MarkusBredelMD

Radiation Oncology • Birmingham, AL

Central Nervous System Cancer

Professor, University of Alabama at Birmingham

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Office
1700 Sixth Ave S
Hazelrig-Salter Radiation Oncology Center
Birmingham, AL 35233
Phone+1 205-975-0224
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Education & Training

University of Alabama Medical CenterResidency, Radiation Oncology, 2010 - 2014
University of Vienna Faculty of MedicineClass of 2001

Certifications & Licensure

AL State Medical License 2011 - 2024
American Board of Radiology Radiation Oncology

Clinical Trials

RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson's Disease Start of enrollment: 2017 Dec 05
Active, not recruiting
Not Applicable

Publications & Presentations

PubMed

The role of annexins in central nervous system development and disease.
Zachary B White 2nd, Sindhu Nair, Markus Bredel> ;Journal of Molecular Medicine. 2024 Apr 19
Understanding the Effect of Prescription Isodose in Single-Fraction Stereotactic Radiosurgery on Plan Quality and Clinical Outcomes for Solid Brain Metastases.
Matthew H Brown, Samuel R Marcrom, Mayank P Patel, Richard A Popple, Roman L Travis, Andrew M McDonald, Kristen O Riley, James M Markert, Christopher D Willey, Markus ...> ;Neurosurgery. 2023 Dec 1
1 citations
Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas.
Markus Bredel, Lluís Espinosa, Hyunsoo Kim, Denise M Scholtens, Joseph P McElroy, Rajani Rajbhandari, Wei Meng, Thomas M Kollmeyer, Tathiane M Malta, Michael A Quezada...> ;Cell Reports. Medicine. 2023 Jun 20
An ErbB Lineage Co-Regulon Harbors Potentially Co-Druggable Targets for Multimodal Precision Therapy in Head and Neck Squamous Cell Carcinoma.
Markus Bredel, Hyunsoo Kim, James A Bonner> ;International Journal of Molecular Sciences. 2022 Nov 4
10 citations
Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling.
Hongxing Shen, Fengyuan Huang, Xiangmin Zhang, Oluwagbemiga A Ojo, Yuebin Li, Hoa Quang Trummell, Joshua C Anderson, John Fiveash, Markus Bredel, Eddy S Yang, Christop...> ;Nature Communications. 2022 Aug 25
21 citations
Mutations in Head and Neck Squamous Cell Carcinoma.
Sindhu Nair, James A Bonner, Markus Bredel> ;International Journal of Molecular Sciences. 2022 Mar 30
Stereotactic radiosurgery for ruptured versus unruptured intracranial arteriovenous malformations.
James Mooney, Arsalaan Salehani, Nicholas Erickson, Evan Thomas, Adeel Ilyas, Sage Rahm, Nicholas Eustace, Pedram Maleknia, Omer Yousuf, Markus Bredel, John Fiveash, C...> ;Surgical Neurology International. 2022 Jan 1
3 citations
Feasibility and Short-Term Toxicity of a Consecutively Delivered Five Fraction Stereotactic Body Radiation Therapy Regimen in Early-Stage Breast Cancer Patients Receiv...
Yilan Liu, Christopher Veale, Diana Hablitz, Helen Krontiras, Allison Dalton, Korie Meyers, Michael Dobelbower, Rachael Lancaster, Markus Bredel, Catherine Parker, Kim...> ;Frontiers in Oncology. 2022 Jan 1
Seizure Rates after Stereotactic Radiosurgery for Cerebral AVMs: A Single Center Study
James Mooney, Nicholas J Erickson, Arsalaan Salehani, Evan M. Thomas, Adeel Ilyas, Sage P. Rahm, Nicholas Eustace, Pedram Maleknia, Omer Yousuf, Ben Saccomano, Markus ...> ;World Neurosurgery. 2021 Nov 11
15 citations
Transition From Manual to Automated Planning and Delivery of Volumetric Modulated Arc Therapy Stereotactic Radiosurgery: Clinical, Dosimetric, and Quality Assurance Re...
Richard A. Popple, Matthew H. Brown, Evan M. Thomas, Christopher D. Willey, Rex A. Cardan, Elizabeth L. Covington, Kristen O. Riley, James M. Markert, Markus Bredel, J...> ;Practical Radiation Oncology. 2021 Mar 1
5 citations
Control and Toxicity in Melanoma Versus Other Brain Metastases in Response to Combined Radiosurgery and PD-(L)1 Immune Checkpoint Inhibition
Roman L. Travis, S. Marcrom, Matthew H. Brown, Mayank Patel, James M. Markert, Kristen O. Riley, Robert M. Conry, Christopher D. Willey, Markus Bredel, John B. Fiveash> ;Advances in Radiation Oncology. 2021 Jan 1
15 citations
Surface guided imaging during stereotactic radiosurgery with automated delivery.
Elizabeth L. Covington, Dennis N. Stanley, John B. Fiveash, Evan M. Thomas, S. Marcrom, M. Bredel, Christopher D. Willey, Kristen O. Riley, Richard A. Popple> ;Journal of Applied Clinical Medical Physics. 2020 Dec 1
12 citations
Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth.
Ling Zeng, Drexell Hunter Boggs, Chuan Xing, Zhuo Zhang, Joshua C. Anderson, Narendra Wajapeyee, Chris Veale, Markus Bredel, Lewis Z. Shi, James A. Bonner, Christopher...> ;Frontiers in Genetics. 2020 Sep 10
