MaikeSanderMD

PubMed

• 14 citations
  Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation
  Sandra Heller, Zhijian Li, Qiong Lin, Ryan J Geusz, Markus Breunig, Meike Hohwieler, Xi Zhang, Gopika G. Nair, Thomas Seufferlein, Matthias Hebrok, Maike Sander, Cécil...> ;Communications Biology. 2021 Nov 17
• 24 citations
  Mutations and variants of ONECUT1 in diabetes.
  Anne Philippi, Sandra Heller, Ivan G. Costa, Valérie Senée, Markus Breunig, Zhijian Li, Gino Kwon, Ronan Russell, Anett Illing, Qiong Lin, Meike Hohwieler, Anne Degavr...> ;Nature Medicine. 2021 Oct 18
• 16 citations
  What is a β cell? - Chapter I in the Human Islet Research Network (HIRN) review series.
  Klaus H. Kaestner, Martha Campbell-Thompson, Yuval Dor, Ronald G. Gill, Benjamin Glaser, Seung K. Kim, Maike Sander, Cherie L. Stabler, Andrew F. Stewart, Alvin C. Powers> ;Molecular Metabolism. 2021 Aug 17
• 3 citations
  A multi-omics roadmap of β-cell failure in type 2 diabetes mellitus.
  Gaowei Wang, Maike Sander> ;Nature Reviews. Endocrinology. 2021 Aug 17
• 19 citations
  Transcriptional mechanisms of pancreatic β-cell maturation and functional adaptation.
  Matthew Wortham, Maike Sander> ;Trends in Endocrinology and Metabolism. 2021 Jul 1
• 4 citations
  Career Advancement for Women in Diabetes-Related Research: Developing and Retaining Female Talent.
  Darleen A. Sandoval, Laura C. Alonso, Maureen Gannon, Maike Sander, Lori Sussel, Jane E.B. Reusch> ;Diabetes Care. 2021 Jun 15
• 14 citations
  Transformation of SOX9+ cells by Pten deletion synergizes with steatotic liver injury to drive development of hepatocellular and cholangiocarcinoma.
  Jingyu Chen, Anketse Debebe, Ni Zeng, Janel L. Kopp, Lina He, Maike Sander, Bangyan L. Stiles> ;Scientific Reports. 2021 Jun 3
• 128 citations
  Interpreting type 1 diabetes risk with genetics and single-cell epigenomics
  Joshua Chiou, Ryan J Geusz, Mei-Lin Okino, Jee Yun Han, Michael Miller, Rebecca L. Melton, Elisha Beebe, Paola Benaglio, Serina Huang, Katha Korgaonkar, Sandra Heller,...> ;Nature. 2021 May 19
• 71 citations
  Single-cell chromatin accessibility identifies pancreatic islet cell type- and state-specific regulatory programs of diabetes risk.
  Joshua Chiou, Chun Zeng, Zhang Cheng, Jee Yun Han, Michael Schlichting, Michael Miller, Robert Mendez, Serina Huang, Jinzhao Wang, Yinghui Sui, Allison Deogaygay, Mei-...> ;Nature Genetics. 2021 Apr 1
• 7 citations
  Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development
  Ryan J Geusz, Allen Wang, Joshua Chiou, Joseph J. Lancman, Nichole Wetton, Samy Kefalopoulou, Jinzhao Wang, Yunjiang Qiu, Jian Yan, Anthony Aylward, Bing Ren, P. Duc S...> ;Elife. 2021 Feb 5
• 63 citations
  Systematic analysis of binding of transcription factors to noncoding variants
  Jian Yan, Yunjiang Qiu, André M. Ribeiro dos Santos, Yimeng Yin, Yang Eric Li, Nick Vinckier, Naoki Nariai, Paola Benaglio, Anugraha Raman, Xiaoyu Li, Shicai Fan, Josh...> ;Nature. 2021 Jan 27
• 2 citations
  Inferring time series chromatin states for promoter-enhancer pairs based on Hi-C data.
  Henriette Miko, Yunjiang Qiu, Bjoern Gaertner, Maike Sander, Uwe Ohler> ;BMC Genomics. 2021 Jan 28
• 15 citations
  A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation.
