MarkO'HaraMD

Oncology • Philadelphia, PA

Physician

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Office
3400 Civic Center Blvd
PCAM 10 SPE
Philadelphia, PA 19146
Phone+1 215-360-0735

Fax+1 215-662-4646
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Education & Training

University of Pennsylvania Health SystemFellowship, Hematology and Medical Oncology, 2012 - 2015
UPMC Medical EducationResidency, Internal Medicine, 2008 - 2012
Stony Brook University Health Sciences Center School of MedicineClass of 2008

Certifications & Licensure

PA State Medical License 2008 - 2024

Clinical Trials

Trial Of Hypofractionated Radiotherapy In Combination With MEDI4736 And Tremelimumab For Patients With Metastatic Melanoma And Lung, Breast And Pancreatic Cancers Start of enrollment: 2016 Jan 26
Completed
Phase 1
A Study of LY2510924 and Durvalumab in Participants With Solid Tumors Start of enrollment: 2016 Sep 01
Terminated
Phase 1
A Study to Evaluate the Safety and Tolerability of AB680 in Participants With Gastrointestinal Malignancies Start of enrollment: 2019 Nov 06
Active, not recruiting
Phase 1
DC Vaccine in Pancreatic Cancer Start of enrollment: 2018 Nov 20
Active, not recruiting
Phase 1
Roles: Principal Investigator, Contact
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Publications & Presentations

