MarlenePFreemanMD

Professor of Psychiatry, Harvard Medical School; Assoc Director, Center for Women's Mental Health; Clinical Trials Network & Institute; Massachusetts General Hospital. Editor-in-Chief, The Journal of Clinical Psychiatry

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Office
15 Parkman St
Boston, MA 02114
Phone+1 617-724-5600

Fax+1 617-643-3080
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Education & Training

University of Cincinnati Medical CenterFellowship, Psychiatry- Research , 1998 - 1999
Brigham and Women's Hospital/Harvard Medical SchoolResidency, Psychiatry, 1994 - 1998
Northwestern University The Feinberg School of MedicineClass of 1994
University of WisconsinBS, Zoology, 1986 - 1990

Certifications & Licensure

MA State Medical License 1996 - 2024
AZ State Medical License 2000 - 2009
TX State Medical License 2007 - 2008
OH State Medical License 1998 - 2001
American Board of Psychiatry and Neurology Psychiatry

Clinical Trials

Use of Omega-3 Fatty Acids for Perinatal Depression Start of enrollment: 2004 Jun 01
Completed
Phase 2
Omega-3 for Peri- and Postmenopausal Depression Start of enrollment: 2008 Nov 01
Completed
Not Applicable
Escitalopram (Lexapro) for the Treatment of Postpartum Depression Start of enrollment: 2009 Jan 01
Completed
Phase 4
Omega-3 Fatty Acids (Lovaza) for Second Generation Antipsychotic-Associated Hypertriglyceridemia Start of enrollment: 2009 Jul 01
Completed
Phase 4
Duloxetine for Menopausal Depression Start of enrollment: 2009 Aug 01
Completed
Phase 4
Trial of Low Field Magnetic Stimulation Augmentation of Antidepressant Therapy in Treatment-Resistant Depression Start of enrollment: 2013 Apr 01
Completed
Not Applicable
Symptom Tracking in Assisted Reproductive Technologies Start of enrollment: 2012 Oct 01
Completed
Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD) Start of enrollment: 2014 Dec 01
Completed
Phase 2
Vortioxetine for Menopausal Depression Start of enrollment: 2015 Jun 12
Completed
Phase 4
EnBrace HR for Depression Treatment and Prevention in Women Trying to Conceive and Early Pregnancy Start of enrollment: 2017 Jan 24
Completed
Not Applicable
Preconception and Pregnancy Obesity Treatment and Prevention Among Women With a History of Depression Start of enrollment: 2017 Feb 17
Recruiting
Not Applicable
A Neurosteroid Intervention for Menopausal and Perimenopausal Depression Start of enrollment: 2018 Sep 01
Recruiting
Phase 1, Phase 2
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Publications & Presentations

