MarcoLuisDavilaMDPhD

PubMed

• Baseline Serum Inflammatory Proteins Predict Poor CAR T Outcomes in Diffuse Large B-cell Lymphoma.
  Dean, E., Rawan G Faramand, Sae Bom Lee, Michael D Jain, Biwei Cao, Xuefeng Wang, Kai Rejeski, Marion Subklewe, Johannes F Fahrmann, Neeraj Y Saini, Samir M Hanash, Yu...> ;Blood Cancer Discovery. 2024 Mar 1
• Bispecific CD33/CD123 targeted chimeric antigen receptor T cells for the treatment of acute myeloid leukemia.
  Boucher, J., Shrestha, B., Vishwasrao, P., Cervantes, E., Ghafoor, T., Reid, K., Spitler, K., Yu, B., Guevara-Patino, J., Leick, M., Betts, B., Maus, M., Davila, M.> ;Molecular Therapy Oncolytics. 2023 Dec 19
• 5 citations
  Severe hematotoxicity after CD19 CAR-T therapy is associated with suppressive immune dysregulation and limited CAR-T expansion.
  Kai Rejeski, Ariel Perez, Gloria Iacoboni, Viktoria Blumenberg, Veit L Bücklein, Simon Völkl, Olaf Penack, Omar Albanyan, Sophia Stock, Fabian Müller, Philipp Karschni...> ;Science Advances. 2023 Sep 22
• 4 citations
  Cardiac and inflammatory biomarker differences in adverse cardiac events after chimeric antigen receptor T-Cell therapy: an exploratory study.
  Dae Hyun Lee, Sanjay Chandrasekhar, Michael D Jain, Rahul Mhaskar, Kayla Reid, Sae Bom Lee, Salvatore Corallo, Melanie J Hidalgo-Vargas, Abhishek Kumar, Julio Chavez, ...> ;Cardio-Oncology. 2023 Apr 1
• 44 citations
  A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy.
  Christoph K Stein-Thoeringer, Neeraj Y Saini, Eli Zamir, Viktoria Blumenberg, Maria-Luisa Schubert, Uria Mor, Matthias A Fante, Sabine Schmidt, Eiko Hayase, Tomo Hayas...> ;Nature Medicine. 2023 Apr 1
• 4 citations
  Outcomes of CD19-Directed Chimeric Antigen Receptor T Cell Therapy for Transformed Nonfollicular Lymphoma.
  Ning Dong, Lucía Rubio Lopes-Garcia, David Viñal, Christina Bachmeier, Bijal D Shah, Taiga Nishihori, Farhad Khimani, Marco L Davila, Aleksandr Lazaryan, Javier Pinill...> ;Transplantation and Cellular Therapy. 2023 Jun 1
• 16 citations
  CYAD-01, an autologous NKG2D-based CAR T-cell therapy, in relapsed or refractory acute myeloid leukaemia and myelodysplastic syndromes or multiple myeloma (THINK): hae...
  David A Sallman, Tessa Kerre, Violaine Havelange, Xavier Poiré, Philippe Lewalle, Eunice S Wang, Jason B Brayer, Marco L Davila, Ine Moors, Jean-Pascal Machiels, Ahmad...> ;The Lancet. Haematology. 2023 Mar 1
• 5 citations
  Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality.
  Shernan G Holtan, Constanza Savid-Frontera, Kelly Walton, Anne A Eaton, Connor Demorest, Andrea Hoeschen, Ling Zhang, Kayla Reid, Tony Kurian, Zena Sayegh, Estefania J...> ;Clinical Cancer Research. 2023 Mar 14
• 3 citations
  CAR T cell therapy: looking back and looking forward.
  Marco L Davila, Renier J Brentjens> ;Nature Cancer. 2022 Dec 1
• 5 citations
  Outcomes of CD19-Targeted Chimeric Antigen Receptor T Cell Therapy for Patients with Reduced Renal Function Including Dialysis.
