MartinPLefkowitzMD

PubMed

• 94 citations
  Outcomes and Effect of Treatment According to Etiology in HFrEF: An Analysis of PARADIGM-HF
  Craig Balmforth, Joanne Simpson, Li Shen, Pardeep S. Jhund, Martin Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor Shi, Scott D. Solomon, Karl Swedberg, Michael R....> ;JACC. Heart Failure. 2019 Jun 1
• 137 citations
  B-TYPE NATRIURETIC PEPTIDE DURING TREATMENT WITH SACUBITRIL/VALSARTAN: THE PARADIGM-HF TRIAL
  Peder L. Myhre, Muthiah Vaduganathan, Brian Claggett, Milton Packer, Akshay S. Desai, Jean L. Rouleau, Michael R. Zile, Karl Swedberg, Martin Lefkowitz, Victor Shi, Jo...> ;Journal of the American College of Cardiology. 2019 Mar 26
• Effects of Sacubitril/Valsartan on Biomarkers of Extracellular Matrix Regulation in Patients With HFrEF.
  Zile, M. R.,O'Meara, E.,Claggett, B.,Prescott, M. F.,Solomon, S. D.,Swedberg, K.,Packer, M.,McMurray, JJV.,Shi, V.,Lefkowitz, M.,Rouleau, J.> ;J. Am. Coll. Cardiol.. 2019 Feb 21
• 35 citations
  IGFBP7 (Insulin-Like Growth Factor-Binding Protein-7) and Neprilysin Inhibition in Patients With Heart Failure.
  James L. Januzzi, Milton Packer, Brian Claggett, Jiankang Liu, Amil M. Shah, Michael R. Zile, Burkert Pieske, Adriaan A. Voors, Parul U. Gandhi, Margaret F. Prescott, ...> ;Circulation. Heart Failure. 2018 Oct 1
• 105 citations
  Baseline Characteristics of Patients With Heart Failure and Preserved Ejection Fraction in the PARAGON-HF Trial.
  Scott D. Solomon, Adel R. Rizkala, Martin Lefkowitz, Victor Shi, Jianjian Gong, Nagesh S. Anavekar, Stefan D. Anker, Juan Luis Arango, Jose L. Arenas, Dan Atar, Turia ...> ;Circulation. Heart Failure. 2018 Jul 1
• 35 citations
  Sacubitril/valsartan reduces serum uric acid concentration, an independent predictor of adverse outcomes in PARADIGM-HF.
  Ulrik M. Mogensen, Lars Køber, Pardeep S. Jhund, Akshay S. Desai, Michele Senni, Søren Lund Kristensen, Andrej Dukát, Chen Huan Chen, Felix J. A. Ramires, Martin Lefko...> ;European Journal of Heart Failure. 2018 Mar 1
• 54 citations
  Effect of sacubitril/valsartan on recurrent events in the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and morbidity in Heart Failu...
  Ulrik M. Mogensen, Jianjian Gong, Pardeep S. Jhund, Li Shen, Lars Køber, Akshay S. Desai, Martin Lefkowitz, Milton Packer, Jean L. Rouleau, Scott D. Solomon, Brian Cla...> ;European Journal of Heart Failure. 2018 Feb 12
• 143 citations
  Health-Related Quality of Life Outcomes in PARADIGM-HF.
  Eldrin F. Lewis, Brian Claggett, John J.V. McMurray, Milton Packer, Martin Lefkowitz, Jean L. Rouleau, Jiankang Liu, Victor Shi, Michael R. Zile, Akshay S. Desai, Scot...> ;Circulation. Heart Failure. 2017 Aug 1
• 99 citations
  Challenges in conducting clinical trials in nephrology: conclusions from a Kidney Disease-Improving Global Outcomes (KDIGO) Controversies Conference.
