MarkRapaportMD

PubMed

• Individuals with depression exhibiting a pro-inflammatory phenotype receiving omega-3 polyunsaturated fatty acids experience improved motivation-related cognitive func...
  Naoise Mac Giollabhui, David Mischoulon, Boadie W Dunlop, Becky Kinkead, Pamela J Schettler, Richard T Liu, Olivia I Okereke, Stefania Lamon-Fava, Maurizio Fava, Mark ...> ;Brain, Behavior, & Immunity - Health. 2023 Oct 1
• 6 citations
  Clinical response to EPA supplementation in patients with major depressive disorder is associated with higher plasma concentrations of pro-resolving lipid mediators.
  Stefania Lamon-Fava, Minying Liu, Boadie W Dunlop, Becky Kinkead, Pamela J Schettler, Jennifer C Felger, Thomas R Ziegler, Maurizio Fava, David Mischoulon, Mark Hyman ...> ;Neuropsychopharmacology. 2023 May 1
• 1 citations
  Longitudinal study of inflammation and relapse in schizophrenia.
  Brian J Miller, Henrique Lemos, Nina R Schooler, Donald C Goff, Alexander Kopelowicz, John Lauriello, Theo Manschreck, Alan Mendelowitz, Del D Miller, Joanne B Severe,...> ;Schizophrenia Research. 2023 Feb 1
• A preliminary descriptive report of the longevity of the effects of Swedish Massage therapy for subjects with Generalized Anxiety Disorder.
  Mark Hyman Rapaport, Pamela J Schettler, Erika R Larson, Sherry A Edwards, Boadie W Dunlop, Jeffrey J Rakofsky, Becky Kinkead> ;Journal of Bodywork and Movement Therapies. 2023 Jan 1
• 1 citations
  The Relationship Between Major Depressive Disorder and Multiple Medical Conditions: A Call to Improve Integrated Care Services.
  Rachel A Weir, Mark Hyman Rapaport> ;The Journal of Clinical Psychiatry. 2022 Oct 19
• 11 citations
  Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Randomized Dose-Finding Clinical Trial.
  David Mischoulon, Boadie W Dunlop, Becky Kinkead, Pamela J Schettler, Stefania Lamon-Fava, Jeffrey J Rakofsky, Andrew A Nierenberg, Alisabet J Clain, Tanja Mletzko Cro...> ;The Journal of Clinical Psychiatry. 2022 Aug 22
• 738 citations
  Mapping genomic loci implicates genes and synaptic biology in schizophrenia.
  Trubetskoy, V., Pardiñas, A., Qi, T., Panagiotaropoulou, G., Awasthi, S., Bigdeli, T., Bryois, J., Chen, C., Dennison, C., Hall, L., Lam, M., Watanabe, K., Frei, O., G...> ;Nature. 2022 Apr 1
• 257 citations
  Rare coding variants in ten genes confer substantial risk for schizophrenia.
  Tarjinder Singh, Timothy Poterba, David Curtis, Huda Akil, Mariam Al Eissa, Jack D Barchas, Nicholas Bass, Tim B Bigdeli, Gerome Breen, Evelyn J Bromet, Peter F Buckle...> ;Nature. 2022 Apr 1
• 9 citations
  A novel peripheral biomarker for depression and antidepressant response.
  Steven D Targum, Jeffrey Schappi, Athanasia Koutsouris, Runa Bhaumik, Mark H Rapaport, Natalie Rasgon, Mark M Rasenick> ;Molecular Psychiatry. 2022 Mar 1
• 3 citations
  The United States index of socioeconomic deprivation for individuals (USiDep).
  Boadie W Dunlop, Jeffrey J Rakofsky, David Mischoulon, Helen S Mayberg, Becky Kinkead, Andrew A Nierenberg, Thomas R Ziegler, Maurizio Fava, Mark H Rapaport> ;Personalized Medicine in Psychiatry. 2022 Jan 12
• 3 citations
  Longitudinal impact of bladder cancer diagnosis on common psychiatric disorders
  Ian Cooke, Dattatraya Patil, Katherine Bobrek, Vikram M. Narayan, Viraj A. Master, Mark Rapaport, Christopher P. Filson, Shreyas S. Joshi> ;Cancer Medicine. 2021 Nov 12
• 2 citations
  Locus Coeruleus Noradrenergic Modulation of Diurnal Corticosterone, Stress Reactivity and Cardiovascular Homeostasis in Male Rats.