  Anthony C Wood, Ariel Perez Perez, Brian Arciola, Kedar Patel, Grace Johnson, Elizabeth DiMaggio, Christina A Bachmeier, Kayla Reid, Salvatore Carallo, Melanie H Varga...> ;Transplantation and Cellular Therapy. 2022 Dec 1
• 26 citations
  Early cytopenias and infections after standard of care idecabtagene vicleucel in relapsed or refractory multiple myeloma.
  Jennifer M Logue, Lauren C Peres, Hamza Hashmi, Christelle M Colin-Leitzinger, Alexandria M Shrewsbury, Hitomi Hosoya, Rebecca M Gonzalez, Christina Copponex, Krista H...> ;Blood Advances. 2022 Dec 27
• 28 citations
  Whole-genome sequencing reveals complex genomic features underlying anti-CD19 CAR T-cell treatment failures in lymphoma.
  Michael D Jain, Bachisio Ziccheddu, Caroline A Coughlin, Rawan Faramand, Anthony J Griswold, Kayla M Reid, Meghan Menges, Yonghong Zhang, Ling Cen, Xuefeng Wang, Moham...> ;Blood. 2022 Aug 4
• 5 citations
  Primary progression during frontline CIT associates with decreased efficacy of subsequent CD19 CAR T-cell therapy in LBCL.
  Ariel Perez, Grace Johnson, Kedar Patel, Brian Arciola, Anthony Wood, Christina A Bachmeier, Julio C Chavez, Bijal D Shah, Farhad Khimani, Taiga Nishihori, Aleksandr L...> ;Blood Advances. 2022 Jul 12
• 3 citations
  Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy.
  Nada S Aboelella, Caitlin Brandle, Ogacheko Okoko, Md Yeashin Gazi, Zhi-Chun Ding, Hongyan Xu, Gregory Gorman, Roni Bollag, Marco L Davila, Locke J Bryan, David H Munn...> ;Journal for Immunotherapy of Cancer. 2022 Jul 1
• 1 citations
  CD3 engagement as a new strategy for allogeneic "off-the-shelf" T cell therapy.
  Gongbo Li, Kayla M Reid, Kristen Spitler, Nolan Beatty, Justin Boucher, Marco L Davila> ;Molecular Therapy Oncolytics. 2022 Mar 17
• Transverse myelitis after anti-CD19 directed CAR T cell therapy for relapsed large B cell lymphoma.
  Semira Sheikh, Sepideh Mokhtari, Jeffrey A Silverman, Kayla Reid, Rawan Faramand, Marco L Davila, Norman Franke, Frederick L Locke, Michael D Jain, Daniel Wong, John G...> ;Ejhaem. 2022 Feb 1
• 3 citations
  CAR T-cell hematotoxicity: is inflammation the key?
  Rawan G Faramand, Marco L Davila> ;Blood. 2021 Dec 16
• 16 citations
  Increased Infections and Delayed CD4+ T Cell but Faster B Cell Immune Reconstitution after Post-Transplantation Cyclophosphamide Compared to Conventional GVHD Prophyla...
  Farhad Khimani, Peter Ranspach, Hany Elmariah, Jongphil Kim, Junmin Whiting, Taiga Nishihori, Frederick L. Locke, Ariel Perez Perez, Erin Dean, Asmita Mishra, Lia Pere...> ;Transplantation and Cellular Therapy. 2021 Nov 1
• 3 citations
  Phase 2 multicenter trial of ofatumumab and prednisone as initial therapy of chronic graft-vs-host disease
  Aleksandr Lazaryan, Stephanie J. Lee, Mukta Arora, Jongphil Kim, Brian C. Betts, Farhad Khimani, Taiga Nishihori, Nelli Bejanyan, Hien Liu, Mohamed A. Kharfan-Dabaja, ...> ;Blood Advances. 2021 Oct 14
• 39 citations
  4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells.
