MaureenReneeHortonMD

Pulmonology • Baltimore, MD

Critical Care Medicine, Interstitial Lung Diseases, Restrictive Lung Disease

Professor of Medicine, Johns Hopkins University School of Medicine

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Office
The Johns Hopkins Hospital
601 N. Caroline St. 1830 Building 5th Floor Pulmonary
Baltimore, MD 21287
Phone+1 410-955-4176

Fax+1 410-614-1652
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Education & Training

Johns Hopkins UniversityFellowship, Pulmonary Disease and Critical Care Medicine, 1995 - 1999
Johns Hopkins UniversityResidency, Internal Medicine, 1992 - 1995
Johns Hopkins University School of MedicineClass of 1992

Certifications & Licensure

CA State Medical License 2022 - 2026
MD State Medical License 1995 - 2022
National Board of Physicians and Surgeons Critical Care Medicine
National Board of Physicians and Surgeons Internal Medicine
National Board of Physicians and Surgeons Pulmonary Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013-2014

Clinical Trials

Treatment of Idiopathic Pulmonary Fibrosis With Thalidomide Start of enrollment: 2003 Oct 01
Completed
Phase 2
Treatment of Chronic Cough in Idiopathic Pulmonary Fibrosis With Thalidomide Start of enrollment: 2007 Dec 01
Completed
Phase 3
A Trial to Investigate Recovery From COVID-19 With C21 in Adult Subjects Start of enrollment: 2021 Sep 16
Completed
Phase 3