  K. V. Thrivikraman, Becky Kinkead, Michael J. Owens, Mark Hyman Rapaport, Paul M. Plotsky> ;Neuroendocrinology. 2021 Oct 14
• 24 citations
  Prognostic value of polygenic risk scores for adults with psychosis
  Isotta Landi, Deepak Kaji, Liam Cotter, Tielman Van Vleck, Gillian M. Belbin, Michael Preuss, Ruth J. F. Loos, Eimear E. Kenny, Benjamin S. Glicksberg, Noam D. Beckman...> ;Nature Medicine. 2021 Sep 1
• 10 citations
  Transcutaneous Cervical Vagal Nerve Stimulation in Patients with Posttraumatic Stress Disorder (PTSD): A Pilot Study of Effects on PTSD Symptoms and Interleukin-6 Resp...
  J. Douglas Bremner, Matthew T. Wittbrodt, Nil Z. Gurel, MdMobashir H. Shandhi, Asim H. Gazi, Yunshen Jiao, Oleksiy Levantsevych, Minxuan Huang, Joy Beckwith, Isaias He...> ;Journal of Affective Disorders Reports. 2021 Jul 10
• 7 citations
  Psychiatry's modern role in functional neurological disorder: join the renaissance.
  Indrit Bègue, Timothy R Nicholson, Kasia Kozlowska, W. Curt LaFrance, James L. Levenson, Mark Hyman Rapaport, Alan Carson, David L. Perez> ;Psychological Medicine. 2021 Jun 24
• 411 citations
  Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
  Niamh Mullins, Andreas J. Forstner, Kevin S. O’Connell, Brandon J. Coombes, Jonathan R. I. Coleman, Zhen Qiao, Thomas Damm Als, Tim B. Bigdeli, Sigrid Børte, Julien Br...> ;Nature Genetics. 2021 May 17
• 29 citations
  Dose- and time-dependent increase in circulating anti-inflammatory and pro-resolving lipid mediators following eicosapentaenoic acid supplementation in patients with m...
  Stefania Lamon-Fava, Jisun So, David Mischoulon, Thomas R. Ziegler, Boadie W. Dunlop, Becky Kinkead, Pamela J. Schettler, Andrew A. Nierenberg, Jennifer C. Felger, Kri...> ;Prostaglandins, Leukotrienes, and Essential Fatty Acids. 2021 Jan 1
• 5 citations
  Six versus twelve weeks of Swedish massage therapy for generalized anxiety disorder: Preliminary findings.
  Mark Hyman Rapaport, Pamela J. Schettler, Erika R. Larson, Boadie W. Dunlop, Jeffrey J. Rakofsky, Becky Kinkead> ;Complementary Therapies in Medicine. 2021 Jan 1
• 17 citations
  Treatment of functional neurological disorder: current state, future directions, and a research agenda.
  Kathrin LaFaver, William Curt LaFrance, Michele Price, Phyllis Rosen, Mark Hyman Rapaport> ;CNS Spectrums. 2020 Dec 7
• 35 citations
  Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans
  Tim B. Bigdeli, Ayman H. Fanous, Yuli Li, Nallakkandi Rajeevan, Frederick G. Sayward, Giulio Genovese, Rishab Gupta, Krishnan Radhakrishnan, Anil K. Malhotra, Ning Sun...> ;Schizophrenia Bulletin. 2020 May 18
• An agenda for functional neurological disorders: care and research.
  Karen S. Rommelfanger, Mark Hyman Rapaport> ;CNS Spectrums. 2020 Oct 7
• 64 citations
  Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry
  Tim B. Bigdeli, Giulio Genovese, Penelope Georgakopoulos, Jacquelyn L. Meyers, Roseann E. Peterson, Conrad Iyegbe, Helena Medeiros, Jorge Valderrama, Eric D. Achtyes, ...> ;Molecular Psychiatry. 2020 Oct 1
• 20 citations
  Transcutaneous vagal nerve stimulation blocks stress-induced activation of Interleukin-6 and interferon-γ in posttraumatic stress disorder: A double-blind, randomized,...
