MarkHiramGotfriedMD

Pulmonology • Phoenix, AZ

Critical Care Medicine, Interstitial Lung Diseases, Sleep Medicine

Physician

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Office
3811 E Bell Rd
Suite 107
Phoenix, AZ 85032
Phone+1 602-258-4951

Fax+1 602-257-4252
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Education & Training

University of Arizona College of Medicine-TucsonFellowship, Pulmonary Disease and Critical Care Medicine, 1981 - 1983
Michael Reese Hospital and Medical CenterResidency, Internal Medicine, 1977 - 1980
University of Illinois College of MedicineClass of 1977

Certifications & Licensure

AZ State Medical License 1981 - 2026
CA State Medical License 1983 - 2024
IL State Medical License 1978 - 1987
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Pulmonary Disease

Awards, Honors, & Recognition

Meaningful Use Stage 1 Certification Centers for Medicare & Medicaid Services, 2012

Clinical Trials

Intrapulmonary Pharmacokinetics of Antibiotics Start of enrollment: 2006 Jan 01
Terminated
Phase 4
US 10 mL Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study Start of enrollment: 2007 Feb 01
Completed
Phase 2
US Biologic Lung Volume Reduction (BLVR) Phase 2 Emphysema Study Start of enrollment: 2007 Aug 01
Completed
Phase 2
Biologic Lung Volume Reduction (BLVR) Phase 2 Homogeneous Study Start of enrollment: 2008 Feb 01
Completed
Phase 2
Doripenem Intrapulmonary Pharmacokinetics in Healthy Adult Subjects Start of enrollment: 2009 Jun 01
Completed
Phase 1
Comparison Study of the ICON™ CPAP Series With and Without SensAwake™ Start of enrollment: 2013 Mar 01
Completed
Not Applicable
Evaluating the Plasma, Epithelial Lining, and Alveolar Macrophage Concentrations of Intravenous Carbavance™ (RPX2014/RPX7009) in Healthy Adult Subjects Start of enrollment: 2014 Feb 01
Completed
Phase 1
CPAP (Continuous Positive Airway Pressure) Study Educational Materials and Usage Feedback to Promote CPAP Adherence Start of enrollment: 2014 Jan 01
Completed
Not Applicable
Study to Determine and Compare Plasma and Intrapulmonary Pharmacokinetics of WCK 2349 in Healthy Adult Human Subjects Start of enrollment: 2014 Sep 01
Completed
Phase 1
Formoterol Dose Ranging Study (ACHIEVE Duaklir USA Phase IIb) Start of enrollment: 2016 Jun 30
Completed
Phase 2
Trial of AD036 in Obstructive Sleep Apnea Start of enrollment: 2019 Mar 07
Completed
Phase 2
Study of Trans Sodium Crocetinate in Patients With Interstitial Lung Disease Start of enrollment: 2021 Dec 02
Terminated
Phase 2
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

