MarianIwamotoMDPhD

PubMed

• 1 citations
  Assessment of pharmacokinetics, safety, and tolerability following twice-daily administration of molnupiravir for 10 days in healthy participants.
  Marian Iwamoto, Kelly E Duncan, Prachi K Wickremasingha, Tian Zhao, Maria V Liberti, Lieselotte Lemoine, Tatjana Decaesteker, Sylvie Rottey, Brian M Maas, Gillian Gill...> ;Clinical and Translational Science. 2023 Oct 1
• 2 citations
  Evaluation of the inhibitory effects of itraconazole on letermovir.
  Jacqueline B McCrea, Karsten Menzel, Craig Fancourt, Rose Witter, Tian Zhao, Jonathan A Robbins, S Aubrey Stoch, Marian Iwamoto> ;British Journal of Clinical Pharmacology. 2023 Jul 1
• A drug-drug interaction study with letermovir and acyclovir in healthy participants.
  Karsten Menzel, Jacqueline B McCrea, Craig Fancourt, Rose Witter, Tian Zhao, S Aubrey Stoch, Marian Iwamoto> ;British Journal of Clinical Pharmacology. 2023 May 1
• 5 citations
  A Randomized, Double-Blind, Placebo-Controlled, Phase 1 Trial of Radiopaque Islatravir-Eluting Subdermal Implants for Pre-exposure Prophylaxis Against HIV-1 Infection.
  Randolph P Matthews, Xiaowei Zang, Stephanie E Barrett, Athanas Koynov, Adrian Goodey, Tycho Heimbach, Vanessa L Weissler, Carlien Leyssens, Tom Reynders, Zhiqing Xu, ...> ;Journal of Acquired Immune Deficiency Syndromes. 2023 Apr 1
• 2 citations
  Safety and Pharmacokinetics of Islatravir in Individuals with Severe Renal Insufficiency.
  Randolph P Matthews, Youfang Cao, Munjal Patel, Vanessa L Weissler, Arinjita Bhattacharyya, Inge De Lepeleire, Stefanie Last, Juan C Rondon, Ryan Vargo, S Aubrey Stoch...> ;Antimicrobial Agents and Chemotherapy. 2022 Dec 20
• 3 citations
  Clinical Formulation Bridging of Gefapixant, a P2X3-Receptor Antagonist, for the Treatment of Chronic Cough.
  Pranav Gupta, Azher Hussain, Anthony P Ford, Steven Smith, Jesse C Nussbaum, Aubrey Stoch, Marian Iwamoto> ;Clinical Pharmacology in Drug Development. 2022 Sep 1
• 3 citations
  A phase I, randomized, placebo-controlled study of molnupiravir in healthy Japanese to support special approval in Japan to treat COVID-19.
  Keisuke Nakamura, Katsukuni Fujimoto, Chihiro Hasegawa, Ikuo Aoki, Hiroyuki Yoshitsugu, Hiroyuki Ugai, Naoyoshi Yatsuzuka, Yoshiyuki Tanaka, Kenichi Furihata, Brian M ...> ;Clinical and Translational Science. 2022 Nov 1
• 5 citations
  Pharmacokinetics, Safety, and Tolerability of Letermovir Following Single- and Multiple-Dose Administration in Healthy Japanese Subjects.
  Kazuhiko Asari, Mikio Ishii, Hiroyuki Yoshitsugu, Akira Wakana, Craig Fancourt, Esther Yoon, Kenichi Furihata, Jacqueline B McCrea, S Aubrey Stoch, Marian Iwamoto> ;Clinical Pharmacology in Drug Development. 2022 Aug 1
• 1 citations
  Effects of Renal Impairment on the Pharmacokinetics of Gefapixant, a P2X3 Receptor Antagonist.