  J. Douglas Bremner, Nil Z. Gurel, Yunshen Jiao, Matthew T. Wittbrodt, Oleksiy Levantsevych, Minxuan Huang, Hewon Jung, MdMobashir H. Shandhi, Joy Beckwith, Isaias Herr...> ;Brain, Behavior, & Immunity - Health. 2020 Sep 11
• 33 citations
  Application of Noninvasive Vagal Nerve Stimulation to Stress-Related Psychiatric Disorders.
  J D Bremner, Nil Z. Gurel, Matthew T. Wittbrodt, Md. Mobashir Hasan Shandhi, Mark Hyman Rapaport, Jonathon A. Nye, Bradley D. Pearce, Viola Vaccarino, Amit J. Shah, Je...> ;Journal of Personalized Medicine. 2020 Sep 9
• 22 citations
  Non-invasive vagal nerve stimulation decreases brain activity during trauma scripts.
  Matthew T. Wittbrodt, Nil Z. Gurel, Jonathon A. Nye, Stacy L. Ladd, Md. Mobashir Hasan Shandhi, Minxuan Huang, Amit J. Shah, Bradley D. Pearce, Zuhayr S. Alam, Mark Hy...> ;Brain Stimulation. 2020 Jul 10
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Journal Articles

• Insomnia and Suicidal Ideation in Non-Affective Psychosis  
  Brian J Miller, Mark H Rapaport, Peter F Buckley, Sleep

Books/Book Chapters

• Psychiatry, 
  Chapter: "Anxiolytic Drugs" 
  Saah TC, Garlow SJ, Rapaport MH, Edwards DM, Hale KL, Maddux, REEditors: A Tasman, J Kay, J Lieberman, M First and M Maj.John Wiley & Sons, Ltd.Edition 4th,2014
• Child Adolesc Psychiatric Clin N Am 
  Chapter: "Building an Evidence Base in Complementary and Integrative Healthcare for Child & Adolescent Psychiatry" 
  Page 509 - 529Edwards E, Mischoulon D, Rapaport MH, Stussman B, Weber WElsevier, Inc.2013
• FOCUS, Maintenance of Certification (MOC) Workbook 
  Chapter: "Major Depressive Disorder" 
  Hales DJ, Rapaport MH, Moeller KAPPI Press2013
• FOCUS, Psychiatry Review 
  Chapter: "400 All New Multiple Choice Questions." 
  Hales DJ, Rapaport MHAPPI Press2011
• The American College of Neuropsycho Pharmacology Textbook of Psychopharmacology 
  Chapter: "Treatment of Depression." 
  Page 1081 - 1111Bresee CJ, Gotto J, Rapaport MHEditors: Schatzberg AF, Nemeroff CB.APPIEdition Four,2009
• Mood and Anxiety Disorders 
  Chapter: "Quality of life impairment in anxiety disorders." 
  Page 275 - 291Koury MA, Rapaport MHEditors: M.S.Ritsner and A.G. Awad.Springer2007
• FOCUS, Psychiatry Review 
  Chapter: "400 Self-Assessment Questions." 
  Hales DJ, Rapaport MHAPPI Press2007
• Handbook of Chronic Depression: Diagnoses and Therapeutic Management 
  Chapter: "Psychopharmacology and psychotherapy of subsyndromal depressions." 
  Page 183 - 206Maddux RE, Rapaport MHEditors: Alpert, Fava.Marcel Dekker2004
• World Psychiatric Association: Evidence and Experience in Psychiatry 
  Chapter: "Burden of phobias: Focus on health-related quality of life." 
  Rapaport MH, Delrahim KK, Maddux REJohn Wiley & Sons Ltd., London2004
• Psychiatry 
  Chapter: "Anxiolytic Drugs." 
  Page 2033 - 2049Maddux RE, Rapaport MHEditors: Tasman A, Kay J, Lieberman J.Wiley & SonsEdition Seco,2003
• Psychoneuroimmunology 
  Chapter: "Immunological states associated with schizophrenia." 
  Page 373 - 382Rapaport MH, Muller NEditors: Ader, Felten, Cohen.Edition Thir,2001
• Psychiatric Clinics of North America 
  Chapter: "Anxiety Disorders." 