  Bjoern Gaertner, Sebastiaan van Heesch, Valentin Schneider-Lunitz, Jana Felicitas Schulz, Franziska Witte, Susanne Blachut, Steven Nguyen, Regina Wong, Ileana Matta, N...> ;Elife. 2020 Aug 3
• 20 citations
  LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development.
  Nicholas Vinckier, Nisha A. Patel, Ryan J Geusz, Allen Wang, Jinzhao Wang, Ileana Matta, Austin R. Harrington, Matthew Wortham, Nichole Wetton, Jianxun Wang, Ulupi S. ...> ;Nature Communications. 2020 Apr 29
• 10 citations
  PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response
  Jie Ye, Anpei Huang, Haitao Wang, Anni M.Y. Zhang, Xiaojun Huang, Qingping Lan, Tomohiko Sato, Susumu Goyama, Mineo Kurokawa, Chu-Xia Deng, Maike Sander, David F. Scha...> ;Cell Death & Disease. 2020 Mar 16
• 87 citations
  Epigenetics and Epigenomics: Implications for Diabetes and Obesity
  Evan D. Rosen, Klaus H. Kaestner, Rama Natarajan, Mary-Elizabeth Patti, Richard C Sallari, Maike Sander, Katalin Susztak> ;Diabetes. 2018 Oct 1
• 55 citations
  Loss of Pten and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice
  Janel L. Kopp, Claire L. Dubois, David F. Schaeffer, Atefeh Samani, Farnaz Taghizadeh, Robert W. Cowan, Andrew D. Rhim, Bangyan L. Stiles, Mark A. Valasek, Maike Sander> ;Gastroenterology. 2018 Apr 1
• 3 citations
  High T Gives β Cells a Boost
  Matthew Wortham, Maike Sander> ;Cell Metabolism. 2016 May 10
• 55 citations
  A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells
  Hung Ping Shih, Philip A. Seymour, Nisha A. Patel, Ruiyu Xie, Allen Wang, Patrick Liu, Gene W. Yeo, Mark A. Magnuson, Maike Sander> ;Cell Reports. 2015 Oct 13
• 36 citations
  Prdm12 specifies V1 interneurons through cross-repressive interactions with Dbx1 and Nkx6 genes in Xenopus.
  Aurore Thelie, Simon Desiderio, Julie Hanotel, Ian K. Quigley, Benoît Van Driessche, Anthony Rodari, Mark D. Borromeo, Sadia Kricha, François Lahaye, Jenifer C. Croce,...> ;Development. 2015 Oct 1
• 354 citations
  Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer.
  Joan Font-Burgada, Shabnam Shalapour, Suvasini Ramaswamy, Brian Hsueh, David Rossell, Atsushi Umemura, Koji Taniguchi, Hayato Nakagawa, Mark A. Valasek, Li Ye, Janel L...> ;Cell. 2015 Aug 13
• 123 citations
  Lineage fate of ductular reactions in liver injury and carcinogenesis
  S Jörs, Petia Jeliazkova, Marc Ringelhan, Julian Thalhammer, S Dürl, Jorge Ferrer, Maike Sander, Mathias Heikenwalder, Roland M. Schmid, Jens T. Siveke, Fabian Geisler> ;The Journal of Clinical Investigation. 2015 Jun 1
• 170 citations
  Epigenetic priming of enhancers predicts developmental competence of hESC-derived endodermal lineage intermediates
  Allen Wang, Feng Yue, Yan Li, Ruiyu Xie, Thomas Harper, Nisha A. Patel, Kayla Muth, Jeffrey Palmer, Yunjiang Qiu, Jinzhao Wang, Dieter K. Lam, Jeffrey C. Raum, Doris A...> ;Cell Stem Cell. 2015 Apr 2
• 89 citations
  Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors
  Matias G. De Vas, Janel L. Kopp, Claire Heliot, Maike Sander, Silvia Cereghini, Cécile Haumaitre> ;Development. 2015 Mar 1
• 27 citations
  Postnatal β-Cell Proliferation and Mass Expansion Is Dependent on the Transcription Factor Nkx6.1
  Brandon L. Taylor, Jacqueline R. Benthuysen, Maike Sander> ;Diabetes. 2015 Mar 1
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Journal Articles

• Pancreatic islet chromatin accessibility and conformation defines distal enhancer networks of type 2 diabetes risk.  
