MarcAlanSimonMDMS, FACP

Cardiology • San Francisco, CA

Heart Failure & Transplantation

Professor, Medicine, UCSF

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Office
505 Parnassus Ave
Moffitt Bldg M-1182 Box 0124
San Francisco, CA 94143
Phone+1 415-476-1325
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Education & Training

UPMC Medical EducationFellowship, Advanced Heart Failure and Transplant Cardiology, 2004 - 2005
UPMC Medical EducationFellowship, Cardiovascular Disease, 2001 - 2004
University of ColoradoResidency, Internal Medicine, 1998 - 2001
University of Maryland School of MedicineClass of 1998

Certifications & Licensure

CA State Medical License 2021 - 2025
PA State Medical License 1988 - 2022
CO State Medical License 2000 - 2003
American Board of Internal Medicine Advanced Heart Failure and Transplant Cardiology
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011

Clinical Trials

Inhaled Nitrite in Subjects With Pulmonary Hypertension Start of enrollment: 2012 Jun 01
Completed
Phase 2
A Pivotal Trial to Establish the Efficacy and Long-term Safety of the Parachute Implant System Start of enrollment: 2012 Dec 01
Terminated
Phase 3
Efficacy and Safety of Allogeneic Mesenchymal Precursor Cells (Rexlemestrocel-L) for the Treatment of Heart Failure. Start of enrollment: 2014 Feb 14
Completed
Phase 3
Phase 1/1b Study With Nab-sirolimus for Patients With Severe Pulmonary Arterial Hypertension Start of enrollment: 2017 Apr 01
Completed
Phase 1
Oral Nitrite in Patients With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction Start of enrollment: 2017 Oct 30
Completed
Phase 2
Phase 2 Study to Assess Safety, Tolerability and Efficacy of Once Weekly SC Pemziviptadil (PB1046) in Subjects With Symptomatic PAH Start of enrollment: 2018 Jul 15
Terminated
Phase 2
Metformin for Pulmonary Hypertension HFpEF Start of enrollment: 2019 Feb 26
Recruiting
Phase 2
Long-Term, Open Label Extension Study of Pemziviptadil (PB1046) in PAH Subjects Following Completion of Study PB1046-PT-CL-0004 Start of enrollment: 2019 Apr 10
Terminated
Phase 2
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Publications & Presentations