  Page 181 - 208Barrett C, Rapaport MH2001
• Psychiatry, Psychoimmunology, and Viruse 
  Chapter: "A preliminary analysis investigating immune activation in schizophrenia." 
  Page 101 - 114Rapaport MH, Caliguiri M, Lohr JB, Dolnak D, Chavez S, Kulesh C, Hahn TEditors: Muller N.1999
• Basic and Clinical Science of Mental and Addictive Disorders 
  Chapter: "The role of subsyndromal depressive symptoms in unipolar major depression." 
  Page 6 - 10Judd LL, Paulus M, Akiskal HS, Rapaport MH, Kunovac JLEditors: Judd LL, Saletu B, and Filip V.Karger Press, Basel, Switzerland1997
• Excerpta Medica IX World Congress of Psychiatry 
  Chapter: "New subtypes of depression: implications for research." 
  Rapaport MH, Judd LLElsevier Press1994
• Exerpta Medica VIII World Congress of Psychiatry 
  Chapter: "Immunological findings in schizophrenia." 
  Rapaport MHElsevier1991
• Psychoimmunology Updates 
  Chapter: "Neuroimmunological factor in schizophrenia." 
  Page 31 - 54Rapaport MH, McAllister CGEditors: Gorman and Kertzner.Amer Psych Press1991
• Schizophrenia 
  Chapter: "The role of autoimmunity in schizophrenia." 
  McAllister CG, Rapaport MH, Paul SMEditors: Schultz and Tamminga.Raven Press1991
• Augmentation Strategies for Treatment Refractory Schizophrenic Patients 
  Chapter: Benzodiazepine augmentation of neuroleptics 
  Wolkowitz OM, Rapaport MH, Pickar DEditors: Schultz and Angrist.Amer Psych Press, Washington, DC1990
• Amer Psych Assoc Annual Update 
  Chapter: "The neurobiology of sleep: basic concepts and clinical implications." 
  Shiromani P, Rapaport MH, Gillin JCEditors: Hales and France.Washington, DC1987
• The American College Neuropsychopharmacology Textbook of Psychopharmacology 
  Chapter: "Treatment of Depression" 
  Shaywitz J, Rapaport MHEditors: Schatzberg AF, Nemeroff CB.APPIEdition Fift,
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Abstracts/Posters

• "Inflammation, Depression and N-3 Fatty Acids: A Case of Personalized Medicine"
  Rapaport MH, Schettler PJ, Pace TW, Kinkead B, Nierenberg AA, Mischoulon D, ACNP 52nd Annual Meeting, Hollywood, FL, 1/1/2013
• "Innovations in Lifelong Learning for Psychiatrists: The Focus System"
  Rapaport MH, Hales D, Moeller K, 52nd Annual NCDEU Meeting, Phoenix, AZ, 1/1/2012
• "The Efficacy of Memantine for Cognitive Deficits in Euthymic Subjects with Bipolar Disorder"
  Isofescu D, Gilmer W, Fan A, Gonenc A, Moore C, Randolph C, Rapaport MH, Deckersbach T, and Nierenberg A, 52nd Annual NCDEU Meeting, Phoenix, AZ, 1/1/2012
• "The Efficacy of the Glutamate NMDA Receptor Antagonist Memantine for Cognitive Deficits in Euthymic Subjects with Bipolar Disorder"
  Iosifescu D, Gilmer W, Fan A, Gonenc A, Moore C, Randolph C, Rapaport MH, Deckersbach T, and Nirenberg A, ACNP 51st Annual Meeting, Hollywood, FL, 1/1/2012
• "Use of Audio-Digital Recordings for External Monitoring to Improve Subject Selection in a Schizophrenia Trial."
  Rapaport MH, Little J, Ereshefsky L, Demartinis N, Targum S, 51st Annual NCDEU Meeting, Boca Raton, FL, 1/1/2011
• "Treating Major Depressive Disorder by Creating Positive Expectations for the Future: A Study for the Efficacy of Future Directed Therapy (FDT)"
  Rapaport, MH, 51st Annual NCDEU Meeting, Boca Raton, FL, 1/1/2011
• "The Biology of Massage: Implications for Psychiatry."
  Rapaport MH, Bresee C, Schettler P, ACNP 49th Annual Meeting, Miami Beach, FL, 1/1/2010
• "Compound Identified by Neurogenesis Platform Shows Promising Efficacy in Treatment of Patients with Major Depressive Disorder with Concomitant Generalized Anxiety Dis...
