MatthiasKretzlerMD

PubMed

• Neuronally differentiated macula densa cells regulate tissue remodeling and regeneration in the kidney.
  Georgina Gyarmati, Urvi Nikhil Shroff, Anne Riquier-Brison, Dorinne Desposito, Wenjun Ju, Sean D Stocker, Audrey Izuhara, Sachin Deepak, Alejandra Becerra Calderon, Ja...> ;The Journal of Clinical Investigation. 2024 Apr 10
• The authors reply.
  Ju, W., Heerspink, H., Kretzler, M., Bjornstad, P.> ;Kidney International. 2024 Mar 1
• Multi-omics data integration shines a light on the renal medulla.
  Smith, C., Hodgin, J., Kretzler, M.> ;Kidney International. 2024 Feb 1
• 1 citations
  Rationale and design of the Nephrotic Syndrome Study Network (NEPTUNE) Match in glomerular diseases: designing the right trial for the right patient, today.
  Trachtman, H., Desmond, H., Williams, A., Mariani, L., Eddy, S., Ju, W., Barisoni, L., Ascani, H., Uhlmann, W., Spino, C., Holzman, L., Sedor, J., Gadegbeku, C., Subra...> ;Kidney International. 2024 Feb 1
• Unbiased kidney-centric molecular categorization of chronic kidney disease as a step towards precision medicine.
  Reznichenko, A., Nair, V., Eddy, S., Fermin, D., Tomilo, M., Slidel, T., Ju, W., Henry, I., Badal, S., Wesley, J., Liles, J., Moosmang, S., Williams, J., Quinn, C., Bi...> ;Kidney International. 2024 Jan 27
• WNT-dependent interaction between inflammatory fibroblasts and FOLR2+ macrophages promotes fibrosis in chronic kidney disease.
  Cohen, C., Mhaidly, R., Croizer, H., Kieffer, Y., Leclere, R., Vincent-Salomon, A., Robley, C., Anglicheau, D., Rabant, M., Sannier, A., Timsit, M., Eddy, S., Ju, W., ...> ;Nature Communications. 2024 Jan 25
• Pediatric contributions and lessons learned from the NEPTUNE cohort study.
  Zhai, Y., Desmond, H., Hao, W., Sethna, C., , Modi, Z., Yee, J., Sampson, M., Wang, C., Gipson, D., Trachtman, H., Kretzler, M.> ;Pediatric Nephrology. 2024 Jan 18
• The chromatin landscape of healthy and injured cell types in the human kidney.
  Gisch, D., Brennan, M., Lake, B., Basta, J., Keller, M., Melo Ferreira, R., Akilesh, S., Ghag, R., Lu, C., Cheng, Y., Collins, K., Parikh, S., Rovin, B., Robbins, L., ...> ;Nature Communications. 2024 Jan 10
• TRPC6 Inhibitor BI 764198 in Focal Segmental Glomerulosclerosis: Phase 2 Study Design.
  Desmond, H., Choi, W., Manuel, R., Soleymanlou, N., Trachtman, H., Kretzler, M.> ;Kidney International Reports. 2023 Dec 1
• 3 citations
  Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease.
  Yask Gupta, David J Friedman, Michelle T McNulty, Atlas Khan, Brandon Lane, Chen Wang, Juntao Ke, Gina Jin, Benjamin Wooden, Andrea L Knob, Tze Y Lim, Gerald B Appel, ...> ;Nature Communications. 2023 Nov 30
• Interactive Effects of Empagliflozin and Hyperglycemia on Urinary Amino Acids in Individuals With Type 1 Diabetes.
  Luxcia Kugathasan, Vikas S Sridhar, Leif Erik Lovblom, Shane Matta, Afaf Saliba, Subrata Debnath, Fadhl M AlAkwaa, Viji Nair, Petter Bjornstad, Matthias Kretzler, Bruc...> ;Diabetes. 2024 Mar 1
• FSGS Recurrence Collaboration: Report of a Symposium.
  Debbie S Gipson, Chia-Shi Wang, Eloise Salmon, Rasheed Gbadegesin, Abhijit Naik, Simone Sanna-Cherchi, Alessia Fornoni, Matthias Kretzler, Sandra Merscher, Paul Hoover...> ;Glomerular Diseases. 2023 Nov 14
• Tubular dysfunction impairs renal excretion of pseudouridine in diabetic kidney disease.
  Anna V Mathew, Pradeep Kayampilly, Jaeman Byun, Viji Nair, Farsad Afshinnia, Biaoxin Chai, Frank C Brosius 3rd, Matthias Kretzler, Subramaniam Pennathur> ;American Journal of Physiology. Renal Physiology. 2024 Jan 1
• 3 citations
  Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients.
  Sharma, K., Zhang, G., Hansen, J., Bjornstad, P., Lee, H., Menon, R., Hejazi, L., Liu, J., Franzone, A., Looker, H., Choi, B., Fernandez, R., Venkatachalam, M., Kugath...> ;The Journal of Clinical Investigation. 2023 Oct 16
• 1 citations
  Precision Medicine in Nephrology: An Integrative Framework of Multidimensional Data in the Kidney Precision Medicine Project.
  Tarek M El-Achkar, Michael T Eadon, Matthias Kretzler, Jonathan Himmelfarb> ;American Journal of Kidney Diseases. 2024 Mar 1
• Transcriptomic analysis of diabetic kidney disease and neuropathy in mouse models of type 1 and type 2 diabetes.
