MatthiasAngelosKarajannisMDMS

PubMed

• Hypofractionated re-irradiation for diffuse intrinsic pontine glioma.
  Nikhil P Mankuzhy, Kathryn R Tringale, Ira J Dunkel, Sameer Farouk Sait, Mark M Souweidane, Yasmin Khakoo, Matthias A Karajannis, Suzanne Wolden> ;Pediatric Blood & Cancer. 2024 May 1
• 1 citations
  Clinical outcome of pediatric medulloblastoma patients with Li-Fraumeni syndrome.
  Anna S Kolodziejczak, Lea Guerrini-Rousseau, Julien Masliah Planchon, Jonas Ecker, Florian Selt, Martin Mynarek, Denise Obrecht, Martin Sill, Robert J Autry, Eric Stut...> ;Neuro-Oncology. 2023 Dec 8
• Cotargeting Phosphoinositide 3-Kinase and Focal Adhesion Kinase Pathways Inhibits Proliferation of NF2 Schwannoma Cells.
  Haley M Hardin, Christine T Dinh, Julianne Huegel, Alejandra M Petrilli, Olena Bracho, Abdulrahman M Allaf, Matthias A Karajannis, Anthony J Griswold, Michael E Ivan, ...> ;Molecular Cancer Therapeutics. 2023 Nov 1
• Recurrent TRAK1::RAF1 Fusions in pediatric low-grade gliomas.
  Jamal K Benhamida, Hannah J Harmsen, Deqin Ma, Christopher M William, Bryan K Li, Liliana Villafania, Purvil Sukhadia, Kerry A Mullaney, Michael C Dewan, Efsevia Vakia...> ;Brain Pathology. 2023 Sep 1
• 2 citations
  Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors-A prospective study and guidelines...
  Galbraith, K., Vasudevaraja, V., Serrano, J., Shen, G., Tran, I., Abdallat, N., Wen, M., Patel, S., Movahed-Ezazi, M., Faustin, A., Spino-Keeton, M., Roberts, L., Malo...> ;Neuro-Oncology Advances. 2023 Jun 26
• 1 citations
  Leptomeningeal disease in histone-mutant gliomas.
  Maria Diaz, Satshil Rana, Carlos Eduardo Silva Correia, Anne S Reiner, Andrew L Lin, Alexandra M Miller, Maya S Graham, Sofia Chudsky, Tejus A Bale, Marc Rosenblum, Ma...> ;Neuro-Oncology Advances. 2023 May 29
• 2 citations
  Slipped capital femoral epiphyses: A major on-target adverse event associated with FGFR tyrosine kinase inhibitors in pediatric patients.
  Sameer Farouk Sait, Cheryl Fischer, Zoltan Antal, Krisoula Spatz, Daniel E Prince, Katarzyna Ibanez, Gerald G Behr, Ira J Dunkel, Matthias A Karajannis> ;Pediatric Blood & Cancer. 2023 May 9
• Cerebrospinal fluid: The new frontier for methylome-based diagnostic classification of brain tumors.
  Alexandra M Miller, Matthias A Karajannis> ;Neuro-Oncology. 2023 Aug 3
• 4 citations
  Multicenter, prospective, phase II study of maintenance bevacizumab for children and adults with NF2-related schwannomatosis and progressive vestibular schwannoma.
  Scott R Plotkin, Jeffrey Allen, Girish Dhall, Jian L Campian, D Wade Clapp, Michael J Fisher, Rakesh K Jain, James Tonsgard, Nicole J Ullrich, Coretta Thomas, Lloyd J ...> ;Neuro-Oncology. 2023 Aug 3
• 4 citations
  Treatment of Pediatric Low-Grade Gliomas.
  Sameer Farouk Sait, Alexandra M Giantini-Larsen, Kathryn R Tringale, Mark M Souweidane, Matthias A Karajannis> ;Current Neurology and Neuroscience Reports. 2023 Apr 1
• Outcomes of intraventricular 131-I-omburtamab and external beam radiotherapy in patients with recurrent medulloblastoma and ependymoma.
