MarkThomasWorthingtonMDAGAF

Gastroenterology • Charlottesville, VA

Inflammatory Bowel Disease

Gastroenterologist

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Office
1215 Lee Street
Charlottesville, VA 22903
Phone+1 434-243-3090
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Education & Training

Johns Hopkins UniversityFellowship, Gastroenterology, 1991 - 1994
Johns Hopkins UniversityResidency, Internal Medicine, 1987 - 1990
Vanderbilt University School of MedicineClass of 1987

Certifications & Licensure

AZ State Medical License 2010 - 2025
VA State Medical License 1996 - 2024
MD State Medical License 1990 - 2013
American Board of Internal Medicine Gastroenterology

Awards, Honors, & Recognition

Top Doctors:Arizona State Castle Connolly, 2013-2022
Doctor of the Year Yavapai Regional Medical Center, 2016
Fellow (AGAF) American Gastroenterological Association, 2007

Publications & Presentations

PubMed

81 citations
A phase Ib, dose-finding study of multiple doses of remimazolam (CNS 7056) in volunteers undergoing colonoscopy
Mark T. Worthington, Laurie J. Antonik, D. Ronald Goldwater, James P. Lees, Karin Wilhelm-Ogunbiyi, Keith M. Borkett, Mack C. Mitchell> ;Anesthesia and Analgesia. 2013 Nov 1
14 citations
Inhibition of tristetraprolin deadenylation by poly(A) binding protein.
Robert M. Rowlett, Carol A. Chrestensen, Melanie J. Schroeder, Mary G. Harp, Jared W. Pelo, J. Shabanowitz, Robert DeRose, Donald F. Hunt, Thomas W. Sturgill, Mark T. ...> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2008 Sep 1
61 citations
MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages
Robert M. Rowlett, Carol A. Chrestensen, Mark Nyce, Mary G. Harp, Jared W. Pelo, Fabio Cominelli, Peter B. Ernst, Theresa T. Pizarro, Thomas W. Sturgill, Mark T. Worth...> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2008 Feb 1
44 citations
MNK1 and MNK2 Regulation in HER2-overexpressing Breast Cancer Lines
Carol A. Chrestensen, Jacquelyn K. Shuman, Andrew Eschenroeder, Mark T. Worthington, Hermann Gram, Thomas W. Sturgill> ;The Journal of Biological Chemistry. 2007 Feb 16
196 citations
Cutting edge : Critical role for A2A adenosine receptors in the T cell-mediated regulation of colitis
Makoto Naganuma, Elizabeth B. Wiznerowicz, Courtney M. Lappas, Joel Linden, Mark T. Worthington, Peter B. Ernst> ;Journal of Immunology. 2006 Sep 1
300 citations
Identification of a human heme exporter that is essential for erythropoiesis.
John G. Quigley, Zhantao Yang, Mark T. Worthington, John D. Phillips, Kathleen M. Sabo, Daniel E. Sabath, Carl L. Berg, Shigeru Sassa, Brent L. Wood, Janis L. Abkowitz> ;Cell. 2004 Sep 17
228 citations
MAPKAP Kinase 2 Phosphorylates Tristetraprolin on in Vivo Sites Including Ser178, a Site Required for 14-3-3 Binding
Carol A. Chrestensen, Melanie J. Schroeder, Jeffrey Shabanowitz, Donald F. Hunt, Jared W. Pelo, Mark T. Worthington, Thomas W. Sturgill> ;The Journal of Biological Chemistry. 2004 Mar 12
39 citations
A Cys3His zinc-binding domain from Nup475/tristetraprolin: a novel fold with a disklike structure.
Barbara T. Amann, Mark T. Worthington, Jeremy M Berg> ;Biochemistry. 2003 Jan 14
102 citations
RNA binding properties of the AU-rich element-binding recombinant Nup475/TIS11/tristetraprolin protein.
Mark T. Worthington, Jared W. Pelo, Muhammadreza A. Sachedina, Joan L. Applegate, Kristen O. Arseneau, Theresa T. Pizarro> ;The Journal of Biological Chemistry. 2002 Dec 13
9 citations
B cells engineered to express Fas ligand suppress pre-sensitized antigen-specific T cell responses in vivo.
Michele M. Kosiewicz, Anasuya Krishnan, Mark T. Worthington, James A. Matriano, William Ross> ;European Journal of Immunology. 2002 Jun 1
7 citations
Cloning of random oligonucleotides to create single-insert plasmid libraries.
Mark T. Worthington, Jared W. Pelo, Roger Qi Luo> ;Analytical Biochemistry. 2001 Jul 15
67 citations
Characterization of a human plasma membrane heme transporter in intestinal and hepatocyte cell lines
Mark T. Worthington, Steven M. Cohn, Suzanne K. Miller, Roger Qi Luo, Carl L. Berg> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2001 Jun 1
9 citations
Copacabana method for spreading E. coli and yeast colonies
Mark T. Worthington, Roger Qi Luo, Jared W. Pelo> ;Biotechniques. 2001 Apr 1
Transfection Assays for Transformation of Model Colonic Cell Lines
Mark T. Worthington, Roger Qi Luo> ;Methods in Molecular Medicine. 2001 Jan 1
23 citations
Functional properties of transfected human DMT1 iron transporter.
Mark T. Worthington, Lauren Browne, Emily H. Battle, Roger Qi Luo> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2000 Dec 1
Expression of heterologous proteins in Saccharomyces cerevisiae using the ADH2 promoter.
Price, V. L., Taylor, W. E., Clevenger, W., Worthington, M., Young, E. T.> ;Methods Enzymol. 1990
Metal binding properties and secondary structure of the zinc-binding domain of Nup475.
Worthington, M. T., Amann, B. T., Nathans, D., Berg, J. M.> ;Proc Natl Acad Sci U S A. 1996 Nov 26
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Press Mentions

Athira Pharma Extends Alzheimer’s Clinical Trial, Adds New Execs After CEO Placed on LeaveAugust 16th, 2021
Two Months After Inking a SPAC Deal, Renovacor Taps New CMO; CureVac Reels in a New Development Chief from Merck KGaAJune 4th, 2021
Athira Pharma Appoints Mark Worthington as General CounselJune 1st, 2021
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Grant Support

Function Of Nup475 In The Gastrointestinal TrackNational Institute Of Diabetes And Digestive And Kidney Diseases2002–2005
Function Of Nup475 In The Gastrointestinal TractNational Institute Of Diabetes And Digestive And Kidney Diseases1998–2002