MatthewExlineMD

Pulmonology • Columbus, OH

Critical Care Medicine, Pleural Disease, Sleep Medicine

Professor, Internal Medicine, Ohio State University College of Medicine

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Office
2050 Kenny Rd
Pavilion Ste 2200
Columbus, OH 43221
Phone+1 614-293-4925

Fax+1 614-293-5503
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Education & Training

Ohio State University HospitalFellowship, Pulmonary Disease and Critical Care Medicine, 2003 - 2006
Ohio State University HospitalResidency, Internal Medicine, 2000 - 2003
University of Nevada, Reno School of MedicineClass of 2000

Certifications & Licensure

OH State Medical License 2000 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Critical Care Medicine
American Board of Internal Medicine Pulmonary Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

Immune Suppression and Ventilator Associated Pneumonias Start of enrollment: 2010 Feb 01
Completed
The Modifying the Impact of ICU-Associated Neurological Dysfunction-USA (MIND-USA) Study Start of enrollment: 2011 Dec 14
Completed
Phase 3
Ganciclovir/Valganciclovir for Prevention of CMV Reactivation in Acute Injury of the Lung and Respiratory Failure Start of enrollment: 2011 Mar 10
Completed
Phase 2
Procalcitonin Antibiotic Consensus Trial (ProACT) Start of enrollment: 2014 Nov 03
Completed
Not Applicable
Pragmatic Trial Examining Oxygenation Prior to Intubation Start of enrollment: 2022 Mar 10
Completed
Not Applicable
Roles: Contact
Ganciclovir to Prevent Reactivation of Cytomegalovirus in Patients With Acute Respiratory Failure and Sepsis Start of enrollment: 2021 Jun 29
Recruiting
Phase 3
Roles: Contact
Supplemental Citicoline Administration to Reduce Lung Injury Efficacy Trial (SCARLET) Start of enrollment: 2023 Jun 06
Recruiting
Phase 1, Phase 2
Roles: Contact
Behavioral Economic & Staffing Strategies in the ICU Start of enrollment: 2024 Apr 01
Not yet recruiting
Not Applicable
Roles: Contact
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Publications & Presentations

