ManuelModianoMD

Oncology • Tucson, AZ

Breast Cancer, Gastrointestinal Cancer, Thoracic Cancer

Arizona Blood and Cancer Specialists. Medical Director, ACRC/Arizona Clinical Research Center. Tucson, AZ

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Office
3945 E Paradise Falls Dr
suite 105
Tucson, AZ 85712
Phone+1 520-689-7022

Fax+1 520-230-3310
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Education & Training

University of Arizona College of Medicine-TucsonFellowship, Hematology and Medical Oncology, 1987 - 1989
Aurora Health CareResidency, Internal Medicine, 1984 - 1987
Universidad Nacional Autonoma de MexicoClass of 1981

Certifications & Licensure

AZ State Medical License 1987 - 2025
WI State Medical License 1985 - 2011

Awards, Honors, & Recognition

Past President The Arizona Clinical Oncology Society
Certificate of Merit United States Surgeon General, 1991
Outstanding Fellow University of Arizona Cancer Center, 1988
Chief Resident Mount Sinai Medical Center, 1986
Outstanding Senior Resident Mount Sinai Medical Center, 1985-1986
Outstanding Medical Resident Mount Sinai Hospital, 1985
Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012
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Clinical Trials

E7050 in Combination With Sorafenib Versus Sorafenib Alone as First Line Therapy in Participants With Hepatocellular Carcinoma Start of enrollment: 2011 Jul 19
Completed
Phase 1, Phase 2
Comparison of Pixantrone + Rituximab With Gemcitabine + Rituximab in Patients With Aggressive B-cell Non-Hodgkin Lymphoma or Follicular Grade 3 Lymphoma Who Have Relapsed After Therapy and Are Not Eligible for Stem Cell Transplant Start of enrollment: 2011 Apr 20
Completed
Phase 3
E7050 in Combination With Cetuximab Versus Cetuximab Alone in the Treatment of Platinum-Resistant Squamous Cell Carcinoma of the Head and Neck Start of enrollment: 2011 Sep 19
Completed
Phase 1, Phase 2
E7050 in Combination With Cisplatin and Capecitabine Versus Cisplatin and Capecitabine Alone in Patients With Advanced or Metastatic Solid Tumors and Previously Untreated Gastric Cancer Start of enrollment: 2011 Nov 01
Terminated
Phase 1, Phase 2
Mifepristone and Eribulin in Patients With Metastatic Triple Negative Breast Cancer or Other Specified Solid Tumors Start of enrollment: 2014 Jan 01
Completed
Phase 1
A Study of Abemaciclib (LY2835219) In Participants With Previously Treated Breast Cancer That Has Spread Start of enrollment: 2014 Jun 10
Completed
Phase 2
Safety, Pharmacokinetics and Preliminary Anti-Tumor Activity of Intravenous TKM-080301 in Subjects With Advanced Hepatocellular Carcinoma Start of enrollment: 2014 Jun 01
Completed
Phase 1, Phase 2
A Phase 2 Study of Ramucirumab (LY3009806) in Participants With Gastric or Gastroesophageal Junction (GEJ) Cancer Start of enrollment: 2015 Jul 07
Completed
Phase 2
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Publications & Presentations