3 citations
Incidence and duration of common early-onset adverse events in randomized controlled trials of solriamfetol for treatment of excessive daytime sleepiness in obstructiv...
Russell Rosenberg, Michael J. Thorpy, Yves Dauvilliers, Paula K. Schweitzer, Gary Zammit, Mark H. Gotfried, Shay Bujanover, Brian Scheckner, Atul Malhotra> ;Journal of Clinical Sleep Medicine. 2021 Jul 20
11 citations
Randomized Controlled Trial of Solriamfetol for Excessive Daytime Sleepiness in OSA: An Analysis of Subgroups Adherent or Nonadherent to OSA Treatment.
Paula K. Schweitzer, Geert Mayer, Russell Rosenberg, Atul Malhotra, Gary Zammit, Mark H. Gotfried, Patricia Chandler, Michelle G. Baladi, Kingman P. Strohl> ;Chest. 2021 Feb 22
8 citations
A randomized, controlled, repeat-dose study of batefenterol/fluticasone furoate compared with placebo in the treatment of COPD
Courtney Crim, Mark Gotfried, Selwyn Spangenthal, Michael T. Watkins, Amanda Emmett, Catriona Crawford, Charlotte Baidoo, Ramiro Castro-Santamaria> ;BMC Pulmonary Medicine. 2020 May 4
77 citations
Solriamfetol for Excessive Sleepiness in Obstructive Sleep Apnea (TONES 3). A Randomized Controlled Trial.
Paula K. Schweitzer, Russell Rosenberg, Gary Zammit, Mark H. Gotfried, Dan Chen, Lawrence P. Carter, Hao Wang, Yuan Lu, Jed Black, Atul Malhotra, Kingman P. Strohl, To...> ;American Journal of Respiratory and Critical Care Medicine. 2019 Jun 1
35 citations
Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam following Intravenous Administration of ETX2514SUL to Healthy Adult Subjects.
Keith A. Rodvold, Mark H. Gotfried, Robin Isaacs, John P. O'Donnell, Emily Stone> ;Antimicrobial Agents and Chemotherapy. 2018 Oct 24
23 citations
Plasma and Intrapulmonary Concentrations of Cefepime and Zidebactam following Intravenous Administration of WCK 5222 to Healthy Adult Subjects.
Keith A. Rodvold, Mark H. Gotfried, Rakesh Chugh, Mugdha Gupta, Anasuya Patel, Rajesh Chavan, Ravindra D. Yeole, H. David Friedland, Ashima Bhatia> ;Antimicrobial Agents and Chemotherapy. 2018 Jul 27
3 citations
An Open-Label, Phase II Study of the Safety of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis (PIPF-002)
Mark H. Gotfried, Carlos E. Girod, Danielle Antin-Ozerkis, Tracy Burgess, John L. Stauffer, Klaus Uwe Kirchgaessler, Maria Padilla> ;Pulmonary Therapy. 2018 Apr 5
52 citations
Intrapulmonary Pharmacokinetics of Relebactam, a Novel β-Lactamase Inhibitor, Dosed in Combination with Imipenem-Cilastatin in Healthy Subjects.
Matthew L. Rizk, Elizabeth G. Rhee, Patricia Jumes, Mark H. Gotfried, Tian Zhao, Eric Mangin, Sheng Bi, Cynthia Chavez-Eng, Zufei Zhang, Joan R. Butterton> ;Antimicrobial Agents and Chemotherapy. 2018 Feb 23
25 citations
Intrapulmonary Pharmacokinetics of Levonadifloxacin following Oral Administration of Alalevonadifloxacin to Healthy Adult Subjects.
Keith A. Rodvold, Mark H. Gotfried, Rakesh Chugh, Mugdha Gupta, Ravindra D. Yeole, Anasuya Patel, Ashima Bhatia> ;Antimicrobial Agents and Chemotherapy. 2017 Dec 20
80 citations
Comparison of Omadacycline and Tigecycline Pharmacokinetics in the Plasma, Epithelial Lining Fluid, and Alveolar Cells of Healthy Adult Subjects.
Mark H. Gotfried, Karolyn S. Horn, Lynne Garrity-Ryan, Stephen Villano, Evan Tzanis, Surya Chitra, Amy Manley, S. Ken Tanaka, Keith A. Rodvold> ;Antimicrobial Agents and Chemotherapy. 2017 Sep 1
14 citations
Comparison of Plasma and Intrapulmonary Concentrations of Nafithromycin (WCK 4873) in Healthy Adult Subjects.
Keith A. Rodvold, Mark H. Gotfried, Rakesh Chugh, Mugdha Gupta, H. David Friedland, Ashima Bhatia> ;Antimicrobial Agents and Chemotherapy. 2017 Aug 24
4 citations
Corrigendum to "A multicenter, randomized, double-blind dose-ranging study of glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler compared t...
Donald P. Tashkin, Fernando J. Martinez, Roberto Rodriguez-Roisin, Charles Fogarty, Mark Gotfried, Michael Denenberg, Gregory Gottschlich, James F. Donohue, Chad Orevi...> ;Respiratory Medicine. 2017 Aug 1
18 citations
A multicenter, randomized, double-blind dose-ranging study of glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler compared to the monocompon...