  Emiliano Roselli, Justin C Boucher, Gongbo Li, Hiroshi Kotani, Kristen Spitler, Kayla Reid, Estelle V Cervantes, Yannick Bulliard, Nhan Tu, Sae Bom Lee, Bin Yu, Freder...> ;Journal for Immunotherapy of Cancer. 2021 Oct 1
• 9 citations
  Expansion and Enrichment of Gamma-Delta (γδ) T Cells from Apheresed Human Product.
  Ana Marie Landin, Cheryl Cox, Bin Yu, Nelli Bejanyan, Marco L. Davila, Linda L. Kelley> ;Journal of Visualized Experiments. 2021 Sep 22
• Advances in CAR T cell clinical development.
  Marco L. Davila, Christina A Bachmeier> ;Best Practice & Research. Clinical Haematology. 2021 Sep 1
• 2 citations
  Outcomes of CD19 Chimeric Antigen Receptor T Cell Therapy in Patients with Gastrointestinal Tract Involvement of Large B Cell Lymphoma
  Albert Cortes-Bullich, Ariel Perez Perez, Christina A Bachmeier, Rahul Mhaskar, Julio C. Chavez, Bijal D. Shah, Taiga Nishihori, Farhad Khimani, Aleksandr Lazaryan, Ma...> ;Transplantation and Cellular Therapy. 2021 Sep 1
• 38 citations
  Interventions and outcomes of adult patients with B-ALL progressing after CD19 chimeric antigen receptor T-cell therapy
  Kitsada Wudhikarn, Jessica Flynn, Isabelle Riviere, Mithat Gonen, Xiuyan Wang, Brigitte Senechal, Kevin J. Curran, Mikhail Roshal, Peter Maslak, Mark B. Geyer, Elizabe...> ;Blood. 2021 Aug 19
• 20 citations
  Patterns and Predictors of Failure in Recurrent or Refractory Large B-Cell Lymphomas After Chimeric Antigen Receptor T-Cell Therapy.
  Nicholas B Figura, Timothy J. Robinson, Austin J. Sim, Xuefeng Wang, Biwei Cao, Julio C. Chavez, Bijal D. Shah, Farhad Khimani, Aleksandr Lazaryan, Marco L. Davila, Ch...> ;International Journal of Radiation Oncology, Biology, Physics. 2021 Jul 6
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Journal Articles

• CARs move to the Fast Lane  
  Davila ML and Papetrou E, Molecular Therapy, 1/1/2014
• Chimeric Antigen Receptors for the Adoptive T Cell Therapy Of Hematologic Malignancies  
  Davila, ML, Bouhassira DC, Park JH, Curran KJ, Smith EL, Pegram HJ, and Brentjens R., International Journal of Hematology, 1/1/2014
• Chimeric Antigen Receptor Therapy for Chronic Lymphocytic Leukemia: What are the Challenges?  