  Kathryn R Tringale, Suzanne L Wolden, Matthias Karajannis, Sofia Haque, Luca Pasquini, Onur Yildirim, Marc Rosenblum, Jamal K Benhamida, Nai-Kong Cheung, Mark Souweida...> ;Journal of Neuro-Oncology. 2023 Mar 1
• Phase II study of everolimus for recurrent or progressive pediatric ependymoma.
  Daniel C Bowers, Veena Rajaram, Matthias A Karajannis, Sharon L Gardner, Jack Meng-Fen Su, Patricia Baxter, Sonia Partap, Laura J Klesse> ;Neuro-Oncology Advances. 2023 Feb 10
• 5 citations
  Multi-institutional study of the frequency, genomic landscape, and outcome of IDH-mutant glioma in pediatrics.
  Kee Kiat Yeo, Sanda Alexandrescu, Jennifer A Cotter, Jayne Vogelzang, Varun Bhave, Marilyn M Li, Jianling Ji, Jamal K Benhamida, Marc K Rosenblum, Tejus A Bale, Nancy ...> ;Neuro-Oncology. 2023 Jan 5
• Lack of complete response pretransplant is not associated with inferior overall survival for stage 4a metastatic retinoblastoma.
  Sameer Farouk Sait, Mauricio Rendon Bernot, Elizabeth Klein, David H Abramson, Jasmine H Francis, Stephen Gilheeney, Matthias A Karajannis, Barbara Spitzer, Suzanne Wo...> ;Pediatric Blood & Cancer. 2023 Jan 1
• 1 citations
  Current Role and Future Potential of CSF ctDNA for the Diagnosis and Clinical Management of Pediatric Central Nervous System Tumors.
  Alexandra M Miller, Matthias A Karajannis> ;Journal of the National Comprehensive Cancer Network. 2022 Dec 1
• 3 citations
  Tapping into the genome: the role of CSF ctDNA liquid biopsy in glioma.
  Joshua S Friedman, Charli Ann J Hertz, Matthias A Karajannis, Alexandra M Miller> ;Neuro-Oncology Advances. 2022 Nov 1
• 7 citations
  Next-generation sequencing of cerebrospinal fluid for clinical molecular diagnostics in pediatric, adolescent and young adult brain tumor patients.
  Alexandra M Miller, Luca Szalontay, Nancy Bouvier, Katherine Hill, Hamza Ahmad, Johnathan Rafailov, Alex J Lee, M Irene Rodriguez-Sanchez, Onur Yildirim, Arti Patel, T...> ;Neuro-Oncology. 2022 Oct 3
• 1 citations
  YAP1-MAML2 fusion in a pediatric NF2-wildtype intraparenchymal brainstem schwannoma.
  Matthias A Karajannis, Bryan K Li, Mark M Souweidane, Benjamin Liechty, JinJuan Yao, Jamal K Benhamida, Tejus A Bale, Marc K Rosenblum> ;Acta Neuropathologica Communications. 2022 Aug 19
• 2 citations
  Chemotherapy plus focal radiation therapy for localized intracranial germinoma: How little is enough?
  Sameer Farouk Sait, Matthias A Karajannis> ;Neuro-Oncology. 2022 Jun 1
• 14 citations
  Upfront molecular targeted therapy for the treatment of BRAF-mutant pediatric high-grade glioma.
  Tom Rosenberg, Kee Kiat Yeo, Audrey Mauguen, Sanda Alexandrescu, Sanjay P Prabhu, Jessica W Tsai, Seth Malinowski, Mrinal Joshirao, Karishma Parikh, Sameer Farouk Sait...> ;Neuro-Oncology. 2022 Nov 2
• Carboplatin During Craniospinal Radiotherapy for Children With Group 3 Medulloblastoma-A New Standard of Care?
  Matthias A Karajannis, Audrey Mauguen, Kim Kramer> ;JAMA Oncology. 2022 Feb 1
• 11 citations
  Molecular profiling of pediatric meningiomas shows tumor characteristics distinct from adult meningiomas.
