MarkO'ConnorMD

PubMed

• Anti-tumor activity of the ATR inhibitor AZD6738 in HER2 positive breast cancer cells.
  Kim H, Min A, Im S, Jang H, Lee KH, Lau A, Lee M, Kim S, Yang Y, Kim J, Kim TY, Oh D, Brown J, O'Connor MJ, Bang Y> ;Int. J. Cancer. 2017-01-01
• The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models.
  Oplustil O'Connor L, Rulten SL, Cranston AN, Odedra R, Brown H, Jaspers JE, Jones L, Knights C, Evers B, Ting A, Bradbury RH, Pajic M, Rottenberg S, Jonkers J, Rudge D...> ;Cancer Res.. 2016-10-15
• The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in ...
  Vendetti FP, Lau A, Schamus S, Conrads TP, O'Connor MJ, Bakkenist CJ> ;Oncotarget. 2015-12-29
• Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti-tumor effects of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in tri...
  Min A, Im S, Kim DK, Song S, Kim H, Lee K, Kim T, Han S, Oh D, Kim T, O'Connor MJ, Bang Y> ;Breast Cancer Res.. 2015-03-07
• ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation.
  Biddlestone-Thorpe L, Sajjad M, Rosenberg E, Beckta JM, Valerie NCK, Tokarz M, Adams BR, Wagner AF, Khalil A, Gilfor D, Golding SE, Deb S, Temesi DG, Lau A, O'Connor M...> ;Clin. Cancer Res.. 2013-06-15
• RAD51C-deficient cancer cells are highly sensitive to the PARP inhibitor olaparib.
  Min A, Im S, Yoon Y, Song S, Nam H, Hur H, Kim H, Lee K, Han S, Oh D, Kim T, O'Connor MJ, Kim W, Bang Y> ;Mol. Cancer Ther.. 2013-06-01
• A new phenanthroline-oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction.
  McCann M, McGinley J, Ni K, O'Connor M, Kavanagh K, McKee V, Colleran J, Devereux M, Gathergood N, Barron N, Prisecaru A, Kellett A> ;Chem. Commun. (Camb.). 2013-03-21
• Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors.
  Jaspers JE, Kersbergen A, Boon U, Sol W, van Deemter L, Zander SA, Drost R, Wientjens E, Ji J, Aly A, Doroshow JH, Cranston A, Martin NMB, Lau A, O'Connor MJ, Ganesan ...> ;Cancer Discov. 2013-01-01
• Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment.
  Oplustilova L, Wolanin K, Mistrik M, Korinkova G, Simkova D, Bouchal J, Lenobel R, Bartkova J, Lau A, O'Connor MJ, Lukas J, Bartek J> ;Cell Cycle. 2012-10-15
• Sleep problems in cancer patients: prevalence and association with distress and pain.
  Sharma N, Hansen CH, O'Connor M, Thekkumpurath P, Walker J, Kleiboer A, Murray G, Espie C, Storey D, Sharpe M, Fleming L> ;Psychooncology. 2012-09-01
• Radical-induced DNA damage by cytotoxic square-planar copper(II) complexes incorporating o-phthalate and 1,10-phenanthroline or 2,2'-dipyridyl.
  Kellett A, Howe O, O'Connor M, McCann M, Creaven BS, McClean S, Foltyn-Arfa Kia A, Casey A, Devereux M> ;Free Radic. Biol. Med.. 2012-08-01
• Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities display promising chemotherapeutic ...
  O'Connor M, Kellett A, McCann M, Rosair G, McNamara M, Howe O, Creaven BS, McClean S, Kia AF, O'Shea D, Devereux M> ;J. Med. Chem.. 2012-03-08
• Pain in patients attending a specialist cancer service: prevalence and association with emotional distress.
  O'Connor M, Weir J, Butcher I, Kleiboer A, Murray G, Sharma N, Thekkumpurath P, Walker J, Fallon M, Storey DJ, Sharpe M> ;J Pain Symptom Manage. 2012-01-01
• 47 citations
  Bis-phenanthroline copper(II) phthalate complexes are potent in vitro antitumour agents with ‘self-activating’ metallo-nuclease and DNA binding properties
  Andrew Kellett, Mark O'Connor, Malachy McCann, Mary McNamara, Patrick Lynch, Georgina M. Rosair, Vickie McKee, Bernie Creaven, Maureen Walsh, Siobhán McClean, Agnieszk...> ;Dalton Transactions. 2011 Jan 19
• Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks.
  Bañuelos CA, Banáth JP, MacPhail SH, Zhao J, Eaves CA, O'Connor MD, Lansdorp PM, Olive PL> ;DNA Repair (Amst.). 2008-09-01
• Patients who strive to be ill: factitious disorder with physical symptoms.
  Krahn LE, Li H, O'Connor MK> ;Am J Psychiatry. 2003-06-01
• In vivo sodium iodide symporter gene therapy of prostate cancer.
  Spitzweg C, Dietz AB, O'Connor MK, Bergert ER, Tindall DJ, Young CY, Morris JC> ;Gene Ther.. 2001-10-01
• Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit.
  Thompson J, Kim DF, O'Connor M, Lieberman KR, Bayfield MA, Gregory ST, Green R, Noller HF, Dahlberg AE> ;Proc. Natl. Acad. Sci. U.S.A.. 2001-07-31
• Altered discrimination of start codons and initiator tRNAs by mutant initiation factor 3.
  O'Connor M, Gregory ST, Rajbhandary UL, Dahlberg AE> ;RNA. 2001-07-01
• Probing ribosome structure and function by mutagenesis.
  Gregory ST, Bayfield MA, O'Connor M, Thompson J, Dahlberg AE> ;Cold Spring Harb. Symp. Quant. Biol.. 2001-01-01
• Treatment of prostate cancer by radioiodine therapy after tissue-specific expression of the sodium iodide symporter.
  Spitzweg C, O'Connor MK, Bergert ER, Tindall DJ, Young CY, Morris JC> ;Cancer Res.. 2000-11-15
• The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels.
  Chávez VM, Marqués G, Delbecque JP, Kobayashi K, Hollingsworth M, Burr J, Natzle JE, O'Connor MB> ;Development. 2000-10-01
• Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation.
  Kress JP, Pohlman AS, O'Connor MF, Hall JB> ;N. Engl. J. Med.. 2000-05-18
• Functional analysis of repressor binding sites in the iab-2 regulatory region of the abdominal-A homeotic gene.
  Shimell MJ, Peterson AJ, Burr J, Simon JA, O'Connor MB> ;Dev. Biol.. 2000-02-01
• Requirement of intracellular calcium mobilization for peroxynitrite-induced poly(ADP-ribose) synthetase activation and cytotoxicity.
  Viráģ L, Scott GS, Antal-Szalmás P, O'Connor M, Ohshima H, Szabó C> ;Mol. Pharmacol.. 1999-10-01
• Join now to see all