Matthew Philip Frosch MD PhD (He/Him)

Neuropathology, Anatomic Pathology

Lawrence J. Henderson Professor of Pathology, Harvard Medical School and Director, C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital

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55 Fruit StBoston, MA 02114
Phone+1 617-726-5156
Fax+1 617-724-1813

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Education & Training

Mass General BrighamFellowship, Neuropathology, 1990 - 1992
Mass General Brigham/Brigham and Women's HospitalResidency, Pathology-Anatomic and Clinical, 1987 - 1990
Harvard UniversityPhD, Biophysics, 1979 - 1987
Harvard Medical SchoolClass of 1987
Amherst CollegeBA, Chemistry, Summa cum laude, 1974 - 1978

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Certifications & Licensure

MA State Medical License 1988 - 2027
NH State Medical License 2022 - 2024
American Board of Pathology Anatomic Pathology
American Board of Pathology Neuropathology

Awards, Honors, & Recognition

President American Association of Neuropathologists, 2018-2019
Irving M. London Teaching Award Harvard-MIT Division of Health Sciences & Technology (HST), 2011
Donald O'Hara, PhD, Faculty Prize for Excellence in Teaching Harvard Medical School, 2011

Publications & Presentations

PubMed

Neuropathologic Features of Adult-Onset Progressive Leukodystrophy Due toPathogenic Variants: A Case Report.
Amanda Nagy, Michael S Marshall, Matthew P Frosch, Yedda Li, Melissa A Walker
Neurology. Genetics. 2026-10-01
Assessing AI and Neurologist Diagnostic Reasoning Against Neuropathological Ground Truth.
Yu Leng, Ayush Noori, John R Dickson, Alberto Serrano-Pozo, Marina Avetisyan
Medrxiv. 2026-07-10
Neuropathological study of the effects of aducanumab anti-Aβ immunotherapy on patients with Alzheimer's disease.
Lindsay A Welikovitch, Derek H Oakley, Rachel E Bennett, Alberto Serrano-Pozo, Haoyang Zhu
Acta Neuropathologica. 2026-06-16

Press Mentions

Is Alzheimer’s Disease Infectious?October 20th, 2020
Case 32-2019: A 70-Year-Old Woman with Rapidly Progressive AtaxiaOctober 17th, 2019
The Lancet: Zika Virus Identified in Brain and Placenta Tissue, Strengthening Link to Birth DefectsJune 29th, 2016