MarkCurrieMD

PubMed

• 12 citations
  The CNS-penetrant soluble guanylate cyclase stimulator CYR119 attenuates markers of inflammation in the central nervous system.
  Susana S. Correia, Guang Liu, Sarah Jacobson, Sylvie G. Bernier, Jenny Tobin, Chad D. Schwartzkopf, Emily Atwater, Elisabeth Lonie, Sam Rivers, Andrew Carvalho, Peter ...> ;Journal of Neuroinflammation. 2021 Sep 18
• 16 citations
  The CNS-Penetrant Soluble Guanylate Cyclase Stimulator CY6463 Reveals its Therapeutic Potential in Neurodegenerative Diseases.
  Susana S. Correia, Rajesh R. Iyengar, Peter Germano, Kim Tang, Sylvie G. Bernier, Chad D. Schwartzkopf, Jenny Tobin, Thomas W.-H. Lee, Guang Liu, Sarah Jacobson, Andre...> ;Frontiers in Pharmacology. 2021 May 24
• 2 citations
  Differential Bile Acid Detection in Refractory GERD Patient Saliva Using a Simple and Sensitive Liquid Chromatography Tandem Mass Spectrometry Approach.
  Nisha Perez, Kimberly Chambert, Maria D. Ribadeneira, Mark G. Currie, Yan Chen, Marco Kessler> ;Journal of Clinical Gastroenterology. 2021 Mar 18
• 17 citations
  Effects of the Soluble Guanylate Cyclase Stimulator Praliciguat in Diabetic Kidney Disease: A Randomized Placebo-Controlled Clinical Trial
  John P. Hanrahan, Ian H. de Boer, George Bakris, Phebe J. Wilson, James Wakefield, Jelena P. Seferovic, Jennifer G. Chickering, Yueh-Tyng Chien, Kenneth E. Carlson, Mi...> ;Clinical Journal of the American Society of Nephrology. 2021 Jan 7
• 9 citations
  Praliciguat inhibits progression of diabetic nephropathy in ZSF1 rats and suppresses inflammation and apoptosis in human renal proximal tubular cells
  Guang Liu, Courtney Shea, Juli E. Jones, Gavrielle M Price, William Warren, Elisabeth Lonie, Shu Yan, Mark G. Currie, Albert T. Profy, Jaime L. Masferrer, Daniel P. Zi...> ;American Journal of Physiology. Renal Physiology. 2020 Oct 1
• 7 citations
  An Impaired Natriuretic Peptide Hormone System May Play a Role in COVID-19 Severity in Vulnerable Populations.
  Mark G. Currie, Daniel P. Zimmer, Perry V. Halushka> ;FASEB Bioadvances. 2020 Aug 14
• 22 citations
  IW-3718 Reduces Heartburn Severity in Patients With Refractory Gastroesophageal Reflux Disease in a Randomized Trial.
  Michael F. Vaezi, Ronnie Fass, Nimish Vakil, David S. Reasner, Robert S. Mittleman, Michael Hall, James Z. Shao, Yan Chen, Lara Lane, Amy M. Gates, Mark G. Currie> ;Gastroenterology. 2020 Jun 1
• 20 citations
  Olinciguat, an Oral sGC Stimulator, Exhibits Diverse Pharmacology Across Preclinical Models of Cardiovascular, Metabolic, Renal, and Inflammatory Disease.
  Daniel P. Zimmer, Courtney Shea, Jenny Tobin, Boris Tchernychev, Peter Germano, Kristie Sykes, Ali R. Banijamali, Sarah Jacobson, Sylvie G. Bernier, Renee Sarno, Andre...> ;Frontiers in Pharmacology. 2020 Apr 8
• 3 citations
  Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical-stage soluble guanylate cyclase stimulator in rats.
  Ali R. Banijamali, Andrew Carvalho, James Wakefield, Peter Germano, Barden Timothy Claude, Jenny Tobin, Daniel P. Zimmer, Jaime L. Masferrer, Albert T. Profy, Mark G. ...> ;Pharmacology Research & Perspectives. 2020 Apr 1
• 14 citations
  An exploratory, randomised, placebo-controlled, 14 day trial of the soluble guanylate cyclase stimulator praliciguat in participants with type 2 diabetes and hypertension
  John P. Hanrahan, Jelena P. Seferovic, James Wakefield, Phebe J. Wilson, Jennifer G. Chickering, Joon Jung, Kenneth E. Carlson, Daniel P. Zimmer, Andrew L. Frelinger, ...> ;Diabetologia. 2020 Apr 1
• 23 citations
  Soluble guanylate cyclase stimulator praliciguat attenuates inflammation, fibrosis, and end-organ damage in the Dahl model of cardiorenal failure
  Courtney Shea, Gavrielle M Price, Guang Liu, Renee Sarno, Emmanuel S. Buys, Mark G. Currie, Jaime L. Masferrer> ;American Journal of Physiology. Renal Physiology. 2020 Jan 1
• 17 citations
  A Randomized, Placebo-Controlled, Multiple-Ascending-Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Soluble Guanylate Cyc...