  Jesse C Nussbaum, Azher Hussain, K Chris Min, Thomas C Marbury, Kenneth Lasseter, S Aubrey Stoch, Marian Iwamoto> ;Journal of Clinical Pharmacology. 2022 Nov 1
• 1 citations
  A Randomized, Placebo-Controlled Study to Investigate the Safety, Tolerability, and Pharmacokinetics of 3 Weeks of Orally Administered Gefapixant in Healthy Younger an...
  Jesse Nussbaum, Azher Hussain, Anthony Ford, Peter Butera, Michael Kitt, Steve Smith, Aubrey Stoch, Marian Iwamoto> ;Lung. 2022 Jun 1
• 2 citations
  Drug-Drug Interaction of Letermovir and Atorvastatin in Healthy Participants.
  Jacqueline B McCrea, Karsten Menzel, Adedayo Adedoyin, Carolyn R Cho, Sabrina Fox-Bosetti, Sreeraj Macha, Tian Zhao, Fang Liu, Deborah Panebianco, S Aubrey Stoch, Mari...> ;Clinical Pharmacology in Drug Development. 2022 Apr 1
• 10 citations
  Acute and Chronic Effects of Rifampin on Letermovir Suggest Transporter Inhibition and Induction Contribute to Letermovir Pharmacokinetics.
  Jonathan A Robbins, Karsten Menzel, Michael Lassman, Tian Zhao, Craig Fancourt, Xiaoyan Chu, Kate Mostoller, Rose Witter, Rachel Marceau West, S Aubrey Stoch, Jacqueli...> ;Clinical Pharmacology and Therapeutics. 2022 Mar 1
• 4 citations
  Characterization of the absorption, metabolism, excretion, and mass balance of gefapixant in humans.
  Jesse C Nussbaum, Azher Hussain, Bennett Ma, K Chris Min, Qing Chen, Charles Tomek, Marian Iwamoto, S Aubrey Stoch> ;Pharmacology Research & Perspectives. 2022 Feb 1
• 3 citations
  A phase 1, open-label study to evaluate the drug interaction between islatravir (MK-8591) and the oral contraceptive levonorgestrel/ethinyl estradiol in healthy adult ...
  Wendy Ankrom, Deanne Jackson Rudd, Saijuan Zhang, Kerry L Fillgrove, Kezia N Gravesande, Randolph P Matthews, Darin Brimhall, S Aubrey Stoch, Marian N Iwamoto> ;Journal of the International AIDS Society. 2021 Dec 1
• 4 citations
  Assessment of Pharmacokinetic Interaction Between Gefapixant (MK-7264), a P2X3 Receptor Antagonist, and the OATP1B1 Drug Transporter Substrate Pitavastatin.
  Jacqueline B. McCrea, Azher Hussain, Bennett Ma, Graigory Garrett, Raymond Evers, John E. Laabs, S. Aubrey Stoch, Marian Iwamoto> ;Clinical Pharmacology in Drug Development. 2021 Nov 24
• 10 citations
  Safety and Pharmacokinetics of Once-Daily Multiple-Dose Administration of Islatravir in Adults Without HIV.
  Randolph P. Matthews, Deanne Jackson Rudd, Saijuan Zhang, Kerry L. Fillgrove, Laura M. Sterling, Jay A. Grobler, Ryan C. Vargo, S. Aubrey Stoch, Marian Iwamoto> ;Journal of Acquired Immune Deficiency Syndromes. 2021 Nov 1
• 2 citations
  Lack of a Clinically Meaningful Drug Interaction Between the HIV-1 Antiretroviral Agents Islatravir, Dolutegravir, and Tenofovir Disoproxil Fumarate.