  Elmar Kirches, Felix Sahm, Andrey Korshunov, Christina Bluecher, Natalie Waldt, Siegfried Kropf, Daniel Schrimpf, Philipp Sievers, Damian Stichel, Ulrich Schüller, Jen...> ;Acta Neuropathologica. 2021 Sep 8
• 30 citations
  PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum
  Karam T. Alhalabi, Damian Stichel, Philipp Sievers, Heike Peterziel, Alexander C Sommerkamp, Dominik Sturm, Andrea Wittmann, Martin Sill, Natalie Jäger, Pengbo Beck, K...> ;Acta Neuropathologica. 2021 Aug 21
• 7 citations
  Phase 0 Clinical Trial of Everolimus in Patients with Vestibular Schwannoma or Meningioma.
  Matthias A. Karajannis, Audrey Mauguen, Ekrem Maloku, Qingwen Xu, Erin M. Dunbar, Scott R. Plotkin, Anna Yaffee, Shiyang Wang, J. Thomas Roland, Chandranath Sen, Dimit...> ;Molecular Cancer Therapeutics. 2021 Jun 17
• 10 citations
  Debio1347, an Oral FGFR Inhibitor: Results From a Single-Center Study in Pediatric Patients With Recurrent or Refractory FGFR-Altered Gliomas.
  Sameer Farouk Sait, Stephen Gilheeney, Tejus Bale, Sofia Haque, Marc Dinkin, Stephanie Vitolano, Marc K. Rosenblum, Katarzyna Ibanez, Daniel E. Prince, Krisoula Spatz,...> ;JCO Precision Oncology. 2021 May 20
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Journal Articles

• Heterogeneity Within the PF-EPN-B Ependymoma Subgroup  
  Andrew Grossbach, Vijay Ramaswamy, Benjamin Lu, Mariarita Santi, Caterina Giannini, Linda M Liau, Terri S Armstrong, Sarah Leary, Matthias A Karajannis, Kenneth Aldape..., Acta Neuropathologica
• Clinical Response to Bevacizumab in Schwannomatosis  
  Blakeley J, Schreck KC, Evans DG, Korf BR, Zagzag D, Karajannis MA, Bergner AL, Belzberg AJ, Neurology, 10/22/2014
• Phase II Study of Everolimus in Children and Adults with Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas  
  Karajannis MA, Legault G, Hagiwara M, Giancotti FP, Filatov A, Derman A, Hochman T, Goldberg JD, Vega E, Wisoff JH, Golfinos JG, Merkelson A, Roland JT, Allen JC, Neuro-Oncology, 1/1/2014
• Recurrent Ascites in a Pediatric Patient with Low-grade Astrocytoma and Ventriculo-peritoneal Shunt Treated with the Multi-kinase Inhibitor Sorafenib  
  Legault G, Kieran MW, Scott RM, Chordas C, Milla SS, Karajannis MA, Journal of Pediatric Hematology/Oncology, 1/1/2014
• Comprehensive Genomic Analysis of Diffuse Intrinsic Pontine Gliomas Unravels Three Molecular Subgroups and a Novel Cancer Driver ACVR1  
  Buczkowicz P, Hoeman C, Rakopoulos P, Pajovic S, Letourneau L, Dzamba M, Morrison A, Lewis P, Bouffet E, Bartels U, Zuccaro J, Agnihotri S, Ryall S, Barszczyk M, Chorn..., Nature Genetics, 1/1/2014
• CRL4DCAF1-mediated Inhibition of Lats1/2 Promotes YAP-dependent Oncogenesis in NF2 Mutant Tumor Cells  
  Li W, Cooper J, Zhou L, Yang C, Erdjument-Bromage H, Zagzag D, Snuderl M, Ladanyi M, Hanemann CO, Zhou P, Karajannis MA, Giancotti FG, Cancer Cell, 1/1/2014
• Glioblastoma Multiforme: State of the Art and Future Therapeutics  
  Wilson T, Karajannis MA, Harter DH, Surgical Neurology International, 1/1/2014
• Recurrent Somatic Alterations of FGFR1 and NTRK2 in Pilocytic Astrocytoma  
  Jones DTW, Hutter B, Jager N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Khuong Quang DA, Fontebasso A, Stutz AM, Hutter S, Zuckermann M, Sturm..., Nature Genetics, 1/1/2013
• Recurrence Patterns across Medulloblastoma Subgroups- an Integrated Clinical and Molecular Analysis  
