MarkPDunphyDO

Nuclear Medicine • New York, NY

Assistant Professor, Radiology, Weill Cornell Medical College

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Office
1275 York Ave
New York, NY 10065
Phone+1 212-639-8131
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Education & Training

Memorial Sloan Kettering Cancer CenterResidency, Nuclear Medicine, 2000 - 2003
Michigan State University College of Osteopathic MedicineClass of 2000

Certifications & Licensure

NY State License 2002 - 2025
NJ State License 2007 - 2025
OH State License 2001 - 2002
American Board of Nuclear Medicine Nuclear Medicine

Clinical Trials

PET Imaging of Cancer Patients Using 124I-PUH71: A Pilot Study Start of enrollment: 2010 Dec 01
Active, not recruiting
Early Phase 1
A Phase I Study: PET Imaging of Cancer Patients Using [18F] 4-L-Fluoroglutamine (2S,4R) Start of enrollment: 2012 Sep 01
Recruiting
Phase 1
PET Imaging of Cancer Patients Using [18F]-SKI-249380, a Radiolabeled Dasatinib-Derivative Start of enrollment: 2013 Jul 01
Completed
Phase 1
PET Imaging of Patients With Cancer Using 124I-PU-AD Start of enrollment: 2016 Apr 01
PET and MRI Imaging of Brain Tumors Using [18F]PARPi Start of enrollment: 2019 Nov 01
Active, not recruiting
PET/CT Imaging of Small Cell Lung Cancer Using 89Zr-DFO-SC16.56 Start of enrollment: 2019 Dec 11
Recruiting
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Publications & Presentations