  Deanne Jackson Rudd, Saijuan Zhang, Kerry L. Fillgrove, Sabrina Fox-Bosetti, Randolph P. Matthews, Evan J. Friedman, Danielle Armas, S. Aubrey Stoch, Marian Iwamoto> ;Clinical Pharmacology in Drug Development. 2021 Oct 22
• 3 citations
  Single oral doses of MK-8507, a novel non-nucleoside reverse transcriptase inhibitor, suppress HIV-1 RNA for a week
  Dirk Schürmann, Deanne Jackson Rudd, Andrea K. Schaeffer, Inge De Lepeleire, Evan J. Friedman, Martine Robberechts, Saijuan Zhang, Yang Liu, Bhargava Kandala, Christia...> ;Journal of Acquired Immune Deficiency Syndromes. 2021 Oct 13
• 36 citations
  Safety and pharmacokinetics of islatravir subdermal implant for HIV-1 pre-exposure prophylaxis: a randomized, placebo-controlled phase 1 trial.
  Randolph P. Matthews, Munjal Patel, Stephanie E. Barrett, Liesbeth Haspeslagh, Tom Reynders, Saijuan Zhang, Sylvie Rottey, Adrian Goodey, Ryan C. Vargo, Jay A. Grobler...> ;Nature Medicine. 2021 Oct 1
• 1 citations
  Pharmacokinetic and Safety Profile of the Novel HIV Nonnucleoside Reverse Transcriptase Inhibitor MK-8507 in Adults without HIV.
  Wendy Ankrom, Deanne Jackson Rudd, Andrea K. Schaeffer, Deborah Panebianco, Evan J. Friedman, Charles Tomek, S. Aubrey Stoch, Marian Iwamoto> ;Antimicrobial Agents and Chemotherapy. 2021 Sep 13
• 17 citations
  Safety, tolerability, and pharmacokinetics of single- and multiple-dose administration of islatravir (MK-8591) in adults without HIV
  Randolph P. Matthews, Wendy Ankrom, Evan J. Friedman, Deanne Jackson Rudd, Yang Liu, Robin Mogg, Deborah Panebianco, Inge De Lepeleire, Magdalena Petkova, Jay A. Grobl...> ;Clinical and Translational Science. 2021 Sep 1
• 1 citations
  A Phase 1 Trial to Evaluate the Relationship Between Fluoride Intake and Urinary Fluoride Excretion in Healthy Participants.
  Gillian Gillespie, Deanne Jackson Rudd, Saijuan Zhang, Andrea K. Schaeffer, Charles Tomek, Patrick Larson, S. Aubrey Stoch, Marian Iwamoto> ;Journal of Clinical Pharmacology. 2021 Aug 25
• 1 citations
  Fluoride Pharmacokinetics in Urine and Plasma Following Multiple Doses of MK-8507, an Investigational, Oral, Once-Weekly Nonnucleoside Reverse Transcriptase Inhibitor.
  Gillian Gillespie, Deanne Jackson Rudd, Saijuan Zhang, Andrea K. Schaeffer, Charles Tomek, Patrick Larson, S. Aubrey Stoch, Marian Iwamoto> ;Journal of Clinical Pharmacology. 2021 Aug 25
• 4 citations
  A Phase 1 Study to Evaluate the Drug Interaction Between Islatravir (MK-8591) and Doravirine in Adults Without HIV
  Randolph P. Matthews, Deanne Jackson Rudd, Kerry L. Fillgrove, Saijuan Zhang, Charles Tomek, S. Aubrey Stoch, Marian Iwamoto> ;Clinical Drug Investigation. 2021 Jun 21
• 5 citations
  Assessment of the Effect of Pyrimethamine, a Potent Inhibitor of Multidrug and Toxin Extrusion Protein 1/2K, on the Pharmacokinetics of Gefapixant (MK-7264), a P2X3 Re...
  Jesse C. Nussbaum, Azher Hussain, Bennett Ma, K. Chris Min, Raymond Evers, Yun Li, Graigory Garrett, S. Aubrey Stoch, Marian Iwamoto> ;Clinical Pharmacology in Drug Development. 2021 Jun 19
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Journal Articles

• Clinical Evaluation of MK‐2640: An Insulin Analog with Glucose‐Responsive Properties  
  Marian Iwamoto, MD, Clinical Pharmacology & Therapeutics