MargaretLeighMD

Pediatric Pulmonology • Chapel Hill, NC

Cystic Fibrosis Pulmonology, Pediatric Bronchoscopy, Pediatric Infectious Disease Pulmonology

Professor of Pediatrics / Director, UNC Cystic Fibrosis Care Center

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Office
101 Manning Dr
Chapel Hill, NC 27599
Phone+1 919-966-8596

Fax+1 919-843-5515
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Education & Training

University of North Carolina HospitalsFellowship, Infectious Disease, 1982 - 1985
University of Kentucky College of MedicineResidency, Pediatrics, 1978 - 1980
Eastern Virginia Medical SchoolInternship, Pediatrics, 1976 - 1977
Eastern Virginia Medical SchoolClass of 1976

Certifications & Licensure

NC State Medical License 2023 - 2023
American Board of Pediatrics Pediatrics

Awards, Honors, & Recognition

Regional Top Doctor Castle Connolly, 2014

Clinical Trials

Evaluating Progression of and Diagnostic Tools for Primary Ciliary Dyskinesia in Children and Adolescents Start of enrollment: 2006 Aug 01
Completed
Long-term Lung Function and Disease Progression in Children With Early Onset Primary Ciliary Dyskinesia Lung Disease Start of enrollment: 2008 Jul 01
Completed

