MarkATarnopolskyMDPhD

Professor of Pediatrics and Medicine at McMaster University / President and CEO of Exerkine Corporation / Director of Neuromuscular and Neurometabolic Clinic at McMaster University Medical Center

Join to view full profile

Dr. Tarnopolsky is on Doximity

As a Doximity member you'll join over two million verified healthcare professionals in a private, secure network.

Connect with other colleagues in the same hospital or clinic
Search all U.S. specialist profiles and refer a patient
Read the latest clinical news and earn CME/CEU credits

See Dr. Tarnopolsky's full profile

Already have an account?

Office
McMaster University Medical Center
(Canada)
Rochester, NY 14642
Is this information wrong?

Education & Training

Michael G. DeGroote School of MedicineClass of 1988

Clinical Trials

(Mol-SHARE) Molecular Study of Health Assessment and Risk in Ethnic Groups Start of enrollment: 2005 Nov 01
Unknown status
Older Adult Training Study With Creatine and CLA Start of enrollment: 2003 Aug 01
Completed
Not Applicable
A Study Investigating the Safety and Tolerability of Deferiprone in Patients With Friedreich's Ataxia Start of enrollment: 2008 Apr 01
Completed
Phase 1, Phase 2
GNE-Myopathy Disease Monitoring Program (GNEM-DMP): A Registry and Prospective Observational Natural History Study to Assess GNE Myopathy or Hereditary Inclusion Body Myopathy (HIBM) Start of enrollment: 2013 Apr 05
Completed
Evaluation of a Supplement for Weight Management in Obese and Overweight Individuals Start of enrollment: 2019 Mar 01
Completed
Not Applicable
Myotonic Dystrophy Type 1 Aerobic Exercise Study Start of enrollment: 2019 Dec 06
Completed
Not Applicable
Supplementation for Male Subfertility Start of enrollment: 2024 Feb 02
Not yet recruiting
Phase 2
Roles: Principal Investigator, Contact
Home-based Training and Supplementation in DM1 Patients Start of enrollment: 2024 Jan 01
Not yet recruiting
Phase 3
Roles: Contact, Principal Investigator
Nutritional Therapy in Late-onset Pompe Disease Start of enrollment: 2024 Apr 01
Not yet recruiting
Phase 2
Roles: Principal Investigator
Join now to see all