  Colin Baigent, William G. Herrington, Josef Coresh, Martin J Landray, Adeera Levin, Vlado Perkovic, Marc A. Pfeffer, Peter Rossing, Michael Walsh, Christoph Wanner, Da...> ;Kidney International. 2017 Aug 1
• 7 citations
  Navigating the Future of Cardiovascular Drug Development-Leveraging Novel Approaches to Drive Innovation and Drug Discovery: Summary of Findings from the Novel Cardiov...
  Thomas J. Povsic, Robert A. Scott, Kenneth W. Mahaffey, Robert O. Blaustein, Jay M. Edelberg, Martin Lefkowitz, Scott D. Solomon, Jonathan C. Fox, Kevin E. Healy, Aari...> ;Cardiovascular Drugs and Therapy. 2017 Jul 22
• 190 citations
  Angiotensin Receptor Neprilysin Inhibition in Heart Failure With Preserved Ejection Fraction: Rationale and Design of the PARAGON-HF Trial
  Scott D. Solomon, Adel R. Rizkala, Jianjian Gong, Wenyan Wang, Inder S. Anand, J.B. Ge, Carolyn S.P. Lam, Aldo P. Maggioni, Felipe Martinez, Milton Packer, Marc A. Pfe...> ;JACC. Heart Failure. 2017 Jun 26
• 29 citations
  The effects of sacubitril/valsartan on coronary outcomes in PARADIGM-HF
  Ulrik M. Mogensen, Lars Køber, Søren Lund Kristensen, Pardeep S. Jhund, Jianjian Gong, Martin Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor Shi, Karl Swedberg, M...> ;American Heart Journal. 2017 Jun 1
• 16 citations
  New medicinal products for chronic heart failure: Advances in clinical trial design and efficacy assessment
  Martin R. Cowie, Gerasimos Filippatos, Maria Angeles Alonso Garcia, Stefan D. Anker, Anna Baczynska, Daniel M. Bloomfield, Maria Borentain, Karsten Bruins Slot, Mauree...> ;European Journal of Heart Failure. 2017 Jun 1
• 209 citations
  Effect of sacubitril/valsartan versus enalapril on glycaemic control in patients with heart failure and diabetes: a post-hoc analysis from the PARADIGM-HF trial
  Jelena P. Seferovic, Brian Claggett, Sara B. Seidelmann, Ellen W. Seely, Milton Packer, Michael R. Zile, Jean L. Rouleau, Karl Swedberg, Martin Lefkowitz, Victor Shi, ...> ;The Lancet. Diabetes & Endocrinology. 2017 May 1
• 131 citations
  Systolic blood pressure, cardiovascular outcomes and efficacy and safety of sacubitril/valsartan (LCZ696) in patients with chronic heart failure and reduced ejection f...
  Michael Böhm, Robin Young, Pardeep S. Jhund, Scott D. Solomon, Jianjian Gong, Martin Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor Shi, Karl Swedberg, Michael R....> ;European Heart Journal. 2017 Apr 14
• 120 citations
  Reduced Risk of hyperkalemia during treatment of heart failure with mineralocorticoid receptor antagonists by use of sacubitril/valsartan compared with enalapril: A se...
  Akshay S. Desai, Orly Vardeny, Brian Claggett, John J.V. McMurray, Milton Packer, Karl Swedberg, Jean L. Rouleau, Michael R. Zile, Martin Lefkowitz, Victor Shi, Scott ...> ;JAMA Cardiology. 2017 Jan 1
• 23 citations
  Evaluating the Efficacy, Safety, and Tolerability of Serelaxin When Added to Standard Therapy in Asian Patients With Acute Heart Failure: Design and Rationale of RELAX...
  Naoki Sato, Carolyn S.P. Lam, John R. Teerlink, Barry H. Greenberg, Hiroyuki Tsutsui, Byung Hee Oh, Jian Zhang, Martin Lefkowitz, Tsushung A. Hua, Thomas Holbro, Miria...> ;Journal of Cardiac Failure. 2017 Jan 1
• 23 citations
  Sacubitril/Valsartan (LCZ696) in Heart Failure.
