Matthew John Weiss MD

Hepatobiliary Surgery, Pancreas, Surgical Oncology (Other than Breast)

Deputy Physician-in-Chief & Surgical Director of Northwell Health Cancer Institute

Summary

Dr. Matthew Weiss is a general surgeon in New Hyde Park, NY and is affiliated with the Northwell Health System. He received his medical degree from Sidney Kimmel Medical College and has been in practice 14 years. He was previously the chief of hepatopancreatobiliary surgery at Johns Hopkins. He specializes in hepatobiliary surgery, pancreas, and surgical oncology (other than breast) and is experienced in trauma and surgical critical care, surgical oncology (non-breast), colorectal surgery, general / gastrointestinal surgery, and hepatopancreatobiliary surgery.

Memorial Sloan Kettering Cancer CenterFellowship, Complex General Surgical Oncology, 2010 - 2012
Johns Hopkins UniversityResidency, Surgery, 2003 - 2010
Massachusetts General HospitalPost-Doctoral Fellowship, 2005 - 2007
Sidney Kimmel Medical College at Thomas Jefferson UniversityClass of 2003

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory - Core EMR, Epic Systems Corporation, 2014, 2016-2017
CMS Meaningful Use Stage 2 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2014, 2016-2017
CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2014, 2016-2017

PubMed

Machine learning-based clustering differentiates bilateral hepatocellular carcinoma characteristics and prognosis.
Yutaka Endo, Jun Kawashima, Odysseas Chatzipanagiotou, Selamawit Woldesenbet, Federico Aucejo
Surgery. 2026-04-08
Implementing a System-Wide Comprehensive Cancer Navigation Program in a Rapidly Expanding Health System.
Julien T Hohenleitner, Shruti Koti, David Hyman, Kristen M Beyer, Tara McEvoy
JCO Oncology Practice. 2026-04-02
Utility of pancreatic tumor scrapings for organoid development and precision medicine strategies.
Caitlin F Tsang, Hardik Patel, Fatim M Kouassi, Binny Khandakar, Luce G St Surin
The Journal of Pathology. 2026-04-01

Journal Articles

Pancreatic Cancer Arising in the Remnant Pancreas Is Not Always a Relapse of the Preceding Primary
John L Cameron, Christopher L Wolfgang, Jin He, Matthew J Weiss, Ralph H Hruban, Michael Goggins, Nature
Single‐Cell Sequencing Defines Genetic Heterogeneity in Pancreatic Cancer Precursor Lesions
Kevin Waters, Jin He, Christopher L Wolfgang, Ralph H Hruban, Michael G Goggins, Matthew J Weiss, Justin Poling, The Journal of Pathology
Outcome of Patients with Borderline Resectable Pancreatic Cancer in the Contemporary Era of Neoadjuvant Chemotherapy
Alex B Blair, Joseph Herman, Martin Makary, John L Cameron, Amol Narang, Daniel Laheru, Christopher Wolfgang, Matthew J Weiss, Ammar A Javed, Jin He, Journal of gastrointestinal surgery

Lectures

BRAF V600E Mutation as a Negative Prognostic Determinant in Resected Colorectal Liver Metastases—Reply
ASCO Gastrointestinal Cancers Symposium - San Francisco, CA - 1/24/2020

Northwell Health Performs First New Liver Tumor Treatment on Long IslandJuly 25th, 2025
Northwell Cancer Institute Only Center on Long Island to Develop Program to Treat Liver Tumors With Noninvasive Targeted Ultrasound BeamsNovember 20th, 2024
Targeting Cancer’s Achilles HeelSeptember 9th, 2022