  Ramaswamy V, Remke M, Bouffet E, Farial CC, Perreault S, Cho YJ, Shih D, Luu B, Dubuc AM, Northcott PA, Schuller U, Gururangan S, McLendon R, Bigner D, Fouladi M, Ligo..., Lancet Oncology, 1/1/2013
• Activation of MTORC1/mTORC2 Signaling in Pediatric Low Grade Glioma and Pilocytic Astrocytoma Reveals MTOR as a Therapeutic Target  
  Hutt-Cabezas M, Karajannis MA, Zagzag D, Shah S, Horkayne-Szakaly I, Rushing EJ, Cameron JD, Jain D, Eberhart CG, Raabe EH, Rodriguez FJ, Neuro-Oncology, 1/1/2013
• Recommendations for Imaging Tumor Response in Neurofibromatosis Clinical Trials  
  Dombi E, Ardern-Holmes SL, Babovic-Vuksanovic D, Barker FG, Connor S, Evans DG, Fisher MJ, Goutagny S, Harris GJ, Jaramillo D, Karajannis MA, Korf BR, Mautner V, Plotk..., Neurology, 1/1/2013
• Consensus Recommendations for Current Treatments and Accelerating Clinical Trials for Patients with Neurofibromatosis Type 2  
  Blakeley JO, Evans DG, Adler J, Brackmann D, Chen R, Ferner RE, Hanemann CO, Harris G, Huson SM, Jacob A, Kalamarides M, Karajannis MA, Korf BR, Mautner VF, McClatchey..., American Journal of Medical Genetics, 1/1/2012
• BRAF Alterations in Primary Glial and Glioneuronal Neoplasms of the Central Nervous System with Identification of Two Novel KIAA1549:BRAF Fusion Variants  
  Lin A, Rodriguez FJ, Karajannis MA, Williams SC, Legault G, Zagzag D, Burger PC, Allen JC, Eberhart CG, Bar E, Journal of Neuropathology and Experimental Neurology, 1/1/2012
• Phase II Clinical Trial of Lapatinib in Adult and Pediatric Patients with Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas  
  Karajannis MA, Legault G, Hagiwara M, Ballas MS, Brown K, Nusbaum AO, Hochman T, Goldberg JD, Koch KM, Golfinos JG, Roland JT, Allen JC, Neuro-Oncology, 1/1/2012
• MicroRNA Profiling in Pediatric Pilocytic Astrocytoma Reveals Biologically Relevant Targets including PBX3, NFIB, and METAP2  
  Ho CY, Bar E, Giannini C, Karajannis MA, Zagzag D, Eberhart CG, Rodriguez FJ, Neuro-Oncology, 1/1/2012
• Merlin: A Tumor Suppressor with Functions at the Cell Cortex and in the Nucleus  
  Li W, Cooper J, Karajannis, MA, Giancotti FG, EMBO Reports, 1/1/2012
• ErbB/HER Receptor Activation and Preclinical Efficacy of Lapatinib in Vestibular Schwannoma  
  Ammoun S, Cunliffe CH, Allen JC, Chiriboga L, Giancotti FG, Zagzag D, Hanemann CO, Karajannis MA, Neuro-Oncology, 1/1/2010
• Overexpression and Activation of Epidermal Growth Factor Receptor in Hemangioblastomas  
  Chen GJ, Karajannis MA, Newcomb EW, Zagzag D, Journal of Neuro-Oncology, 1/1/2010
• Bevacizumab in Recurrent High-grade Pediatric Gliomas  
  Narayana A, Kunnakkat S, Chacko-Mathew J, Gardner S, Karajannis M, Raza S, Wisoff J, Weiner H, Harter D, Allen J, Neuro-Oncology, 1/1/2010
• Prospective Neuraxis MRI Surveillance Reveals a High Risk of Leptomeningeal Dissemination in Diffuse Intrinsic Pontine Glioma  
  Sethi R, Allen J, Donahue B, Karajannis M, Gardner S, Wisoff J, Kunnakkat S, Mathew J, Zagzag D, Newman K, Narayana A, Journal of Neuro-Oncology, 1/1/2010
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  Williams SC, Karajannis MA, Chiriboga L, Golfinos JG, von Deimling A, Zagzag D, Acta Neuropathologica, 1/1/2010
• Synchronous Mixed Germ Cell Tumor of the Pineal Gland and Suprasellar Region with a Predominant Angiomatous Component: A Diagnostic Challenge  