Publications & Presentations

PubMed

23 citations
Management of mitochondrial diabetes in the era of novel therapies.
Roseanne O. Yeung, Mohammad Al Jundi, Sriram Gubbi, Maria E. Bompu, Sandra Sirrs, Mark A. Tarnopolsky, Fady Hannah-Shmouni> ;Journal of Diabetes and Its Complications. 2021 Jan 1
38 citations
A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly.
Mats I. Nilsson, Andrew S. Mikhail, Lucy Lan, Alessia Di Carlo, Bethanie Hamilton, Kristin Barnard, Bart P. Hettinga, Erin Hatcher, Milla G. Tarnopolsky, Joshua P. Ned...> ;Nutrients. 2020 Aug 10
4 citations
Bone marrow-derived mitochondrial DNA has limited capacity for inter-tissue transfer in vivo.
Mark A. Tarnopolsky, Jennifer Kerkhof, Alan Graham Stuart, Adam L. Bujak, Mats I. Nilsson, Bart P. Hettinga, Linda May, C. Anthony Rupar, Bekim Sadikovic> ;FASEB Journal. 2020 Jul 1
9 citations
Muscle and serum myostatin expression in type 1 diabetes.
Athan G. Dial, Cynthia M. F. Monaco, Grace K. Grafham, Nadya Romanova, Jeremy A. Simpson, Mark A. Tarnopolsky, Christopher G. R. Perry, Evangelia Kalaitzoglou, Thomas ...> ;Physiological Reports. 2020 Jul 1
10 citations
Increased intra-mitochondrial lipofuscin aggregates with spherical dense body formation in mitochondrial myopathy.
Jian-Qiang Lu, Cynthia M. F. Monaco, Thomas J. Hawke, Chuanzhu Yan, Mark A. Tarnopolsky> ;Journal of the Neurological Sciences. 2020 Jun 15
1 citations
A mitochondrial disorder with ptosis and exercise intolerance without ophthalmoparesis secondary to m.5865 T > C variant.
Rashid Alshahoumi, Lauren Brady, Mark A. Tarnopolsky> ;Mitochondrion. 2020 Jul 1
Response to “Relation between intra-mitochondrial inclusions and pathophysiology of mitochondrial myopathy remains unprecise”
Jian-Qiang Lu, Mark A. Tarnopolsky> ;Journal of the Neurological Sciences. 2020 May 11
1 citations
Correction: Lifelong aerobic exercise protects against inflammaging and cancer
Mats I. Nilsson, Jacqueline M. Bourgeois, Joshua P. Nederveen, Marlon R. Leite, Bart P. Hettinga, Adam L. Bujak, Linda May, Ethan Lin, Michael Crozier, Daniel Rusiecki...> ;Plos One. 2020 May 13
17 citations
A biallelic pathogenic variant in the OGDH gene results in a neurological disorder with features of a mitochondrial disease.
Zheng Yie Yap, Klaudia Strucinska, Satoshi Matsuzaki, Sukyeong Lee, Yue Si, Kenneth M. Humphries, Mark A. Tarnopolsky, Wan Hee Yoon> ;Journal of Inherited Metabolic Disease. 2021 Mar 1
13 citations
Congenital myasthenic syndrome-associated agrin variants affect clustering of acetylcholine receptors in a domain-specific manner.
Bisei Ohkawara, Xin Ming Shen, Duygu Selcen, Mohammad Nazim, Vera Bril, Mark A. Tarnopolsky, Lauren Brady, Sae Fukami, Anthony A. Amato, Uluç Yiş, Kinji Ohno, Andrew G...> ;JCI Insight. 2020 Apr 9
28 citations
Intracellular calcium leak as a therapeutic target for RYR1-related myopathies.
Alexander Kushnir, Joshua J. Todd, Jessica W Witherspoon, Qi Yuan, Steven Reiken, Harvey Lin, Ross H Munce, Benjamin Wajsberg, Zephan Melville, Oliver B. Clarke, Kayle...> ;Acta Neuropathologica. 2020 Mar 31
27 citations
Mitochondrial diseases in North America: An analysis of the NAMDC Registry.
Emanuele Barca, Yuelin Long, Victoria Cooley, Robert Schoenaker, Valentina Emmanuele, Salvatore DiMauro, Bruce H. Cohen, Amel Karaa, Georgirene D. Vladutiu, Richard Ha...> ;Neurology. Genetics. 2020 Mar 2
1 citations
Correction to: Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes.
Cynthia M. F. Monaco, Meghan C. Hughes, Sofhia V. Ramos, Nina E. Varah, Christian Lamberz, Fasih A. Rahman, Chris McGlory, Mark A. Tarnopolsky, Matthew P. Krause, Robe...> ;Diabetologia. 2020 Jan 28
15 citations
Choline transporter-like 1 deficiency causes a new type of childhood-onset neurodegeneration
Christina Fagerberg, Adrian Taylor, Felix Distelmaier, Henrik Daa Schrøder, Maria Kibaek, Dagmar Wieczorek, Mark A. Tarnopolsky, Lauren Brady, Martin Jakob Larsen, Ram...> ;Brain. 2020 Jan 1
13 citations
Infantile-onset syndromic cerebellar ataxia and CACNA1G mutations
Sabina Barresi, Maria Lisa Dentici, Francesca Manzoni, Emanuele Bellacchio, Emanuele Agolini, Simone Pizzi, Andrea Ciolfi, Mark A. Tarnopolsky, Lauren Brady, Giacomo G...> ;Pediatric Neurology. 2020 Mar 1
8 citations
An evaluation of genetic causes and environmental risks for bilateral optic atrophy.
Andrew T. Chen, Lauren Brady, Dennis E. Bulman, Arun N E Sundaram, Amadeo R. Rodriguez, Edward Margolin, John S. Waye, Mark A. Tarnopolsky> ;Plos One. 2019 Nov 25
5 citations
Severe chorioretinal atrophy in Boucher-Neuhauser syndrome.
Laura Donaldson, Mark A. Tarnopolsky, James Martin, Amadeo R. Rodriguez> ;Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie. 2020 Feb 1
3 citations
Health Care for Mitochondrial Disorders in Canada: A Survey of Physicians.
Karen Paik, Matthew A. Lines, Pranesh Chakraborty, Sara D. Khangura, Maureen Latocki, Walla Al-Hertani, Catherine Brunel-Guitton, Aneal Khan, Blaine Penny, Cheryl Rock...> ;The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 2019 Nov 1
3 citations
Effect of short-term, high-intensity exercise training on human skeletal muscle citrate synthase maximal activity: single versus multiple bouts per session.
Martin J. MacInnis, Lauren E. Skelly, F. Elizabeth Godkin, Brian J. Martin, Thomas R. Tripp, Mark A. Tarnopolsky, Martin J. Gibala> ;Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme. 2019 Oct 16
14 citations
Genotypes of chronic progressive external ophthalmoplegia in a large adult-onset cohort.
Julia N. Heighton, Lauren Brady, Bekim Sadikovic, Dennis E. Bulman, Mark A. Tarnopolsky> ;Mitochondrion. 2019 Nov 1
5 citations
Statin administration activates system xC− in skeletal muscle: a potential mechanism explaining statin-induced muscle pain
Irena A. Rebalka, Andrew W. Cao, Linda May, Mark A. Tarnopolsky, Thomas J. Hawke> ;American Journal of Physiology. Cell Physiology. 2019 Nov 1
2 citations
Neurodevelopmental and associated changes in a patient with Xp22.31 duplication.
Christine MacColl, Nina Stein, Mark A. Tarnopolsky, Jian-Qiang Lu> ;Neurological Sciences. 2020 Mar 1
5 citations
Obesity and muscle-macrophage crosstalk in humans and mice: A systematic review.
Srikesh Rudrapatna, Meha Bhatt, Kuan-Wen Wang, Rachel Bierbrier, Pei-Wen Wang, Laura Banfield, Wagdi Elsheikh, E. Danielle Sims, Devin Peterson, Lehana Thabane, Mark A...> ;Obesity Reviews. 2019 Aug 13
3 citations
Expanding the Phenotype: Neurodevelopmental Disorder, Mitochondrial, With Abnormal Movements and Lactic Acidosis, With or Without Seizures (NEMMLAS) due to WARS2 Biall...
Manveen Virdee, Eroshini Swarnalingam, Mariya Kozenko, Mark Tarnopolsky, Kevin Jones> ;Journal of Child Neurology. 2019 Oct 1
9 citations
Nutrition and exercise in Pompe disease.
Mark A. Tarnopolsky, Mats I. Nilsson> ;Annals of Translational Medicine. 2019 Jul 1
Join now to see all

Press Mentions

This Scientist Made a Skin-Care Brand That Mimics the Effects of Exercise on Your Skin—Here’s HowApril 16th, 2021
An Autosomal Dominant Neurological Disorder Caused by De Novo Variants in FAR1 Resulting in Uncontrolled Synthesis of Ether LipidsNovember 26th, 2020
Tips for Diagnosing Metabolic MyopathiesSeptember 17th, 2019
Join now to see all