PubMed

4 citations
Filanesib plus bortezomib and dexamethasone in relapsed/refractory t(11;14) and 1q21 gain multiple myeloma.
Jonathan L Kaufman, Myo Htut, Manish Agrawal, Amitabha Mazumder, Jeffrey A Zonder, Joseph W Fay, Manuel R Modiano, Erin L Moshier, Selena A Rush, Brian J Tunquist, Aja...> ;Cancer Medicine. 2022 Jan 1
40 citations
PSMA ADC monotherapy in patients with progressive metastatic castration-resistant prostate cancer following abiraterone and/or enzalutamide: Efficacy and safety in ope...
Daniel P. Petrylak, Nicholas J. Vogelzang, Kamal Chatta, Mark D. Fleming, David Smith, Leonard Joseph Appleman, Arif Hussain, Manuel Modiano, Parminder Singh, Scott T....> ;The Prostate. 2020 Jan 1
28 citations
Randomized Phase II Trial of Seribantumab in Combination with Erlotinib in Patients with EGFR Wild-Type Non-Small Cell Lung Cancer
Lecia V. Sequist, Jhanelle E. Gray, Wael A. Harb, Ariel Lopez-Chavez, Robert C. Doebele, Manuel Modiano, David M. Jackman, Maria Q. Baggstrom, Akin Atmaca, Enriqueta F...> ;The Oncologist. 2019 Aug 1
61 citations
An Open‐Label, Multicenter, Phase I, Dose Escalation Study with Phase II Expansion Cohort to Determine the Safety, Pharmacokinetics, and Preliminary Antitumor Activity...
Imane El Dika, Ho Yeong Lim, Wei Peng Yong, Chia-Chi Lin, Jung Hwan Yoon, Manuel Modiano, Bradley Freilich, Hye Jin Choi, Tsu Yi Chao, Robin Kate Kelley, Joanne Brown,...> ;The Oncologist. 2019 Jun 1
7 citations
nab-Paclitaxel-Based Therapy in Underserved Patient Populations: The ABOUND.70+ Study in Elderly Patients With Advanced NSCLC.
Corey J. Langer, Edward S. Kim, Eric C. Anderson, Robert M. Jotte, Manuel Modiano, Daniel Haggstrom, Matei P. Socoteanu, David Smith, Christopher Dakhil, Kartik Kondur...> ;Frontiers in Oncology. 2018 Jul 24
59 citations
A randomized trial of iron isomaltoside versus iron sucrose in patients with iron deficiency anemia.
Richard J. Derman, Eloy Roman, Manuel R. Modiano, Maureen Achebe, Lars L. Thomsen, Michael Auerbach> ;American Journal of Hematology. 2017 Feb 1
47 citations
Efficacy of the Neurokinin-1 Receptor Antagonist Rolapitant in Preventing Nausea and Vomiting in Patients Receiving Carboplatin-Based Chemotherapy
Paul J. Hesketh, Ian D. Schnadig, Lee S. Schwartzberg, Manuel Modiano, Karin Jordan, Sujata Arora, Dan Powers, Matti Aapro> ;Cancer. 2016 Aug 1
6 citations
A Phase 2 Randomized, Double-Blind, Multicenter Trial of Imexon Plus Gemcitabine Versus Gemcitabine Plus Placebo in Patients With Metastatic Chemotherapy-naïve Pancrea...
Steven J. Cohen, Mark M. Zalupski, Paul Conkling, Francis W. Nugent, Wen Wee Ma, Manuel Modiano, Rolan Pascual, Fa-Chyi Lee, Lucas Wong, Evan M. Hersh> ;American Journal of Clinical Oncology. 2015 Dec 24
102 citations
Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of moderately emetogenic chemotherapy or anthracyclin...
Lee S. Schwartzberg, Manuel Modiano, Bernardo Leon Rapoport, Martin Chasen, Cesare Gridelli, Laszlo Urban, Allen Poma, Sujata Arora, Rudolph M. Navari, Ian D. Schnadig> ;The Lancet. Oncology. 2015 Sep 1
102 citations
Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of cisplatin-based highly emetogenic chemotherapy in ...
Bernardo Leon Rapoport, Martin Chasen, Cesare Gridelli, Laszlo Urban, Manuel Modiano, Ian D. Schnadig, Allen Poma, Sujata Arora, Vikram Kansra, Lee S. Schwartzberg, Ru...> ;The Lancet. Oncology. 2015 Sep 1
114 citations
PRONOUNCE: randomized, open-label, phase III study of first-line pemetrexed + carboplatin followed by maintenance pemetrexed versus paclitaxel + carboplatin + bevacizu...
Ralph Zinner, Coleman K. Obasaju, David R. Spigel, Robert W. Weaver, J. Thaddeus Beck, David M. Waterhouse, Manuel R. Modiano, Borys Hrinczenko, Petros G. Nikolinakos,...> ;Journal of Thoracic Oncology. 2015 Jan 1
6 citations
Phase 1/2 study of KRN330, a fully human anti-A33 monoclonal antibody, plus irinotecan as second-line treatment for patients with metastatic colorectal cancer
Johanna C. Bendell, Heinz-Josef Lenz, Theresa Ryan, Bassel F. El-Rayes, John L. Marshall, Manuel Modiano, Lowell L. Hart, Clint D. Kingsley, Thomas J. George, Daisuke ...> ;Investigational New Drugs. 2014 Apr 3
Preclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: results of a phase I study.