  Cunliffe CH, Fischer I, Karajannis M, Monoky D, Allen J, Wisoff J, Zagzag D, Journal of Neuro-Oncology, 1/1/2009
• Consensus Recommendations to Accelerate Clinical Trials for Neurofibromatosis Type 2  
  Evans DG, Kalamarides M, Hunter-Schaedle K, Blakeley J, Allen J, Babovic-Vuskanovic D, Belzberg A, Bollag G, Chen R, Ditomaso E, Golfinos J, Harris G, Jacob A, Kalpana..., Clinical Cancer Research, 1/1/2009
• The Microtubule Targeting Agent, CA4P, Regresses Leukemic Xenografts by Disrupting Interaction with Vascular Cells and Mitochondrial-dependent Cell Death  
  Petit I, Karajannis MA, Vincent L, Young LM, Butler J, Hooper AT, Shido K, Steller H, Chaplin DJ, Feldman E, Rafii S, Blood, 1/1/2008
• Treatment of Pediatric Brain Tumors  
  Karajannis M, Allen JC, Newcomb EW, Journal of Cellular Physiology, 1/1/2008
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Books/Book Chapters

• Neurofibromatosis Type 1: Symptoms, Treatment and Prognosis 
  Editors: Karajannis MA and Allen JC.Nova Science Publishers, New York2013
• Bradley's Neurology in Clinical Practice 
  Chapter: Management of Primary Nervous System Tumors in Infants and Children 
  Karajannis MA, Gardner SL, Allen JCEditors: Daroff RB et al.Elsevier Science, PhiladelphiaEdition 6th,2012
• Genome and Proteome in Oncology 
  Chapter: Epstein-Barr Virus Infection and Viral Gene Expression in Pediatric Non-Hodgkin Lymphomas 
  Karajannis MA, Hummel M, Oschlies I, Anagnostopoulos I, Zimmermann M, Parwaresch R, Reiter, AEditors: Stathopoulou FT.Nova Science Publishers, New York2005

Abstracts/Posters

• Her2 Amplification or Polysomy Chromosome 17 (PCH17) in Pilocytic Astrocytoma
  Michael Deel M, McLendon R, Becher O, Karajannis M, Wisoff J, Muh C, Schroeder K, Gururangan S, 16th International Symposium on Pediatric Neuro-Oncology, Singapore, 6/1/2014
• DNA Methylation Profiling identifies New Tumor Subgroups and Aids Diagnostic Accuracy in a Clinical Neuropathology Setting
  Jones DTW, Capper D, Sill M, Hovestadt V, Schweizer L, Lichter P, Zagzag D, Karajannis MA, Aldape KD, Korshunov A, von Deimling A, Pfister S, 16th International Symposium on Pediatric Neuro-Oncology, Singapore, 6/1/2014
• Molecular Subgroups of Paediatric Ependymoma
  Witt H, Mack S, Jones DTW, Jager N, Bender S, Ryzhova M, Northcott PA, Remke M, Pfaff E, Tzaridis T, Sill M, Benner A, Isserlin R, Milde T, Gupta N, Karajannis M, Fult..., 44th Congress of the International Society of Paediatric Oncology (SIOP), London, UK, 10/1/2012
• Intratumoral Concentration and Molecular Pharmacodynamics of Lapatinib in vivo in Sporadic and NF2-related Vestibular Schwannomas
  Karajannis MA, Bergner A, Giovannini A, Welling DB, Niparko J, Slattery W, Roland JT, Golfinos J, Allen J, Blakeley J, 15th International Symposium on Pediatric Neuro-Oncology, Toronto, Canada, 6/1/2012
• The Genetic Heterogeneity of Posterior Fossa Ependymoma
  Witt H, Mack S, Jager N, Jones DT, Bender S, Stutz A, Milde T, Northcott PA, Fults DW, Gupta N, Karajannis M, Kulozik AE, Deimling AV, Witt O, Rutka JT, Lichter P, Kor..., 15th International Symposium on Pediatric Neuro-Oncology, Toronto, Canada, 6/1/2012
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Lectures

• Genomics, Personalized Medicine and Acoustic Neuroma 
  Berkeley Heights, NJ - 10/28/2014
