MatthewThomasWheelerMDPhD

Cardiology • Stanford, CA

Heart Failure & Transplantation, Cardiovascular Disease Genetics

Associate Professor of Cardiovascular Medicine at Stanford University

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Office
300 Pasteur Dr
Falk Cvrc
Stanford, CA 94305
Phone+1 650-723-6141

Fax+1 650-725-1599
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Education & Training

Stanford Health Care-Sponsored Stanford UniversityFellowship, Advanced Heart Failure and Transplant Cardiology, 2012 - 2013
Stanford Health Care-Sponsored Stanford UniversityFellowship, Cardiovascular Disease, 2007 - 2012
Stanford Health CarePost-Doctoral Fellowship, Stanford Prevention Research Center, 2007 - 2008
Stanford Health Care-Sponsored Stanford UniversityResidency, Internal Medicine, 2005 - 2007
University of Chicago Division of the Biological Sciences The Pritzker School of MedicineClass of 2005

Certifications & Licensure

CA State Medical License 2007 - 2024
American Board of Internal Medicine Advanced Heart Failure and Transplant Cardiology
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013

Clinical Trials

Study of Exercise Training in Hypertrophic Cardiomyopathy Start of enrollment: 2010 Apr 01
Completed
Not Applicable
Valsartan for Attenuating Disease Evolution In Early Sarcomeric HCM Start of enrollment: 2014 Mar 01
Completed
Phase 2
A Clinical Trial to Evaluate the HeartWare™ Ventricular Assist System (ENDURANCE SUPPLEMENTAL TRIAL) Start of enrollment: 2013 Oct 01
Completed
Not Applicable
Safety and Efficacy of Tafamidis in Patients With Transthyretin Cardiomyopathy Start of enrollment: 2013 Dec 09
Completed
Phase 3
Effect of Eleclazine (GS-6615) on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy Start of enrollment: 2015 Feb 05
Terminated
Phase 2, Phase 3
International Consortium for Multimodality Phenotyping in Adults With Non-compaction Start of enrollment: 2021 Jan 01
Recruiting
Roles: Contact
A Study of Mavacamten in Non-Obstructive Hypertrophic Cardiomyopathy Start of enrollment: 2022 Dec 14
Recruiting
Phase 3
Clinical and Genetic Evaluation of Individuals With Undiagnosed Disorders Through the Undiagnosed Diseases Network Start of enrollment: 2015 Sep 16
Recruiting
A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive HCM) Start of enrollment: 2022 Aug 16
Recruiting
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Publications & Presentations