Donald P. Tashkin, Fernando J. Martinez, Roberto Rodriguez-Roisin, Charles Fogarty, Mark Gotfried, Michael Denenberg, Gregory Gottschlich, James F. Donohue, Chad Orevi...> ;Respiratory Medicine. 2016 Nov 1
83 citations
Meropenem-RPX7009 Concentrations in Plasma, Epithelial Lining Fluid, and Alveolar Macrophages of Healthy Adult Subjects
Eric Wenzler, Mark H. Gotfried, Jeffrey S Loutit, Stephanie Durso, David C. Griffith, Michael N. Dudley, Keith A. Rodvold> ;Antimicrobial Agents and Chemotherapy. 2015 Dec 1
86 citations
A randomised trial of lung sealant versus medical therapy for advanced emphysema.
Carolyn E. Come, Mordechai R. Kramer, Mark T. Dransfield, Muhanned Abu-Hijleh, David M. Berkowitz, Michela Bezzi, Surya P. Bhatt, Michael Boyd, Enrique Cases, Alexande...> ;The European Respiratory Journal. 2015 Apr 2
54 citations
A Preliminary Quality of Life Questionnaire-Bronchiectasis: A Patient-Reported Outcome Measure for Bronchiectasis
Alexandra L. Quittner, Kristen Marciel, Matthias Salathe, Anne E. O'Donnell, Mark H. Gotfried, Jonathan Ilowite, Mark L. Metersky, Patrick A. Flume, Sandra A Lewis, Ma...> ;Chest. 2014 Aug 1
11 citations
Reassessment of tigecycline bone concentrations in volunteers undergoing elective orthopedic procedures
Indranil Bhattacharya, Mark H. Gotfried, Allena J. Ji, James P. Saunders, Ian Gourley, Annette Diehl, Joan M. Korth-Bradley> ;Journal of Clinical Pharmacology. 2014 Jan 1
6 citations
Role of indacaterol, a once-daily bronchodilator, in chronic obstructive pulmonary disease
Heemesh D. Seth, Samir Sultan, Mark H. Gotfried> ;Journal of Thoracic Disease. 2013 Dec 30
45 citations
The localized inflammatory response to bronchoscopic thermal vapor ablation.
Daniela Gompelmann, Ralf Eberhardt, Armin Ernst, Peter Hopkins, Jim J. Egan, Franz Stanzel, Arschang Valipour, Manfred Wagner, Christian Witt, Kimberly M. Baker, Mark ...> ;Respiration; International Review of Thoracic Diseases. 2013 Jan 1
13 citations
Efficacy of inhaled ciprofloxacin in the management of non-cystic fibrosis bronchiectasis:
Julie Ann Justo, Larry H. Danziger, Mark H. Gotfried> ;Therapeutic Advances in Respiratory Disease. 2013 May 20
14 citations
Efficacy of Indacaterol 75 μg Once-Daily on Dyspnea and Health Status: Results of Two Double-Blind, Placebo-Controlled 12-Week Studies
Mark H. Gotfried, Edward Kerwin, David Lawrence, Cheryl Lassen, Benjamin Kramer> ;COPD. 2012 Dec 17
11 citations
Summary of Pharmacokinetics and Tissue Distribution of a Broad-Spectrum Fluoroquinolone, JNJ-Q2.
J. M. Davenport, Paul S. Covington, M. Gotfried, M. Medlock, P. Watanalumlerd, Gail McIntyre, L. Turner, J. Almenoff> ;Clinical Pharmacology in Drug Development. 2012 Oct 1
99 citations
Intrapulmonary penetration of ceftolozane/tazobactam and piperacillin/tazobactam in healthy adult subjects
Gurudatt Chandorkar, Jennifer A. Huntington, Mark H. Gotfried, Keith A. Rodvold, Obiamiwe Umeh> ;The Journal of Antimicrobial Chemotherapy. 2012 Oct 1
37 citations
Characterization of outcomes 1 year after endoscopic thermal vapor ablation for patients with heterogeneous emphysema.
Felix J.F. Herth, Armin Ernst, Kimberly M. Baker, Jim J. Egan, Mark H Gotfried, Peter Hopkins, Franz Stanzel, Arschang Valipour, Manfred Wagner, Christian Witt, Steven...> ;International Journal of Chronic Obstructive Pulmonary Disease. 2012 Jul 18
42 citations
Comparison of Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations of Solithromycin (CEM-101) in Healthy Adult Subjects
Keith A. Rodvold, Mark H. Gotfried, J. Gordon Still, Kay Clark, Prabhavathi Fernandes> ;Antimicrobial Agents and Chemotherapy. 2012 Oct 1
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Hospital Affiliations

HonorHealth John C. Lincoln Medical CenterPhoenix, Arizona
Banner - University Medical Center PhoenixPhoenix, Arizona
Banner Thunderbird Medical CenterGlendale, Arizona
Abrazo Scottsdale CampusPhoenix, Arizona
Abrazo Central CampusPhoenix, Arizona

MarkHiramGotfriedMD

Dr. Gotfried is on Doximity

Education & Training

Certifications & Licensure

Awards, Honors, & Recognition

Clinical Trials

Publications & Presentations

Hospital Affiliations

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