MariaFLopes-VirellaMD

Endocrinology • Charleston, SC

Professor, Medicine, Medical University of South Carolina College of Medicine

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Office
109 Bee St
Charleston, SC 29401
Phone+1 843-577-5011

Fax+1 843-937-6110
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Education & Training

Medical University of South CarolinaResidency, Pathology-Anatomic and Clinical, 1978 - 1979
University of Lisbon Faculty of MedicineClass of 1967

Certifications & Licensure

SC State Medical License 1979 - 2025
American Board of Pathology Clinical Pathology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

Markers and Mechanisms of Macrovascular Disease in IDDM Start of enrollment: 1996 Sep 01
Completed

Publications & Presentations

PubMed

Circulating Lipoprotein Sphingolipids in Chronic Kidney Disease with and without Diabetes.
Hammad, S., Baker, N., Klein, R., Hunt, K., Lopes-Virella, M.> ;Biomedicines. 2024 Jan 15
4 citations
Circulating Sphingolipids in Insulin Resistance, Diabetes and Associated Complications.
Samar M Hammad, Maria F Lopes-Virella> ;International Journal of Molecular Sciences. 2023 Sep 13
1 citations
The Presence of Periodontitis Exacerbates Non-Alcoholic Fatty Liver Disease via Sphingolipid Metabolism-Associated Insulin Resistance and Hepatic Inflammation in Mice ...
Zhongyang Lu, Yanchun Li, Nityananda Chowdhury, Hong Yu, Wing-Kin Syn, Maria Lopes-Virella, Özlem Yilmaz, Yan Huang> ;International Journal of Molecular Sciences. 2023 May 5
GPR40 deficiency worsens metabolic syndrome-associated periodontitis in mice.
Yanchun Li, Zhongyang Lu, Cameron L Kirkwood, Keith L Kirkwood, Stephen A Wank, Ai-Jun Li, Maria F Lopes-Virella, Yan Huang> ;Journal of Periodontal Research. 2023 Jun 1
1 citations
Plasma apoM Levels and Progression to Kidney Dysfunction in Patients With Type 1 Diabetes.
Nathaniel L Baker, Samar M Hammad, Kelly J Hunt, Andrea Semler, Richard L Klein, Maria F Lopes-Virella> ;Diabetes. 2022 Aug 1
4 citations
Diabetes and kidney dysfunction markedly alter the content of sphingolipids carried by circulating lipoproteins.
Samar M Hammad, Kelly J Hunt, Nathaniel L Baker, Richard L Klein, Maria F Lopes-Virella> ;Journal of Clinical Lipidology. 2022 Jan 4
4 citations
Loss of GPR40 in LDL receptor-deficient mice exacerbates high-fat diet-induced hyperlipidemia and nonalcoholic steatohepatitis.
Zhongyang Lu, Yanchun Li, Ai-Jun Li, Wing-Kin Syn, Stephen A Wank, Maria F Lopes-Virella, Yan Huang> ;Plos One. 2022 Jan 1
5 citations
High-fat diet-induced metabolic syndrome increases ligature-induced alveolar bone loss in mice.
Zhongyang Lu, Yanchun Li, Hong Yu, Maria F Lopes-Virella, Yan Huang> ;Oral Diseases. 2023 Apr 1
5 citations
Deoxysphingolipids Upregulate MMP-1, Downregulate TIMP-1, and Induce Cytotoxicity in Human Schwann Cells.
Andrea J. Semler, Samar M. Hammad, Maria F. Lopes-Virella, Richard L. Klein, Yan Huang> ;Neuromolecular Medicine. 2021 Dec 1
9 citations
Inhibition of acid sphingomyelinase by imipramine abolishes the synergy between metabolic syndrome and periodontitis on alveolar bone loss.
Yanchun Li, Zhongyang Lu, Lixia Zhang, Cameron L. Kirkwood, Keith L. Kirkwood, Maria F. Lopes-Virella, Yan Huang> ;Journal of Periodontal Research. 2021 Nov 8
1 citations
Serum urate and cardiovascular events in the DCCT/EDIC study.
Alicia J. Jenkins, Barbara H. Braffett, Arpita Basu, Ionut Bebu, Samuel Dagogo-Jack, Trevor J. Orchard, Amisha Wallia, Maria F. Lopes-Virella, W. Timothy Garvey, John ...> ;Scientific Reports. 2021 Jul 9
13 citations
LPS and palmitic acid Co-upregulate microglia activation and neuroinflammatory response.
Zhongyang Lu, Shufeng Liu, Maria F Lopes-Virella, Zhewu Wang> ;Comprehensive Psychoneuroendocrinology. 2021 May 1
11 citations
GPR40 deficiency is associated with hepatic FAT/CD36 upregulation, steatosis, inflammation, and cell injury in C57BL/6 mice.
Zhongyang Lu, Yanchun Li, Wing-Kin Syn, Ai-Jun Li, W Sue Ritter, Stephen A. Wank, Maria F. Lopes-Virella, Yan Huang> ;American Journal of Physiology. Endocrinology and Metabolism. 2021 Jan 1
