MarkCPoznanskyMD

Internal Medicine • Boston, MA

Associate Professor, Medicine, Massachusetts General Hospital, Harvard Medical School

Join to view full profile

Dr. Poznansky is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Poznansky's full profile

Already have an account?

Office
Infectious Disease Associates
55 Fruit Street Cox 5
Boston, MA 02114
Phone+1 617-726-3906
Is this information wrong?

Education & Training

University of Edinburg Medical SchoolClass of 1985

Certifications & Licensure

MA State Medical License 1998 - 2025

Publications & Presentations

PubMed

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine response in adults with predominantly antibody deficiency.
Anna M Zhang, Ahmed Elmoursi, Daniel V DiGiacomo, Baijun Zhou, Megha Tandon, Joseph S Hong, Nancy J Yang, Mei-Sing Ong, Anand S Dighe, Cristhian Berrios, Mark C Poznan...> ;The Journal of Allergy and Clinical Immunology. Global. 2024 May 1
Ongoing evolution of SARS-CoV-2 drives escape from mRNA vaccine-induced humoral immunity.
Alex L Roederer, Yi Cao, Maegan L Sheehan, Chia Jung Li, Evan C Lam, David J Gregory, A John Iafrate, David H Canaday, Wilfredo F Garcia-Beltran, Alejandro B Balazs, K...> ;Medrxiv. 2024 Mar 7
Short-term function and immune-protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non-human primates witho...
Marinko Sremac, Hao Luo, Hongping Deng, Madeline F E Parr, Jessica Hutcheson, Pushkar S Verde, David A Alagpulinsa, Jenna Miner Kitzmann, Klearchos K Papas, Timothy Br...> ;Xenotransplantation. 2023 Sep 15
Combinatorial islet protective therapeutic approaches in β-cell transplantation: Rationally designed solutions using a target product profile.
Katie Lu, Timothy Brauns, Ann E Sluder, Mark C Poznansky, Fatma Dogan> ;FASEB Bioadvances. 2023 Jul 1
2 citations
B cell treatment promotes a neuroprotective microenvironment after traumatic brain injury through reciprocal immunomodulation with infiltrating peripheral myeloid cells.
Liam J Dwyer, Saumya Maheshwari, Emily Levy, Mark C Poznansky, Michael J Whalen, Ruxandra F Sîrbulescu> ;Journal of Neuroinflammation. 2023 May 31
Intruders or protectors - the multifaceted role of B cells in CNS disorders.
Aspden, J., Murphy, M., Kashlan, R., Xiong, Y., Sîrbulescu, R., Poznansky, M.> ;Frontiers in Cellular Neuroscience. 2023 Jan 1
Cytometry profiling ofrecall responses toin previously naturally exposed individuals reveals long-term changes in both adaptive and innate immune cellular compartments.
Susan Raju Paul, Anja Scholzen, Patrick M Reeves, Robert Shepard, Joshua M Hess, Richard K Dzeng, Skylar Korek, Anja Garritsen, Mark C Poznansky, Ann E Sluder> ;Frontiers in Immunology. 2023 Jan 1
8 citations
Optimized ACE2 decoys neutralize antibody-resistant SARS-CoV-2 variants through functional receptor mimicry and treat infection in vivo.
James A Torchia, Alexander H Tavares, Laura S Carstensen, Da-Yuan Chen, Jessie Huang, Tianshu Xiao, Sonia Mukherjee, Patrick M Reeves, Hua Tu, Ann E Sluder, Bing Chen,...> ;Science Advances. 2022 Dec 9
6 citations
Repertoires of SARS-CoV-2 epitopes targeted by antibodies vary according to severity of COVID-19.
