Mark Pepin MD , PhD, MS (He/Him)
MD, PhD, MS | PGY1 | Brigham and Womens Hospital | Harvard Medical School | Boston, MA, USA
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75 Francis StBoston, MA 02115
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Summary
- Mark Pepin, MD, PhD is currently a resident physician at Brigham and Women's Hospital and Harvard Medical School. His clinical and scientific interests are centered in end-stage heart failure, specifically the targeted molecular and epigenetic therapies for myocardial disease. He was recently a Humboldt postdoctoral fellow at the Institute for Experimental Cardiology at Heidelberg University (Heidelberg, DE), where his main project defined a causal role of catecholaminergic histone modifications in heart failure-induced carcinogenesis.
Education & Training
Mass General Brigham/Brigham and Women's HospitalResidency, Internal Medicine, 2022
Universitätsklinikum HeidelbergPost-Doctoral Fellowship, 2020 - 2022
University of Alabama School of MedicineClass of 2020, MD, AOA Member- University of Alabama at BirminghamPhD, Biomedical Engineering, Suma Cum Laude, 2015 - 2019
- UC DavisMS, Biomedical Engineering, Cum Laude, 2011 - 2013
Certifications & Licensure
CA State Medical License 2024 - 2026
MA State Medical License 2022 - 2024
Awards, Honors, & Recognition
- "Tinsley Harrison" Excellence in Clinical Medicine UAB Department of Medicine, 2022
- Valedictorian UAB Graduate Commencement Ceremony, 2019
- "Samuel B Barker" Award for Excellence in Graduate Studies UAB Graduate School, 2019
Publications & Presentations
PubMed
- Dysregulated smooth muscle cell proliferation and gene expression underlievariant-associated aortopathy.Mark E Pepin, Richard N Mitchell, Rajat M Gupta
American Journal of Physiology. Heart and Circulatory Physiology. 2025-11-01 - 3 citationsDNA hypermethylation of MED1 and MED23 as early diagnostic biomarkers for unsolved issues in atrial fibrillation.Concetta Schiano, Teresa Infante, Giuditta Benincasa, Jacopo Burrello, Antonio Ruocco
International Journal of Cardiology. 2025-06-15 - 10 citationsMitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF.Mark E Pepin, Philipp J M Konrad, Sumra Nazir, Farhad Bazgir, Christoph Maack
Circulation Research. 2025-06-06
Journal Articles
- Glucagon-Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21Stephen Barnes, Mark Pepin, Diabetes Care
Press Mentions
Race and Poverty Appear to Guide Heart Muscle DNA Methylation in Heart-Failure PatientsApril 7th, 2021
Epigenetic Reprogramming of Human Hearts Found in Congestive Heart FailureAugust 10th, 2018
Genome-Wide DNA Methylation Encodes Cardiac Transcriptional Reprogramming in Human Ischemic Heart FailureAugust 10th, 2018
Grant Support
- "DZHK-Omics: Intuitive and Standardized Bulk RNA-Sequencing Analysis for the Coding-Naïve Basic Scientist."DZHK - German Society for Heart Research2021–2022
- "Gadd45b and Metabolic Memory in Diabetic Heart Failure."NIH National Heart, Lung, and Blood Institute (NHLBI)2017–2020
Committees
- Director, Academic Engagement Committee 2015 - 2020
Research History
- First AuthorDoes an optimal learning style exist in preclinical medicine? A Learning Assessment and Study Skills Inventory.2016 - 2019
- First AuthorHAART-Induced Metabolic Syndrome and Adipocyte-Infiltrating Macrophages.2016 - 2018
- Middle-AuthorGamificaiton of medical knowledge as a retention tool for physician scientists.2017 - 2017
- First AuthorEtiology-specific heart failure susceptibility: of mice and men.
- First AuthorEpigenetic reprogramming of the failing diabetic heart.
Professional Memberships
- Member
- American Physiology SocietyMember
Other Languages
- German
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