14 citations
Rationale, Design, and Implementation of Intensive Risk Factor Treatment in the CREST2 Trial.
Tanya N. Turan, Jenifer H. Voeks, Marc I. Chimowitz, Ana Roldan, Todd LeMatty, William Haley, Maria F. Lopes-Virella, Seemant Chaturvedi, Michael R. Jones, Donald Heck...> ;Stroke. 2020 Sep 21
2 citations
Longitudinal Plasma Kallikrein Levels and Their Association With the Risk of Cardiovascular Disease Outcomes in Type 1 Diabetes in DCCT/EDIC.
Miran A. Jaffa, Ionut Bebu, Deirdre K. Luttrell, Barbara H. Braffett, John M. Lachin, Kelly J. Hunt, Maria F. Lopes-Virella, Louis M. Luttrell, Timothy J. Lyons, Ayad ...> ;Diabetes. 2020 Aug 17
24 citations
DNA methylation age calculators reveal association with diabetic neuropathy in type 1 diabetes.
Delnaz Roshandel, Zhuo Chen, Angelo J. Canty, Shelley B. Bull, Rama Natarajan, Andrew D. Paterson, Stephen W. Scherer, F. Miao, L. Zhang, J. Brown-Friday, Jill P. Cran...> ;Clinical Epigenetics. 2020 Apr 5
77 citations
Risk Factors for Diabetic Peripheral Neuropathy and Cardiovascular Autonomic Neuropathy in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interv...
Barbara H. Braffett, Rose Gubitosi-Klug, James W. Albers, Eva L. Feldman, Catherine L. Martin, Neil H. White, Trevor J. Orchard, Maria F. Lopes-Virella, John M. Lachin...> ;Diabetes. 2020 Feb 12
20 citations
Amitriptyline inhibits nonalcoholic steatohepatitis and atherosclerosis induced by high-fat diet and LPS through modulation of sphingolipid metabolism
Zhongyang Lu, Yanchun Li, Wing-Kin Syn, Zhewu Wang, Maria F. Lopes-Virella, Timothy J. Lyons, Yan Huang> ;American Journal of Physiology. Endocrinology and Metabolism. 2020 Feb 1
51 citations
Risk Factors for First and Subsequent CVD Events in Type 1 Diabetes: The DCCT/EDIC Study
Ionut Bebu, David S. Schade, Barbara H. Braffett, Mikhail Kosiborod, Maria F. Lopes-Virella, Elsayed Z. Soliman, William H. Herman, David A. Bluemke, Amisha Wallia, Tr...> ;Diabetes Care. 2020 Jan 29
3 citations
ASSOCIATIONS BETWEEN ACCELERATED ATHEROSCLEROSIS, OXIDIZED LDL IMMUNE COMPLEXES, AND IN VITRO ENDOTHELIAL DYSFUNCTION IN SYSTEMIC LUPUS ERYTHEMATOSUS.
Jim C. Oates, Viswanathan Ramakrishnan, Paul J. Nietert, J. David Spence, Thomas W. Fleury, Margaret Markiewicz, Dayvia L Russell, Maria F Lopes-Virella> ;Transactions of the American Clinical and Climatological Association. 2020 Jan 1
13 citations
Acid sphingomyelinase deficiency exacerbates LPS-induced experimental periodontitis.
Yanchun Li, Zhongyang Lu, Lixia Zhang, Keith L. Kirkwood, Maria F. Lopes-Virella, Yan Huang> ;Oral Diseases. 2020 Jan 30
4 citations
Serum pigment epithelium-derived factor: Relationships with cardiovascular events, renal dysfunction, and mortality in the Veterans Affairs Diabetes Trial (VADT) cohort.
Kelly J. Hunt, Alicia J. Jenkins, Dongxu Fu, Danielle R. Stevens, Jian Xing Ma, Richard L. Klein, Madona Azar, Sarah X. Zhang, Maria F. Lopes-Virella, Timothy J. Lyons...> ;Journal of Diabetes and Its Complications. 2019 Oct 1
11 citations
Immune Complexes and the Risk of CVD in Type 1 Diabetes
Maria F. Lopes-Virella, Ionut Bebu, Kelly J. Hunt, Gabriel Virella, Nathaniel L. Baker, Barbara H. Braffett, Xiaoyu Gao, John M. Lachin, Dcct> ;Diabetes. 2019 Jun 19
22 citations
Serum apolipoproteins and apolipoprotein-defined lipoprotein subclasses: a hypothesis-generating prospective study of cardiovascular events in T1D.
Arpita Basu, Ionut Bebu, Alicia J. Jenkins, Julie A. Stoner, Ying Zhang, Richard L. Klein, Maria F. Lopes-Virella, W. Timothy Garvey, Matthew J. Budoff, Petar Alaupovi...> ;Journal of Lipid Research. 2019 Jun 15
22 citations
Glycosylated sphingolipids and progression to kidney dysfunction in type 1 diabetes.
Maria F. Lopes-Virella, Nathaniel L. Baker, Kelly J. Hunt, Samar M. Hammad, John M. Arthur, Gabriel Virella, Richard L. Klein, Dcct> ;Journal of Clinical Lipidology. 2019 Apr 3
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Lectures