  Greenwald, W.W., Chiou, J., Yan, J., Qiu, Y., Dai, N., Wang, A., Nariai, N., Aylward, A., Han, J., Kadakia, N., Barrufet, L., Okino, M., Drees, F., Vinckier, N., Minic..., Nature Communications, 2019
• A network of microRNAs acts to promote cell cycle exit and differentiation of human pancreatic endocrine cells.  
  Jin, W., Mulas, F., Gaertner, B., Sui, Y., Wang, J., Zeng, C., Vinckier, N., Wang, A., Nguyen-Ngoc, K.V., Chiou, J., Kaestner, K.H., Frazer, K., Carrano, A.C., Shih, H..., iScience, 2019
• Differential cell susceptibilities to KrasG12D in the setting of obstructive chronic pancreatitis.  
  Shi, C., Pan, F.P., Kim, J.N., Washington, M.K., Padmanabhan, C., Meyer, C.T., Kopp, J.L., Sander, M., Gannon, M., Beauchamp, R.D., Wright, C.V., Means, A.L., Cellular and Molecular Gastroenterology and Hepatology, 2019
• In vivo-mimicking microfluidic perfusion culture of pancreatic islet spheroids.  
  Jun, Y., Lee, J.S., Choi, S., Yang, J.H., Sander, M.*, Chung, S.*, Lee, S.H., Science Advances, 2019
• Single cell chromatin accessibility reveals pancreatic islet cell type- and state-specific regulatory programs of diabetes risk.  
  Chiou, J.,* Zeng, C.,* Cheng, Z., Han, J.Y., Schlichting, M., Huang, S., Wang, J., Sui, Y., Deogaygay, A., Okino, M.L., Qui, Y., Sun, Y., Kudtarkar, P., Fang, R., Prei..., BioRxiv, 2019
• Nomenclature for Cellular Plasticity: Are the Terms as Plastic as the Cells Themselves?  
  Mills, J.C., Stanger, B.Z., Sander M., Embo J., 2019
• Beta-cell dysfunction induced by non-cytotoxic concentrations of Interleukin-1β is associated with changes in expression of beta-cell maturity genes and associated his...  
  Ibarra, A.U., Prause, M., Wortham, M., Sui, Y., Thams, P., Sander, M., Christensen G.L., Billestrup, N., Molecular and Cellular Endocrinology, 2019
• LSD1-mediated enhancer silencing enables endocrine cell development through attenuation of retinoic acid signaling.  
  Vinckier, N.K., Patel, N.A., Wang, A., Wang, J., Shih, H.P., Wang, J., Jhala, U.S., Rosenfeld, M.G., Benner, C.W., Sander, M., Nature Communications, 2019
• Nutrient regulation of the islet epigenome controls adaptive insulin secretion.  
  Wortham, M., Liu, F.F., Fleischman, J.Y., Wallace, M., Mulas, F., Vinckier, N.K., Harrington, A.R., Cross, B.R., Chiou, J., Patel, N.A., Sui, Y., Jhala, U.S., Shirihai..., BioRxiv, 2019
• Human stem cell models: lessons for pancreatic development and disease.  
  Gaertner, B., Carrano, A.C., Sander, M., Genes & Development, 2019
• PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response.  
  Ye, J.,* Huang, A.,* Wang, H., Zhang, A. M. Y., Huang, X., Lan, Q., Sato, T., Goyama, S., Kurokawa, M., Deng, C., Sander, M., Schaeffer, D. F., Li, W., Kopp, J. L., Xi..., BioRxiv, 2019
• Loss of PTEN and activation of Kras synergistically induce formation of intraductal papillary mucinous neoplasia from pancreatic ductal cells in mice.  
  Kopp, J.L., Dubois, C.L., Schaeffer, D.F., Samani, A., Taghizadeh, F., Cowan, R.W., Rhim, A.D., Stiles, B.L., Valasek, M., Sander M., Gastroenterology, 2018
• Cell of origin affects tumor development and phenotype in pancreatic ductal adenocarcinoma.  