  Wedel PC, Barlow C, Bleicher LS, Carter TA, Dearie AR, Defratis-robinson J, Drayer JI, Lee DM, Lorrain KI, Pires JC, Rapaport MH, Seehus CR, Schettler PJ, Stoveken BS,..., Society of Neuroscience, 40th Annual Meeting, San Diego, CA, 1/1/2010
• "Use of a Relapse Monitoring Board for Independent Assessment of the Primary End Point in an International Clinical Trial of Bipolar Disorder."
  Turner N, Macfadden W, Anand R, Khanna S, Rapaport MH, Haskins T, Turkoz I, Alphs L, ISCTM Annual Meeting, 1/1/2009
• "Quality of Life in Major Depressive Disorder in a Naturalistic Treatment Setting."
  IsHak WW, Rapaport MH, 49th Annual NCDEU Meeting, 1/1/2009
• "Assessment of the Maximum Tolerated Dose (MTD) of Lurasidone in Patients with Schizophrenia."
  Ereshefsky L, Jhee S, Phillips D, Peterson M, Ogasa M, Gertsik, Loebel A, Rapaport MH, ACNP 48th Annual Meeting, Hollywood, FL, 1/1/2009
• "Quality of Life of Patients with Major Depression in a Natural Clinical Setting"
  Rapaport MH, IsHak WW, FOCUS Live Session, APA Annual Meeting, Washington, DC, 1/1/2008
• "The Role of Oxytocin, Vasopressin and Cortisol in the Beneficial Effects of Massage."
  Rapaport MH, Hale KL, Koury MA, Shubov A, Bresee KJ, Society of Biological Psychiatry, 1/1/2008
• "The Beneficial Effects of Massage Therapy on Psychiatric and Biological Measures."
  Rapaport MH, Koury MA, Hale KL, Bresee KJ, Society of Biological Psychiatry 62nd Annual Scientific Convention and Meeting, 1/1/2007
• "The Effects of Acute and Continuous Massage Therapy on the HPA Axis and Immune Function."
  Rapaport MH, Bresee KJ, American College of Neuropsychopharmacology, 1/1/2007
• "Cytokine Alterations in Medication-Stabilized Patients with Schizophrenia."
  Rapaport MH, Bresee K, Society for Biological Psychiatry 61st Annual Meeting, 1/1/2006
• "A New Approach for Assessing Patients with Generalized Anxiety Disorder or Major Depression and Residual Symptoms."
  Anand R, Gharabawi G, Greist J, Rapaport MH, Sheehan D, American Psychiatric Association 159th Annual Meeting, 1/1/2006
• "Clinical Psychopharmacology and Neurosciences: Keeping-up by Tailoring the Curriculum to the Constituency."
  Glick ID, Rapaport MH, Ketter TA, Zisook S, NCDEU, 1/1/2006
• "Efficacy and Safety of Bifeprunox versus Placebo in the Treatment of Patients with Acute Exacerbations of Schizophrenia."
  Rapaport MH, Barbato LM, Heisterberg J, Yeung PP, Shapiro NA, American College of Neuropsychopharmacology 45th Annual Meeting, 1/1/2006
• "COX-2 Inhibitor Augmentation Therapy for Schizophrenia."
  Rapaport MH, et al, Biological Psychiatry 60th Annual Convention and Scientific Program, 1/1/2005
• "Risperidone Augmentation of Treatment-Resistant Depression: Brain Metabolite Alterations Associated with Treatment Response"
  Gertsik L, Moser F, Rapaport MH, et al, Biological Psychiatry 60th Annual Convention and Scientific Program, 1/1/2005
• "Fluoxetine Not Found to Increase Suicidality Over Placebo During Treatment of Adults with Minor Depressive Disorder."
  Thase ME, Rush JA, Rapaport MH, et al, Biological Psychiatry 60th Annual Convention and Scientific Program, 1/1/2005
• "Clinical Characteristics of Patients With Minor Depression."
  Howland RH, Nierenberg A, Rapaport MH, APA, 1/1/2005
• "Treatment Augmentation with Risperidone for Patients with Resistant Depression."