PubMed

Effects of Prenatal Exposure to Second-Generation Antipsychotics on Development and Behavior Among Preschool-Aged Children: Preliminary Results From the National Pregn...
Carol Swetlik, Lee S Cohen, Lauren A Kobylski, Ellen T Sojka, Parker C Killenberg, Marlene P Freeman, Adele C Viguera> ;The Journal of Clinical Psychiatry. 2024 Mar 13
1 citations
The lived experiences of individuals with postpartum psychosis: A qualitative analysis.
Vanderkruik, R., Kobylski, L., Dunk, M., Arakelian, M., Gaw, M., Dineen, H., Kanamori, M., Freeman, M., Cohen, L.> ;Journal of Affective Disorders. 2024 Mar 1
1 citations
Optimizing Mental Health for Women: Recognizing and Treating Mood Disorders Throughout the Lifespan.
Kathryn M Abel, Marlene P Freeman> ;The Journal of Clinical Psychiatry. 2023 Sep 18
Stressors and coping mechanisms among pregnant women with psychiatric disorders during the COVID-19 pandemic.
Rebecca S Hock, Anna Feeney, Heather A Harmon, Phoebe S Caplin, Lauren A Kobylski, Ella T Rossa, Adele C Viguera, Lee S Cohen, Marlene P Freeman> ;Annals of Clinical Psychiatry. 2023 Aug 1
22 citations
Zuranolone for the Treatment of Postpartum Depression.
Kristina M Deligiannidis, Samantha Meltzer-Brody, Bassem Maximos, E Quinn Peeper, Marlene Freeman, Robert Lasser, Amy Bullock, Mona Kotecha, Sigui Li, Fiona Forrestal,...> ;The American Journal of Psychiatry. 2023 Sep 1
1 citations
The Challenge of Clinical Research and Suicidality: Participant Feedback on a Safety Protocol.
Rachel Vanderkruik, Marlene P Freeman, Katherine A Dunn, Charlotte A Clifford, Sona Dimidjian, Lee S Cohen> ;The Journal of Clinical Psychiatry. 2023 May 15
To screen or not to screen: Are we asking the right question? In response to considering de-implementation of universal perinatal depression screening.
Rachel Vanderkruik, Marlene P Freeman, Ruta Nonacs, Michael Jellinek, Margaret L Gaw, Charlotte A Clifford, Stephen Bartels, Lee S Cohen> ;General Hospital Psychiatry. 2023 Apr 23
Risk of Major Malformations Following First-Trimester Exposure to Olanzapine: Preliminary Data From the Massachusetts General Hospital National Pregnancy Registry for ...
Adele C Viguera, Marlene P Freeman, Lauren A Kobylski, Ella T Rossa, Peter Gaccione, David Chitayat, Sonia Hernández-Díaz, Lee S Cohen> ;Journal of Clinical Psychopharmacology. 2023 Feb 24
2 citations
Reproductive Safety of Lurasidone and Quetiapine: Update from the National Pregnancy Registry for Psychiatric Medications.
Lee S Cohen, Taylor R Church, Marlene P Freeman, Peter Gaccione, Phoebe S Caplin, Lauren A Kobylski, Miranda Arakelian, Ella T Rossa, David Chitayat, Sonia Hernández-D...> ;Journal of Women's Health. 2023 Apr 1
2 citations
Risk of Poor Neonatal Adaptation Syndrome Among Infants Exposed to Second-Generation Atypical Antipsychotics Compared to Antidepressants: Results From the National Pre...
Adele C Viguera, Sara A McElheny, Phoebe S Caplin, Lauren A Kobylski, Ella T Rossa, Amanda V Young, Peter Gaccione, Lina Góez-Mogollón, Marlene P Freeman, Lee S Cohen> ;The Journal of Clinical Psychiatry. 2023 Jan 4
2 citations
Establishment of the MGH Postpartum Psychosis Project: MGHP3.
Lee S Cohen, Rachel Vanderkruik, Miranda Arakelian, Taylor R Church, Madison M Dunk, Marlene P Freeman> ;Plos One. 2023 Jan 1
3 citations
Effect of Concomitant Benzodiazepines on the Antidepressant Effects of Ketamine: Findings From the RAPID Intravenous Ketamine Study.
Anna Feeney, Bettina B Hoeppner, Marlene P Freeman, Martina Flynn, Dan V Iosifescu, Madhukar H Trivedi, Gerard Sanacora, Sanjay J Mathew, Charles DeBattista, Dawn F Io...> ;The Journal of Clinical Psychiatry. 2022 Nov 14
Prescribing Guideline for Valproic Acid and Women of Reproductive Potential: Forget It Exists.
Marlene P Freeman> ;The Journal of Clinical Psychiatry. 2022 Oct 12
Neurobehavioral follow-up of children exposed to selective serotonin reuptake inhibitors in utero.
Lee S Cohen, Sinéad M Rhodes, Lauren D Claypoole, Lina Góez-Mogollón, Alexandra Z Sosinsky, Danna Moustafa, Olivia B Noe, Sara A McElheny, Laura J Cheng, Johanna R Bic...> ;Annals of Clinical Psychiatry. 2022 Aug 1
2 citations
Risk of major malformations in infants after first-trimester exposure to benzodiazepines: Results from the Massachusetts General Hospital National Pregnancy Registry f...
Mercedes J Szpunar, Marlene P Freeman, Lauren A Kobylski, Phoebe S Caplin, Peter Gaccione, Adele C Viguera, David Chitayat, Sonia Hernández-Díaz, Lee S Cohen> ;Depression and Anxiety. 2022 Dec 1
2 citations
Pregnancy outcomes after first-trimester exposure to buspirone: prospective longitudinal outcomes from the MGH National Pregnancy Registry for Psychiatric Medications.
Marlene P Freeman, Mercedes J Szpunar, Lauren A Kobylski, Heather Harmon, Adele C Viguera, Lee S Cohen> ;Archives of Women's Mental Health. 2022 Oct 1
The Pursuit to Recognize Bipolar Disorder in Pregnant and Postpartum Women.
Marlene P Freeman, Joseph F Goldberg> ;The Journal of Clinical Psychiatry. 2022 Jul 13
5 citations
Body dissatisfaction and disordered eating in the perinatal period: an underrecognized high-risk timeframe and the opportunity to intervene.
Rachel Vanderkruik, Kalin Ellison, Margaux Kanamori, Marlene P Freeman, Lee S Cohen, Eric Stice> ;Archives of Women's Mental Health. 2022 Aug 1
11 citations
Efficacy and safety of esketamine nasal spray by sex in patients with treatment-resistant depression: findings from short-term randomized, controlled trials.
Robyn R Jones, Marlene P Freeman, Susan G Kornstein, Kimberly Cooper, Carla M Canuso, Susan Nicholson, Daly, E.> ;Archives of Women's Mental Health. 2022 Apr 1
41 citations
Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFS...
Jerome Sarris, Arun Ravindran, Lakshmi N Yatham, Wolfgang Marx, Julia J Rucklidge, Roger S McIntyre, Shahin Akhondzadeh, Francesco Benedetti, Constanza Caneo, Holger C...> ;The World Journal of Biological Psychiatry. 2022 Jul 1
1 citations
Perinatal experiences of pregnant women with psychiatric disorders during the COVID-19 pandemic.
Anna Feeney, Rebecca S. Hock, Heather A Harmon, Phoebe S. Caplin, Lauren A Kobylski, Adele C. Viguera, Marlene P. Freeman, Lee S. Cohen> ;General Hospital Psychiatry. 2021 Nov 6
3 citations
Postpartum depression screening: Treatment engagement, barriers to care, and change in depressive symptoms.
Rachel Vanderkruik, Marlene P. Freeman, Lauren D. Claypoole, Miranda Arakelian, Anjali J Kaimal, Hiyam Nadel, Lee S. Cohen> ;Annals of Clinical Psychiatry. 2021 Nov 1
Correction. Reproductive Safety of Second-Generation Antipsychotics: Updated Data From the Massachusetts General Hospital National Pregnancy Registry for Atypical Anti...
Adele C Viguera, Marlene P Freeman, Lina Góez-Mogollón, Alexandra Z Sosinsky, Sara A McElheny, Taylor R Church, Amanda V Young, Phoebe S Caplin, David Chitayat, Sonia ...> ;The Journal of Clinical Psychiatry. 2021 Oct 5
3 citations
Perinatal depression screening using smartphone technology: Exploring uptake, engagement and future directions for the MGH Perinatal Depression Scale (MGHPDS).
Rachel Vanderkruik, Edwin R. Raffi, Marlene P. Freeman, Rebecca Wales, Lee S. Cohen> ;Plos One. 2021 Sep 29
10 citations
Reproductive Safety of Second-Generation Antipsychotics: Updated Data From the Massachusetts General Hospital National Pregnancy Registry for Atypical Antipsychotics.
Adele C Viguera, Marlene P Freeman, Lina Góez-Mogollón, Alexandra Z Sosinsky, Sara A McElheny, Taylor R Church, Amanda V Young, Phoebe S Caplin, David Chitayat, Sonia ...> ;The Journal of Clinical Psychiatry. 2021 Aug 3
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Journal Articles

