MarkKarlWedelMD

PubMed

• 20 citations
  Antisense inhibition of apoB synthesis with mipomersen reduces plasma apoC-III and apoC-III-containing lipoproteins
  Jeremy D. Furtado, M. K. Wedel, Frank M. Sacks> ;Journal of Lipid Research. 2012 Apr 1
• 93 citations
  Efficacy of apolipoprotein B synthesis inhibition in subjects with mild-to-moderate hyperlipidaemia.
  Fatima Akdim, Diane Tribble, JoAnn Flaim, Rosie Z. Yu, John Su, Richard S. Geary, Brenda F. Baker, Rainard Fuhr, Mark K. Wedel, John J.P. Kastelein> ;European Heart Journal. 2011 May 18
• 115 citations
  Efficacy and Safety of Mipomersen, an Antisense Inhibitor of Apolipoprotein B, in Hypercholesterolemic Subjects Receiving Stable Statin Therapy
  Fatima Akdim, Erik S.G. Stroes, Eric J.G. Sijbrands, Diane Tribble, Mieke D. Trip, J. Wouter Jukema, JoAnn Flaim, John Su, Rosie Z. Yu, Brenda F. Baker, Mark K. Wedel,...> ;Journal of the American College of Cardiology. 2010 Apr 13
• 87 citations
  Cross-species comparison of in vivo PK/PD relationships for second-generation antisense oligonucleotides targeting apolipoprotein B-100
  Rosie Z. Yu, Kristina M. Lemonidis, Mark J. Graham, John Matson, Rosanne M. Crooke, Diane Tribble, Mark K. Wedel, Arthur A. Levin, Richard S. Geary> ;Biochemical Pharmacology. 2009 Mar 1
• 73 citations
  Lack of Pharmacokinetic Interaction of Mipomersen Sodium (ISIS 301012), a 2′-—O-Methoxyethyl Modified Antisense Oligonucleotide Targeting Apolipoprotein B-100 Messenge...
  Rosie Z. Yu, Richard S. Geary, Jo Ann D. Flaim, Gina C. Riley, Diane Tribble, André A. vanVliet, Mark K. Wedel> ;Clinical Pharmacokinetics. 2009 Jan 1
• 92 citations
  A randomized, double-masked, placebo-controlled study of alicaforsen, an antisense inhibitor of intercellular adhesion molecule 1, for the treatment of subjects with a...
  Bruce R. Yacyshyn, William Y. Chey, Mark K. Wedel, Rosie Z. Yu, David L. Paul, Emil Chuang> ;Clinical Gastroenterology and Hepatology. 2007 Feb 1
• 267 citations
  Potent Reduction of Apolipoprotein B and Low-Density Lipoprotein Cholesterol by Short-Term Administration of an Antisense Inhibitor of Apolipoprotein B
  John J.P. Kastelein, Mark Wedel, Brenda F. Baker, John Su, Joann D. Bradley, Rosie Z. Yu, Emil Chuang, Mark J. Graham, Rosanne M. Crooke> ;Circulation. 2006 Oct 17
• 40 citations
  Bioavailability and therapeutic activity of alicaforsen (ISIS 2302) administered as a rectal retention enema to subjects with active ulcerative colitis.
  P. B. Miner, Richard S. Geary, John Matson, Emil Chuang, Shuting Xia, Brenda F. Baker, Mark K. Wedel> ;Alimentary Pharmacology & Therapeutics. 2006 May 1
• 76 citations
  Safety and efficacy of two dose formulations of alicaforsen enema compared with mesalazine enema for treatment of mild to moderate left-sided ulcerative colitis: a ran...
  P. B. Miner, Mark K. Wedel, Shuting Xia, Brenda F. Baker> ;Alimentary Pharmacology & Therapeutics. 2006 May 1
• 97 citations
  A phase II dose ranging, double-blind, placebo-controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left-sided ulcerative coli...
  S. J. H. Van Deventer, Mark K. Wedel, Brenda F. Baker, Shuting Xia, Emil Chuang, P. B. Miner> ;Alimentary Pharmacology & Therapeutics. 2006 May 1
• 123 citations
  Partial liquid ventilation in adult patients with acute respiratory distress syndrome.
  Robert M. Kacmarek, Herbert P. Wiedemann, Philip T. Lavin, Mark K. Wedel, Ahmet Tutuncu, Arthur S. Slutsky> ;American Journal of Respiratory and Critical Care Medicine. 2006 Apr 15
• 31 citations
  Lack of pharmacokinetic interaction for ISIS 113715, a 2'-0-methoxyethyl modified antisense oligonucleotide targeting protein tyrosine phosphatase 1B messenger RNA, wi...
  Richard S. Geary, JoAnn D Bradley, Tanya Watanabe, Younggil Kwon, Mark K. Wedel, Jan J van Lier, André A. vanVliet> ;Clinical Pharmacokinetics. 2006 Jan 1
• 111 citations
  A randomised, controlled, double blind, escalating dose study of alicaforsen enema in active ulcerative colitis
  S. J. H. Van Deventer, J A Tami, Mark K. Wedel> ;Gut. 2004 Nov 1
• 102 citations
  An enema formulation of alicaforsen, an antisense inhibitor of intercellular adhesion molecule-1, in the treatment of chronic, unremitting pouchitis.
  Philip B. Miner, Mark K. Wedel, B. Bane, J. Bradley> ;Alimentary Pharmacology & Therapeutics. 2004 Feb 1
• 4 citations
  Clinical Correlation With Changing Radiographic Appearance During Partial Liquid Ventilation
  Daniel P. Schuster, Ahmet Tutuncu, Mark K. Wedel> ;Chest. 2001 May 1
• 3 citations
  Toxic Shock Syndrome
  Mark K. Wedel, Thomas K. Slack, David N. Williams> ;Chest. 1981 May 1
• 7 citations
  Prolonged survival in an adult with cystic fibrosis.
  J. Scott Sanders, Timothy D. Pryor, Mark K. Wedel> ;Chest. 1980 Feb 1
• 26 citations
  Adult Respiratory Distress Syndrome Associated with Colchicine Intoxication
  Robert N. Hill, Roger G. Spragg, Mark K. Wedel, Kenneth M. Moser> ;Annals of Internal Medicine. 1975 Oct 1
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