PubMed

129 citations
An NK-like CAR T cell transition in CAR T cell dysfunction.
Charly R. Good, M. Angela Aznar, Shunichiro Kuramitsu, Parisa Samareh, Sangya Agarwal, Greg Donahue, Kenichi Ishiyama, Nils Wellhausen, Austin K. Rennels, Yujie Ma, Li...> ;Cell. 2021 Dec 2
1 citations
THSB2 as a prognostic biomarker for patients diagnosed with metastatic pancreatic ductal adenocarcinoma.
Phyllis A. Gimotty, Jacob Till, Shirsa Udgata, Naomi Takenaka, Stephanie S. Yee, Michael J. LaRiviere, Mark H. O'Hara, Kim A. Reiss, Peter O'Dwyer, Bryson W. Katona, D...> ;Oncotarget. 2021 Oct 26
3 citations
Optimization of sources of circulating cell-free DNA variability for downstream molecular analysis
Jacob Till, Taylor A. Black, Caren Gentile, Aseel Abdalla, Zhuoyang Wang, Hareena Sangha, Jacquelyn J. Roth, Robyn T. Sussman, Stephanie S. Yee, Mark H. O'Hara, Jeffre...> ;The Journal of Molecular Diagnostics. 2021 Aug 25
39 citations
Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting.
Adham S. Bear, Tatiana Blanchard, Joseph Cesare, Michael J. Ford, Lee P. Richman, Chong Xu, Miren L. Baroja, Sarah McCuaig, Christina Costeas, Khatuna Gabunia, John Sc...> ;Nature Communications. 2021 Jul 16
65 citations
Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer.
Katelyn T. Byrne, Courtney Betts, Rosemarie Mick, Shamilene Sivagnanam, David L. Bajor, Daniel A. Laheru, E. Gabriela Chiorean, Mark H. O'Hara, Shannon M. Liudahl, Cra...> ;Clinical Cancer Research. 2021 Aug 15
8 citations
Adoptive Cellular Therapy for Solid Tumors.
Adham S. Bear, Joseph A. Fraietta, Vivek Narayan, Mark H. O'Hara, Naomi B. Haas> ;American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. 2021 May 19
77 citations
Phase II Study of Maintenance Rucaparib in Patients With Platinum-Sensitive Advanced Pancreatic Cancer and a Pathogenic Germline or Somatic Variant in BRCA1, BRCA2, or...
Kim A. Reiss, Rosemarie Mick, Mark H. O'Hara, Ursina R. Teitelbaum, Thomas B. Karasic, Charles Schneider, Stacy Cowden, Traci Southwell, Janae Romeo, Natallia Izgur, Z...> ;Journal of Clinical Oncology. 2021 May 10
4 citations
Comparative Effectiveness of Total Neoadjuvant Therapy Versus Standard Adjuvant Chemotherapy for Locally Advanced Rectal Cancer.
Shun Yu, Ronac Mamtani, Mark H. O'Hara, P. J. O'Dwyer, Ofer Margalit, Bruce J. Giantonio, Einat Shacham Shmueli, Kim A. Reiss, Ben Boursi> ;Clinical Colorectal Cancer. 2021 Jan 22
4 citations
Evaluation of the Cost-effectiveness of Doublet Therapy in Metastatic BRAF Variant Colorectal Cancer.
Kishan Patel, Stacey Stein, Jill Lacy, Mark H. O'Hara, Scott F. Huntington> ;JAMA Network Open. 2021 Jan 4
125 citations
CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an ope...
Mark H. O'Hara, Eileen M. O'Reilly, Gauri R. Varadhachary, Robert A. Wolff, Zev A. Wainberg, Andrew H. Ko, George A. Fisher, Osama E. Rahma, Jaclyn P. Lyman, Christoph...> ;The Lancet. Oncology. 2021 Jan 1
230 citations
Challenges and Opportunities for Pancreatic Cancer Immunotherapy
Adham S. Bear, Robert H. Vonderheide, Mark H. O'Hara> ;Cancer Cell. 2020 Dec 14
20 citations
Phase II Trial of Palbociclib in Patients with Advanced Esophageal or Gastric Cancer.
Thomas B. Karasic, Mark H. O'Hara, Ursina R. Teitelbaum, Nevena Damjanov, Bruce J. Giantonio, Tracy S. d'Entremont, Maryann Gallagher, Paul J. Zhang, Peter J. O'Dwyer> ;The Oncologist. 2020 Dec 1
20 citations
Dual Targeting of Mesothelin and CD19 with Chimeric Antigen Receptor-Modified T Cells in Patients with Metastatic Pancreatic Cancer.
Andrew H. Ko, Alexander C. Jordan, Evan Tooker, Simon F. Lacey, Renee B. Chang, Yan Li, Alan P. Venook, Margaret A. Tempero, Lloyd E. Damon, Lawrence Fong, Mark H. O'H...> ;Molecular Therapy. 2020 Jul 21
13 citations
Early treatment-related neutropenia predicts response to palbociclib.
Nicholas P. McAndrew, Mark A. Dickson, Amy S. Clark, Andrea B. Troxel, Mark H. O'Hara, Christopher Colameco, Maryann Gallager, Kristi Gramlich, Kelly Zafman, David J. ...> ;British Journal of Cancer. 2020 Jul 9