PubMed

Quantifying assumptions underlying peak oxygen consumption equations across the body mass spectrum.
Vincent Busque, Jeffrey W Christle, Kegan J Moneghetti, Nicholas Cauwenberghs, Tatiana Kouznetsova, Yair Blumberg, Matthew T Wheeler, Euan Ashley, Francois Haddad, Jon...> ;Clinical Obesity. 2024 Mar 12
Knowledge and attitudes on implementing cardiovascular pharmacogenomic testing.
Callan Russell, MaryAnn Campion, Megan E Grove, Kelly Matsuda, Teri E Klein, Euan Ashley, Hetanshi Naik, Matthew T Wheeler, Stuart A Scott> ;Clinical and Translational Science. 2024 Mar 1
Prevalence of frequent premature ventricular contractions and nonsustained ventricular tachycardia in older women screened for atrial fibrillation in the Women's Healt...
Sofia E Gomez, Joseph Larson, Mark A Hlatky, Fatima Rodriguez, Matthew Wheeler, Philip Greenland, Michael LaMonte, Victor Froelicher, Marcia L Stefanick, Robert Wallac...> ;Heart Rhythm. 2024 Feb 23
Improving Reporting of Exercise Capacity Across Age Ranges Using Novel Workload Reference Equations.
Santana, E., Christle, J., Cauwenberghs, N., Peterman, J., Busque, V., Gomes, B., Moneghetti, K., Kuznetsova, T., Harber, M., Arena, R., Kaminsky, L., Myers, J., Baghe...> ;The American Journal of Cardiology. 2024 Mar 15
5 citations
Mavacamten Treatment for Symptomatic Obstructive Hypertrophic Cardiomyopathy: Interim Results From the MAVA-LTE Study, EXPLORER-LTE Cohort.
Rader, F., Oręziak, A., Choudhury, L., Saberi, S., Fermin, D., Wheeler, M., Abraham, T., Garcia-Pavia, P., Zwas, D., Masri, A., Owens, A., Hegde, S., Seidler, T., Fox,...> ;JACC. Heart Failure. 2024 Jan 1
Arrhythmias including atrial fibrillation and congenital heart disease in Kleefstra syndrome: a possible epigenetic link.
Sunil K Vasireddi, Tanja Zdolsek Draksler, Arianne Bouman, Joost Kummeling, Matthew Wheeler, Chloe Reuter, Siddharth Srivastava, Jacqueline Harris, Paul G Fisher, Sanj...> ;Europace. 2023 Dec 28
Quantitative metrics of the LV trabeculated layer by cardiac CT and cardiac MRI in patients with suspected noncompaction cardiomyopathy.
Manohar, A., Caliskan, K., Budde, R., Hirsch, A., Lee, S., Lee, W., Mistelbauer, G., Tang, W., Vigneault, D., Kwon, D., Owens, A., Litt, H., Haddad, F., Wheeler, M., R...> ;European Radiology. 2023 Dec 19
Assessing the Assisted Six-Minute Cycling Test as a Measure of Endurance in Non-Ambulatory Patients with Spinal Muscular Atrophy (SMA).
Tang, W., Gu, B., Montalvo, S., Dunaway Young, S., Parker, D., de Monts, C., Ataide, P., Ni Ghiollagain, N., Tesi Rocha, C., Christle, J., He, Z., Duong, T., Wheeler, ...> ;Journal of Clinical Medicine. 2023 Dec 8
Improved Cardiac Performance and Decreased Arrhythmia in Hypertrophic Cardiomyopathy With Non-β-Blocking R-Enantiomer Carvedilol.
Kinya Seo, Yuta Yamamoto, Anna Kirillova, Masataka Kawana, Sunil Yadav, Yong Huang, Qianru Wang, Kerry V Lane, Beth L Pruitt, Marco V Perez, Daniel Bernstein, Joseph C...> ;Circulation. 2023 Nov 21
1 citations
The functional impact of rare variation across the regulatory cascade.
Li, T., Li, T., Taibo Li, Nicole Ferraro, Benjamin J Strober, Francois Aguet, Silva Kasela, Marios Arvanitis, Bohan Ni, Laurens Wiel, Elliot Hershberg, Kristin Ardlie,...> ;Cell Genomics. 2023 Oct 11
1 citations
Personalized digital behaviour interventions increase short-term physical activity: a randomized control crossover trial substudy of the MyHeart Counts Cardiovascular ...
Ali Javed, Daniel Seung Kim, Steven G Hershman, Anna Shcherbina, Anders Johnson, Alexander Tolas, Jack W O'Sullivan, Michael V McConnell, Laura Lazzeroni, Abby C King,...> ;European Heart Journal. Digital Health. 2023 Oct 1
Generation of two induced pluripotent stem cell lines from Duchenne muscular dystrophy patients.
Wenqiang Liu, Wenshu Zeng, Xiaohui Kong, Min Htet, Rebecca Yu, Matthew Wheeler, John W Day, Joseph C Wu> ;Stem Cell Research. 2023 Oct 1
3 citations
Rare Variant Genetics and Dilated Cardiomyopathy Severity: The DCM Precision Medicine Study.
Hofmeyer, M. R., Mark Hofmeyer, Garrie J Haas, Elizabeth Jordan, Jinwen Cao, Evan Kransdorf, Gregory A Ewald, Alanna A Morris, Anjali Owens, Brian Lowes, Douglas Stoll...> ;Circulation. 2023 Sep 12
2 citations
Cardiac Remodeling in Subclinical Hypertrophic Cardiomyopathy: The VANISH Randomized Clinical Trial.
Christoffer Rasmus Vissing, Anna Axelsson Raja, Sharlene M Day, Mark W Russell, Kenneth Zahka, Harry M Lever, Alexandre C Pereira, Steven D Colan, Renee Margossian, An...> ;JAMA Cardiology. 2023 Nov 1
2 citations
A defect in mitochondrial fatty acid synthesis impairs iron metabolism and causes elevated ceramide levels.
Debdeep Dutta, Oguz Kanca, Seul Kee Byeon, Paul C Marcogliese, Zhongyuan Zuo, Rishi V Shridharan, Jun Hyoung Park, , Guang Lin, Ming Ge, Gali Heimer, Jennefer N Kohler...> ;Nature Metabolism. 2023 Sep 1
8 citations
Beyond the exome: What's next in diagnostic testing for Mendelian conditions.
Monica H Wojcik, Chloe M Reuter, Shruti Marwaha, Medhat Mahmoud, Michael H Duyzend, Hayk Barseghyan, Bo Yuan, Philip M Boone, Emily E Groopman, Emmanuèle C Délot, Deep...> ;American Journal of Human Genetics. 2023 Aug 3
2 citations
Genetic Architecture of Dilated Cardiomyopathy in Individuals of African and European Ancestry.
Elizabeth Jordan, Daniel D Kinnamon, Garrie J Haas, Mark Hofmeyer, Evan Kransdorf, Gregory A Ewald, Alanna A Morris, Anjali Owens, Brian Lowes, Douglas Stoller, W H Wi...> ;JAMA. 2023 Aug 1
Assessment of Oxygen Pulse in Hypertrophic Cardiomyopathy-Reply.
Matthew T Wheeler, Yu-Mao Chen, Jonathan Myers> ;JAMA Cardiology. 2023 Aug 1
Genomics Research with Undiagnosed Children: Ethical Challenges at the Boundaries of Research and Clinical Care.
Halley MC, Young JL, Tang C, Mintz KT, Lucas-Griffin S, Maghiro A, Ashley EA, Tabor HK, Undiagnosed Diseases Network> ;The Journal of pediatrics. 2023-06-02
4 citations
Screening for Dilated Cardiomyopathy in At-Risk First-Degree Relatives.
Hanyu Ni, Elizabeth Jordan, Daniel D Kinnamon, Jinwen Cao, Garrie J Haas, Mark Hofmeyer, Evan Kransdorf, Gregory A Ewald, Alanna A Morris, Anjali Owens, Brian Lowes, D...> ;Journal of the American College of Cardiology. 2023 May 30
Transforming Growth Factor-β Analysis of the VANISH Trial Cohort.
Yuri Kim, Mitra Mastali, Jennifer E Van Eyk, E John Orav, Christoffer R Vissing, Sharlene M Day, Anna Axelsson Raja, Mark W Russell, Kenneth Zahka, Harry M Lever, Alex...> ;Circulation. Heart Failure. 2023 Apr 1
4 citations
Effectiveness of theCommunication Tool in Improving Family Member Screening for Dilated Cardiomyopathy: Results of a Randomized Trial.
Hofmeyer, M. R., Daniel D Kinnamon, Elizabeth Jordan, Garrie J Haas, Mark Hofmeyer, Evan Kransdorf, Gregory A Ewald, Alanna A Morris, Anjali Owens, Brian Lowes, Dougla...> ;Circulation. 2023 Apr 25
1 citations
Plain Language Summary of Publication of the safety and efficacy of ARRY-371797 in people with dilated cardiomyopathy and a faultygene.
Calum A MacRae, Matthew Rg Taylor, Luisa Mestroni, John Moses, Euan A Ashley, Matthew T Wheeler, Neal K Lakdawala, Ray E Hershberger, Victor Sandor, Michael E Saunders...> ;Future Cardiology. 2023 Feb 1
10 citations
Effects of Mavacamten on Measures of Cardiopulmonary Exercise Testing Beyond Peak Oxygen Consumption: A Secondary Analysis of the EXPLORER-HCM Randomized Trial.
Matthew T Wheeler, Iacopo Olivotto, Perry M Elliott, Sara Saberi, Anjali T Owens, Mathew S Maurer, Ahmad Masri, Amy J Sehnert, Jay M Edelberg, Yu-Mao Chen, Victoria Fl...> ;JAMA Cardiology. 2023 Mar 1
15 citations
Beyond the exome: what's next in diagnostic testing for Mendelian conditions.
Monica H Wojcik, Chloe M Reuter, Shruti Marwaha, Medhat Mahmoud, Michael H Duyzend, Hayk Barseghyan, Bo Yuan, Philip M Boone, Emily E Groopman, Emmanuèle C Délot, Deep...> ;Arxiv. 2023 Jan 18
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Journal Articles

Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease
Carlos A Bacino, Vandana Shashi, Euan A Ashley, Cynthia J Tifft, William A Gahl, Brendan H Lee, John J Mulvihill, Rizwan Hamid, Matthew T Wheeler, Jonathan A Bernstein..., The New England Journal of Medicine
Original Investigation Editorial Comment Genome Sequencing in Hypertrophic Cardiomyopathy∗
Euan A Ashley, Matthew T Wheeler, Chloe M Reuter, ScienceDirect

Press Mentions

Intellia, with First Results, Delivers a 'Landmark' for CRISPR Gene EditingJune 26th, 2021
Fitness Trackers Accurately Measure Heart Rate but Not Calories BurnedMay 24th, 2017
DCM Precision Medicine StudyJanuary 31st, 2017

Grant Support

GREGoR Stanford SiteNHGRI2021–Present
Center for Undiagnosed Diseases at Stanford U01NINDS2014–Present

Professional Memberships

American Heart Association - AHA
Member
American Society of Human Genetics
Member

Hospital Affiliations

Stanford Health CarePalo Alto, California

External Links

Stanford Center for Inherited Cardiovascular Diseasehttp://familyheart.stanford.edu/
Stanford Amyloid Centerhttp://stanfordhealthcare.org/medical-clinics/amyloid-center.html
Stanford Program in Mechanical Circulatory Supporthttps://stanfordhealthcare.org/programs-services/mechanical-circulatory-support.html