PubMed

Protocol and statistical analysis plan for the PREOXI trial of preoxygenation with noninvasive ventilation vs oxygen mask.
Malhotra, R., Kevin W Gibbs, Adit A Ginde, Matthew E Prekker, Kevin P Seitz, Susan B Stempek, Caleb Taylor, Sheetal Gandotra, Heath White, Daniel Resnick-Ault, Akram K...> ;Medrxiv. 2023 Mar 24
63 citations
Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension.
, Nathan I Shapiro, Ivor S Douglas, Roy G Brower, Samuel M Brown, Matthew C Exline, Adit A Ginde, Michelle N Gong, Colin K Grissom, Douglas Hayden, Catherine L Hough, ...> ;The New England Journal of Medicine. 2023 Feb 9
Early onset delirium incidence and risk factors in hematology oncology patients admitted to the intensive care unit: A retrospective cohort study.
Rachel C Klosko, Joshua R Arnold, Claire V Murphy, Jessica Brimmer, Natalie Hagy, Matthew C Exline, Eric McLaughlin, Jessica L Elefritz> ;International Journal of Critical Illness and Injury Science. 2022 Dec 26
National opioid shortage is associated with increased use of ketamine infusion for analgosedation in the medical intensive care unit.
Gregory Eisinger, Matthew Huang, Michael S Cardone, Jessica L Elefritz, Bruce Doepker, Matthew Exline, Jennifer McCallister> ;Journal of Opioid Management. 2022 Dec 16
1 citations
Early Titration of Oxygen During Mechanical Ventilation Reduces Hyperoxemia in a Pilot, Feasibility, Randomized Control Trial for Automated Titration of Oxygen Levels.
Sonal R Pannu, Matthew Exline, Brett Klamer, Guy Brock, Elliott D Crouser, John W Christman, Philip Diaz> ;Critical Care Explorations. 2022 Jun 1
Rationale and design of a randomized controlled clinical trial; Titration of Oxygen Levels (TOOL) during mechanical ventilation.
Sonal R Pannu, Tyler Haddad, Matthew Exline, John W Christman, Jeffrey C Horowitz, Jonathan Peters, Guy Brock, Philip Diaz, Elliott D Crouser> ;Contemporary Clinical Trials. 2022 Aug 1
371 citations
Association Between mRNA Vaccination and COVID-19 Hospitalization and Disease Severity.
Mark W Tenforde, Wesley H. Self, Katherine Adams, Manjusha Gaglani, Adit A. Ginde, Tresa McNeal, Shekhar Ghamande, David J. Douin, H. Keipp Talbot, Jonathan D Casey, N...> ;JAMA. 2021 Nov 23
15 citations
Exhaled nitric oxide detection for diagnosis of COVID-19 in critically ill patients.
Matthew C. Exline, Milutin Stanacevic, Andrew S. Bowman, Pelagia-Irene Gouma> ;Plos One. 2021 Oct 28
280 citations
Comparative Effectiveness of Moderna, Pfizer-BioNTech, and Janssen (Johnson & Johnson) Vaccines in Preventing COVID-19 Hospitalizations Among Adults Without Immunocomp...
Wesley H. Self, Mark W Tenforde, Jillian P. Rhoads, Manjusha Gaglani, Adit A. Ginde, David J. Douin, Samantha M. Olson, H. Keipp Talbot, Jonathan D Casey, Nicholas M. ...> ;MMWR. Morbidity and Mortality Weekly Report. 2021 Sep 24
145 citations
Sustained Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Associated Hospitalizations Among Adults - United States, March-July 2021.
Mark W Tenforde, Wesley H. Self, Eric A. Naioti, Adit A. Ginde, David J. Douin, Samantha M. Olson, H. Keipp Talbot, Jonathan D Casey, Nicholas M. Mohr, Anne Zepeski, M...> ;MMWR. Morbidity and Mortality Weekly Report. 2021 Aug 27
7 citations
Influenza vaccine acceptance and hesitancy among adults hospitalized with severe acute respiratory illnesses, United States 2019-2020.
Kelsey L Lytle, Sean P. Collins, Leora R. Feldstein, Adrienne Baughman, Samuel M. Brown, Jonathan D Casey, Heidi L Erickson, Matthew C. Exline, D. Clark Files, Kevin W...> ;Vaccine. 2021 Aug 7
88 citations
Effectiveness of SARS-CoV-2 mRNA Vaccines for Preventing Covid-19 Hospitalizations in the United States.
Mark W Tenforde, Manish M. Patel, Adit A. Ginde, David J. Douin, H. Keipp Talbot, Jonathan D Casey, Nicholas M. Mohr, Anne Zepeski, Manjusha Gaglani, Tresa McNeal, She...> ;Clinical Infectious Diseases. 2021 Aug 6
91 citations
Effectiveness of SARS-CoV-2 mRNA Vaccines for Preventing Covid-19 Hospitalizations in the United States
Mark W Tenforde, Manish M. Patel, Adit A. Ginde, David J. Douin, H. Keipp Talbot, Jonathan D Casey, Nicholas M. Mohr, Anne Zepeski, Manjusha Gaglani, Tresa McNeal, She...> ;Medrxiv. 2021 Jul 8
4 citations
Reducing Unnecessary Laboratory Utilization in the Medical ICU: A Fellow-Driven Quality Improvement Initiative