London CA, Bernabe LF, Barnard S, Kisseberth WC, Borgatti A, Henson M, Wilson H, Jensen K, Ito D, Modiano JF, Bear MD, Pennell ML, Saint-Martin JR, McCauley D, Kauffma...> ;PLoS One. 2014
22 citations
A phase II multicentre study of ziv-aflibercept in combination with cisplatin and pemetrexed in patients with previously untreated advanced/metastatic non-squamous non...
Hongbin Chen, Manuel Modiano, Joel W. Neal, Julie R. Brahmer, James R. Rigas, Robert M. Jotte, Natasha B. Leighl, Jonathan W. Riess, Calvin J. Kuo, Liming Liu, B. Gao,...> ;British Journal of Cancer. 2014 Feb 4
160 citations
Adjuvant docetaxel, doxorubicin, and cyclophosphamide in node-positive breast cancer: 10-year follow-up of the phase 3 randomised BCIRG 001 trial
John R. Mackey, Miguel Martin, Tadeusz Pienkowski, Janusz Rolski, Jean-Paul Guastalla, Amer Sami, John A. Glaspy, Eva Juhos, Andrew M Wardley, Tommy Fornander, John D....> ;The Lancet. Oncology. 2013 Jan 1
Phase Ib/II study of eribulin mesylate administered in combination with gemcitabine/cisplatin as first-line therapy for locally advanced or metastatic bladder cancer: ...
Vogelzang NJ, Conkling P, Duran I, Maroto JP, Modiano M, De Leonardis P, Hodge JP, Lieberman R> ;J. Clin. Oncol.. 2012-02-10
Apricot-P: A randomized placebo-controlled phase II study of COX-2 inhibitor apricoxib or placebo in combination with gemcitabine and erlotinib in advanced or metastat...
Modiano M, Keogh GP, Manges R, Stella PJ, Milne G, Looper E, Zaknoen SL> ;J. Clin. Oncol.. 2012-02-01
15 citations
Pixantrone dimaleate in combination with fludarabine, dexamethasone, and rituximab in patients with relapsed or refractory indolent non-Hodgkin lymphoma: phase 1 study...
Tomasz P. Srokowski, James Liebmann, Manuel Modiano, Gary I. Cohen, Barbara Pro, Jorge E. Romaguera, Christine Kuepfer, Jack W. Singer, Luis Fayad> ;Cancer. 2011 Nov 15
A phase I/II trial of MM-121 in combination with erlotinib in patients (pts) with non-small cell lung cancer (NSCLC).
Sequist LV, Harb WA, Modiano M, Jackman DM, Wong K, Engelman JA, Nering R, Onsum M, Moyo VM> ;J. Clin. Oncol.. 2011-05-20
18 citations
A phase I study of imexon plus gemcitabine as first-line therapy for advanced pancreatic cancer
Steven J. Cohen, Mark M. Zalupski, Manuel Modiano, Paul Conkling, Yehuda Z. Patt, Peg Davis, Robert T. Dorr, Michelle L. Boytim, Evan M. Hersh> ;Cancer Chemotherapy and Pharmacology. 2010 Jul 1
20 citations
Phase III Multicenter Trial of Doxorubicin Plus Cyclophosphamide Followed by Paclitaxel Compared With Doxorubicin Plus Paclitaxel Followed by Weekly Paclitaxel As Adju...
David M. Loesch, F. Anthony Greco, Neil Senzer, Howard A. Burris, John D. Hainsworth, Stephen E. Jones, Svetislava J. Vukelja, John Sandbach, Frankie A. Holmes, Scot S...> ;Journal of Clinical Oncology. 2010 Jun 20
A phase Ib trial of Bcl-2 inhibitor obatoclax in combination with carboplatin and etoposide for previously untreated patients with extensive-stage small cell lung canc...
Chiappori A, Schreeder MT, Moezi MM, Stephenson J, Blakely JL, Salgia R, Chu QS, Malik SM, Modiano MM, Berger MS> ;J. Clin. Oncol.. 2009-05-20
A phase I study of TPI 287, a novel taxane, administered every 21 days in patients (pts) with advanced cancer.
Modiano MR, Plezia P, Basche M, Cohn AL, Baram Y, Tapolsky G, Yancik S, Pugliese L, Silberman S> ;J. Clin. Oncol.. 2008-05-20
A phase I study of imexon inj plus gemcitabine as first-line therapy for advanced pancreatic cancer with preclinical mechanistic study of dose limiting toxicity.
Cohen SJ, Zalupski MM, Modiano MR, Conkling PR, Patt YZ, Davis P, Dorr RT, Boytim ML, Hersh EM> ;J. Clin. Oncol.. 2008-05-20
A phase I study of TPI 287, a novel taxane, administered weekly in patients with advanced cancer.
Silberman S, Hwang JH, Marshall JL, Ahmed T, Basche M, Cohn AL, Modiano MR, Tapolsky G, Yancik S, Pugliese L> ;J. Clin. Oncol.. 2008-05-20
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Research History

Principal Investigator1989 - 2015

Professional Memberships

Other Languages

French, Spanish

Hospital Affiliations

Mt. Graham Regional Medical CenterSafford, Arizona
Carondelet St. Mary's HospitalTucson, Arizona
Carondelet St. Mary's HospitalTucson, Arizona