MarkLCunninghamMD

PubMed

• 64 citations
  Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with pote...
  Leslie W. Tari, Michael Trzoss, Daniel C. Bensen, Xiaoming Li, Zhiyong Chen, Thanh Lam, Junhu Zhang, Christopher J. Creighton, Mark L. Cunningham, Bryan P. Kwan, Mark ...> ;Bioorganic & Medicinal Chemistry Letters. 2013 Mar 1
• 1 citations
  The role of enzymology in a structure-based drug discovery program: bacterial DNA gyrase.
  Mark L. Cunningham> ;Methods in Molecular Biology. 2012 Jan 1
• Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani.
  Wyllie, S., Cunningham, M.L., Fairlamb, A.H.> ;J Biol Chem. 2004 Sep 17
• Characterization of quinonoid-dihydropteridine reductase (QDPR) from the lower eukaryote Leishmania major.
  Lye, L., Cunningham, M.L., Beverley, S.M.> ;J Biol Chem. 2002 Oct 11
• Regulation of differentiation to the infective stage of the protozoan parasite Leishmania major by tetrahydrobiopterin.
  Cunningham, M. L., Titus, R. G., Turco, S. J., Beverley, S. M.> ;Science. 2001 Apr 13
• Conservation of the LD1 region in Leishmania includes DNA implicated in LD1 amplification.
  Sunkin, S. M., McDonagh, P., Cunningham, M. L., Beverley, S. M., Stuart, K., Myler, P. J.> ;Mol Biochem Parasitol. 2001 Apr 6
• Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy.
  Cunningham, M. L., Beverley, S. M.> ;Mol Biochem Parasitol. 2001 Apr 6
• The Leishmania donovani LD1 locus gene ORFG encodes a biopterin transporter (BT1).
  Lemley, C., Yan, S., Dole, V. S., Madhubala, R., Cunningham, M. L., Beverley, S. M., Myler, P. J., Stuart, K. D.> ;Mol Biochem Parasitol. 1999 Oct 25
• Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors.
  Bond, C. S., Zhang, Y., Berriman, M., Cunningham, M. L., Fairlamb, A. H., Hunter, W. N.> ;Structure. 1999 Jan 15
• Down-regulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival.
  Tovar, J., Cunningham, M. L., Smith, A. C., Croft, S. L., Fairlamb, A. H.> ;Proc Natl Acad Sci U S A. 1998 Apr 28
• Anti-plasmodial and anti-trypanosomal activity of synthetic naphtho[2,3-b]thiopen-4,9-quinones.
  Zani, C. L., Chiari, E., Krettli, A. U., Murta, S. M., Cunningham, M. L., Fairlamb, A. H., Romanha, A. J.> ;Bioorg Med Chem. 1997 Dec
• Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages.
  Dumas, C., Ouellette, M., Tovar, J., Cunningham, M. L., Fairlamb, A. H., Tamar, S., Olivier, M., Papadopoulou, B.> ;EMBO J. 1997 May 15
• Overlapping expression and redundant activation of mesenchymal fibroblast growth factor (FGF) receptors by alternatively spliced FGF-8 ligands.
  Blunt, A. G., Lawshé, A., Cunningham, M. L., Seto, M. L., Ornitz, D. M., MacArthur, C. A.> ;J Biol Chem. 1997 Feb 7
• The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 A resolution.
  Zhang, Y., Bond, C. S., Bailey, S., Cunningham, M. L., Fairlamb, A. H., Hunter, W. N.> ;Protein Sci. 1996 Jan
• Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials.
  Cunningham, M. L., Fairlamb, A. H.> ;Eur J Biochem. 1995 Jun 1
• Site-directed mutagenesis of the redox-active cysteines of Trypanosoma cruzi trypanothione reductase.
  Borges, A., Cunningham, M. L., Tovar, J., Fairlamb, A. H.> ;Eur J Biochem. 1995 Mar 15
• Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals.
  Cunningham, M. L., Zvelebil, M. J., Fairlamb, A. H.> ;Eur J Biochem. 1994 Apr 1
• Bleomycin cytotoxicity is prevented by superoxide dismutase in vitro.
  Cunningham, M. L., Ringrose, P. S., Lokesh, B. R.> ;Cancer Lett. 1983 Dec
• Join now to see all