Megan Conroy, Elie Homsy, Jennica N Johns, Kevin C. Patterson, Arindam Singha, Ryan Story, Geoffrey I. Finnegan, Kevin Shively, Kathrine Faherty, Matthew Gephart, Kari...> ;Critical Care Explorations. 2021 Jul 1
27 citations
Use of Continuous Glucose Monitor in Critically Ill COVID-19 Patients Requiring Insulin Infusion: An Observational Study.
Eileen R Faulds, Andrew S Boutsicaris, Lyndsey Sumner, Laureen Jones, Molly McNett, Keaton S. Smetana, Casey C. May, Elizabeth O. Buschur, Matthew C. Exline, Matthew D...> ;The Journal of Clinical Endocrinology and Metabolism. 2021 Sep 27
4 citations
Modeling the impacts of clinical influenza testing on influenza vaccine effectiveness estimates.
Leora R. Feldstein, Jill M. Ferdinands, Wesley H. Self, Adrienne G. Randolph, Michael S. Aboodi, Adrienne Baughman, Samuel M. Brown, Matthew C. Exline, D. Clark Files,...> ;The Journal of Infectious Diseases. 2021 May 20
14 citations
Influenza Vaccine Effectiveness for Prevention of Severe Influenza-Associated Illness Among Adults in the United States, 2019-2020: A Test-Negative Study.
Carlos G. Grijalva, Leora R. Feldstein, H. Keipp Talbot, Michael S. Aboodi, Adrienne Baughman, Samuel M. Brown, Jonathan D Casey, Heidi L Erickson, Matthew C. Exline, ...> ;Clinical Infectious Diseases. 2021 Oct 20
2 citations
Adults Hospitalized With Coronavirus Disease 2019 (COVID-19)-United States, March-June and October-December 2020: Implications for the Potential Effects of COVID-19 Ti...
Samira Sami, Mark W Tenforde, H. Keipp Talbot, Christopher J. Lindsell, Jay S. Steingrub, Nathan I. Shapiro, Adit A. Ginde, David J. Douin, Matthew E. Prekker, Heidi L...> ;Clinical Infectious Diseases. 2021 Jul 15
198 citations
Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Among Hospitalized Adults Aged ≥65 Years - United States, January-March 2021.
Mark W Tenforde, Samantha M. Olson, Wesley H. Self, H. Keipp Talbot, Christopher J. Lindsell, Jay S. Steingrub, Nathan I. Shapiro, Adit A. Ginde, David J. Douin, Matth...> ;MMWR. Morbidity and Mortality Weekly Report. 2021 May 7
2 citations
Cancer Is an Independent Risk Factor for Acute Respiratory Distress Syndrome in Critically Ill Patients: A Single Center Retrospective Cohort Study
Kevin Ho, Joshua Gordon, Kevin T Litzenberg, Matthew C. Exline, Joshua A. Englert, Derrick D. Herman> ;Journal of Intensive Care Medicine. 2021 Mar 29
22 citations
ICU Bed Utilization During the Coronavirus Disease 2019 Pandemic in a Multistate Analysis-March to June 2020.
David J. Douin, Michael J. Ward, Christopher J. Lindsell, Michelle P Howell, Catherine L. Hough, Matthew C. Exline, Michelle N. Gong, Michael S. Aboodi, Mark W Tenford...> ;Critical Care Explorations. 2021 Mar 12
1 citations
Evaluation of the Perceived Barriers and Facilitators to Timely Extubation of Critically Ill Adults: An Interprofessional Survey.
Michele C. Balas, Judith A. Tate, Alai Tan, Brennon Pinion, Matthew C. Exline> ;Worldviews on Evidence-Based Nursing. 2021 Jun 1
21 citations
Facilitators and Barriers to Nursing Implementation of Continuous Glucose Monitoring (CGM) in Critically Ill Patients With COVID-19.
Eileen R Faulds, Laureen Jones, Molly McNett, Keaton S. Smetana, Casey C. May, Lyndsey Sumner, Elizabeth O. Buschur, Matthew C. Exline, Matthew D. Ringel, Kathleen Dungan> ;Endocrine Practice. 2021 Jan 27
17 citations
Symptoms and recovery among adult outpatients with and without COVID-19 at 11 healthcare facilities-July 2020, United States.
Kiva A Fisher, Samantha M. Olson, Mark W Tenforde, Wesley H. Self, Michael Wu, Christopher J. Lindsell, Nathan I. Shapiro, D. Clark Files, Kevin W Gibbs, Heidi L Erick...> ;Influenza and Other Respiratory Viruses. 2021 Jan 6
2 citations
Diagnosing Dyspneic Older Adult Emergency Department Patients: A Pilot Study
Katherine M. Hunold, Andrew L. Schwaderer, Matthew C. Exline, Courtney Hebert, Brent C. Lampert, Lauren T. Southerland, Julie A. Stephens, Jason J. Bischof, Jeffrey M....> ;Academic Emergency Medicine. 2020 Nov 28
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Press Mentions

Greek Scientist Creates COVID Breathalyzer in the U.S.November 19th, 2021
New Breath Test Detects COVID in Just SecondsNovember 18th, 2021
Ohio State Breath Test Can Identify COVID-19 in Critically Ill PatientsNovember 9th, 2021
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