  Yasser Khder, Victor Shi, John J.V. McMurray, Martin Lefkowitz> ;Handbook of Experimental Pharmacology. 2016 Dec 22
• 40 citations
  Exploring New Endpoints for Patients With Heart Failure With Preserved Ejection Fraction.
  Javed Butler, Carine E. Hamo, James E. Udelson, Bertram Pitt, Clyde W. Yancy, Sanjiv J. Shah, Patrice Desvigne-Nickens, Harold S. Bernstein, Richard L. Clark, Christop...> ;Circulation. Heart Failure. 2016 Nov 1
• 71 citations
  Efficacy of Sacubitril/Valsartan Relative to a Prior Decompensation: The PARADIGM-HF Trial.
  Scott D. Solomon, Brian Claggett, Milton Packer, Akshay S. Desai, Michael R. Zile, Karl Swedberg, Jean L. Rouleau, Victor Shi, Martin Lefkowitz, John J.V. McMurray> ;JACC. Heart Failure. 2016 Oct 1
• 159 citations
  Efficacy of sacubitril/valsartan vs. enalapril at lower than target doses in heart failure with reduced ejection fraction: the PARADIGM‐HF trial
  Orly Vardeny, Brian Claggett, Milton Packer, Michael R. Zile, Jean L. Rouleau, Karl Swedberg, John R. Teerlink, Akshay S. Desai, Martin Lefkowitz, Victor Shi, John J.V...> ;European Journal of Heart Failure. 2016 Oct 1
• 69 citations
  Effects of Sacubitril/Valsartan in the PARADIGM-HF Trial (Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failu...
  Naoki Okumura, Pardeep S. Jhund, Jianjian Gong, Martin Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor Shi, Karl Swedberg, Michael R. Zile, Scott D. Solomon, Milto...> ;Circulation. Heart Failure. 2016 Sep 1
• 84 citations
  Influence of Sacubitril/Valsartan (LCZ696) on 30-Day Readmission After Heart Failure Hospitalization
  Akshay S. Desai, Brian Claggett, Milton Packer, Michael R. Zile, Jean L. Rouleau, Karl Swedberg, Victor Shi, Martin Lefkowitz, Randall C. Starling, John R. Teerlink, J...> ;Journal of the American College of Cardiology. 2016 Jul 19
• 96 citations
  Geographic variations in the PARADIGM-HF heart failure trial.
  Søren Lund Kristensen, Felipe Martinez, Pardeep S. Jhund, Juan Luis Arango, Jan Bĕlohlávek, Sergey Boytsov, Walter Cabrera, Efrain Gomez, Albert Hagège, Jun Huang, Son...> ;European Heart Journal. 2016 Jun 28
• 125 citations
  Importance of Clinical Worsening of Heart Failure Treated in the Outpatient Setting: Evidence from the Prospective Comparison of ARNI with ACEI to Determine Impact on ...
  Naoki Okumura, Pardeep S. Jhund, Jianjian Gong, Martin Lefkowitz, Adel R. Rizkala, Jean L. Rouleau, Victor Shi, Karl Swedberg, Michael R. Zile, Scott D. Solomon, Milto...> ;Circulation. 2016 Jun 7
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Journal Articles

• Effects of Sacubitril/Valsartan on Physical and Social Activity Limitations in Patients with Heart Failure  
  Milton Packer, Alvin Chandra, Akshay S. Desai, Martin P Lefkowitz, Martin P. Lefkowitz, Milton Packer, Michael R. Zile, Scot D. Solomon, Michael R Zile, Alvin Chandra,..., JAMA
• Renal Effects and Associated Outcomes During Angiotensin-Neprilysin Inhibition in Heart Failure  
  Michael R Zile, Martin P Lefkowitz, Scott D Solomon, Milton Packer, Akshay S Desai, ScienceDirect