PubMed

First-in-human imaging with [Zr]Zr-DFO-SC16.56 anti-DLL3 antibody in patients with high-grade neuroendocrine tumors of the lung and prostate.
Tendler, S., Dunphy, M., Agee, M., O'Donoghue, J., Aly, R., Choudhury, N., Kesner, A., Kirov, A., Mauguen, A., Baine, M., Schoder, H., Weber, W., Rekhtman, N., Lyashch...> ;Medrxiv. 2024 Jan 11
10 citations
Sex differences in brain tumor glutamine metabolism reveal sex-specific vulnerabilities to treatment.
Jasmin Sponagel, Jill K Jones, Cheryl Frankfater, Shanshan Zhang, Olivia Tung, Kevin Cho, Kelsey L Tinkum, Hannah Gass, Elena Nunez, Douglas R Spitz, Prakash Chinnaiya...> ;Med. 2022 Nov 11
Correction to: OptimizingY Particle Density Improves Outcomes After Radioembolization.
Aaron W P Maxwell, Humberto G Mendoza, Matthew J Sellitti, Juan C Camacho, Amy R Deipolyi, Etay Ziv, Constantinos T Sofocleous, Hooman Yarmohammadi, Majid Maybody, Joh...> ;Cardiovascular and Interventional Radiology. 2022 Jul 1
7 citations
OptimizingY Particle Density Improves Outcomes After Radioembolization.
Aaron W P Maxwell, Humberto G Mendoza, Matthew J Sellitti, Juan C Camacho, Amy R Deipolyi, Etay Ziv, Constantinos T Sofocleous, Hooman Yarmohammadi, Majid Maybody, Joh...> ;Cardiovascular and Interventional Radiology. 2022 Jul 1
4 citations
Treatment Response and Clinical Outcomes of Well-Differentiated High-Grade Neuroendocrine Tumors to Lutetium-177-DOTATATE.
Nitya Raj, Kelley Coffman, Tiffany Le, Richard Kinh Gian Do, Johnathan Rafailov, Ye Choi, Joanne F Chou, Marinela Capanu, Mark Dunphy, Josef J Fox, Ravinder K Grewal, ...> ;Neuroendocrinology. 2022 Jan 1
15 citations
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system.
Alexander Bolaender, Danuta Zatorska, Huazhong He, Suhasini Joshi, Sahil Sharma, Chander Singh Digwal, Hardik J. Patel, Weilin Sun, Brandon S Imber, Stefan O. Ochiana,...> ;Nature Communications. 2021 Aug 3
28 citations
Phase 1 Trial of MLN0128 (Sapanisertib) and CB-839 HCl (Telaglenastat) in Patients With Advanced NSCLC (NCI 10327): Rationale and Study Design.
Jonathan W. Riess, Paul Frankel, David Shackelford, Mark Dunphy, Ramsey D. Badawi, Lorenzo Nardo, Simon R. Cherry, Ian Lanza, Joel Reid, Wilson I. Gonsalves, Charles A...> ;Clinical Lung Cancer. 2021 Jan 1
11 citations
Measuring Tumor Epichaperome Expression Using [124I] PU-H71 Positron Emission Tomography as a Biomarker of Response for PU-H71 Plus Nab-Paclitaxel in HER2-Negative Met...
Komal Jhaveri, Carlos Henrique dos Anjos, Tony Taldone, Rui Wang, Elizabeth A. Comen, Monica Fornier, Jacqueline Bromberg, W. Ma, Sujata Patil, Anna Rodina, Nagavaraki...> ;JCO Precision Oncology. 2020 Nov 17
5 citations
The Unique Pharmacometrics of Small Molecule Therapeutic Drug Tracer Imaging for Clinical Oncology.
Mark Dunphy, Nagavarakishore Pillarsetty> ;Cancers. 2020 Sep 22
29 citations
18 F-Fluciclovine ( 18 F-FACBC) PET imaging of recurrent brain tumors
Laure Michaud, Brad Beattie, Tim Akhurst, Mark Dunphy, Pat Zanzonico, Ronald D. Finn, Audrey Mauguen, Heiko Schöder, Wolfgang A. Weber, A B Lassman, Ronald G. Blasberg> ;European Journal of Nuclear Medicine and Molecular Imaging. 2020 Jun 1
13 citations
First-in-Human Trial of Epichaperome-Targeted PET in Patients with Cancer
Mark Dunphy, Christina Pressl, Nagavarakishore Pillarsetty, Milan Grkovski, Shanu Modi, Komal Jhaveri, Larry Norton, Bradley J. Beattie, Pat Zanzonico, Danuta Zatorska...> ;Clinical Cancer Research. 2020 May 4
28 citations
Safety and feasibility of PARP1/2 imaging with 18F-PARPi in patients with head and neck cancer
Heiko Schöder, Paula Demétrio De Souza França, Reiko Nakajima, Eva Burnazi, Sheryl Roberts, Christian Brand, Milan Grkovski, Audrey Mauguen, Mark Dunphy, Ronald Ghosse...> ;Clinical Cancer Research. 2020 Apr 3
5 citations
First-in-Humans Trial of Dasatinib-Derivative Tracer for Tumor Kinase-Targeted PET