David J Gregory, Augustin Vannier, Akiro H Duey, Tyler J Roady, Richard K Dzeng, Maia N Pavlovic, Michael H Chapin, Sonia Mukherjee, Hannah Wilmot, Nic Chronos, Richel...> ;Virulence. 2022 Dec 1
31 citations
Precise reconstruction of the TME using bulk RNA-seq and a machine learning algorithm trained on artificial transcriptomes.
Aleksandr Zaitsev, Maksim Chelushkin, Daniiar Dyikanov, Ilya Cheremushkin, Boris Shpak, Krystle Nomie, Vladimir Zyrin, Ekaterina Nuzhdina, Yaroslav Lozinsky, Anastasia...> ;Cancer Cell. 2022 Aug 8
The 2022 FASEB virtual Catalyst Conference on B Cells in Injury and Regeneration, March 30, 2022.
Liam J Dwyer, Ann M Stowe, Kristian Doyle, Phillip Popovich, Elizabeth Engler-Chiurazzi, Christian LeGuern, Marion S Buckwalter, Mark C Poznansky, Ruxandra F Sîrbulescu> ;FASEB Journal. 2022 Aug 1
11 citations
Response to Severe Acute Respiratory Syndrome Coronavirus 2 Initial Series and Additional Dose Vaccine in Patients With Predominant Antibody Deficiency.
Sara Barmettler, Daniel V DiGiacomo, Nancy J Yang, Tiffany Lam, Vivek Naranbhai, Anand S Dighe, Kristin E Burke, Kimberly G Blumenthal, Morris Ling, Paul E Hesterberg,...> ;The Journal of Allergy and Clinical Immunology. in Practice. 2022 Jun 1
77 citations
Comparative Immunogenicity and Effectiveness of mRNA-1273, BNT162b2, and Ad26.COV2.S COVID-19 Vaccines.
Vivek Naranbhai, Wilfredo F Garcia-Beltran, Christina C Chang, Cristhian Berrios Mairena, Julia C Thierauf, Grace Kirkpatrick, Maristela L Onozato, Ju Cheng, Kerri J S...> ;The Journal of Infectious Diseases. 2022 Apr 1
Differential Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Profiles After Allergic Reactions to Messenger RNA Coronavirus Disease 2019 Vaccine.
Jenny S Maron, Michelle Conroy, Vivek Naranbai, Upeka Samarakoon, Tina Motazedi, Jocelyn R Farmer, Esther Freeman, Aleena Banerji, Yannic C Bartsch, David J Gregory, M...> ;The Journal of Infectious Diseases. 2022 Sep 28
753 citations
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant.
Wilfredo F Garcia-Beltran, Kerri J St Denis, Angelique Hoelzemer, Evan C Lam, Adam D Nitido, Maegan L Sheehan, Cristhian Berrios, Onosereme Ofoman, Christina C Chang, ...> ;Cell. 2022 Feb 3
6 citations
Evaluation of a Human T Cell-Targeted Multi-Epitope Vaccine for Q Fever in Animal Models ofImmunity.
Ann E Sluder, Susan Raju Paul, Leonard Moise, Christina Dold, Guilhem Richard, Laura Silva-Reyes, Laurie A Baeten, Anja Scholzen, Patrick M Reeves, Andrew J Pollard, A...> ;Frontiers in Immunology. 2022 Jan 1
2 citations
Natural Exposure- and Vaccination-Induced Profiles ofWhole Blood Cytokine Responses to.
Susan Raju Paul, Anja Scholzen, Ghazel Mukhtar, Stephanie Wilkinson, Peter Hobson, Richard K Dzeng, Jennifer Evans, Jennifer Robson, Rowland Cobbold, Stephen Graves, M...> ;Frontiers in Immunology. 2022 Jan 1
2 citations
Q fever vaccine development: Challenges and progress in balancing safety and efficacy.
Ann E Sluder, Mark C Poznansky> ;Cell Reports. Medicine. 2021 Dec 21
468 citations
mRNA-based COVID-19 vaccine boosters induce neutralizing immunity against SARS-CoV-2 Omicron variant.