Diabetes and Hypertriglyceridemia: Cardiovascular Risk, Mechanisms, and Indications for Treatment
ENDO 2019 - New Orleans, LA - 3/26/2019
TLR4 Antagonist Reduces Atherosclerosis in Diabetic LDL Receptor-Deficient Mice
Charleston, SC - 6/15/2014

Grant Support

Biomarkers Of Vascular Disease Progression In Type 1 Diabetes MellitusNational Institute Of Diabetes And Digestive And Kidney Diseases2008–2011
Markers And Mechanisms Of Macrovascular Disease In IDDMNational Center For Research Resources2004–2005
Markers And Mechanisms Of Vascular Disease In DiabetesNational Heart, Lung, And Blood Institute2002–2005
Modified LDL, Autoimmunity And Vascular Disease In DiabetesNational Heart, Lung, And Blood Institute2001–2005
Macrophage Activation And Lipoprotein MetabolismNational Heart, Lung, And Blood Institute1994–2001
Modified LDL, Autoimmunity And Vascular Disease In IDDMNational Heart, Lung, And Blood Institute1996–2000
Lipoprotein Metabolism And Cell Lipoprotein InteractionsNational Heart, Lung, And Blood Institute1985

Hospital Affiliations

MUSC Health University Medical CenterCharleston, South Carolina
Ralph H. Johnson Veterans Affairs Medical CenterCharleston, South Carolina