MarkJosephWoyshvilleMDClinical Research and Practice

Psychiatry • Cleveland, OH

Addiction, Sleep Medicine

CEO and Medical Director North Star Medical Research, LLC

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Office
18660 Bagley Rd
Building Ii Suite 205
Cleveland, OH 44130
Phone+1 440-234-5700

Fax+1 440-234-5710
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Education & Training

Case Western Reserve University/University Hospitals Cleveland Medical CenterFellowship, Consultation-Liaison Psychiatry, 1992 - 1993
University of California (San Diego) Medical CenterResidency, Psychiatry, 1990 - 1992
Cleveland Clinic FoundationInternship, Transitional Year, 1989 - 1990
University of Cincinnati College of MedicineClass of 1989
University of California San Diego School of MedicinePost-Baccalaureate Studies, Chemistry, Biology, Mathematics, 1984 - 1985
Cleveland State UniversityB.S., Physics, 1976 - 1982

Certifications & Licensure

CA State Medical License 1990 - Present
OH State Medical License 1992 - 2025
American Board of Psychiatry and Neurology Psychiatry
American Board of Preventive Medicine Addiction Medicine
State of OhioCertificate to Recommend Medical Marijuana

Awards, Honors, & Recognition

Young Investigator Award National Alliance for Research on Schizophrenia and Depression (NARSAD), 1994

Clinical Trials

Efficacy, Safety and Tolerability of CX157 in Treatment Resistant Depression Start of enrollment: 2010 Nov 01
Completed
Phase 2
12-Week Study of Plecanatide for CIC (The National CIC3 Study) Start of enrollment: 2014 Apr 01
Completed
Phase 3
Dasotraline Pediatric ADHD Study Start of enrollment: 2015 Apr 01
Completed
Phase 2, Phase 3
Ecopipam Tablets to Study Tourette Syndrome in Children and Adolescents - Open Label Extension Start of enrollment: 2019 Oct 04
Completed
Phase 2
OXD01 in Combination With Sublingual Buprenorphine/Naloxone for Treatment of Opioid Use Disorder Start of enrollment: 2021 Jun 30
Completed
Not Applicable
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

73 citations
On the meaning and measurement of affective instability: clues from chaos theory.
Mark J. Woyshville, Jeanne Lackamp, Jonathan A Eisengart, Joyce A.M Gilliland> ;Biological Psychiatry. 1999 Feb 1
81 citations
Antidepressant effects of lamotrigine in rapid cycling bipolar disorder
Joseph R. Calabrese, S H Fatemi, Mark J. Woyshville> ;The American Journal of Psychiatry. 1996 Sep 1
72 citations
Predictors of response to mood stabilizers
Joseph R. Calabrese, S. Hossein Fatemi, Mary J. Kujawa, Mark J. Woyshville> ;Journal of Clinical Psychopharmacology. 1996 Apr 1
178 citations
Clozapine for Treatment-Refractory Mania
Joseph R. Calabrese, Susan E. Kimmel, Mark J. Woyshville, Daniel J. Rapport, Carl J. Faust, Paul M. Thompson, Herbert Y. Meltzer> ;The American Journal of Psychiatry. 1996 Jun 1
26 citations
Lithium therapy: limitations and alternatives in the treatment of bipolar disorders.
Joseph R. Calabrese, Mark J. Woyshville> ;Annals of Clinical Psychiatry. 1995 Jun 1
50 citations
Quantification of occipital EEG changes in Alzheimer's disease utilizing a new metric: The fractal dimension
Mark J. Woyshville, Joseph R. Calabrese> ;Biological Psychiatry. 1994 Mar 15
79 citations
Predictors of valproate response in bipolar rapid cycling.
Joseph R. Calabrese, Mark J. Woyshville, Susan E. Kimmel, Daniel J. Rapport> ;Journal of Clinical Psychopharmacology. 1993 Aug 1
39 citations
Rapid cycling bipolar disorder and its treatment with valproate.
Joseph R. Calabrese, Daniel J. Rapport, Susan E. Kimmel, B Reece, Mark J. Woyshville> ;Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie. 1993 Apr 1
A medication algorithm for treatment of bipolar rapid cycling?
Calabrese, J. R., Woyshville, M. J.> ;J Clin Psychiatry. 1995
Clozapine in treatment-refractory mood disorders.
Kimmel, S. E., Calabrese, J. R., Woyshville, M. J., Meltzer, H. Y.> ;J Clin Psychiatry. 1994 Sep
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Journal Articles