Simone Krebs, Darren R. Veach, Lukas M. Carter, Milan Grkovski, Monica Fornier, Michael Mauro, Martin H. Voss, Daniel C. Danila, Eva Burnazi, Manda Null, Kevin Staton,...> ;Journal of Nuclear Medicine. 2020 Mar 13
17 citations
Pharmacokinetic Assessment of 18F-(2S,4R)-4-Fluoroglutamine in Patients with Cancer.
Milan Grkovski, Reema Goel, Simone Krebs, Kevin Staton, James J. Harding, Ingo K. Mellinghoff, John L. Humm, Mark Dunphy> ;Journal of Nuclear Medicine. 2020 Mar 1
62 citations
Circulating Tumor DNA Analysis to Assess Risk of Progression after Long-term Response to PD-(L)1 Blockade in NSCLC
Matthew D. Hellmann, Barzin Y. Nabet, Hira Rizvi, Aadel A. Chaudhuri, Daniel K. Wells, Mark Dunphy, Jacob J. Chabon, Chih Long Liu, Angela B. Hui, Kathryn C. Arbour, J...> ;Clinical Cancer Research. 2020 Jun 15
130 citations
Off-the-shelf EBV-specific T cell immunotherapy for rituximab-refractory EBV-associated lymphoma following transplantation
Susan E. Prockop, Ekaterina Doubrovina, Stephanie Suser, Glenn Heller, Juliet N. Barker, Parastoo B. Dahi, Miguel Perales, Esperanza B. Papadopoulos, Craig S. Sauter, ...> ;The Journal of Clinical Investigation. 2020 Feb 3
37 citations
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.
Maria Carmen Inda, Suhasini Joshi, Tai Wang, Alexander Bolaender, Srinivasa Gandu, John Koren, Alicia Yue Che, Tony Taldone, Pengrong Yan, Weilin Sun, Mohammad Nasir U...> ;Nature Communications. 2020 Jan 16
17 citations
Preclinical and first-in-human-brain-cancer applications of [18F]poly (ADP-ribose) polymerase inhibitor PET/MR.
Robert J. Young, Paula Demétrio De Souza França, Giacomo Pirovano, Anna F. Piotrowski, Philip J. Nicklin, Christopher C. Riedl, Jazmin Schwartz, Tejus Bale, Patrick L....> ;Neuro-Oncology Advances. 2020 Jan 1
2 citations
Correction to: 18F-Fluciclovine (18F-FACBC) PET imaging of recurrent brain tumors.
Laure Michaud, Brad Beattie, Tim Akhurst, Mark Dunphy, Pat Zanzonico, Ronald D. Finn, Audrey Mauguen, Heiko Schöder, Wolfgang A. Weber, Andrew B. Lassman, Ronald G. Bl...> ;European Journal of Nuclear Medicine and Molecular Imaging. 2020 Jan 1
2 citations
Value of [18F]-FDG positron emission tomography in patients with recurrent glioblastoma receiving bevacizumab.
Maya S. Graham, Simone Krebs, Tejus Bale, Kwaku Domfe, Stephanie Lobaugh, Zhigang Zhang, Mark Dunphy, Thomas Kaley, Robert J. Young> ;Neuro-Oncology Advances. 2020 Jan 1
34 citations
Paradigms for Precision Medicine in Epichaperome Cancer Therapy.
Nagavarakishore Pillarsetty, Komal Jhaveri, Tony Taldone, Eloisi Caldas-Lopes, Blesida Punzalan, Suhasini Joshi, Alexander Bolaender, Mohammad M. Uddin, Anna Rodina, P...> ;Cancer Cell. 2019 Nov 11
7 citations
Detection of recurrent pancreatic cancer: value of second-opinion interpretations of cross-sectional images by subspecialized radiologists
Sandra Huicochea Castellanos, Giuseppe Corrias, Gary A. Ulaner, Mark Dunphy, Zheng Junting, Marinela Capanu, Vinod P. Balachandran, Romina Grazia Giancipoli, Serena Mo...> ;Abdominal Radiology. 2019 Feb 1
31 citations
Chaperome heterogeneity and its implications for cancer study and treatment
Tai Wang, Anna Rodina, Mark Dunphy, Adriana D. Corben, Shanu Modi, Monica L. Guzman, Daniel T. Gewirth, Gabriela Chiosis> ;The Journal of Biological Chemistry. 2019 Feb 8
11 citations
Imaging skeletal muscle volume, density, and FDG uptake before and after induction therapy for non-small cell lung cancer.
Marcus D. Goncalves, Samuel Taylor, Darragh Halpenny, Emily Schwitzer, Stephanie Gandelman, J. Jackson, A. Lukose, Andrew J. Plodkowski, Kay See Tan, Mark Dunphy, Lee ...> ;Clinical Radiology. 2018 Jan 6
66 citations
In Vivo PET Assay of Tumor Glutamine Flux and Metabolism: In-Human Trial of 18F-(2S,4R )-4-Fluoroglutamine
Mark Dunphy, James J. Harding, Sriram Venneti, Hanwen Zhang, Eva Burnazi, Jacqueline Bromberg, Antonio Omuro, James J. Hsieh, Ingo K. Mellinghoff, Kevin Staton, Christ...> ;Radiology. 2018 Jan 31
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