MatthewJCampbellMD

PubMed

• Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.
  Westaway SM, Preston AGS, Barker MD, Brown F, Brown JA, Campbell M, Chung C, Drewes G, Eagle R, Garton N, Gordon L, Haslam C, Hayhow TG, Humphreys PG, Joberty G, Katso...> ;J. Med. Chem.. 2016-02-25
• Alkene anti-Dihydroxylation with Malonoyl Peroxides.
  Alamillo-Ferrer C, Davidson SC, Rawling MJ, Theodoulou NH, Campbell M, Humphreys PG, Kennedy AR, Tomkinson NCO> ;Org. Lett.. 2015-10-16
• The pre-clinical absorption, distribution, metabolism and excretion properties of IPI-926, an orally bioavailable antagonist of the hedgehog signal transduction pathway.
  Smith, S.,Hoyt, J.,Whitebread, N.,Manna, J.,Peluso, M.,Faia, K.,Campbell, V.,Tremblay, M.,Nair, S.,Grogan, M.,Castro, A.,Campbell, M.,Ferguson, J.,Arsenault, B.,Neveja...> ;Xenobiotica. 2013 Oct
• Alkene dihydroxylation with malonoyl peroxides: catalysis using fluorinated alcohols.
  Picon S, Rawling M, Campbell M, Tomkinson NCO> ;Org. Lett.. 2012-12-21
• Complexity-building annulations of strained cycloalkanes and C═O π bonds.
  Campbell, M.J., Johnson, J.S., Parsons, A.T., Pohlhaus, P.D., Sanders, S.D.> ;J Org Chem. 2010 Oct 1
• Electron attachment to sulfur oxyhalides: SOF2, SOCl2, SO2F2, SO2Cl2, and SO2FCl attachment rate coefficients, 300-900 K.
  Miller, T.M., Friedman, J.F., Caples, C.M., Shuman, N.S., Van Doren, J.M., Bardaro, M.F., Nguyen, P., Zweiben, C., Campbell, M.J., Viggiano, A.A.> ;J Chem Phys. 2010 Jun 7
• Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs.
  Kleanthous S, Borthwick AD, Brown D, Burns-Kurtis CL, Campbell M, Chaudry L, Chan C, Clarte M, Convery MA, Harling JD, Hortense E, Irving WR, Irvine S, Pateman AJ, Pat...> ;Bioorg. Med. Chem. Lett.. 2010-01-15
• Asymmetric synthesis of (+)-polyanthellin A.
  Campbell, M.J., Johnson, J.S.> ;J Am Chem Soc. 2009-08-05
• Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).
  Tremblay, M.R., Lescarbeau, A., Grogan, M.J., Tan, E., Lin, G., Austad, B.C., Yu, L., Behnke, M.L., Nair, S.J., Hagel, M., White, K., Conley, J., Manna, J.D., Alvarez-...> ;J Med Chem. 2009-07-23
• Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists.
  Tremblay, M.R., Nevalainen, M., Nair, S.J., Porter, J.R., Castro, A.C., Behnke, M.L., Yu, L., Hagel, M., White, K., Faia, K., Grenier, L., Campbell, M.J., Cushing, J.,...> ;J Med Chem. 2008-11-13
• An "anti-Baldwin" 3-exo-dig cyclization: preparation of vinylidene cyclopropanes from electron-poor alkenes.
  Campbell, M.J., Pohlhaus, P.D., Min, G., Ohmatsu, K., Johnson, J.S.> ;J Am Chem Soc. 2008 Jul 23
• Diastereoselective synthesis of tetrahydrofurans via Palladium(0)-catalyzed [3 + 2] cycloaddition of vinylcyclopropanes and aldehydes.
  Parsons, A.T., Campbell, M.J., Johnson, J.S.> ;Org Lett. 2008 Jun 19
• Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with biaryl P4 motifs.
  Young RJ, Borthwick AD, Brown D, Burns-Kurtis CL, Campbell M, Chan C, Charbaut M, Chung C, Convery MA, Kelly HA, Paul King N, Kleanthous S, Mason AM, Pateman AJ, Patik...> ;Bioorg. Med. Chem. Lett.. 2008-01-01
• Structure and property based design of factor Xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs.
  Young RJ, Borthwick AD, Brown D, Burns-Kurtis CL, Campbell M, Chan C, Charbaut M, Convery MA, Diallo H, Hortense E, Irving WR, Kelly HA, King NP, Kleanthous S, Mason A...> ;Bioorg. Med. Chem. Lett.. 2008-01-01
• Mechanistic studies of the copper-catalyzed electrophilic amination of diorganozinc reagents and development of a zinc-free protocol.
  Campbell, M.J., Johnson, J.S.> ;Org Lett. 2007 Apr 12
• Design and synthesis of orally active pyrrolidin-2-one-based factor Xa inhibitors.
  Watson NS, Brown D, Campbell M, Chan C, Chaudry L, Convery MA, Fenwick R, Hamblin JN, Haslam C, Kelly HA, King NP, Kurtis CL, Leach AR, Manchee GR, Mason AM, Mitchell ...> ;Bioorg. Med. Chem. Lett.. 2006-07-15
• Structure- and property-based design of factor Xa inhibitors: pyrrolidin-2-ones with acyclic alanyl amides as P4 motifs.
  Young, R. J., Campbell, M., Borthwick, A. D., Brown, D., Burns-Kurtis, C. L., Chan, C., Convery, M. A., Crowe, M. C., Dayal, S., Diallo, H., Kelly, H. A., King, N. P.,...> ;Bioorg Med Chem Lett. 2006 Dec 1
• Alkene syn dihydroxylation with malonoyl peroxides.
  Griffith, J. C., Jones, K. M., Picon, S., Rawling, M. J., Kariuki, B. M., Campbell, M., Tomkinson, N. C.> ;J Am Chem Soc. 2010 Oct 20
• Synthesis and reactions of fluorous carbobenzyloxy (FCbz) derivatives of alpha-amino acids.
  Curran, D. P., Amatore, M., Guthrie, D., Campbell, M., Go, E., Luo, Z.> ;J Org Chem. 2003 Jun 13
• Factor Xa inhibitors: S1 binding interactions of a series of N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2-oxoethyl]-2-oxopyrrolidin-3-yl}sulfonamides.
  Chan, C., Borthwick, A. D., Brown, D., Burns-Kurtis, C. L., Campbell, M., Chaudry, L., Chung, C. W., Convery, M. A., Hamblin, J. N., Johnstone, L., Kelly, H. A., Klean...> ;J Med Chem. 2007 Apr 5
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