Publications & Presentations

PubMed

1 citations
Association of Neonatal Hospital Length of Stay with Lung Function in Primary Ciliary Dyskinesia.
Wallace B Wee, Margaret W Leigh, Stephanie D Davis, Margaret Rosenfeld, Kelli M Sullivan, Michael G Sawras, Thomas W Ferkol, Michael R Knowles, Carlos Milla, Scott D S...> ;Annals of the American Thoracic Society. 2022 Nov 1
4 citations
A multi-disciplinary, comprehensive approach to management of children with heterotaxy.
Thomas G Saba, Gabrielle C Geddes, Stephanie M Ware, David N Schidlow, Pedro J Del Nido, Nathan S Rubalcava, Samir K Gadepalli, Terri Stillwell, Anne Griffiths, Laura ...> ;Orphanet Journal of Rare Diseases. 2022 Sep 9
3 citations
The Impact on Parents of Diagnosing PCD in Young Children.
Corine Driessens, Siobhan Carr, Edel Clough, Fiona Copeland, Sharon Dell, Lucy Dixon, Amanda Harris, Rebecca Knibb, Margaret Leigh, Manjith Narayanan, Beatrice Redfern...> ;Journal of Clinical Medicine. 2022 Aug 16
1 citations
Going beyond the chest X-ray: Investigating laterality defects in primary ciliary dyskinesia.
Wallace B Wee, Kimberley R Kaspy, Michael G Sawras, Michael R Knowles, Maimoona A Zariwala, Margaret W Leigh, Sharon D Dell, Adam J Shapiro> ;Pediatric Pulmonology. 2022 May 1
1 citations
Leveraging Open Electronic Health Record Data and Environmental Exposures Data to Derive Insights Into Rare Pulmonary Disease.
Karamarie Fecho, Stanley C Ahalt, Michael Knowles, Ashok Krishnamurthy, Margaret Leigh, Kenneth Morton, Emily Pfaff, Max Wang, Hong Yi> ;Frontiers in Artificial Intelligence. 2022 Jan 1
2 citations
Use caution interpreting nasal nitric oxide: Overlap in primary ciliary dyskinesia and primary immunodeficiency.
Andrew T. Barber, Stephanie D. Davis, Hannah Boutros, Maimoona A. Zariwala, Michael R. Knowles, Margaret W. Leigh> ;Pediatric Pulmonology. 2021 Sep 2
12 citations
Otolaryngology Manifestations of Primary Ciliary Dyskinesia: A Multicenter Study.
Faisal Zawawi, Adam J. Shapiro, Sharon D. Dell, Nikolaus E. Wolter, Cinzia L. Marchica, Michael R. Knowles, Maimoona A. Zariwala, Margaret W. Leigh, Mariana M. Smith, ...> ;Otolaryngology--Head and Neck Surgery. 2021 Jun 22
11 citations
Sinus Development and Pneumatization in a Primary Ciliary Dyskinesia Cohort.
Andrew K. Pappa, Kelli M. Sullivan, Erin M. Lopez, Katherine Adams, Adam M. Zanation, Charles S. Ebert, Brian D. Thorp, Brent A. Senior, Margaret W. Leigh, Mike R. Kno...> ;American Journal of Rhinology & Allergy. 2021 Jan 1
1 citations
Access to medicines for rare diseases: beating the drum for primary ciliary dyskinesia
Suzanne Crowley, Inês Azevedo, Mieke Boon, Andrew Bush, Ernst Eber, Eric G. Haarman, Bulent Karadag, Karsten Kötz, Margaret W. Leigh, Antonio Moreno-Galdó, Huda Mussaf...> ;ERJ Open Research. 2020 Jul 1
16 citations
Comparison of Multiple Breath Washout and Spirometry in Children with Primary Ciliary Dyskinesia and Cystic Fibrosis and Healthy Controls
Bre Anna Kinghorn, Sharon McNamara, Alan Genatossio, Erin Sullivan, Molly Siegel, Irma K. Bauer, Charles Clem, Robin Johnson, Miriam Davis, Anne Griffiths, William Whe...> ;Annals of the American Thoracic Society. 2020 Sep 1
17 citations
Limitations of Nasal Nitric Oxide Testing in Primary Ciliary Dyskinesia.
Adam J. Shapiro, Stephanie D. Davis, Margaret W. Leigh, Michael R. Knowles, Valery Lavergne, Thomas W. Ferkol> ;American Journal of Respiratory and Critical Care Medicine. 2020 Aug 1
59 citations
International consensus guideline for reporting transmission electron microscopy results in the diagnosis of primary ciliary dyskinesia (BEAT PCD TEM Criteria)
Amelia Shoemark, Mieke Boon, Christoph Brochhausen, Zuzanna Bukowy-Bieryllo, Maria Margherita De Santi, Patricia Goggin, Paul Griffin, Richard G. Hegele, Robert A. Hir...> ;The European Respiratory Journal. 2020 Apr 1
37 citations
Nasal Nitric Oxide Measurement in Primary Ciliary Dyskinesia. A Technical Paper on Standardized Testing Protocols.
Adam J. Shapiro, Sharon D. Dell, Benjamin Gaston, Michael Glenn O’Connor, Nadzeya Marozkina, Michele Manion, Milan J. Hazucha, Margaret W. Leigh> ;Annals of the American Thoracic Society. 2020 Jan 31