Wilfredo F Garcia-Beltran, Kerri J St Denis, Angelique Hoelzemer, Evan C Lam, Adam D Nitido, Maegan L Sheehan, Cristhian Berrios, Onosereme Ofoman, Christina C Chang, ...> ;Medrxiv. 2021 Dec 14
209.6: Long-term Functional Survival of Human Stem Cell-derived Islets Microencapsulated in Alginate With CXCL12 in Non-human Primates Without Immunosuppression
David A. Alagpulinsa, Li Jei, Ramona Pop, Adrian Veres, Helen Deng, Jingping Zhang, Kento Kawai, Samantha S. Collins, Don Sobell, Michael H. Chapin, David Verill, Doug...> ;Transplantation. 2021 Dec 1
9 citations
B cells support the repair of injured tissues by adopting MyD88-dependent regulatory functions and phenotype
Ruxandra F. Sîrbulescu, Akshay Mamidi, Shu-Yi Claire Chan, Gina Jin, Myriam Boukhali, Don Sobell, Iulian Ilieş, Wilhelm Haas, Michael J. Whalen, Ann E. Sluder, Mark C....> ;FASEB Journal. 2021 Dec 1
15 citations
Mathematical modeling to simulate the effect of adding radiotherapy to immunotherapy and application to hepatocellular carcinoma.
Wonmo Sung, Theodore S. Hong, Mark C. Poznansky, Harald Paganetti, Clemens Grassberger> ;International Journal of Radiation Oncology, Biology, Physics. 2021 Nov 11
6 citations
Fresh Tissue Multi-omics Profiling Reveals Immune Classification and Suggests Immunotherapy Candidates for Conventional Chondrosarcoma.
Binghao Li, Guo-Qi Li, Xiaobo Yan, Dan Zhu, Patrick P. Lin, Zenan Wang, Hao Qu, Xuexin He, Yanbiao Fu, Xiuliang Zhu, Peng Lin, Jiangnan Zhang, Xiaoya Li, Hui Dai, Huab...> ;Clinical Cancer Research. 2021 Aug 23
The 2021 FASEB virtual Catalyst Conference on B Cells in Injury and Regeneration, April 21, 2021
Kento Kawai, Ann M. Stowe, Conor L. Evans, Ruxandra F. Sîrbulescu, Dusan Hanidziar, Kang Mi Lee, Thomas F. Tedder, Mark C. Poznansky> ;FASEB Journal. 2021 Aug 1
4 citations
Whole Blood Interferon γ Release Is a More Sensitive Marker of Prior Exposure to Coxiella burnetii Than Are Antibody Responses.
Anja Scholzen, Margot de Vries, Hans Peter Duerr, Hendrik Jan Roest, Ann E. Sluder, Mark C. Poznansky, Milou L.C.E. Kouwijzer, Anja Garritsen> ;Frontiers in Immunology. 2021 Jul 28
Join now to see all

Journal Articles

Brief Exposure of Skin to near-Infrared Laser Modulates Mast Cell Function and Augments the Immune Response
Jeffrey Gelfand, Mark C Poznansky, The Journal of Immunology

Press Mentions

Amid a ‘Huge Collective Trauma,’ a Harvard Program Aims to Train Ukrainian DoctorsFebruary 2nd, 2023
Hate Needles? Flu Vaccines of the Future Could Be Skin Patches Delivered to Your DoorNovember 2nd, 2022
United in Providing Urgent Medical Aid in a Time of WarApril 6th, 2022
Join now to see all

Grant Support

HIV-1 GP120 Induced CTL Chemorepulsion:Dysregulation Of Migration &LocalizationNational Institute Of Allergy And Infectious Diseases2006–2010
Novel Agents For Mitigation Of Radiation-Induced Pulmonary InjuryNational Institute Of Allergy And Infectious Diseases2009
Active Movement Of Immune Cells Away From HIV-1 GP120National Institute Of Allergy And Infectious Diseases2001–2005
Movement Of Recipient T-Cells Away From An AllograftNational Institute Of Allergy And Infectious Diseases2001–2003

Hospital Affiliations

Massachusetts General HospitalBoston, Massachusetts