MarkMHuyckeMD

Infectious Disease • Oklahoma City, OK

Clinical Professor, Stephenson Cancer Center, University of Oklahoma Health Sciences Center

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Office
975 NE 10th St.
Biomedical Research Center, Room 211
Oklahoma City, OK 73104
Phone+1 405-271-8001
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Education & Training

University of Wisconsin Hospitals and ClinicsFellowship, Infectious Disease, 1985 - 1989
University of Oklahoma Health Sciences CenterResidency, Internal Medicine, 1982 - 1985
University of Kansas School of MedicineClass of 1982

Certifications & Licensure

OK State Medical License 1983 - 2024
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Infectious Disease

Awards, Honors, & Recognition

Frances Duffy Endowed Chair OUHSC, 1996-2018
Fellow (IDSA) Infectious Diseases Society of America, 1999
Fellow (FACP) American College of Physicians, 1999

Publications & Presentations

PubMed

3 citations
Targeting Doublecortin-Like Kinase 1 (DCLK1)-Regulated SARS-CoV-2 Pathogenesis in COVID-19.
Ram Babu Undi, Jason L Larabee, Adrian Filiberti, Susanna Ulahannan, Sheeja Aravindan, Edana Stroberg, Lisa M Barton, Eric J Duval, Sanjay Mukhopadhyay, James C Hentho...> ;Journal of Virology. 2022 Sep 14
3 citations
Cellular Carcinogenesis: Role of Polarized Macrophages in Cancer Initiation.
Ram Babu Undi, Adrian Filiberti, Naushad Ali, Mark M Huycke> ;Cancers. 2022 Jun 6
9 citations
It takes a village: microbiota, parainflammation, paligenosis and bystander effects in colorectal cancer initiation.
Xingmin Wang, Ram Babu Undi, Naushad Ali, Mark M. Huycke> ;Disease Models & Mechanisms. 2021 May 1
6 citations
Doublecortin-like kinase 1 promotes hepatocyte clonogenicity and oncogenic programming via non-canonical β-catenin-dependent mechanism.
Naushad Ali, Charles B. Nguyen, Parthasarathy Chandrakesan, Roman F. Wolf, Dongfeng Qu, Randal May, Tatiana Goretsky, Javid Fazili, Terrence A. Barrett, Min Li, Mark M...> ;Scientific Reports. 2020 Jun 29
20 citations
Risks associated with enterococci as probiotics.
Xingmin Wang, Yonghong Yang, Mark M. Huycke> ;Food Research International. 2020 Mar 1
25 citations
Impact of antibiotic treatment and host innate immune pressure on enterococcal adaptation in the human bloodstream
Daria Van Tyne, Abigail L. Manson, Mark M. Huycke, John Karanicolas, Ashlee M. Earl, Michael S. Gilmore> ;Science Translational Medicine. 2019 Apr 10
37 citations
Commensal-infected macrophages induce dedifferentiation and reprogramming of epithelial cells during colorectal carcinogenesis
Xingmin Wang, Yonghong Yang, Mark M. Huycke> ;Oncotarget. 2017 Nov 1
55 citations
Microbiome-driven carcinogenesis in colorectal cancer: Models and mechanisms.
Xingmin Wang, Yonghong Yang, Mark M. Huycke> ;Free Radical Biology & Medicine. 2017 Apr 1
35 citations
Intestinal tuft cells regulate the ATM mediated DNA Damage response via Dclk1 dependent mechanism for crypt restitution following radiation injury
Parthasarathy Chandrakesan, Randal May, Nathaniel Weygant, Dongfeng Qu, William L. Berry, Sripathi M. Sureban, Naushad Ali, Chinthalapally V. Rao, Mark M. Huycke, Mich...> ;Scientific Reports. 2016 Nov 23
94 citations
Defective Intestinal Mucin-Type O-Glycosylation Causes Spontaneous Colitis-Associated Cancer in Mice
Kirk Bergstrom, Xiaowei Liu, Yiming Zhao, Nan Gao, Qian Wu, Kai Song, Yi Cui, Yun Li, J. Michael McDaniel, Samuel McGee, Weichang Chen, Mark M. Huycke, Courtney W. Hou...> ;Gastroenterology. 2016 Jul 1
24 citations
Glutathione S-transferase alpha 4 induction by activator protein 1 in colorectal cancer.
Y Yang, Mark M. Huycke, T S Herman, Xingmin Wang> ;Oncogene. 2016 Apr 11
23 citations
Colorectal cancer: role of commensal bacteria and bystander effects.
Xingmin Wang, Mark M. Huycke> ;Gut Microbes. 2015 Jan 1
