MarkStephenDennisMD

PubMed

• 119 citations
  An anti-CD3/anti-CLL-1 bispecific antibody for the treatment of acute myeloid leukemia.
  Steven R. Leong, Siddharth Sukumaran, Maria Hristopoulos, Klara Totpal, Shannon Stainton, Elizabeth Lu, Alfred Wong, Lucinda Tam, Robert J. Newman, Brian R. Vuillemeno...> ;Blood. 2017 Feb 2
• Prospective Design of Anti-Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain.
  Kanodia JS, Gadkar K, Bumbaca D, Zhang Y, Tong RK, Luk W, Hoyte K, Lu Y, Wildsmith KR, Couch JA, Watts RJ, Dennis MS, Ernst JA, Scearce-Levie K, Atwal JK, Ramanujan S,...> ;CPT Pharmacometrics Syst Pharmacol. 2016-05-01
• 33 citations
  Mathematical PKPD and safety model of bispecific TfR/BACE1 antibodies for the optimization of antibody uptake in brain.
  Kapil Gadkar, Daniela Bumbaca Yadav, Joy Yu Zuchero, Jessica Couch, Jitendra Kanodia, Margaret Kenrick, Jasvinder K. Atwal, Mark S. Dennis, Saileta Prabhu, Ryan J. Wat...> ;European Journal of Pharmaceutics and Biopharmaceutics. 2016 Apr 1
• 160 citations
  Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies
  Y. Joy Yu Zuchero, Xiaocheng Chen, Nga Bien-Ly, Daniela Bumbaca, Raymond K. Tong, Xiaoying Gao, Shuo Zhang, Kwame Hoyte, Wilman Luk, Melanie A. Huntley, Lilian Phu, Ch...> ;Neuron. 2016 Jan 6
• 156 citations
  Anti-CD20/CD3 T cell–dependent bispecific antibody for the treatment of B cell malignancies
  Liping L. Sun, Diego Ellerman, Mary Mathieu, Maria Hristopoulos, Xiaocheng Chen, Yijin Li, Xiao-Jie Yan, Robyn Clark, Arthur E. Reyes, Eric Stefanich, Elaine Mai, Judy...> ;Science Translational Medicine. 2015 May 13
• 233 citations
  Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates
  Y. Joy Yu, Jasvinder K. Atwal, Yin Zhang, Raymond K. Tong, Kristin R. Wildsmith, Christine Tan, Nga Bien-Ly, Maria Hersom, Janice A. Maloney, William J. Meilandt, Dani...> ;Science Translational Medicine. 2014 Nov 5
• 50 citations
  An Antimesothelin-Monomethyl Auristatin E Conjugate with Potent Antitumor Activity in Ovarian, Pancreatic, and Mesothelioma Models
  Suzie J. Scales, Nidhi Gupta, Glenn Pacheco, Ron Firestein, Dorothy French, Hartmut Koeppen, Linda Rangell, Vivian Barry-Hamilton, Elizabeth Luis, Josefa Chuh, Yin Zha...> ;Molecular Cancer Therapeutics. 2014 Nov 1
• 118 citations
  Antitumor Efficacy of a Bispecific Antibody That Targets HER2 and Activates T Cells
  Teemu T. Junttila, Ji Li, Jennifer Johnston, Maria Hristopoulos, Robyn Clark, Diego Ellerman, Bu Er Wang, Yijin Li, Mary Mathieu, Guangmin Li, Judy Young, Elizabeth Lu...> ;Cancer Research. 2014 Oct 1
• 205 citations
  Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants
  Nga Bien-Ly, Y. Joy Yu, Daniela Bumbaca, Justin Elstrott, C. Andrew Boswell, Yin Zhang, Wilman Luk, Yanmei Lu, Mark S. Dennis, Robby M. Weimer, Inhee Chung, Ryan J. Watts> ;The Journal of Experimental Medicine. 2014 Feb 10
• 51 citations
  Development of a Human IgG4 Bispecific Antibody for Dual Targeting of Interleukin-4 (IL-4) and Interleukin-13 (IL-13) Cytokines *
  Christoph Spiess, Jack Bevers, Janet Jackman, Nan Chiang, Gerald R. Nakamura, Michael Dillon, Hongfang Liu, Patricia Molina, J. Michael Elliott, Whitney Shatz, Justin ...> ;The Journal of Biological Chemistry. 2013 Sep 13
• 26 citations
  Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy.