45 citations
A Multianalyte Panel Consisting of Extracellular Vesicle miRNAs and mRNAs, cfDNA, and CA19-9 Shows Utility for Diagnosis and Staging of Pancreatic Ductal Adenocarcinoma.
Zijian Yang, Michael J. LaRiviere, Jina Ko, Jacob Till, Theresa Christensen, Stephanie S. Yee, Taylor A. Black, Kyle Tien, Andrew Lin, Hanfei Shen, Neha Bhagwat, Danie...> ;Clinical Cancer Research. 2020 Jul 1
6 citations
Combining Radiation with Immunotherapy: The University of Pennsylvania Experience
Leo Y. Luo, Mark H. O'Hara, Tara C. Mitchell, Robert H. Vonderheide, E. John Wherry, Andy J. Minn, Amit Maity> ;Seminars in Radiation Oncology. 2020 Apr 1
29 citations
Safety and Pharmacokinetics of CXCR4 Peptide Antagonist, LY2510924, in Combination with Durvalumab in Advanced Refractory Solid Tumors
Mark H. O'Hara, Wells A. Messersmith, Hedy L. Kindler, Wei Zhang, Celine Pitou, Anna M. Szpurka, Dan Wang, Sheng-Bin Peng, Burkhard Vangerow, Anis A. Khan, Mythili Kon...> ;Journal of Pancreatic Cancer. 2020 Mar 12
189 citations
Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers.
Andrew R. Haas, Janos L. Tanyi, Mark H. O'Hara, Whitney L. Gladney, Simon F. Lacey, Drew A. Torigian, Michael C. Soulen, Lifeng Tian, Maureen McGarvey, Anne Marie Nels...> ;Molecular Therapy. 2019 Nov 6
190 citations
Effect of Gemcitabine and nab-Paclitaxel With or Without Hydroxychloroquine on Patients With Advanced Pancreatic Cancer: A Phase 2 Randomized Clinical Trial.
Thomas B. Karasic, Mark H. O'Hara, Arturo Loaiza-Bonilla, Kim A. Reiss, Ursina R. Teitelbaum, Erkut Borazanci, Ana De Jesus-Acosta, Colleen Redlinger, Jessica A. Burre...> ;JAMA Oncology. 2019 Jul 1
4 citations
Efficacy of Oral Cryotherapy During Oxaliplatin Infusion in Preventing Oral Thermal Hyperalgesia: A Randomized Trial.
Brittany Bauman, Rosemarie Mick, Eileen Martinez, Theresa M Lawless, Lindsey Zinck, Paige Sinclair, Mary Jane Fuhrer, Mark H. O'Hara, Charles J. Schneider, Peter O'Dwy...> ;Journal of the National Comprehensive Cancer Network. 2019 Apr 1
214 citations
Hepatocytes direct the formation of a pro-metastatic niche in the liver
Jae W. Lee, Meredith L. Stone, Paige M. Porrett, Stacy K. Thomas, Chad A. Komar, Joey H. Li, Devora Delman, Kathleen Graham, Whitney L. Gladney, Xia Hua, Taylor A. Bla...> ;Nature. 2019 Mar 6
72 citations
A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours.
Amit Maity, Rosemarie Mick, Alexander C. Huang, Sangeeth M. George, Michael D. Farwell, John N. Lukens, Abigail T. Berman, Tara C. Mitchell, Josh Bauml, Lynn M. Schuch...> ;British Journal of Cancer. 2018 Oct 15
293 citations
Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial
Gregory L. Beatty, Mark H. O'Hara, Simon F. Lacey, Drew A. Torigian, Farzana Nazimuddin, Fang Chen, Irina Kulikovskaya, Michael C. Soulen, Maureen McGarvey, Anne Marie...> ;Gastroenterology. 2018 Jul 1
7 citations
A phase I dose escalation trial of nab-paclitaxel and fixed dose radiation in patients with unresectable or borderline resectable pancreatic cancer
Jacob E. Shabason, Jerry Chen, Smith Apisarnthanarax, Nevena Damjanov, Bruce J. Giantonio, Arturo Loaiza-Bonilla, Peter J. O'Dwyer, Mark H. O'Hara, Kim A. Reiss, Ursin...> ;Cancer Chemotherapy and Pharmacology. 2018 Jan 23
132 citations
Combining Machine Learning and Nanofluidic Technology To Diagnose Pancreatic Cancer Using Exosomes
Jina Ko, Neha Bhagwat, Stephanie S. Yee, Natalia Ortiz, Amine Sahmoud, Taylor A. Black, Nicole M. Aiello, Lydie McKenzie, Mark H. O'Hara, Colleen Redlinger, Janae Rome...> ;ACS Nano. 2017 Oct 17
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Press Mentions

Verismo Therapeutics Announces the Activation of Its STAR-101 Clinical Trial at the University of PennsylvaniaMay 2nd, 2023
New Approach for Cell Therapy Shows Potential Against Solid Tumors with KRAS MutationsJuly 27th, 2021