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3500 Civic Center BlvdPhiladelphia, PA 19104
Dr. Ruffner is on Doximity
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Education & Training
Children's Hospital of PhiladelphiaFellowship, Allergy and Immunology, 2014 - 2017- Children's Hospital of PhiladelphiaResidency, Pediatrics, 2011 - 2014
University of Pittsburgh School of MedicineClass of 2011
Certifications & Licensure
NJ State Medical License 2025 - 2027
PA State Medical License 2014 - 2026
American Board of Allergy and Immunology Allergy & Immunology
American Board of Pediatrics Pediatrics
Publications & Presentations
PubMed
- Multitrait analysis of genome-wide association studies expands eosinophilic esophagitis genetic susceptibility and polygenic risk scores.Michael P Trimarchi, Bahram Namjou-Khales, Netali Ben-Baruch Morgenstern, Mark Rochman, Xiaoting Chen
The Journal of Allergy and Clinical Immunology. 2026-08-01 - Clinical heterogeneity and endotype stratification in eosinophilic esophagitis.Tetsuo Shoda, Melanie A Ruffner
Annals of Allergy, Asthma & Immunology. 2026-08-01 - Age-Appropriate Low Dosing for Food Protein-Induced Enterocolitis Syndrome Oral Food Challenges: Proposing a Standardized Approach.Sara Anvari, Mary Grace Baker, Theresa Bingemann, J Andrew Bird, Terri Brown-Whitehorn
The Journal of Allergy and Clinical Immunology. in Practice. 2026-07-01
Journal Articles
- Original Article Food Protein-Induced Enterocolitis Syndrome Food Challenges: Experience from a Large Referral CenterJennifer Heimall, Nicholas A Pawlowski, Jonathan M Spergel, Antonella Cianferoni, Joel Fiedler, Melanie A Ruffner, Rushani W Saltzman, Gita S Ram, ScienceDirect
- A Review of Tertiary Referrals for Management of Pediatric Esophageal EosinophiliaAmanda B Muir, Chris Liacouras, Jonathan M Spergel, Atu Agawu, Melanie A Ruffner, Ritu Verma, Joshua Eisenberg, Antonella Cianferoni, Frontiers in Neurology
Press Mentions
Real Talk: Eosinophilic DiseasesApril 30th, 2025- Three Penn Undergraduates: Goldwater ScholarsApril 13th, 2021
Children Are More Likely to Have Other Allergies if They Have FPIESMarch 6th, 2020
Grant Support
- Defining the impact of type 1 cytokine signaling on STAT-mediated epithelial reprogramming and barrier dysfunction in eosinophilic esophagitisCHILDREN'S HOSP OF PHILADELPHIA2025–2029
- Epigenetic regulation of esophageal epithelial barrier function in eosinophilic esophagitisCHILDREN'S HOSP OF PHILADELPHIA2020–2024
- IL-4 Overexpressing Dendritic Cells And Exosomes For Treatment Of Type 1 DiabetesNational Institute Of Diabetes And Digestive And Kidney Diseases2008–2010
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