  Leisa Johnson, Mahrukh Huseni, Tanya Smyczek, Anthony Lima, Stacey Yeung, Jason H. Cheng, Rafael Molina, David Kan, Ann De Mazière, Judith Klumperman, Ian Kasman, Yin ...> ;The Journal of Clinical Investigation. 2013 Sep 3
• 168 citations
  Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier
  Jessica Couch, Y. Joy Yu, Yin Zhang, Jacqueline M. Tarrant, Reina N. Fuji, William J. Meilandt, Hilda Solanoy, Raymond K. Tong, Kwame Hoyte, Wilman Luk, Yanmei Lu, Kap...> ;Science Translational Medicine. 2013 May 1
• 14 citations
  Transferrin Antibodies Into the Brain
  Mark S. Dennis, Ryan J. Watts> ;Neuropsychopharmacology. 2012 Jan 1
• 66 citations
  Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4
  Daniela Bumbaca, Anne Wong, Elizabeth Drake, Arthur E. Reyes, Benjamin C. Lin, Jean-Philippe Stephan, Luc Desnoyers, Ben-Quan Shen, Mark S. Dennis> ;Mabs. 2011 Jul 1
• 503 citations
  Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target
  Y. Joy Yu, Yin Zhang, Margaret Kenrick, Kwame Hoyte, Wilman Luk, Yanmei Lu, Jasvinder K. Atwal, J. Michael Elliott, Saileta Prabhu, Ryan J. Watts, Mark S. Dennis> ;Science Translational Medicine. 2011 May 25
• 77 citations
  Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice
  Hans Brightbill, Surinder Jeet, Zhonghua Lin, Donghong Yan, Meijuan Zhou, Martha Tan, Allen Nguyen, Sherry Yeh, Donnie Delarosa, Steven R. Leong, Terence Wong, Yvonne ...> ;The Journal of Clinical Investigation. 2010 Jun 1
• 176 citations
  Therapeutic potential of an anti-CD79b antibody–drug conjugate, anti–CD79b-vc-MMAE, for the treatment of non-Hodgkin lymphoma
  David Dornan, Fiona Bennett, Yvonne Chen, Mark S. Dennis, Dan L. Eaton, Kristi Elkins, Dorothy French, Mary Ann T. Go, Andrew Jack, Jagath Reddy Junutula, Hartmut Koep...> ;Blood. 2009 Sep 24
• 898 citations
  Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
  Jagath Reddy Junutula, Helga Raab, Suzanna Clark, Sunil Bhakta, Douglas D. Leipold, Sylvia Weir, Yvonne Chen, Michelle Simpson, Siao Ping Tsai, Mark S. Dennis, Yanmei ...> ;Nature Biotechnology. 2008 Aug 1
• 67 citations
  Unveiling a glycation hot spot in a recombinant humanized monoclonal antibody.
  Boyan Zhang, Yi Yang, Inn H. Yuk, Roger Pai, Patrick McKay, Charles Eigenbrot, Mark S. Dennis, Viswanatham Katta, Kathleen Francissen> ;Analytical Chemistry. 2008 Feb 29
• 65 citations
  Armed antibodies targeting the mucin repeats of the ovarian cancer antigen, MUC16, are highly efficacious in animal tumor models.
  Youjun Chen, Suzanna Clark, Wong Terence, Yongmei Chen, Yvonne Chen, Mark S. Dennis, Elizabeth Luis, Fiona Zhong, Sheila Bheddah, Hartmut Koeppen, Alvin Gogineni, Sara...> ;Cancer Research. 2007 May 15
• 104 citations
  Function blocking antibodies to neuropilin-1 generated from a designed human synthetic antibody phage library.
  Wei-Ching Liang, Mark S. Dennis, Scott Stawicki, Yvan Chanthery, Qi Pan, Yongmei Chen, Charles Eigenbrot, Jianping Yin, Alexander W. Koch, Xiumin Wu, Napoleone Ferrara...> ;Journal of Molecular Biology. 2007 Feb 23
• 180 citations
  Imaging Tumors with an Albumin-Binding Fab, a Novel Tumor-Targeting Agent
  Mark S. Dennis, Hongkui Jin, Debra L. Dugger, Renhui Yang, Leanne McFarland, Annie Ogasawara, Simon C. Williams, Mary J. Cole, Sarajane Ross, Ralph H. Schwall> ;Cancer Research. 2007 Jan 1
• 97 citations
  The pharmacokinetics of an albumin-binding Fab (AB.Fab) can be modulated as a function of affinity for albumin
  Allen Nguyen, Arthur E. Reyes, Min Zhang, Paul J. Mcdonald, Wai Lee T. Wong, Lisa A. Damico, Mark S. Dennis> ;Protein Engineering, Design & Selection. 2006 Jul 1
• 185 citations
  High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold.
  Chingwei V. Lee, Wei-Ching Liang, Mark S. Dennis, Charles Eigenbrot, Sachdev S. Sidhu, Germaine Fuh> ;Journal of Molecular Biology. 2004 Jul 23
• 332 citations
  Albumin Binding as a General Strategy for Improving the Pharmacokinetics of Proteins
  Mark S. Dennis, Min Zhang, Y. Gloria Meng, Miryam Kadkhodayan, Daniel Kirchhofer, Dan Combs, Lisa A. Damico> ;The Journal of Biological Chemistry. 2002 Sep 20
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