23 citations
Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases
Naushad Ali, Parthasarathy Chandrakesan, Charles B. Nguyen, Sanam Husain, Allison F. Gillaspy, Mark M. Huycke, William L. Berry, Randal May, Dongfeng Qu, Nathaniel Wey...> ;Oncotarget. 2015 Apr 30
71 citations
Commensal bacteria drive endogenous transformation and tumour stem cell marker expression through a bystander effect
Xingmin Wang, Yonghong Yang, Mark M. Huycke> ;Gut. 2015 Mar 1
32 citations
Fluvastatin Interferes with Hepatitis C Virus Replication via Microtubule Bundling and a Doublecortin-like Kinase-Mediated Mechanism
Naushad Ali, Heba Allam, Ted Bader, Randal May, Kanthesh M. Basalingappa, William L. Berry, Parthasarathy Chandrakesan, Dongfeng Qu, Nathaniel Weygant, Michael S. Bron...> ;Plos One. 2013 Nov 19
61 citations
Colon Macrophages Polarized by Commensal Bacteria Cause Colitis and Cancer through the Bystander Effect.
Yonghong Yang, Xingmin Wang, Thomas Huycke, Danny R. Moore, Stanley Lightfoot, Mark M. Huycke> ;Translational Oncology. 2013 Oct 1
40 citations
Incidence of potentially human papillomavirus–related neoplasms in the United States, 1978 to 2007
George Kurdgelashvili, Graça M. Dores, Samer A. Srour, Anil K. Chaturvedi, Mark M. Huycke, Susan S. Devesa> ;Cancer. 2013 Jun 15
36 citations
Cyclooxygenase-2 Generates the Endogenous Mutagen trans-4-Hydroxy-2-nonenal in Enterococcus faecalis–Infected Macrophages
Xingmin Wang, Toby D. Allen, Yonghong Yang, Danny R. Moore, Mark M. Huycke> ;Cancer Prevention Research. 2013 Jan 15
29 citations
TNF-α mediates macrophage-induced bystander effects through Netrin-1
Yonghong Yang, Xingmin Wang, Danny R. Moore, Stanley Lightfoot, Mark M. Huycke> ;Cancer Research. 2012 Oct 15
2 citations
A multicenter evaluation of the safety of drotrecogin alfa (activated) in patients with baseline bleeding precautions.
Russell J. Benefield, Douglas A. Drevets, Mark M. Huycke, Chris A. Gentry> ;Current Drug Safety. 2012 Jan 31
88 citations
4-Hydroxy-2-Nonenal Mediates Genotoxicity and Bystander Effects Caused by Enterococcus faecalis–Infected Macrophages
Xingmin Wang, Yonghong Yang, Danny R. Moore, Susan L. Nimmo, Stanley Lightfoot, Mark M. Huycke> ;Gastroenterology. 2012 Mar 1
11 citations
Case-control study of statin prevention of mould infections.
Jessica N. Thompson, Mark M. Huycke, Ronald A. Greenfield, George Kurdgelashvili, Chris A. Gentry> ;Mycoses. 2011 Sep 1
18 citations
Melanoma of the skin and laterality
Graça M. Dores, Mark M. Huycke, Susan S. Devesa> ;Journal of the American Academy of Dermatology. 2011 Jan 1
68 citations
Small Intestinal Cancer: a Population-Based Study of Incidence and Survival Patterns in the United States, 1992 to 2006
Osama Qubaiah, Susan S. Devesa, Charles E. Platz, Mark M. Huycke, Graça M. Dores> ;Cancer Epidemiology, Biomarkers & Prevention. 2010 Aug 1
106 citations
Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): a population-based cohort study
Bassam Ghabach, William F. Anderson, Rochelle E. Curtis, Mark M. Huycke, Jackie A. Lavigne, Graça M. Dores> ;Breast Cancer Research. 2010 Jul 23
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Press Mentions

Researchers at OU Medicine Studying Possible Link Between Bacteria, Colon CancerJune 7th, 2019
Researcher Earns $2.3 Million Grant to Study Bacteria’s Role in Triggering Colon CancerJune 5th, 2019
How Enterococcus Faecalis Bacteria Causes Antibiotic Resistant InfectionApril 17th, 2019
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Grant Support

Microbiome-triggered reprogramming and mutation of colon epithelial cells leading to tumor stem-like cellsNCI2019–2024
Enterococcus Faecalis, Colorectal Cancer, And Bystander EffectsNational Cancer Institute2008–2011

Professional Memberships

American Association for Cancer Research - AACR
Member