Matlock Jeffries MD

PubMed

• Ketogenic Diet-Associated Worsening of Osteoarthritis Histologic Secerity, Increased Pain Sensitivity and Gut Microbiome Dysbiosis in Mice.
  Gabby Dyson, Montana Barrett, Leoni Schlupp, Emmaline Prinz, Nicholas Hannebut
  ACR Open Rheumatology. 2025-01-01
• Sexually dimorphic metabolic effects of a high fat diet on knee osteoarthritis in mice.
  Timothy M Griffin, Erika Barboza Prado Lopes, Dominic Cortassa, Albert Batushansky, Matlock A Jeffries
  Biology of Sex Differences. 2024-12-05
• 5 citations
  Murine cartilage microbial DNA deposition occurs rapidly following the introduction of a gut microbiome and changes with obesity, aging, and knee osteoarthritis.
  Vladislav Izda, Leoni Schlupp, Emmaline Prinz, Gabby Dyson, Montana Barrett
  Geroscience. 2024-04-01

Journal Articles

• Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage  
  Jeffries, MA, Donica M, Baker L, Stevenson M, Annand A, Humphrey MB, James JA, Sawalha AH, Arthritis and Rheumatology, 1/30/2014
• Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse  
  Koelsch K, Webb R, Jeffries MA, Dozmorov M, Frank MB, Guthridge J, James JA, Wren J, Sawalha AH, J. Autoimmunity, 1/1/2013
• Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naïve CD4+ T cells from lupus patients  
  Coit P, Jeffries M, Altorok N, Dozmorov MG, Koelsch KA, Wren JD, Merrill JT, McCune WJ, Sawalha AH, J Autoimmun, 1/1/2013
• Epigenetics in disease causation in SLE: leading the way for specific therapeutic agents  
  Jeffries MA, Sawalha AH, Int. J. Clin. Rheum, 1/1/2011
• Uric acid directly promotes human T cell activation  
  Webb R, Jeffries M, Sawalha AH, Am J Med Sci, 1/1/2009
• Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic ...  
  Webb R, Wren JD, Jeffries M, Kelly JA, Kaufman KM, Tang Y, Frank MB, Merrill J, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Alarcón GS, Vilá LM, Al..., Arthritis Rheum, 1/1/2009
• Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients  
  Sawalha AH, Jeffries M, Webb R, Lu Q, Gorelik G, Ray D, Osban J, Knowlton N, Johnson K, Richardson B, Genes Immun, 1/1/2008
• Haemolytic anemia in a multi-ethnic cohort of lupus patients:  a clinical and serological perspective  
  Jeffries M, Hamadeh F, Aberle T, Glenn S, Kamen DL, Kelly JA, Reichlin M, Harley JB, Sawalha AH, Lupus, 1/1/2008
• Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus prone mice  
  Sawalha AH, Jeffries M, European Journal of Immunology, 1/1/2007
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Abstracts/Posters

• Global transcriptomic profiling of osteoarthritic chondrocytes
  Jeffries MA, Multiple Locations, 2014, 1/1/2015
• Epigenome-wide DNA methylation study of osteoarthritic subchondral bone
  Jeffries MA, American College of Rheumatology Annual Meeting, 1/1/2015
• Jeffries MA, American Society of Human Genetics Annual Meeting; American College of Rheumatology Annual Meeting, Boston, 2013; San Diego, 2013, 1/1/2013
• Global DNA methylation profiling of CD4+ T cells from patients with systemic lupus erythematosus
  Jeffries MA, American College of Physicians Meeting, San Diego, 1/1/2011
• Targeting CD70 in MRL/lpr Mice: A Novel Therapeutic Approach for Lupus
  Jeffries MA, Stewart Wolf Day Research Competition, University of Oklahoma, 1/1/2011
• Prevalence of subclinical hypothyroidism in a mid-sized academic medical center: An unrecognized epidemic?
  Jeffries MA, American Assoc. of Clin. Chemistry Annual Meeting, Anaheim, 1/1/2010
• Hemolytic anemia in a multi-ethnic cohort of lupus patients:  A clinical and serological perspective
  Jeffries MA, American College of Rheumatology Research Workshop, Chicago, 1/1/2008
• Hemolytic anemia in a multi-ethnic cohort of lupus patients:  A clinical and serological perspective
  Jeffries MA, American College of Rheumatology Annual Meeting, San Francisco, 1/1/2008
• Defective DNA methylation in CD4+ T cells is associated with loss of immune tolerance in MRL/lpr lupus-prone mice
  Jeffries MA, 51st Annual General Assembly and Scientific Meeting of Japan College of Rheumatology and the 16th International Rheumatology Symposium; The 8th International Congress on SLE, Yokohama, Japan, 2007; Shanghai, China, 2007, 1/1/2007
• Targeting CD70 in MRL/lpr Mice: A Novel Therapeutic Approach for Lupus
  Jeffries MA, American College of Rheumatology Annual Meeting, Boston, 1/1/2007
• Uric Acid Directly Promotes T Cell Autoreactivity
  Jeffries MA, American College of Rheumatology Annual Meeting, Boston, 1/1/2007
• Decreased expression of DNMT1 in lymphoid tissue may contribute to autoimmunity in MRL/lpr mice
  Jeffries MA, Graduate Research Education and Technology Symposium; American Association of Immunologists Annual Meeting, Oklahoma City, 2006; Boston, 2006, 1/1/2006
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Lectures

• Epigenomics of Osteoarthritis 
  Malaga, Spain, 2014; Sun Valley, ID, 2014 - 1/1/2014
• k-RAS, Epigenetics, and Pancreatic Cancer 
  University of Oklahoma - 1/1/2013
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  Oklahoma City - 1/1/2013
• Global DNA methylation profiling of CD4+ T cells from patients with systemic lupus erythematosus 
  University of Oklahoma - 1/1/2011
• Sulfa allergy in lupus patients: A clinical perspective 
  University of Oklahoma Health Sciences Center - 1/1/2007
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