  Rapaport MH, Canuso CM, Rouillon F, Leblanc J, Young AH, Loescher A, Bossie CA, Turkoz I, Gharabawi GM, and the ARISe-RD Study Group, APA, 1/1/2004
• "Improvement in Quality of Life with Risperidone Augmentation in Resistant Depression."
  Walling D, Rapaport MH, Rupnow MFT, Canuso CM, Gharabawi GM, APA, 1/1/2004
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Lectures

• Grand Rounds: "Inflammation, Depression, Omega-3 Fatty Acids: A Proof of Concept" 
  UCLA Semel Institute, Los Angeles, CA - 1/1/2014
• Panel Presentation: "How does Massage Work? Potential Mechanisms" 
  Massage Therapy Foundation, Boston, MA - 1/1/2013
• "Maintenance of Certification Workshop" 
  Atlanta, GA - 1/1/2013
• FOCUS "Major Depressive Disorder Maintenance of Certification (MOC) Workbook", Small Interactive Sessions 
  San Francisco, CA - 1/1/2013
• "Immunotherapeutic approaches for the treatment of depression" 
  Kyoto, Japan - 1/1/2013
• Workshop 69: "ABPN and APA Perspectives on "Maintenance of Certification" 
  San Francisco, CA - 1/1/2013
• NCDEU NIA Program Panel Discussion, "Extramural Perspective" 
  Hollywood, FL - 1/1/2013
• NCDEU NIA Program, "Getting a Job and Keeping It? 
  Hollywood, FL - 1/1/2013
• "Residual Symptoms in Depression: Management and Prognosis" 
  Shanghai Mental Health Center, Shanghai, PR China - 1/1/2012
• Symposium "Psychoneuroimmunology in the Service of Personalized Medicine in Psychiatry" 
  Prague, Czech Republic - 1/1/2012
• Mental Health Lecture Series, "A Review of CAM Treatments for Mood and Anxiety Disorders, the Good, the Bad and the Ugly" 
  School of Public Health, Emory University, Atlanta, GA - 1/1/2012
• "Mood Disorders" 
  The Carter Center, Atlanta, GA - 1/1/2012
• Special Session: "Innovations in Life Long Learning for Psychiatrists: The Focus System" 
  Phoenix, AZ - 1/1/2012
• "CAM: Implications for Mood & Anxiety Disorders" 
  Philadelphia, PA - 1/1/2012
• "Bipolar Spectrum Disorders: Underdiagnosed? Over-diagnosed? Strategies for Treatment" 
  1/1/2012
• "Off the Couch: Why Atlanta Can Transform Psychiatry in the 21st Century" 
  Skyland Trail, Atlanta, GA - 1/1/2011
• "Complementary and Alternative Medicine" 
  Toronto, Canada - 1/1/2011
• "Grant Writing Workshop for Complementary and Integrative Medicine" 
  Toronto, Canada - 1/1/2011
• "Major Depressive disorder: Where are We Going?" 
  Las Vegas, NV - 1/1/2011
• "Diagnosis and Treatment of Bipolar Disorder" 
  Tucson, AZ - 1/1/2011
• Grand Rounds: "Complementary and Alternative Therapies for Mood and Anxiety Disorders: The Good, the Bad, and the Ugly" 
  Georgia Health University, Augusta, GA - 1/1/2011
• "Psychopharmacology for Depression and Mood Disorders: Tips for Success" 
  Atlanta, GA - 1/1/2011
• Case Presentation: "What Next? A case Presentation of Treatment Resistant Depression" 
  Atlanta, GA - 1/1/2011
• Round Table Discussion: "Immunology and Psychiatry" 
  Munich, Germany - 1/1/2010
• "Immune Sequelae in Schizophrenia: the Quest for Testable Hypotheses" 
  Munich, Germany - 1/1/2010
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Other

• "A placebo-controlled study of topiramate in acute mania (bipolar I disorder): Trials and tribulations of conducting an acute mania study." 
  Van Kammen DP, Chengappa KNR, Shiwach R, Lesem M, Wang D, Topamax Psychiatry Phase II Study Group
  1/1/2003
• "Case history: major depressive disorder in a middle-aged female" 
  Zisook S, Rapaport MH
  Medical Age Publishing, Norwalk, CT - 1/1/1997