12 citations
Novel EGFR ectodomain mutations associated with ligand-independent activation and cetuximab resistance in head and neck cancer.
Sindhu Nair, Hoa Q. Trummell, Rajani Rajbhandari, Nanda K. Thudi, Susan Nozell, Jason M. Warram, Christopher D. Willey, Eddy S. Yang, William J. Placzek, James A. Bonn...> ;Plos One. 2020 Feb 18
18 citations
Focal Management of Large Brain Metastases and Risk of Leptomeningeal Disease
S. Marcrom, Paul M. Foreman, Tyler B. Colvin, Andrew M. McDonald, Robert S. Kirkland, Richard A. Popple, Kristen O. Riley, James M. Markert, Christopher D. Willey, Mar...> ;Advances in Radiation Oncology. 2020 Jan 1
45 citations
BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma.
Rohit Sachdeva, Megan Wu, Kevin C. Johnson, Hyun-Soo Kim, Angela Celebre, Uswa Shahzad, Maya Srikanth Graham, John A. Kessler, Jeffrey H. Chuang, Jason Karamchandani, ...> ;Scientific Reports. 2019 Oct 10
9 citations
Differential escape mechanisms in cetuximab-resistant head and neck cancer cells
Christopher D. Willey, Joshua C. Anderson, Hoa Q. Trummell, Faris Naji, Rik de Wijn, Eddy S. Yang, Markus Bredel, Nanda K. Thudi, James A. Bonner> ;Biochemical and Biophysical Research Communications. 2019 Sep 10
8 citations
Diagnosing growth in low-grade gliomas with and without longitudinal volume measurements: A retrospective observational study.
Hassan M. Fathallah-Shaykh, Andrew DeAtkine, Elizabeth Coffee, Elias Khayat, Asim K. Bag, Xiaosi Han, Paula Warren, Markus Bredel, John B. Fiveash, James M. Markert, N...> ;Plos Medicine. 2019 May 28
18 citations
Stereotactic radiosurgery with MLC-defined arcs: Verification of dosimetry, spatial accuracy, and end-to-end tests.
Ivan A. Brezovich, Xingen Wu, Richard A. Popple, Elizabeth L. Covington, Rex A. Cardan, Sui Shen, John B. Fiveash, Markus Bredel, Barton L. Guthrie> ;Journal of Applied Clinical Medical Physics. 2019 May 1
29 citations
Pathologic Predictors of Local Recurrence in Atypical Meningiomas Following Gross Total Resection.
O.C. Barrett, James R. Hackney, Andrew M. McDonald, Christopher D. Willey, Markus Bredel, John B. Fiveash> ;International Journal of Radiation Oncology, Biology, Physics. 2019 Feb 1
11 citations
The virtual cone: A novel technique to generate spherical dose distributions using a multileaf collimator and standardized control-point sequence for small target radi...
Richard A. Popple, Xingen Wu, Ivan A. Brezovich, James M. Markert, Barton L. Guthrie, Evan M. Thomas, Markus Bredel, John B. Fiveash> ;Advances in Radiation Oncology. 2018 Mar 2
13 citations
MicroRNA-31 is required for astrocyte specification.
Gordon P. Meares, Rajani Rajbhandari, Magda Gerigk, Chih-Liang Tien, Chenbei Chang, Samuel C. Fehling, Amber L. Rowse, Kayln C. Mulhern, Sindhu Nair, G. Kenneth Gray, ...> ;Glia. 2018 May 1
28 citations
A method for pre-operative single-subject thalamic segmentation based on probabilistic tractography for essential tremor deep brain stimulation.
Erik H. Middlebrooks, Vanessa M. Holanda, Ibrahim Sacit Tuna, Hrishikesh D. Deshpande, Markus Bredel, Leonardo Almeida, Harrison C. Walker, Barton L. Guthrie, Kelly D....> ;Neuroradiology. 2018 Jan 6
46 citations
Structural connectivity-based segmentation of the thalamus and prediction of tremor improvement following thalamic deep brain stimulation of the ventral intermediate n...
Erik H. Middlebrooks, Ibrahim Sacit Tuna, Leonardo Almeida, Sanjeet S. Grewal, Joshua K. Wong, Michael G. Heckman, Elizabeth R. Lesser, Markus Bredel, Kelly D. Foote, ...> ;Neuroimage. Clinical. 2018 Jan 1
40 citations
Postoperative radiosurgery for the treatment of metastatic brain tumor: Evaluation of local failure and leptomeningeal disease.
Paul M. Foreman, Bradford E. Jackson, Karan P. Singh, Andrew Romeo, Barton L. Guthrie, Winfield S. Fisher, Kristen O. Riley, James M. Markert, Christopher D. Willey, M...> ;Journal of Clinical Neuroscience. 2017 Dec 14
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Journal Articles

Structural Connectivity–Based Segmentation of the Thalamus and Prediction of Tremor Improvement Following Thalamic Deep Brain Stimulation of the Ventral Intermediate N...
Leonardo Almeida, Kelly D Foote, Joshua Wong, Markus Bredel, Erik H Middlebrooks, Sanjeet S Grewal, Michael S Okun, ScienceDirect

Press Mentions

New Radiation Therapy Shows Promise for Treating Essential TremorJune 16th, 2019
New Way Brain Tumors Become More Malignant DiscoveredMay 27th, 2014
Novel Technique Reveals Both Gene Number and Protein Expression SimultaneouslySeptember 23rd, 2011
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