Mark M Souweidane MD
Brain & Spinal Tumor, Pediatric Neurosurgery
Professor of Neurological Surgery and Pediatrics, Weill Cornell Medicine and Memorial Sloan-Kettering Cancer Center
1275 York AvenueNew York, NY 10065
Overview of Dr. Souweidane
Mark M. Souweidane, MD, has dedicated his career to the surgical treatment of children with brain and spinal disorders. His talents as a surgeon are paralleled by a caring attitude and time commitment to patients and their families. That the Weill Cornell Medical College is a recognized leader in Pediatric Neurosurgery is a direct result of his recruitment in 1995 and his ongoing devotion to contemporary surgical techniques and investigative endeavors.
Dr. Souweidane's specialized surgical skills have gained him international reputation for specific procedures, including removal of intraventricular brain tumors, management of pineal region tumors, treatment of congenital cysts, and surgery for Chiari malformation.
In addition to the development of a world-class Pediatric Neurosurgery service, Dr. Souweidane has championed minimal access neurosurgery. His publications, clinical case volume, and practical courses continue to draw patients and practitioners that benefit from his endoscopic talents. His commitment to the education of future pediatric neurosurgeons is reflected in his participation on the Committee of Admissions for the medical college, his lectures to medical school students, his role as resident advisor, and resident mentoring at one of the country's premier training programs.
Education & Training
NYU Grossman School of MedicineResidency, Neurological Surgery, 1989 - 1994
University of Michigan Health SystemInternship, Transitional Year, 1988 - 1989
Wayne State University School of MedicineClass of 1988
Certifications & Licensure
FL State Medical License 2022 - Present
CT State Medical License 2022 - 2026
NY State Medical License 1992 - 2026
American Board of Neurological Surgery Neurological Surgery
Awards, Honors, & Recognition
- America's Top Doctors Castle Connolly, 2011-2014
- New York Magazine: Top Doctors Castle Connolly, 2010-2014
- Top Doctors: New York Metro Area Castle Connolly, 2005-2014
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Clinical Trials
- Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors Start of enrollment: 2004 Feb 16
- Convection-Enhanced Delivery of 124I-Omburtamab for Patients With Non-Progressive Diffuse Pontine Gliomas Previously Treated With External Beam Radiation Therapy Start of enrollment: 2011 Dec 01
- Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 Start of enrollment: 2013 Jun 01
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Publications & Presentations
PubMed
- Diffuse midline glioma with extra central nervous system metastases in the pediatric, adolescent, and young adult population.Alexandra M Giantini-Larsen, Andrew L A Garton, Maricruz Rivera, Rachael Han, David J Pisapia
Child's Nervous System. 2025-10-07 - 4 citationsPhase 1 dose-escalation trial using convection-enhanced delivery of radio-immunotheranostic 124I-Omburtamab for diffuse intrinsic pontine glioma.Mark M Souweidane, Evan D Bander, Pat Zanzonico, Anne S Reiner, Nicole Manino
Neuro-Oncology. 2025-09-17 - Financial toxicity in pediatric and adolescent neurosurgical oncology.Alexandra M Giantini-Larsen, Samantha Brown, Anne S Reiner, Stephanie Doyle Giandalone, Kyle Zappi
Journal of Neuro-Oncology. 2025-09-01
Authored Content
- Do Craniopharyngioma Molecular Signatures Correlate with Clinical Characteristics? RelatedMay 2018
- Do Craniopharyngioma Molecular Signatures Correlate with Clinical Characteristics? RelatedMay 2018
Press Mentions
Novel Treatment Delivers Medication to the Brainstem to Treat Aggressive Pediatric Brain TumorMay 12th, 2025- Trial Shows Targeted Treatment for Childhood Brain Tumor Is SafeApril 3rd, 2025
- Experimental Treatment Borrowed from Blood Cancer Shows Promise for Pediatric Brain TumorsMarch 19th, 2025
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Professional Memberships
- Member
- Fellow
- Fellow
- Member
- Member
Insurance Accepted
- Aetna Choice POS II
Aetna HMO
BCBS Blue Card PPO
CIGNA HMO
CIGNA Open Access
CIGNA PPO
Empire BCBS HMO
Empire BCBS PPO
GHI PPO
Great West PPO
HIP of New York - Select PPOHumana ChoiceCare Network PPO
Multiplan PHCS PPO
Multiplan PPO
MVP Healthcare PPO
Oxford Health Freedom
Oxford Health Liberty
QualCare HMO
QualCare PPO
United Healthcare - Direct Choice Plus POS
United Healthcare - Direct Options PPO - Please verify your coverage with the provider's office directly when scheduling an appointment
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