  Davila ML, Brentjens R, Hematol Oncol Clin North Am, 1/1/2013
• CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with ChemotherapyRefractory Acute Lymphoblastic Leukemia  
  Brentjens RJ, Davila ML, Riviere I, Park J, Wang X, et al., Sci Transl Med, 1/1/2013
• Early Clinical Outcomes of Chimeric Antigen Receptor Modified T Cells and the Generation of "Armored" CAR T Cells for Future Applications to Cancer Immunotherapy  
  Davila, ML, Brentjens, R, Am Assoc Cancer Res Educ Book, 1/1/2013
• How Do CARs Work?: Early Insights from Recent Clinical Studies Targeting CD19  
  Davila ML, Brentjens R, Wang X, Riviere I, Sadelain M, Oncoimmunology, 1/1/2012
• Conserved Cryptic Recombination Signals in Vkappa Gene Segments Are Cleaved in Small Pre-B Cells  
  Lieberman AE, Kuraoka M, Davila M, Kelsoe G, Cowell LG, BMC Immunol, 1/1/2009
• Multiple, Conserved Cryptic Recombination Signals in VH Gene Segments: Detection of Cleavage Products Only in Pro B Cells  
  Davila M, Liu F, Cowell LG, Lieberman AE, Heikamp E, et al., J Exp Med, 1/1/2007
• Computational Tools for Understanding Sequence Variability in Recombination Signals  
  Cowell LG, Davila M, Ramsden D, Kelsoe G, Immunol Rev, 1/1/2004
• Prospective Estimation of Recombination Signal Efficiency and Identification of Functional Cryptic Signals in the Genome by Statistical Modeling  
  Cowell LG, Davila M, Yang K, Kepler TB, Kelsoe G, J Exp Med, 1/1/2003
• Identification and Utilization of Arbitrary Correlations in Models of Recombination Signal Sequences  
  Cowell LG, Davila M, Kepler TB, Kelsoe G, Genome Biol, 1/1/2002
• A Role for Secondary V(D)J Recombination in Oncogenic Chromosomal Translocations?  
  Davila M, Foster S, Kelsoe G, Yang K, Adv Cancer Res, 1/1/2001
• Do Germinal Centers Have a Role in the Generation of Lymphomas?  
  Yang K, Davila M, Kelsoe G, Curr Top Microbiol Immunol, 1/1/1999
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Abstracts/Posters

• Human CD83 Targeted Chimeric Antigen Receptor T Cell for the Prevention of Graft Versus Host Disease and Treatment of Myeloid Leukemia
  Marco L. Davila, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• The Lymphoma Tumor Microenvironment Influences Toxicity after CD19 CAR T Cell Therapy
  Marco L. Davila, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• MDSC Suppression of CAR T Cells Can be Reduced By Targeted Signaling Disruption
  Marco L. Davila, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Mutation of the CD28 Co-Stimulatory Domain Confers Enhanced CAR T Cell Function
  Marco L. Davila, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Tumor Inflammation and Myeloid Derived Suppressor Cells Reduce the Efficacy of CD19 CAR T Cell Therapy in Lymphoma
  Marco L. Davila, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Fever Characteristics Associated with Toxicity and Outcome after Anti-CD19 CAR T-Cell Therapy for Aggressive Lymphoma
  Marco L. Davila, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Safe and Effective Re-Induction Of Complete Remissions In Adults With Relapsed B-ALL Using 19-28z CAR CD19-Targeted T Cell Therapy
  M. L. Davila, I. Riviere, X. Wang, S. Bartido, J. Stefanski, Q. He, O. Borquez-Ojeda, C. Taylor, T. Wasielewska, J. Qu, D. C. Bouhassira, Y. J. Bernal, S. Yoo, T. Purd..., ACTO Meeting, ASH Meeting, New Orleans, LA 2013; Osaka, Japan, 2014, 1/1/2014
• CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy Refractory Acute Leukemia
  Renier Brentjens, Marco L. Davila, Isabelle Riviere, Jae Park, Xiuyan Wang, Shirley Bartido, Jolanta Stefankski, Oriana Borquez-Ojeda, Yvette Bernal, Michel Sadelain, ASGCT Meeting, Salt Lake City, UT, 1/1/2013
• CD19-Targeted Donor T Cells Exert Potent Graft Versus Lymphoma Activity and Attenuated GVHD.