Insomnia: An Overview
Woyshville MJ, Ahmed M, Indian Journal of Sleep Medicine, 1/1/2006
On the meaning and measurement of affective instability: Clues from chaos theory
Woyshville MJ, Lackamp JM, Eisengart JA, Gilliland JAM, Biological Psychiatry, 1/1/1999
Clozapine in treatment refractory mania
Calabrese JR, Kimmel SE, Woyshville MJ, et al, American Journal of Psychiatry, 1/1/1996
Predictors of differential response to mood stabilizers
Calabrese JR, Fatemi SH, Kujawa M, Woyshville MJ, Journal of Clinical Psychopharmacology, 1/1/1996
Lithium therapy: Limitations and alternatives in the treatment of bipolar disorders
Calabrese JR, Woyshville MJ, Annals of Clinical Psychiatry, 1/1/1995
A medication algorithm for treatment of rapid cycling?
Calabrese JR, Woyshville MJ, Journal of Clinical Psychiatry, 1/1/1995
Clozapine in treatment refractory mood disorders
Kimmel SE, Calabrese JR, Woyshville MJ, Meltzer HY, Journal of Clinical Psychiatry, 1/1/1994
Quantification of occipital EEG changes in Alzheimer’s disease utilizing a new metric: The fractal dimension
Woyshville MJ, Calabrese JR, Biological Psychiatry, 1/1/1994
Diagnosis and treatment of rapid-cycling bipolar disorder
Calabrese JR, Woyshville MJ, Directions in Psychiatry, 1/1/1994
Mixed states and bipolar rapid cycling and their treatment with valproate
Calabrese JR, Woyshville MJ, Kimmel SE, and Rapport DJ, Psychiatric Annals, 1/1/1993
Predictors of valproate response in bipolar rapid cycling
Calabrese JR, Woyshville MJ, Kimmel SE, and Rapport DJ, Journal of Clinical Psychopharmacology, 1/1/1993
Rapid cycling bipolar disorder and its treatment with valproate
Calabrese JR, Rapport DJ, Kimmel SE, Reece B, and Woyshville MJ, Canadian Journal of Psychiatry, 1/1/1993
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Books/Book Chapters

Mechanisms Of Antibipolar Disorder Treatments: Focus On Lithium, Valproate, And Carbamazepine
Chapter: Efficacy of lamotrigine in bipolar disorders: Preliminary data on the affective disorders
Calabrese JR, Bowden CL, McElroy S, Cookson J, Andersen J, Rhodes L, Woyshville MJ, Keck P, Kundu S, Paterson G, Ascher J, Bolden-Watson, CEditors: Manji H, Bowden C, Belmaker R.American Psychiatric Press, Washington, DC1997
Current Psychiatric Therapy II
Chapter: Diagnosis and treatment of rapid cycling bipolar disorder
Calabrese JR, Fatemi SH, Woyshville MJEditors: Dunner DL.W.B. Saunders Co.1997
Intelligent Engineering Systems Through Artificial Neural Networks
Chapter: A new chaos-based approach to data conceptualization
Gordon RT, Cantor RJ, Woyshville MJEditors: Dagli CH, Akay M, Chen CL, Fernandez BR, Ghosh J.ASME press, New York, NY1996
Psychopharmacology: The Fourth Generation of Progress
Chapter: Lithium and anticonvulsants in bipolar disorder
Calabrese JR, Bowden C, Woyshville MJEditors: Bloom FE, Kupfer DJ.Raven Press, Inc., New York, NY1995
Anticonvulsants in Mood Disorders
Chapter: Clinical efficacy of valproate
Calabrese JR, Woyshville MJ, Rapport DJEditors: Joffe RT, Calabrese JR.Marcel Dekker, Inc., New York, NY1994
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Abstracts/Posters

Spectrum of efficacy of lamotrigine in treatment-refractory manic depression
Calabrese JR, Woyshville MJ, Bowden C, et al, Second International Conference on Affective Disorders, 1/4/1995