  Sarah E Elzinga, Stephanie A Eid, Brett A McGregor, Dae-Gyu Jang, Lucy M Hinder, Jacqueline R Dauch, John M Hayes, Hongyu Zhang, Kai Guo, Subramaniam Pennathur, Matthi...> ;Disease Models & Mechanisms. 2023 Oct 1
• Assessment of the Needs of Nephrology Divisions to Implement Return of Clinically Significant Research Genetic Results: A Survey of Nephrotic Syndrome Study Network (N...
  Jennifer E Fishbein, Loryn Wilson Dass, Chrysta Lienczewski, Matthias Kretzler, Rasheed A Gbadegesin, J Scott Roberts, , Matthew G Sampson, Wendy R Uhlmann> ;Glomerular Diseases. 2023 Aug 21
• 3 citations
  An integrated organoid omics map extends modeling potential of kidney disease.
  Moritz Lassé, Jamal El Saghir, Celine C Berthier, Sean Eddy, Matthew Fischer, Sandra D Laufer, Dominik Kylies, Arvid Hutzfeldt, Léna Lydie Bonin, Bernhard Dumoulin, Ra...> ;Nature Communications. 2023 Aug 14
• 2 citations
  Clustering-based spatial analysis (CluSA) framework through graph neural network for chronic kidney disease prediction using histopathology images.
  Joonsang Lee, Elisa Warner, Salma Shaikhouni, Markus Bitzer, Matthias Kretzler, Debbie Gipson, Subramaniam Pennathur, Keith Bellovich, Zeenat Bhat, Crystal Gadegbeku, ...> ;Scientific Reports. 2023 Aug 5
• 2 citations
  Sodium glucose co-transporter 2 inhibition increases epidermal growth factor expression and improves outcomes in patients with type 2 diabetes.
  Taha Sen, Wenjun Ju, Viji Nair, Patricia Ladd, Rajasree Menon, Edgar A Otto, Laura Pyle, Tim Vigers, Robert G Nelson, Clare Arnott, Bruce Neal, Michael K Hansen, Matth...> ;Kidney International. 2023 Oct 1
• 110 citations
  An atlas of healthy and injured cell states and niches in the human kidney.
  Blue B Lake, Rajasree Menon, Seth Winfree, Qiwen Hu, Ricardo Melo Ferreira, Kian Kalhor, Daria Barwinska, Edgar A Otto, Michael Ferkowicz, Dinh Diep, Nongluk Plongthon...> ;Nature. 2023 Jul 1
• Clinical Course of Adult FSGS and Minimal Change Disease in North American and Japanese Cohorts.
  Takaya Ozeki, Brenda W Gillespie, Maria Larkina, Shoichi Maruyama, Fadhl Alakwaa, Matthias Kretzler, Laura H Mariani> ;Kidney360. 2023 Jul 1
• 7 citations
  The deacylase sirtuin 5 reduces malonylation in nonmitochondrial metabolic pathways in diabetic kidney disease.
  Judy Baek, Kelli Sas, Chenchen He, Viji Nair, William Giblin, Ayaka Inoki, Hongyu Zhang, Yang Yingbao, Jeffrey Hodgin, Robert G Nelson, Frank C Brosius 3rd, Matthias K...> ;The Journal of Biological Chemistry. 2023 Mar 1
• 2 citations
  Rapid Progression of Focal Segmental Glomerulosclerosis in Patients with High-Risk APOL1 Genotypes.
  Mahmoud Kallash, Yujie Wang, Abigail Smith, Howard Trachtman, Rasheed Gbadegesin, Carla Nester, Pietro Canetta, Chen Wang, Tracy E Hunley, C John Sperati, David Selews...> ;Clinical Journal of the American Society of Nephrology. 2023 Mar 1
• 15 citations
  SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes.
  Jennifer A Schaub, Fadhl M AlAkwaa, Phillip J McCown, Abhijit S Naik, Viji Nair, Sean Eddy, Rajasree Menon, Edgar A Otto, Dawit Demeke, John Hartman, Damian Fermin, Ch...> ;The Journal of Clinical Investigation. 2023 Mar 1
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Journal Articles

• An Integrative Systems Biology Approach for Precision Medicine in Diabetic Kidney Disease  
  Matthias Kretzler, MD, Diabetes, Obesity and Metabolism
• Renal Matrix Gla Protein Expression Increases Progressively with CKD and Predicts Renal Outcome  
  Ramanath Dukkipati, Matthias Kretzler, Cynthia C Nast, Tiane Dai, Sharon G Adler, ScienceDirect
• Transethnic, Genome-Wide Analysis Reveals Immune-Related Risk Alleles and Phenotypic Correlates in Pediatric Steroid-Sensitive Nephrotic Syndrome  
  Matthew G Sampson, Matthias Kretzler, Journal of the American Society of Nephrology

Abstracts/Posters

• Validation of Plasma Biomarker Candidates for the Prediction of eGFR Decline in Patients with Type 2 Diabetes
  Matthias Kretzler, MD, Diabetes Care, Orlando, FL, 12/8/2019

Lectures

• Beating the Law of Averages: Predicting Diabetic Kidney Disease Outcomes Through Integrative Biology 
  American Society of Nephrology Kidney Week 2019 - Washington, D.C. - 11/10/2019