  Arnab Ghosh, Marco L Davila, Lauren F. Young, Christopher Kloss, et al., American Society of Hematology Meeting, Atlanta, GA, 1/1/2012
• Conditioning Intensity and T Cell Dose Determine Efficacy of CD19-Targeted T CellMediated Tumor Eradication in an Immunocompetent Mouse Model of B-ALL
  Marco L Davila, Christopher Kloss, Renier J Brentjens, and Michel Sadelain, American Society of Hematology 2012 Meeting, Atlanta, GA, 1/1/2012
• Molecular Remission and B Cell Aplasia Induced in a First Cohort of Adults with Relapsed B-ALL Treated with 19-28z CAR-Targeted T Cells
  Marco L Davila, Isabelle Riviere, Xiuyan Wang, Jae H. Park, et al., American Society of Hematology 2012 Meeting, Atlanta, GA, 1/1/2012
• Impact of the Conditioning Chemotherapy On Outcomes in Adoptive T Cell Therapy: Results From a Phase I Clinical Trial of Autologous CD19-Targeted T Cells for Patients ...
  Jae H. Park, Isabelle Rivière, Xiuyan Wang, Jolanta Stefanski, Qing He, Clare Taylor, Malgorzata Olszewska, Teresa Wasielewska, Shirley Bartido, Marco L Davila, et al., American Society of Hematology 2012 Meeting, Atlanta, GA, 1/1/2012
• A Phase I Clinical Trial of Autologous, Anti-CD19 Gene Targeted T Cells for Adults with B Cell Acute Lymphoblastic Leukemia (B-ALL).
  Marco L. Davila, Isabelle Riviere, Xiuyan Wang, et al., American Society of Clinical Oncology 2012 Annual Meeting, Chicago, IL, 1/1/2012
• T Cells Genetically Targeted to CD19 Eradicate B-ALL In a Novel Syngeneic Mouse Disease Model.
  Marco L Davila and Michel Sadelain, American Society of Hematology Meeting, Orlando, FL, 1/1/2010
• B Cell Aplasia In a Patient with Relapsed B Cell Acute Lymphoblastic Leukemia Following Re-Induction and Consolidation with Autologous T Cells Genetically Targeted to ...
  Marco L Davila, Clare Taylor, Xiuyan Wang, Jolanta Stefanski, Malgorzata Olszewska, Shirley Bartido, Mark Frattini, Michel Sadelain, Isabelle Rivière, and Renier J. Br..., American Society of Hematology 2010 Meeting, Orlando, FL, 1/1/2010
• VH Gene Replacement Occurs during the Pro-B Stage of Development
  Davila M, E Heikamp, LG Cowell, and G Kelsoe., American Association of Immunologists Meeting, Denver, Colorado, 1/1/2003
• Rag1 and Rag2 in the Periphery
  Marco Davila, Sandra Foster, and Garnett Kelsoe., Canadian Society of Immunologist Meeting, Alberta, Canada, 1/1/2001
• Does the V(D)J Recombinase Mediate Chromosomal Translocations?
  Marco Davila, Kaiyong Yang, and Garnett Kelsoe, American Association of Immunologists Meeting, Orlando, Florida, 1/1/2001
• An Association between V(D)J Rearrangement and Chromosomal Translocations.
  Marco Davila, Kaiyong Yang, and Garnett Kelsoe, 15th Annual M.D./Ph.D. Conference, Aspen, Colorado, 1/1/2000
• The Germinal Center and Lymphomagenesis.
  Marco Davila, Kaiyong Yang, and Garnett Kelsoe., Conferencia Internacional de Lymphoma, Mexico City, Mexico, 1/1/1999
• An In Vitro model for Chromosomal Translocations Driven by RAG1/2.
  Marco Davila, Kaiyong Yang, and Garnett Kelsoe, International Conference on Lymphoma, Lugano, Switzerland, 1/1/1999
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Lectures

• Phase 1 Studies Assessing the Safety and Clinical Activity of Multiple Doses of a NKG2D-Based CAR-T Therapy, Cyad-01, in Acute Myeloid Leukemia 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Prediction of CAR T-Related Toxicities in R/R DLBCL Patients Treated with Axicabtagene Ciloleucel Using Point of Care Cytokine Measurements 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Aged CAR T Cells Exhibit Enhanced Cytotoxicity and Effector Function but Shorter Persistence and Less Memory-like Phenotypes 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018