PubMed

Backscatter tensor imaging and 3D speckle tracking for simultaneous ex vivo structure and deformation measurement of myocardium.
John M Cormack, Marc A Simon, Kang Kim> ;Ultrasound in Medicine & Biology. 2023 May 1
6 citations
Pulmonary artery compliance in different forms of pulmonary hypertension.
Amber McCormick, Amita Krishnan, David Badesch, Raymond L Benza, Todd M Bull, Teresa De Marco, Jeremy Feldman, Anna R Hemnes, Russel Hirsch, Evelyn Horn, Jaime Kennedy...> ;Heart. 2023 Jun 26
Knowing All the Angles (on Right Ventricular Myocardial Remodeling).
Marc A Simon, John M Cormack, Danial Sharifi Kia> ;Circulation. Heart Failure. 2023 Feb 1
Erratum: Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: An analysis of the Pulmonary Hypert...
Hilary M DuBrock, Charles D Burger, Sonja D Bartolome, Jeremy P Feldman, David D Ivy, Erika B Rosenzweig, Jeffrey S Sager, Kenneth W Presberg, Stephen C Mathai, Matthe...> ;Pulmonary Circulation. 2022 Oct 1
1 citations
Refraction-corrected backscatter tensor imaging of excised porcine ventricular myocardium.
John M Cormack, Marc A Simon, Kang Kim> ;JASA Express Letters. 2022 Sep 1
20 citations
Aggressive Afterload Lowering to Improve the Right Ventricle: A New Target for Medical Therapy in Pulmonary Arterial Hypertension?
Carmine Dario Vizza, Irene M Lang, Roberto Badagliacca, Raymond L Benza, Stephan Rosenkranz, R James White, Yochai Adir, Arne K Andreassen, Vijay Balasubramanian, Sonj...> ;American Journal of Respiratory and Critical Care Medicine. 2022 Apr 1
17 citations
Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Insti...
Reena Mehra, Olga A Tjurmina, Olujimi A Ajijola, Rishi Arora, Donald C Bolser, Mark W Chapleau, Peng-Sheng Chen, Colleen E Clancy, Brian P Delisle, Michael R Gold, Jef...> ;JACC. Basic to Translational Science. 2022 Mar 1
6 citations
An open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of GSK2586881 in participants with pu...
Marc A Simon, Kate Hanrott, David C Budd, Fernando Torres, Ekkehard Grünig, Pilar Escribano-Subias, Manuel L Meseguer, Michael Halank, Christian Opitz, David A Hall, D...> ;Pulmonary Circulation. 2022 Jan 1
A clinically applicable strategy to estimate the in vivo distribution of mechanical material properties of the right ventricular wall.
Jing Xu, Timothy C. Wong, Marc A. Simon, John C. Brigham> ;International Journal for Numerical Methods in Biomedical Engineering. 2021 Nov 14
3 citations
Right Ventricular Shape Feature Quantification for Evaluation of Pulmonary Hypertension: Feasibility and Preliminary Associations With Clinical Outcome Submitted for P...
Jing Xu, Eleanor L Desmond, Timothy C. Wong, Colin G Neill, Marc A. Simon, John C. Brigham> ;Journal of Biomechanical Engineering. 2022 Apr 1
69 citations
Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review.
Ambarish Pandey, Sanjiv J. Shah, Javed Butler, Dean L. Kellogg, Gregory D. Lewis, Daniel E. Forman, Robert J. Mentz, Barry A. Borlaug, Marc A. Simon, Julio A. Chirinos...> ;Journal of the American College of Cardiology. 2021 Sep 14
5 citations
Role of Internal Jugular Venous Ultrasound in suspected or confirmed Heart Failure: A Systematic Review.
Rahul Chaudhary, Ajaypaul Sukhi, Marc A. Simon, Flordeliza S. Villanueva, John J. Pacella> ;Journal of Cardiac Failure. 2021 Aug 19
13 citations
Pulmonary Hypertension in the Context of Heart Failure With Preserved Ejection Fraction.
Chakradhari Inampudi, Daniel N. Silverman, Marc A. Simon, Peter J. Leary, Kavita Sharma, Brian A. Houston, Jean-Luc Vachiery, Francois Haddad, Ryan J. Tedford> ;Chest. 2021 Aug 12
5 citations
A pilot study of dimethyl fumarate in pulmonary arterial hypertension associated with systemic sclerosis
Kristi Kong, Diane Koontz, Christina Morse, Eileen Roth, Robyn T. Domsic, Marc A. Simon, Eric A. Stratton, Connor Buchholz, Kimberly Tobin-Finch, Robert W. Simms, M. P...> ;Journal of Scleroderma and Related Disorders. 2021 May 28
3 citations
A pilot study of oral treprostinil pharmacogenomics and treatment persistence in patients with pulmonary arterial hypertension.
James C. Coons, Karryn Crisamore, Solomon M. Adams, Ashley Modany, Marc A. Simon, Wenchen Zhao, Imam H. Shaik, Raman Venkataramanan, Philip E. Empey> ;Therapeutic Advances in Respiratory Disease. 2021 Apr 30
35 citations
Levosimendan Improves Hemodynamics and Exercise Tolerance in PH-HFpEF: Results of the Randomized Placebo-Controlled HELP Trial.
Daniel Burkhoff, Barry A. Borlaug, Sanjiv J. Shah, Ronald Zolty, Ryan J. Tedford, Thenappan Thenappan, Roham T. Zamanian, Jeremy A. Mazurek, Jonathan D. Rich, Marc A. ...> ;JACC. Heart Failure. 2021 Apr 7
18 citations
The Prognostic Value of Right Atrial Strain Imaging in Patients with Precapillary Pulmonary Hypertension
Nina E. Hasselberg, Nobuyuki Kagiyama, Yuko Soyama, Masataka Sugahara, Akiko Goda, Keiko Ryo-Koriyama, Omar Batel, Murali M. Chakinala, Marc A. Simon, John Gorcsan> ;Journal of the American Society of Echocardiography. 2021 Mar 24
2 citations
Induced bioresistance via BNP detection for machine learning-based risk assessment.
Seth So, Aya Khalaf, Xinruo Yi, Connor Herring, Yingze Zhang, Marc A. Simon, Murat Akcakaya, Seung Hee Lee, Minhee Yun> ;Biosensors & Bioelectronics. 2021 Mar 1
4 citations
Right ventricular load and contractility in HIV-associated pulmonary hypertension
Arun Rajaratnam, Sofiya Rehman, Prerna Sharma, Vikas Singh, Melissa Saul, Rebecca Vanderpool, Mark T. Gladwin, Marc A. Simon, Alison Morris> ;Plos One. 2021 Feb 23
4 citations
An exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload.
Danial Sharifi Kia, Ronald N. Fortunato, Spandan Maiti, Marc A. Simon, Kang Kim> ;Scientific Reports. 2021 Feb 11
20 citations
United States Pulmonary Hypertension Scientific Registry: Baseline Characteristics.
J. Badlam, David B. Badesch, Eric D. Austin, Raymond L. Benza, Wendy K. Chung, Harrison W. Farber, K. Feldkircher, Adaani E. Frost, Abby Poms, Katie A. Lutz, Michael W...> ;Chest. 2021 Jan 1
5 citations
The Effects of Healthy Aging on Right Ventricular Structure and Biomechanical Properties: A Pilot Study.
Danial Sharifi Kia, Yuanjun Shen, Timothy N Bachman, Elena A Goncharova, Kang Kim, Marc A Simon> ;Frontiers in Medicine. 2021 Jan 1
12 citations
Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: an analysis of the Pulmonary Hypertension As...
Hilary M. DuBrock, Charles D. Burger, Sonja Bartolome, Jeremy Feldman, D. Dunbar Ivy, Erika B. Rosenzweig, J.S. Sager, Kenneth W. Presberg, Stephen C. Mathai, Matthew ...> ;Pulmonary Circulation. 2021 Jun 6
19 citations
Current Understanding of the Right Ventricle Structure and Function in Pulmonary Arterial Hypertension.
Danial Sharifi Kia, Kang Kim, Marc A. Simon> ;Frontiers in Physiology. 2021 Jan 1
9 citations
Prediction of Health-related Quality of Life and Hospitalization in Pulmonary Arterial Hypertension: The Pulmonary Hypertension Association Registry
Jeff Min, David B. Badesch, Murali M. Chakinala, Jean M. Elwing, Robert P. Frantz, Evelyn M. Horn, James R. Klinger, Matthew R. Lammi, Sula Mazimba, J.S. Sager, Oksana...> ;American Journal of Respiratory and Critical Care Medicine. 2021 Mar 15
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Abstracts/Posters

[Board 482] Patients With Severe Pulmonary Arterial Hypertension Treated With ABI-009 Nab-Sirolimus an mTOR Inhibitor: Interim Results From a Phase 1 Clinical Trial
Marc Simon, 2019 ACC Scientific Session & Expo, New Orleans, New Orleans, 3/17/2019