  John P. Hanrahan, James Wakefield, Phebe J. Wilson, Marina Mihova, Jennifer G. Chickering, Dennis Ruff, Michael Hall, G. Todd Milne, Mark G. Currie, Albert T. Profy> ;Clinical Pharmacology in Drug Development. 2019 Jul 1
• 36 citations
  sGC stimulator praliciguat suppresses stellate cell fibrotic transformation and inhibits fibrosis and inflammation in models of NASH
  Katherine C. Hall, Sylvie G. Bernier, Sarah Jacobson, Guang Liu, Ping Y. Zhang, Renee Sarno, Victoria Catanzano, Mark G. Currie, Jaime L. Masferrer> ;Proceedings of the National Academy of Sciences of the United States of America. 2019 May 28
• 9 citations
  Safety and tolerability of linaclotide for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation: pooled Phase 3 analysis.
  Judy Nee, Jeffrey M. Johnston, Elizabeth P. Shea, Courtney E. Walls, Kenneth Tripp, S J Shiff, Susan M. Fox, Wieslaw Bochenek, Darren Weissman, Mark G. Currie, Anthony...> ;Expert Review of Gastroenterology & Hepatology. 2019 Feb 18
• 17 citations
  High-dose linaclotide is effective and safe in patients with chronic constipation: A phase III randomized, double-blind, placebo-controlled study with a long-term open...
  Shin Fukudo, Hiroto Miwa, Atsushi Nakajima, Yoshikazu Kinoshita, Masanori Kosako, Kenta Hayashi, Hiraku Akiho, Kentaro Kuroishi, Jeffrey M. Johnston, Mark G. Currie, T...> ;Neurogastroenterology and Motility. 2019 Jan 1
• 16 citations
  A randomized controlled and long-term linaclotide study of irritable bowel syndrome with constipation patients in Japan
  Shin Fukudo, Hiroto Miwa, Atsushi Nakajima, Ken Haruma, Masanori Kosako, Ayako Nakagawa, Hiraku Akiho, Yusuke Yamaguchi, Jeffrey M. Johnston, Mark G. Currie, Yoshikazu...> ;Neurogastroenterology and Motility. 2018 Dec 1
• 8 citations
  Dose-finding study of linaclotide in Japanese patients with chronic constipation: A phase II randomized, double-blind, and placebo-controlled study.
  Shin Fukudo, Hiroto Miwa, Atsushi Nakajima, Yoshikazu Kinoshita, Masanori Kosako, Ayako Nakagawa, Hiraku Akiho, Kentaro Kuroishi, Jeffrey M. Johnston, Mark G. Currie, ...> ;Neurogastroenterology and Motility. 2018 Dec 1
• 32 citations
  Linaclotide in irritable bowel syndrome with constipation: A Phase 3 randomized trial in China and other regions
  Yunsheng Yang, Jingyuan Fang, Xiaozhong Guo, Ning Dai, Xizhong Shen, Youlin Yang, Jing Sun, Bal Raj Bhandari, David S. Reasner, Jacquelyn A. Cronin, Mark G. Currie, Je...> ;Journal of Gastroenterology and Hepatology. 2018 May 1
• 49 citations
  The soluble guanylate cyclase stimulator IW‐1973 prevents inflammation and fibrosis in experimental non‐alcoholic steatohepatitis
  Roger Flores-Costa, José Alcaraz-Quiles, Esther Titos, Cristina López-Vicario, Mireia Casulleras, Marta Duran-Güell, Bibiana Rius, Alba Díaz, Katherine C. Hall, Courtn...> ;British Journal of Pharmacology. 2018 Jan 31
• 44 citations
  Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and ...
  Jenny Tobin, Daniel P. Zimmer, Courtney Shea, Peter Germano, Sylvie G. Bernier, Guang Liu, Kim Long, Joy Miyashiro, Sheila Ranganath, Sarah Jacobson, Kim Tang, G-Yoon ...> ;The Journal of Pharmacology and Experimental Therapeutics. 2018 Jan 1
• 41 citations
  Low-Dose Linaclotide (72 μg) for Chronic Idiopathic Constipation: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial
  Philip Schoenfeld, Brian E. Lacy, William D. Chey, Anthony Lembo, Caroline B. Kurtz, David S. Reasner, Wieslaw Bochenek, Kenneth Tripp, Mark G. Currie, Susan M. Fox, R...> ;The American Journal of Gastroenterology. 2018 Jan 1
• Response to Miner et al.
  Mark G. Currie, Steven J. Shiff, Harvey Schneier, Jeffrey M. Johnston> ;The American Journal of Gastroenterology. 2017 Nov 1
• 11 citations
  Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications
  G. Todd Milne, Peter Sandner, Kathleen A Lincoln, Paul C. Harrison, Hongxing Chen, Hong Wang, Holly Clifford, Hu Sheng Qian, Diane Wong, Chris Sarko, Ryan M. Fryer, Je...> ;BMC Pharmacology & Toxicology. 2017 Oct 1
• 2 citations
  US immigration order strikes against biotech
  Jeremy M Levin, Steven H Holtzman, John M. Maraganore, Paul Hastings, Ron Cohen, Bassil Dahiyat, Julian Adams, Chris Adams, Brett Ahrens, Jeff Albers, Mara G Aspinall,...> ;Nature Biotechnology. 2017 Mar 7
• 23 citations
  Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans.
  Takashi Nakai, Nicholas Robert Perl, Barden Timothy Claude, Andrew Carvalho, Angelika Fretzen, Peter Germano, G-Yoon Jamie Im, Hong Jin, Charles Kim, Thomas W.-H. Lee,...> ;ACS Medicinal Chemistry Letters. 2016 Mar 1
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