Research Paper Tachyphylaxis in Major Depressive Disorder: A Review of the Current State of Research
Gustavo Kinrys, Andrew A Nierenberg, George I Papakostas, David Mischoulon, Maurizio Fava, Marlene P Freeman, ScienceDirect
Double-Blind, Placebo-Controlled, Dose-Ranging Trial of Intravenous Ketamine as Adjunctive Therapy in Treatment-Resistant Depression (TRD)
Sanjay J Mathew, Madhukar H Trivedi, Lee C Chang, Dan V Iosifescu, Manish K Jha, Maurizio Fava, Marlene P Freeman, Cristina Cusin, James Murrough, George I Papakostas,..., Nature
Course of Major Depressive Disorder After Pregnancy and the Postpartum Period
Lee S Cohen, Vivien K Burt, Marlene P Freeman, Danna Moustafa, Depression and Anxiety

Press Mentions

No Protection Against Relapse with CBT Added to Maintenance AntidepressantsDecember 3rd, 2019
Register Online MGH Conference on Women’s Mental Health – October 17, 2019September 11th, 2019
Sage’s Zulresso for Postpartum Depression Has Uncertain Payer CoverageJuly 19th, 2019
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Grant Support

A neurosteroid intervention for menopausal and perimenopausal depressionNational Institute on Aging (NIA), NIH, R01 mechanism2018–2023
Postpartum Depression: Omega-3 FA VS PlaceboNational Institute Of Mental Health2002–2006