• Everolimus for Vestibular Schwannomas and Meningiomas: Updates from the Phase 2 and Phase 0 Trials 
  Washington, DC - 6/8/2014
• Exploring the Clinical and Molecular Activity of Everolimus in Vestibular Schwannomas and Meningiomas: Updates from the Phase 2 and Phase 0 Studies 
  Boston, MA - 6/5/2014
• Chemotherapy 
  Boston, MA - 6/5/2014
• Neurofibromatosis Type 2: Clinical Management, Molecular Pathways and Novel Therapies 
  Nationwide Children's Hospital, Columbus, OH - 1/16/2014
• Non-surgical Therapies for NF2-related Tumors 
  NYU Langone Medical Center, New York, NY - 6/21/2013
• Phase II Study of Everolimus in Children and Adults with Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas 
  Monterey, CA - 6/9/2013
• Radiation Therapy and Chemotherapy for Vestibular Schwannomas 
  Monterey, CA - 6/8/2013
• Neurofibromatosis Type 2: Genes, Pathways and Novel Therapies 
  University of Texas Southwestern, Dallas, TX - 3/19/2013
• NF2 Medical Therapies and Clinical Trials 
  New York, NY - 10/27/2012
• Study Concept for the New COG High-Grade Glioma Study 
  Atlanta, GA - 9/13/2012
• Exploring New Agents for Pediatric Low-Grade Gliomas: Sorafenib Phase II Study 
  Atlanta, GA - 9/12/2012
• Intratumoral Concentration and Molecular Pharmacodynamics of Lapatinib in vivo in Sporadic and NF2-related Vestibular Schwannomas 
  Toronto, Canada - 6/27/2012
• NF2 Clinical Trials NF2 Clinical Trials with Molecular Targeted Agents 
  New Orleans, LA - 6/11/2012
• Use of EGFR/ErbB2 Inhibitors in NF2 and Results from the Lapatinib Phase II Clinical Trial 
  Manchester, UK - 5/21/2012
• The Comprehensive NF Center at NYU: Clinical Management of NF2 and Development of Novel Therapies 
  SUNY Downstate Medical Center, Brooklyn, NY - 4/13/2012
• Pediatric Low-Grade Gliomas 
  Woodhull Medical Center, Brooklyn, NY - 12/10/2011
• Developing Molecular Targeted Therapies for Neurofibromatosis Type 2-related Tumors 
  Memorial Sloan-Kettering Cancer Center, New York, NY - 11/6/2011
• Intratumoral Concentration and Molecular Pharmacodynamics of Lapatinib in Sporadic and NF2-related Vestibular Schwannomas 
  New York Academy of Medicine, New York, NY - 10/28/2011
• Neurofibromatosis Type 2 at the NYU Comprehensive NF Center: Clinical Management and Development of Molecular Targeted Therapies 
  German Cancer Research Center, Heidelberg, Germany - 8/30/2011
• Of Mice and Men: Mouse Models in the Development of Molecular Targeted Therapies for Human Cancer 
  Jackson Hole, WY - 6/13/2011
• Neurofibromatosis Type 2: Diagnosis, Clinical Management and Novel Therapies 
  NYU Langone Medical Center, New York, NY - 1/15/2011
• Neurofibromatosis Type 2: Clinical Features, Genetics, Biology and Novel Therapies 
  Woodhull Medical Center, Brooklyn, NY - 12/10/2010
• Phase II Clinical Trial of Lapatinib in Children and Adults with NF2 and Progressive Vestibular Schwannomas 
  New York Academy of Medicine, New York, NY - 10/22/2010
• A Comprehensive Clinic Model for Neurofibromatosis Type 2: Patient Care Delivery at the NYU NF Center 
  Chicago, IL - 10/16/2010
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Other

• Tumours of the Central Nervous System: Hemangioblastoma 
  Zagzag D, Weiner H, Karajannis M, Milla S, PubCan: A Public Database of Human Cancers
  http://www.pubcan.org
  1/1/2010