endothelial Growth Factor Receptor Tyrosine Kinases Reduces Growth and Metastasis of Human Salivary Aden...
  Younes MN, Yazici YD, Park YW, Nong X, Jasser SA, El-Naggar AK, Myers JN, 58th Annual Symposium on Cancer Research, Houston, TX, 10/25/2005
• Blockade of Vascular Endothelial Growth Factor Receptor and Epidermal Growth Factor Receptor Signaling by the Dual Tyrosine Kinase Inhibitor AEE788 and Paclitaxel as T...
  Younes MN, Yigitbasi OG, Park YW, Kim SJ, Jasser SA, Hawthorne VS, Langley RR, Dakak Yazici YD, Mandal M, Bekele BN, Bucana CD, Fidler IJ, Myers JN, 57th Annual Symposium on Fundamental Cancer Research: Signal Transduction: from Pathways to Networks, Combined Otolaryngological Spring Meeting, Houston, TX, 2004; Boca Raton, FL, 2005, 5/13/2005
• Effects of a Novel Inhibitor of STAT3 Signaling on Oral Cavity Squamous Cell Carcinoma Cell Lines.
  Kupferman ME, Mandal M, Younes MN, Zhou G, Xie T, Jasser SA, Priebe W, Myers JN, Combined Otolaryngological Spring Meeting, Boca Raton, FL, 5/13/2005
• AEE788, a dual tyrosine kinase receptor inhibitor, induces endothelial cell apoptosis in human cutaneous squamous cell carcinoma xenografts in nude mice.
  Younes MN, Park YW, Jasser SA, Yigitbasi OG, Zhou G, Bucana CD, Bekele BN, Myers JN, 96th Annual American Association for Cancer Research meeting (AACR), Anaheim, CA, 4/16/2005
• Dual Inhibition of the EGFR and VEGFR Phosphorylation. The role of the new EGFR/VEGFR tyrosine kinase inhibitor NVPAEE788 in Squamous Cell Carcinoma of the Head and Neck.
  Yigitbasi OG, Younes MN, Schiff BA, Doan D, Jasser SA, Myers JN, AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, 6th International Conference on Head and Neck Cancer, Boston, MA, 2003; Washington, DC, 2004, 8/7/2004
• Antitumor Activities of Farnesyltransferase Inhibitor (SCH66336) through Induction of Insulin-like Growth Factor Binding Protein-3 in Head and Neck Squamous Cell Carci...
  Oh SH, Kim DK, Kim E, Younes MN, Myers JN, Hong WK, Lee HY, 95th annual American Association for Cancer Research meeting (AACR), Orlando, FL, 3/1/2004
• A Mouse Model for Follicular Thyroid Cancer Induced Bone Lesions.
  Younes MN, Yigitbasi OG, Kim SJ, Doan D, Al-Muhtaseb Z, Jasser SA, Myers JN, IV International Conference on Cancer-Induced bone Diseases, San Antonio, TX, 12/7/2003
• Treatment with NVPAEE788 - A dual inhibitor of EGFR and VEGFR Tyrosine Kinase- Inhibits Anaplastic Thyroid Carcinoma Growth.
  Kim S, Schiff BA, Younes MN, Doan D, Jasser SA, Myers JN, AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, MA, 11/17/2003
• The Inhibition of Integrin Linked Kinase by Novel ILK Inhibitors Induces Apoptosis and Restores Anoikis to Squamous Cell Carcinoma of the Head and Neck Cancer Cells.
  Younes MN, Yigitbasi OG, Jasser SA, Doan D, Schiff BA, El-Naggar A, Mills GB, Myers JN, 94th Annual American Association for Cancer Research meeting (AACR), Washington, DC, 7/1/2003
• Integrin Linked Kinase (ILK) is Overexpressed and ILK Inhibition Leads to Growth Inhibition of Anaplastic and Papillary Thyroid Cancer Cells.
  Younes MN, Yigitbasi OG, Jasser SA, Doan D, El-Naggar A, Mills GB, Myers JN, Combined Otolaryngological Spring Meeting, Nashville, TN, 5/1/2003
• The effect of the EGF-R inhibitor ZD 1839 (Iressa) on Thyroid Cancer.
  Schiff BA, Jasser SA, Doan D, Yeung SC, Younes MN, McMurphy A, Holsinger FC, El-Naggar A, Sherman SI, Myers JN, Combined Otolaryngological Spring Meeting, Nashville, TN, 5/1/2003
• An Orthotopic Nude Mouse Model of Thyroid Cancer.
  Schiff BA, Younes MN, Jasser SA, Doan D, Yeung SC, Holsinger FC, Myers JN, 94th Annual American Association for Cancer Research meeting (AACR) meeting, 44th Clinical Conference on Molecular Therapeutics for Cancer Metastasis, Houston, TX, 3/1/2003
• AKT as a potential therapeutic target for head and neck cancer.
  Younes MN, Swan EA, Mandal M, Jasser SA, Doan D, Mills GB, Myers JN, 44th Clinical Conference on Molecular Therapeutics for Cancer Metastasis, Houston, TX, 3/1/2003
• Dephosphorylation and down regulation of Akt is associated with farnesyltransferase inhibitor (SCH66336) treatment in head and neck squamous cell carcinoma cell lines.
  Hassan KA, Wu W, Wang L, Lee HY, Younes MN, Hee Jun K, Lotan R, Kim E, Kies MS, Bishop R, Kirschmeier P, Hong WK, Mao L, Khuri FR, 93rd Annual American Association for Cancer Research (AACR) Meeting, San Francisco, CA, 4/6/2002
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Lectures

• Dual EGFR and VEGFR Inhibition with NVP-AEE788 for the Treatment of Aggressive Follicular Thyroid Cancer. 
  Chicago, IL - 8/1/2006
• Molecular Targeted Therapy in Follicular Thyroid Cancer. 
  Houston, TX - 9/16/2005

Other

• Melanoma. 
  Younes MN, Myers JN, Multidisciplinary Care of Head and Neck Cancer. Web Book, 2nd Edition
  http://headneckcancer.bcdecker.com/
  1/1/2005