  Lee, A., Dubois, C.L., Sarai, K., Zarei, S., Schaeffer, D.F., Sander M., Kopp, J.L., Gut, 2018
• ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis.  
  Das, K., Heeg, S., Pitarresi, J., Reichert, M., Bakir, B., Takano, S., Kopp, J., Feuerstein, A., Hicks, P., Sander, M., Rustgi, A., Developmental Dynamics, 2018
• Epigenetics and epigenomics: Implications for diabetes and obesity.  
  Rosen, E.D., Kaestner, K.H., Natarajan, R., Patti, M.E., Sallari, R., Sander ,M., Susztak, K., Diabetes, 2018
• Pancreatic exocrine tissue architecture and integrity are maintained by E-cadherin during postnatal development.  
  Serrill, J.D., Sander, M., Shih, H.P., Sci Rep, 2018
• Pancreatic islet-autonomous insulin and smoothened-mediated signaling modulate identity changes of glucagon+ α-cells.  
  Cigliola, V., Ghila, L., Thorel, F., van Gurp, L., Baronnier, D., Oropeza, D., Gupta, S., Miyatsuka, T., Kaneto, H., Magnuson, M.A., Osipovich, A.B., Sander, M., Wrigh..., Nature Cell Biology, 2018
• N6-methyladenine DNA modification in glioblastoma.  
  Xie, Q., Wu, T., Gimple, R., Li, Z., Prager, B., Wu, Q., Yu, Y., Wang, P., Wang,Y., Gorkin, D., Zhang,C., Dowiak,A., Lin, K., Zeng, C., Sui, Y., Kim, L., Miller, T., J..., Cell, 2018
• Evaluation of different decellularization protocols on the generation of pancreas-derived hydrogel.  
  Gaetani, R., Aouad, S., Demaddalena, L, Straessle, H., Dzieciatkowska, M., Wortham, M., Bender, H., Nguyen-Ngoc, K., Schmid-Schoenbein, G., George, S., Hughes, C., San..., Tissue Eng Part C, 2018
• Integrated in vivo quantitative proteomics and nutrient tracing reveals age-related metabolic rewiring of pancreatic β-cell function.  
  Wortham, M., Benthuysen, J.R., Wallace, M., Savas, J.N., Mulas, F., Divakaruni, A.S., Liu, F., Albert, V., Taylor, B.L., Sui, Y., Saez, E., Murphy, A.N., Yates, J.R. I..., Cell Reports, 2018
• Ldb1 maintains the terminally differentiated state of pancreatic β-cells.  
  Ediger, B., Hee-Wong, L., Juliana, C., Groff, D., Williams, L., Dominguez, G., Taylor, B.L., Walp, E., Kameswaran, V., Yang, J., Liu, C., Hunter, C., Kaestner, K.H., N..., Journal of Clinical Investigation, 2017
• Pseudotemporal ordering of single cells reveals metabolic control of postnatal beta-cell proliferation.  
  Zeng, C., Mulas, F., Sui, Y., Guan, T., Miller, N., Tan, Y., Liu, F., Jin, W., Carrano, A.C., Huising, M.O., Shirihai, O.S., Yeo, G.W., Sander, M., Cell Metabolism, 2017
• Interrogating islets in health and disease with single-cell technologies.  
  Carrano, A.C., Mulas, F., Zeng, C., Sander, M., Molecular Metabolism, 2017
• ECM signaling regulates collective cellular dynamics to control pancreas branching morphogenesis.  
  Shih, H.P., Panlasigui, D., Cirulli, V., Sander, M., Cell Reports, 2016
• Pancreatic differentiation from human pluripotent stem cells.  
  Vinckier, N., Wang, J., Sander, M., In Ulrich, H. (ed.): Working with Stem Cells - Quick and easy methodologies and applications, 2016
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Books/Book Chapters

• Cellular and Molecular Biology of the Renin-Angiotensin System 
  Chapter: Renin Gene Expression and Hypertension in Transgenic Animals 
  Page 59 - 93Bader, M., Lee, M., Zhao, Y., Böhm, M., Bachmann, J., Sander, M., Djavidani, B., Bachmann, S., Zimmermann, F., Wilbertz, J., Zeh, K., Wagner, J., Peters, J., Ganten, D.CRC Press1993