96 citations
De Novo Mutations in FOXJ1 Result in a Motile Ciliopathy with Hydrocephalus and Randomization of Left/Right Body Asymmetry.
Julia Wallmeier, Diana Frank, Amelia Shoemark, Tabea Nöthe-Menchen, Sandra Cindric, Heike Olbrich, Niki T. Loges, Isabella Aprea, Gerard W. Dougherty, Petra Pennekamp,...> ;American Journal of Human Genetics. 2019 Nov 7
5 citations
Errors in Methodology Affect Diagnostic Accuracy of High-Speed Videomicroscopy Analysis in Primary Ciliary Dyskinesia.
Adam J. Shapiro, Margaret W. Leigh, Heymut Omran, Valery Lavergne, Michael R. Knowles> ;Chest. 2019 Nov 1
19 citations
Identification of genetic variants in CFAP221 as a cause of primary ciliary dyskinesia.
Ximena M. Bustamante-Marin, Adam J. Shapiro, Patrick R. Sears, Wu Lin Charng, Donald F. Conrad, Margaret W. Leigh, Michael R. Knowles, Lawrence E. Ostrowski, Maimoona ...> ;Journal of Human Genetics. 2020 Jan 1
2 citations
Cytoplasmic "ciliary inclusions" in isolation are not sufficient for the diagnosis of primary ciliary dyskinesia.
Timothy J. Vece, Scott D. Sagel, Maimoona A. Zariwala, Kelli M. Sullivan, Kimberlie A. Burns, Susan K. Dutcher, Roman Yusupov, Margaret W. Leigh, Michael R. Knowles> ;Pediatric Pulmonology. 2020 Jan 1
16 citations
Validation of pediatric health-related quality of life instruments for primary ciliary dyskinesia (QOL-PCD).
Laura Behan, Margaret W Leigh, Sharon D Dell, Alexandra L Quittner, Claire Hogg, Jane S Lucas> ;Pediatric Pulmonology. 2019 Dec 1
3 citations
High-speed videomicroscopy analysis presents limitations in diagnosis of primary ciliary dyskinesia
Adam J. Shapiro, Thomas W. Ferkol, Michele Manion, Margaret W. Leigh, Stephanie D. Davis, Michael R. Knowles> ;American Journal of Respiratory and Critical Care Medicine. 2020 Jan 1
25 citations
Recurring large deletion in DRC1 (CCDC164) identified as causing primary ciliary dyskinesia in two Asian patients
Kozo Morimoto, Minako Hijikata, Maimoona A. Zariwala, Keith R. Nykamp, Atsushi Inaba, Tz-Chun Guo, Hiroyuki Yamada, Rebecca Truty, Yuka Sasaki, Ken Ohta, Shoji Kudoh, ...> ;Molecular Genetics & Genomic Medicine. 2019 Jul 4
78 citations
Primary Ciliary Dyskinesia: Longitudinal Study of Lung Disease by Ultrastructure Defect and Genotype.
Stephanie D. Davis, Margaret Rosenfeld, Hye-Seung Lee, Thomas W. Ferkol, Scott D. Sagel, Sharon D. Dell, Carlos Milla, Jessica E. Pittman, Adam J. Shapiro, Kelli M. Su...> ;American Journal of Respiratory and Critical Care Medicine. 2019 Jan 15
36 citations
Primary Ciliary Dyskinesia (PCD): A genetic disorder of motile cilia.
Margaret W. Leigh, Amjad Horani, BreAnna Kinghorn, Michael Glenn O’Connor, Maimoona A. Zariwala, Michael R. Knowles> ;Translational Science of Rare Diseases. 2019 Jan 1
2 citations
The prevalence of the defining features of primary ciliary dyskinesia within a cri du chat syndrome cohort
Catherine D. Sanders, Margaret W. Leigh, Kay C. Chao, Karen E. Weck, Ian F. G. King, Whitney E. Wolf, Dennis J. Campbell, Michael R. Knowles, Maimoona A. Zariwala, Ada...> ;Pediatric Pulmonology. 2018 Nov 1
5 citations
Use of telavancin in adolescent patients with cystic fibrosis and prior intolerance to vancomycin: A case series.
Adam T. Bernstein, Margaret W. Leigh, Jennifer L. Goralski, Charles R. Esther, Cameron J. McKinzie> ;Journal of Cystic Fibrosis. 2018 Nov 1
222 citations
Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline
Adam J. Shapiro, Stephanie D. Davis, Deepika Polineni, Michele Manion, Margaret Rosenfeld, Sharon D. Dell, Mark A. Chilvers, Thomas W. Ferkol, Maimoona A. Zariwala, Sc...> ;American Journal of Respiratory and Critical Care Medicine. 2018 Jun 15
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Press Mentions

Early Stage Investigator Spotlight: BreAnna Kinghorn Improves Outcomes for Children with Primary Ciliary DyskinesiaMarch 22nd, 2022
Consortium Spotlight: Advancing Discoveries in Mucociliary Clearance DiseasesMarch 11th, 2022
NIH Awards $7.5 Million to Ramp up Clinical Trials for Rare, Genetic Airway DiseasesOctober 9th, 2019