Publications & Presentations

PubMed

Adoptive transfer of CD49aTissue resident memory cells reverses pulmonary fibrosis in mice.
Samuel L Collins, Yee Chan-Li, Astrid Gillich, Andrew M Nelson, Jeffrey M Loube, Wayne A Mitzner, Kevin Shenderov, Jonathan D Powell, Maureen R Horton> ;Biorxiv. 2024 Mar 14
20 citations
Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in mice
Mithilesh Kumar Jha, Joseph V. Passero, Atul Rawat, Xanthe Heifetz Ament, Fang Yang, Svetlana Vidensky, Samuel L. Collins, Maureen R. Horton, Ahmet Hoke, Guy A. Rutter...> ;The Journal of Clinical Investigation. 2021 Nov 1
23 citations
mTORC1 Signaling Regulates Proinflammatory Macrophage Function and Metabolism.
Samuel L. Collins, Min Hee Oh, Im Hong Sun, Yee Chan-Li, Liang Zhao, Jonathan D. Powell, Maureen R. Horton> ;Journal of Immunology. 2021 Jul 21
6 citations
Airway compliance measurements in mouse models of respiratory diseases
Annette Robichaud, Liah Fereydoonzad, Samuel L. Collins, Jeffrey Martin Loube, Yumiko Ishii, Maureen R. Horton, James G. Martin, Wayne Mitzner> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2021 May 19
69 citations
Metabolic programs define dysfunctional immune responses in severe COVID-19 patients.
Elizabeth A. Thompson, Katherine Cascino, Alvaro A. Ordonez, Weiqiang Zhou, Ajay Vaghasia, Anne Hamacher-Brady, Nathan R. Brady, Im Hong Sun, Rulin Wang, Avi Z. Rosenb...> ;Cell Reports. 2021 Mar 16
91 citations
Immune dysregulation as a driver of idiopathic pulmonary fibrosis.
Kevin Shenderov, Samuel L. Collins, Jonathan D. Powell, Maureen R. Horton> ;The Journal of Clinical Investigation. 2021 Jan 19
37 citations
Mitochondrial induced T cell apoptosis and aberrant myeloid metabolic programs define distinct immune cell subsets during acute and recovered SARS-CoV-2 infection
Elizabeth A. Thompson, Katherine Cascino, Alvaro A. Ordonez, Weiqiang Zhou, Ajay Vaghasia, Anne Hamacher-Brady, Nathan R. Brady, Im-Hong Sun, Rulin Wang, Avi Z. Rosenb...> ;Medrxiv. 2020 Oct 5
103 citations
Takotsubo Syndrome in the Setting of COVID-19.
Anum S. Minhas, Paul J. Scheel, Brian T. Garibaldi, Gigi Liu, Maureen R. Horton, Mark T. Jennings, Steven R. Jones, Erin D. Michos, Allison G. Hays> ;JACC. Case Reports. 2020 Jul 15
187 citations
Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells
Min Hee Oh, Im Hong Sun, Liang Zhao, Robert Leone, Im Meng Sun, Wei Xu, Samuel L. Collins, Ada J. Tam, Richard L. Blosser, Chirag H. Patel, Judson Englert, Matthew L. ...> ;The Journal of Clinical Investigation. 2020 Jul 1
6 citations
Equity and diversity in academic medicine: a perspective from the JCI editors
Linda M.S. Resar, Elizabeth M. Jaffee, Mary Armanios, Sarah Jackson, Nilofer S. Azad, Maureen R. Horton, Mariana J. Kaplan, Marikki Laiho, Marcela V. Maus, Charlotte J...> ;The Journal of Clinical Investigation. 2019 Oct 1
138 citations
Targeting metabolism to regulate immune responses in autoimmunity and cancer.
Chirag H. Patel, Robert Leone, Maureen R. Horton, Jonathan D. Powell> ;Nature Reviews. Drug Discovery. 2019 Jul 30
27 citations
Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma
Jong-Sung Park, Yumin Oh, Yong Joo Park, Ogyi Park, Hoseong S. Yang, Stephanie Slania, Laura K. Hummers, Ami A. Shah, Hyoung Tae An, Jiyeon Jang, Maureen R. Horton, Jo...> ;Nature Communications. 2019 Mar 8
11 citations
Inhibition of glutamine metabolism accelerates resolution of acute lung injury.
Christine L. Vigeland, Henry S. Beggs, Samuel L. Collins, Yee Chan-Li, Jonathan D. Powell, Claire M. Doerschuk, Maureen R. Horton> ;Physiological Reports. 2019 Mar 1
43 citations
mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages.
Min Hee Oh, Samuel L. Collins, Im Hong Sun, Ada J. Tam, Chirag H. Patel, Matthew L. Arwood, Yee Chan-Li, Jonathan D. Powell, Maureen R. Horton> ;Cell Reports. 2017 Sep 5
17 citations
Exploration of the MUC5B promoter variant and ILD risk in patients with autoimmune myositis.
Cheilonda Johnson, Paul Rosen, Thomas E. Lloyd, Maureen R. Horton, Lisa Christopher-Stine, Chester V. Oddis, Andrew L. Mammen, Sonye K. Danoff> ;Respiratory Medicine. 2017 Sep 1
26 citations
Loss of macrophage fatty acid oxidation does not potentiate systemic metabolic dysfunction
Elsie Gonzalez-Hurtado, Jieun Lee, Joseph Choi, Ebru S. Selen Alpergin, Samuel L. Collins, Maureen R. Horton, Michael J. Wolfgang> ;American Journal of Physiology. Endocrinology and Metabolism. 2017 May 1
27 citations
Metabolic variations in normal and fibrotic human laryngotracheal‐derived fibroblasts: A Warburg‐like effect
Garret Ma, Idris Samad, Kevin M. Motz, Linda X. Yin, Madhavi Duvvuri, Dacheng Ding, Daryan R. Namba, Jennifer H. Elisseeff, Maureen R. Horton, Alexander T. Hillel> ;The Laryngoscope. 2017 Mar 1
14 citations
CNS-targeted autoimmunity leads to increased influenza mortality in mice.
Justin D. Glenn, Matthew D. Smith, Pei Xue, Yee Chan-Li, Samuel L. Collins, Peter A. Calabresi, Maureen R. Horton, Katharine A. Whartenby> ;The Journal of Experimental Medicine. 2017 Jan 5
87 citations
MTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis
Robert W. Hallowell, Samuel L. Collins, John M. Craig, Yan Zhang, Min Hee Oh, Peter B. Illei, Yee Chan-Li, Christine L. Vigeland, Wayne Mitzner, Alan L. Scott, Jonatha...> ;Nature Communications. 2017 Jan 27
22 citations
Etiology and treatment of cough in idiopathic pulmonary fibrosis.
Christine L. Vigeland, Andrew H. Hughes, Maureen R. Horton> ;Respiratory Medicine. 2017 Feb 1
4 citations
Deletion of mTORC1 Activity in CD4+ T Cells Is Associated with Lung Fibrosis and Increased γδ T Cells.
Christine L. Vigeland, Samuel L. Collins, Yee Chan-Li, Andrew H. Hughes, Min Hee Oh, Jonathan D. Powell, Maureen R. Horton> ;Plos One. 2016 Sep 20
4 citations
Cough in idiopathic pulmonary fibrosis: more than just a nuisance
Christine L. Vigeland, Maureen R. Horton> ;The Lancet. Respiratory Medicine. 2016 Aug 1
1 citations
Correction: Immunological Priming Requires Regulatory T Cells and IL-10-Producing Macrophages To Accelerate Resolution from Severe Lung Inflammation.
Neil R. Aggarwal, Kenji Tsushima, Yoshiki Eto, Ashutosh Tripathi, Pooja Mandke, Jason R. Mock, Brian T. Garibaldi, Benjamin D. Singer, Venkataramana K. Sidhaye, Mauree...> ;Journal of Immunology. 2016 May 1
19 citations
Vaccinia vaccine–based immunotherapy arrests and reverses established pulmonary fibrosis
Samuel L. Collins, Yee Chan-Li, Min Hee Oh, Christine L. Vigeland, Nathachit Limjunyawong, Wayne Mitzner, Jonathan D. Powell, Maureen R. Horton> ;JCI Insight. 2016 Apr 7
29 citations
Dysregulated macrophages are present in bleomycin-induced murine laryngotracheal stenosis
Alexander T. Hillel, Idris Samad, Garret Ma, Dacheng Ding, Kaitlyn Sadtler, Jonathan D. Powell, Andrew P. Lane, Maureen R. Horton> ;Otolaryngology--Head and Neck Surgery. 2015 Jun 17
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Press Mentions

Study Testing App to Ease Anxiety Opens Nationwide EnrollmentDecember 2nd, 2022
Vicore Trial Testing New AI App for Anxiety in IPF Enrolls 1st PatientApril 29th, 2022
Vicore to Host R&D DayMarch 4th, 2022
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